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R. Klevitsky · SciRah

Researcher profile · Semantic Scholar

R. Klevitsky

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R. Klevitsky — researcher profile on SciRah

h-index: 36
Works: 60
Citations: 7,272

Most-cited papers

The MEK1–ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice
O. Bueno, L. D. de Windt, Kevin M. Tymitz, S. Witt +8 more
2000EMBO Journal820 citations Open access
Semantic Scholar
PKC-α regulates cardiac contractility and propensity toward heart failure
Julian C. Braz, Kimberly N. Gregory, Anand Pathak, Wen Zhao +17 more
2004Nature Medicine561 citations
Semantic Scholar
GDF15/MIC-1 Functions As a Protective and Antihypertrophic Factor Released From the Myocardium in Association With SMAD Protein Activation
Jian Xu, T. Kimball, J. Lorenz, D. Brown +5 more
2006Circulation Research509 citations
Semantic Scholar
Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure.
Hiroyuki Nakayama, Xiong-Wen Chen, C. Baines, R. Klevitsky +8 more
2007Journal of Clinical Investigation441 citations Open access
Semantic Scholar
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling.
Julian C. Braz, O. Bueno, Qiang-Rong Liang, B. Wilkins +8 more
2003Journal of Clinical Investigation348 citations Open access
Semantic Scholar
PKC-alpha regulates cardiac contractility and propensity toward heart failure.
Julian C. Braz, Kimberly N. Gregory, Anand Pathak, Wen Zhao +17 more
2004Nature Medicine347 citations
Semantic Scholar
Expression of R120G–αB-Crystallin Causes Aberrant Desmin and αB-Crystallin Aggregation and Cardiomyopathy in Mice
Xue-Jun Wang, H. Osińska, R. Klevitsky, A. Gerdes +4 more
2001284 citations Open access
Semantic Scholar
Cardiac Myosin-Binding Protein-C Phosphorylation and Cardiac Function
S. Sadayappan, J. Gulick, H. Osińska, Lisa A Martin +6 more
2005Circulation Research255 citations Open access
Semantic Scholar
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart.
J. Heineke, M. Auger-Messier, Jian Xu, T. Oka +9 more
2007Journal of Clinical Investigation244 citations Open access
Semantic Scholar
Cardiac myosin binding protein c phosphorylation is cardioprotective
S. Sadayappan, H. Osińska, R. Klevitsky, J. Lorenz +5 more
2006Proceedings of the National Academy of Sciences of the United States of America227 citations Open access
Semantic Scholar
A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy.
Qinglin Yang, A. Sanbe, H. Osińska, T. Hewett +2 more
1998Journal of Clinical Investigation208 citations Open access
Semantic Scholar
Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1.
Mark A Sussman, S. Welch, A. Walker, R. Klevitsky +4 more
2000Journal of Clinical Investigation197 citations Open access
Semantic Scholar
Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice.
Mark A Sussman, S. Welch, N. Cambon, R. Klevitsky +4 more
1998Journal of Clinical Investigation174 citations Open access
Semantic Scholar
Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice.
X. Wang, H. Osińska, R. Klevitsky, A. Gerdes +4 more
2001Circulation Research172 citations
Semantic Scholar
Cardiomyocyte Expression of a Polyglutamine Preamyloid Oligomer Causes Heart Failure
J. S. Pattison, A. Sanbe, A. Maloyan, H. Osińska +2 more
2008Circulation154 citations Open access
Semantic Scholar
Transgenic modeling of a cardiac troponin I mutation linked to familial hypertrophic cardiomyopathy.
J. James, Yan Zhang, H. Osińska, A. Sanbe +3 more
2000Circulation Research150 citations Open access
Semantic Scholar
Pharmacological- and Gene Therapy–Based Inhibition of Protein Kinase Cα/β Enhances Cardiac Contractility and Attenuates Heart Failure
Michael A. Hambleton, H. Hahn, S. Pleger, M. Kuhn +7 more
2006140 citations Open access
Semantic Scholar
Genetic Inhibition or Activation of JNK1/2 Protects the Myocardium from Ischemia-Reperfusion-induced Cell Death in Vivo*
R. A. Kaiser, Qiang-Rong Liang, O. Bueno, Yuan Huang +4 more
2005Journal of Biological Chemistry133 citations Open access
Semantic Scholar
Cardiac-Specific Overexpression of Fibroblast Growth Factor-2 Protects Against Myocardial Dysfunction and Infarction in a Murine Model of Low-Flow Ischemia
S. House, Craig S. Bolte, Ming Zhou, T. Doetschman +3 more
2003Circulation124 citations
Semantic Scholar
&agr;B-Crystallin Modulates Protein Aggregation of Abnormal Desmin
Xue-Jun Wang, R. Klevitsky, Wei Huang, Joseph W. Glasford +2 more
2003Circulation Research118 citations Open access
Semantic Scholar
Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy.
A. Sanbe, H. Osińska, C. Villa, J. Gulick +4 more
2005Proceedings of the National Academy of Sciences of the United States of America117 citations Open access
Semantic Scholar
Cardiac Myosin Binding Protein-C Phosphorylation in a “Humanized” Mouse Heart
S. Sadayappan, J. Gulick, R. Klevitsky, J. Lorenz +3 more
2009Circulation113 citations Open access
Semantic Scholar
Analysis of Myosin Heavy Chain Functionality in the Heart*
M. Krenz, A. Sanbe, F. Bouyer-Dalloz, J. Gulick +11 more
2003Journal of Biological Chemistry109 citations Open access
Semantic Scholar
In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy.
Qinglin Yang, A. Sanbe, H. Osińska, T. Hewett +2 more
1999Circulation Research104 citations Open access
Semantic Scholar
Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice.
Melissa C. Colbert, D. G. Hall, Thomas R. Kimball, S. Witt +5 more
1997Journal of Clinical Investigation104 citations Open access
Semantic Scholar
A treadmill exercise regimen for identifying cardiovascular phenotypes in transgenic mice.
J. Fewell, H. Osińska, R. Klevitsky, W. Ng +3 more
1997American Journal of Physiology101 citations
Semantic Scholar
Transgenic remodeling of the regulatory myosin light chains in the mammalian heart.
J. Gulick, T. Hewett, R. Klevitsky, Scott H. Buck +2 more
1997Circulation Research101 citations
Semantic Scholar
Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice.
J. Fewell, T. Hewett, A. Sanbe, R. Klevitsky +4 more
1998Journal of Clinical Investigation92 citations Open access
Semantic Scholar
Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure.
Michael A. Hambleton, Harvey Hahn, S. Pleger, M. Kuhn +7 more
2006Circulation88 citations
Semantic Scholar
Forced Expression of &agr;-Myosin Heavy Chain in the Rabbit Ventricle Results in Cardioprotection Under Cardiomyopathic Conditions
J. James, Lisa A Martin, M. Krenz, C. Quatman +4 more
2005Circulation83 citations Open access
Semantic Scholar
Proinflammatory consequences of transgenic fas ligand expression in the heart.
D. Nelson, E. Setser, D. G. Hall, S. Schwartz +6 more
2000Journal of Clinical Investigation82 citations Open access
Semantic Scholar
Transgenic Rabbit Model for Human Troponin I–Based Hypertrophic Cardiomyopathy
A. Sanbe, J. James, V. Tuzcu, Selman Nas +10 more
2005Circulation78 citations Open access
Semantic Scholar
Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved
Lei Wei, G. Taffet, D. Khoury, J. Bo +10 more
2004The FASEB Journal52 citations
Semantic Scholar
Expression of the neural cell adhesion molecule (NCAM) and polysialic acid during taste bud degeneration and regeneration
David V. Smith, R. Klevitsky, R. Akeson, M. T. Shipley
1994The Journal of comparative neurology49 citations
Semantic Scholar
In Vivo Analysis of an Essential Myosin Light Chain Mutation Linked to Familial Hypertrophic Cardiomyopathy
A. Sanbe, D. Nelson, J. Gulick, E. Setser +7 more
2000Circulation Research48 citations Open access
Semantic Scholar
PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice.
Qinglin Yang, T. Hewett, R. Klevitsky, A. Sanbe +2 more
2001Cardiovascular Research37 citations
Semantic Scholar
Transgenic Over-Expression of a Motor Protein at High Levels Results in Severe Cardiac Pathology
J. James, H. Osińska, T. Hewett, T. Kimball +5 more
1999Transgenic research36 citations
Semantic Scholar
Role of the acidic N′ region of cardiac troponin I in regulating myocardial function
S. Sadayappan, N. Finley, Jack W. Howarth, H. Osińska +4 more
2008The FASEB Journal34 citations Open access
Semantic Scholar
Myosin light chain replacement in the heart.
A. Sanbe, J. Gulick, E. Hayes, D. Warshaw +4 more
2000American Journal of Physiology. Heart and Circulatory Physiology33 citations
Semantic Scholar
Phospholamban overexpression in transgenic rabbits
J. S. Pattison, Jason R. Waggoner, J. James, Lisa A Martin +5 more
2008Transgenic research32 citations Open access
Semantic Scholar
Taste bud expression of human blood group antigens
David V. Smith, R. Klevitsky, R. Akeson, M. T. Shipley
1994The Journal of comparative neurology30 citations
Semantic Scholar
Phenotypic deficits in mice expressing a myosin binding protein C lacking the titin and myosin binding domains.
Qinglin Yang, H. Osińska, R. Klevitsky, J. Robbins
2001Journal of Molecular and Cellular Cardiology29 citations
Semantic Scholar
Transgenic rabbits expressing mutant essential light chain do not develop hypertrophic cardiomyopathy.
J. James, Yan Zhang, Kathy Wright, Sra Witt +7 more
2002Journal of Molecular and Cellular Cardiology26 citations
Semantic Scholar
Charged residue changes in the carboxy‐terminus of α‐tropomyosin alter mouse cardiac muscle contractility
Robert D. Gaffin, K. Gokulan, J. Sacchettini, T. Hewett +3 more
2004Journal of Physiology24 citations Open access
Semantic Scholar
Transgenic overexpression of cardiac actin in the mouse heart suggests coregulation of cardiac, skeletal and vascular actin expression
A. Kumar, K. Crawford, R. Flick, R. Klevitsky +4 more
2004Transgenic research23 citations
Semantic Scholar
Genetic manipulation of the rabbit heart via transgenesis.
J. James, A. Sanbe, K. Yager, Lisa A Martin +2 more
2000Circulation21 citations Open access
Semantic Scholar
Hypertrophic defect unmasked by calcineurin expression in asymptomatic tropomodulin overexpressing transgenic mice.
Mark A Sussman, S. Welch, A. Walker, R. Klevitsky +6 more
2000Cardiovascular Research13 citations Open access
Semantic Scholar
Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics.
R. Gaffin, K. Gokulan, J. Sacchettini, T. Hewett +6 more
2006American Journal of Physiology. Heart and Circulatory Physiology8 citations
Semantic Scholar
Charged residue alterations in the inner‐core domain and carboxy‐terminus of α‐tropomyosin differentially affect mouse cardiac muscle contractility
Robert D. Gaffin, C. Tong, D. Zawieja, T. Hewett +3 more
2004Journal of Physiology8 citations
Semantic Scholar
Lethal cardiomyopathy in juvenile mice caused by tropomodulin overexpression
Mark A Sussman, N. Cambon, T. Hewett, R. Klevitsky +2 more
19971 citations
Semantic Scholar

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J. Robbins×28
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J. Robbins — researcher profile on SciRah
H. Osińska×21
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H. Osińska — researcher profile on SciRah
T. Hewett×16
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T. Hewett — researcher profile on SciRah
T. Hewett×13
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J. Gulick — researcher profile on SciRah

J. Molkentin×10

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J. Lorenz — researcher profile on SciRah

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A. Sanbe — researcher profile on SciRah

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J. James — researcher profile on SciRah

Jeffrey Robbins×7

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Jeffrey Robbins — researcher profile on SciRah

Lisa A Martin×6

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Lisa A Martin — researcher profile on SciRah

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A. Sanbe — researcher profile on SciRah