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S. Mukund · SciRah

Researcher profile · Semantic Scholar

S. Mukund

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S. Mukund — researcher profile on SciRah

h-index: 19
Works: 35
Citations: 2,082

Most-cited papers

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability
Benjamin E. L. Lauffer, R. Mintzer, R. Fong, S. Mukund +15 more
2013Journal of Biological Chemistry342 citations Open access
Semantic Scholar
Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist
S. Ahuja, S. Mukund, L. Deng, Kuldip Khakh +31 more
2015Science313 citations
Semantic Scholar
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
I. Wertz, K. Newton, D. Seshasayee, Saritha Kusam +30 more
2015Nature244 citations
Semantic Scholar
Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design.
E. Lansdon, K. Brendza, Magdeleine Hung, Ruth Wang +5 more
2010Journal of Medicinal Chemistry226 citations
Semantic Scholar
Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.
Anthony A. Estrada, Xing-Rong Liu, C. Baker-Glenn, A. Beresford +35 more
2012Journal of Medicinal Chemistry151 citations Open access
Semantic Scholar
Molecular basis for negative regulation of the glucagon receptor
C. Koth, J. Murray, S. Mukund, Azadeh Madjidi +10 more
2012Proceedings of the National Academy of Sciences of the United States of America123 citations Open access
Semantic Scholar
Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding
Aaron H. Nile, S. Mukund, Karen Stanger, Wei-Ru Wang +1 more
2017Proceedings of the National Academy of Sciences of the United States of America107 citations Open access
Semantic Scholar
Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions
E. Chiang, Tian-Bo Li, S. Jeet, I. Peng +10 more
2017Nature Communications97 citations Open access
Semantic Scholar
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells
Aaron H. Nile, F. de Sousa e Melo, S. Mukund, R. Piskol +14 more
2018Nature Chemical Biology76 citations
Semantic Scholar
AMG 193, a Clinical Stage MTA-Cooperative PRMT5 Inhibitor, Drives Antitumor Activity Preclinically and in Patients with MTAP-Deleted Cancers
B. Belmontes, K. Slemmons, Chun Su, Si-Yuan Liu +37 more
2024Cancer Discovery63 citations Open access
Semantic Scholar
Mechanistic studies on Hsp90 inhibition by ansamycin derivatives.
S. Onuoha, S. Mukund, E. Coulstock, Blanka Sengerová +3 more
2007Journal of Molecular Biology57 citations
Semantic Scholar
Evaluation of the immunocontraceptive potential of Escherichia coli-expressed recombinant dog ZP2 and ZP3 in a homologous animal model.
N. Srivastava, R. Santhanam, P. Sheela, S. Mukund +3 more
2002Reproduction56 citations Open access
Semantic Scholar
Affinities between the Binding Partners of the HIV-1 Integrase Dimer-Lens Epithelium-derived Growth Factor (IN Dimer-LEDGF) Complex
M. Tsiang, Gregg S. Jones, Magdeleine Hung, S. Mukund +10 more
2009Journal of Biological Chemistry54 citations Open access
Semantic Scholar
Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor
S. Mukund, Yonglei Shang, Holly J. Clarke, Azadeh Madjidi +10 more
2013Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Amino terminus of Plasmodium falciparum acidic basic repeat antigen interacts with the erythrocyte membrane through band 3 protein.
A. Kushwaha, Ashiya Perween, S. Mukund, Sumana Majumdar +3 more
2002Molecular and biochemical parasitology (Print)30 citations
Semantic Scholar
R-State AMP Complex Reveals Initial Steps of the Quaternary Transition of Fructose-1,6-bisphosphatase*
C. Iancu, S. Mukund, H. Fromm, R. Honzatko
2005Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Discovery of AMG 193, an MTA-Cooperative PRMT5 Inhibitor for the Treatment of MTAP-Deleted Cancers.
L. Pettus, Matthew P. Bourbeau, Nuria A. Tamayo, A. Amegadzie +48 more
2025Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation.
M. Tsiang, Gregg S. Jones, Magdeleine Hung, D. Samuel +9 more
2011Biochemistry20 citations Open access
Semantic Scholar
From DNA-Encoded Library Screening to AM-9747: An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy
Ian Sarvary, Mikkel Vestergaard, Loris Moretti, Jan Andersson +39 more
2025Journal of Medicinal Chemistry19 citations Open access
Semantic Scholar
MTA-cooperative PRMT5 inhibitors from cofactor-directed DNA-encoded library screens
Jan Andersson, Sanne Cowland, Mikkel Vestergaard, Yajing Yang +17 more
2025Proceedings of the National Academy of Sciences of the United States of America7 citations
Semantic Scholar
Abstract 1807: The discovery and preclinical characterization of the MTA cooperative PRMT5 inhibitor AM-9747
B. Belmontes, A. Policheni, Siyuan Liu, K. Slemmons +16 more
2022Cancer Research4 citations
Semantic Scholar
Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
I. Wertz, K. Newton, D. Seshasayee, Saritha Kusam +30 more
2016Nature3 citations Open access
Semantic Scholar
Abstract B177: The discovery and preclinical characterization of AMG 193, a first-in-class MTA-cooperative PRMT5 inhibitor with broad activity against MTAP-null cancers
B. Belmontes, K. Slemmons, Si-Yuan Liu, Antonia N Policheni +18 more
2023Molecular Cancer Therapeutics2 citations
Semantic Scholar
Publisher Correction: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells
Aaron H. Nile, F. de Sousa e Melo, S. Mukund, R. Piskol +14 more
2018Nature Chemical Biology1 citations Open access
Semantic Scholar
AMG193: Discovery and Structural basis for MTA cooperative inhibition of PRMT5(Work done at Amgen with PRMT5 Team)
S. Mukund
2025Structural Dynamics0 citations Open access
Semantic Scholar
Structural basis for allostery in porcine liver fructose-1,6-bisphosphatase
S. Mukund
20200 citations
Semantic Scholar
Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21
Aaron H. Nile, S. Mukund, R. Hannoush, Wei-Ru Wang
20180 citations
Semantic Scholar
Solution structure of phage derived peptide inhibitor of frizzled 7 receptor
Aaron H. Nile, F. de Sousa e Melo, S. Mukund, R. Piskol +14 more
20180 citations
Semantic Scholar
Crystal structure of Frizzled 7 CRD in complex with C24 fatty acid
S. Mukund, Aaron H. Nile, Karen Stanger, R. Hannoush +1 more
20170 citations
Semantic Scholar
Crystal structure of Frizzled 7 CRD
S. Mukund, Aaron H. Nile, Karen Stanger, R. H. Hannous +1 more
20170 citations
Semantic Scholar
Crystal structure of Frizzled 5 CRD in complex with BOG
S. Mukund, Aaron H. Nile, Karen Stanger, R. Hannoush +1 more
20170 citations
Semantic Scholar
Cell Viability Cellular Histone Acetylation but Not Kinetic Rate Constants Correlate with Histone Deacetylase ( HDAC ) Inhibitor Cell Biology :
Steiner, Kaminker, Christopher E. Heise, Pascal +18 more
20130 citations
Semantic Scholar
Unliganded crystal structure of mAb7
J. Murray, S. Mukund
20130 citations
Semantic Scholar
Crystal Structure of AMP complexes of Porcine Liver Fructose-1,6-bisphosphatase Mutant I10D in T-state
C. Iancu, S. Mukund, J. Choe, H. Fromm +1 more
20130 citations
Semantic Scholar
R‐ to T‐ Transition in Fructose‐1,6‐bisphosphatase: Loop Displacement is the Penultimate Step to Inactivation
Yang Gao, C. Iancu, S. Mukund, Richard B. Honzatko
20100 citations
Semantic Scholar

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