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A. Jeltsch · SciRah

Researcher profile · Semantic Scholar

A. Jeltsch

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A. Jeltsch — researcher profile on SciRah

h-index: 75
Works: 312
Citations: 22K

Most-cited papers

Efficient targeted DNA methylation with chimeric dCas9–Dnmt3a–Dnmt3L methyltransferase
Peter Stepper, G. Kungulovski, R. Jurkowska, T. Chandra +5 more
2016Nucleic Acids Research297 citations Open access
Semantic Scholar
Epigenome Editing: State of the Art, Concepts, and Perspectives.
G. Kungulovski, A. Jeltsch
2016Trends in Genetics191 citations
Semantic Scholar
Allosteric control of mammalian DNA methyltransferases – a new regulatory paradigm
A. Jeltsch, R. Jurkowska
2016Nucleic Acids Research188 citations Open access
Semantic Scholar
Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation
A. Jeltsch, A. Ehrenhofer-Murray, T. Jurkowski, F. Lyko +5 more
2016RNA Biology187 citations Open access
Semantic Scholar
Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.
Laure Ferry, A. Fournier, Takeshi Tsusaka, G. Adelmant +18 more
2017Molecules and Cells178 citations Open access
Semantic Scholar
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
Linfeng Gao, Max Emperle, Yi-Ran Guo, Sara A. Grimm +16 more
2020Nature Communications169 citations Open access
Semantic Scholar
Mammalian DNA methyltransferases: new discoveries and open questions
H. Gowher, A. Jeltsch
2018Biochemical Society Transactions135 citations Open access
Semantic Scholar
The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes
E. Davydova, T. Shimazu, Maren Kirstin Schuhmacher, Magnus E. Jakobsson +24 more
2021Nature Communications100 citations Open access
Semantic Scholar
The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates
Magnus E. Jakobsson, J. Malecki, L. Halabelian, Benedikt S. Nilges +10 more
2018Nature Communications95 citations Open access
Semantic Scholar
Targeted epigenome editing of an endogenous locus with chromatin modifiers is not stably maintained
G. Kungulovski, S. Nunna, M. Thomas, U. Zanger +2 more
2015Epigenetics & Chromatin92 citations Open access
Semantic Scholar
H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1
R. Jurkowska, S. Qin, G. Kungulovski, W. Tempel +13 more
2017Nature Communications87 citations Open access
Semantic Scholar
Evolutionary analysis indicates that DNA alkylation damage is a byproduct of cytosine DNA methyltransferase activity
Silvana Rosic, R. Amouroux, Cristina E. Requena, A. Gomes +11 more
2018Nature Genetics83 citations Open access
Semantic Scholar
Cytosine methylation of tRNA-Asp by DNMT2 has a role in translation of proteins containing poly-Asp sequences
Raghuvaran Shanmugam, J. Fierer, Steffen Kaiser, M. Helm +2 more
2015Cell Discovery82 citations Open access
Semantic Scholar
H3K36me2/3 binding and DNA binding of the DNA methyltransferase DNMT3A PWWP domain both contribute to its chromatin interaction.
Michael Dukatz, Katharina Holzer, Michel Choudalakis, Max Emperle +3 more
2019Journal of Molecular Biology74 citations
Semantic Scholar
DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation
Sabrina Adam, H. Anteneh, Maximilian Hornisch, Vincent Wagner +5 more
2020Nature Communications72 citations Open access
Semantic Scholar
Modular fluorescence complementation sensors for live cell detection of epigenetic signals at endogenous genomic sites
Cristiana Lungu, Sabine Pinter, Julian Broche, Philipp Rathert +1 more
2017Nature Communications65 citations Open access
Semantic Scholar
Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes
A. Jeltsch, Julian Broche, P. Bashtrykov
2018Genes62 citations Open access
Semantic Scholar
Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns
Max Emperle, Sabrina Adam, Stefan Kunert, Michael Dukatz +5 more
2019Nucleic Acids Research59 citations Open access
Semantic Scholar
The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA
Steffen Kaiser, T. Jurkowski, Stefanie M. Kellner, D. Schneider +2 more
2016RNA Biology59 citations Open access
Semantic Scholar
PWWP-DOMAIN INTERACTOR OF POLYCOMBS1 Interacts with Polycomb-Group Proteins and Histones and Regulates Arabidopsis Flowering and Development
Mareike L. Hohenstatt, P. Mikulski, O. Komarynets, Constanze Klose +4 more
2018The Plant Cell57 citations Open access
Semantic Scholar
Cocaine-induced chromatin modifications associate with increased expression and 3D looping of Auts2
Olivia Engmann, B. Labonté, A. Mitchell, P. Bashtrykov +16 more
2017Biological Psychiatry53 citations Open access
Semantic Scholar
Activity and specificity of the human SUV39H2 protein lysine methyltransferase.
Maren Kirstin Schuhmacher, Srikanth Kudithipudi, Denis Kušević, Sara Weirich +1 more
2015Biochimica et Biophysica Acta50 citations
Semantic Scholar
Enzymology of Mammalian DNA Methyltransferases.
R. Jurkowska, A. Jeltsch
2016Advances in Experimental Medicine and Biology49 citations
Semantic Scholar
Engineering of Effector Domains for Targeted DNA Methylation with Reduced Off-Target Effects
D. Hofacker, Julian Broche, L. Laistner, Sabrina Adam +2 more
2020International Journal of Molecular Sciences47 citations Open access
Semantic Scholar
Design of synthetic epigenetic circuits featuring memory effects and reversible switching based on DNA methylation
Johannes A H Maier, Raphael Möhrle, A. Jeltsch
2017Nature Communications47 citations Open access
Semantic Scholar
Recognition of nonproline N-terminal residues by the Pro/N-degron pathway
C. Dong, Shun-Jia Chen, A. Melnykov, Sara Weirich +4 more
2020Proceedings of the National Academy of Sciences of the United States of America46 citations Open access
Semantic Scholar
The DNMT3A R882H mutant displays altered flanking sequence preferences
Max Emperle, A. Rajavelu, Stefan Kunert, P. Arimondo +3 more
2018Nucleic Acids Research46 citations Open access
Semantic Scholar
Structure, Activity and Function of the Suv39h1 and Suv39h2 Protein Lysine Methyltransferases
Sara Weirich, Mina S. Khella, A. Jeltsch
2021Life45 citations Open access
Semantic Scholar
Mechanisms and Biological Roles of DNA Methyltransferases and DNA Methylation: From Past Achievements to Future Challenges.
R. Jurkowska, A. Jeltsch
2016Advances in Experimental Medicine and Biology44 citations Open access
Semantic Scholar
Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state
R. Mauser, G. Kungulovski, C. Keup, R. Reinhardt +1 more
2017Epigenetics & Chromatin38 citations Open access
Semantic Scholar
Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2
A. Rajavelu, Cristiana Lungu, Max Emperle, Michael Dukatz +11 more
2018Nucleic Acids Research37 citations Open access
Semantic Scholar
Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme
Sara Weirich, Srikanth Kudithipudi, Ina Kycia, A. Jeltsch
2015Clinical Epigenetics37 citations Open access
Semantic Scholar
The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes
Max Emperle, Michael Dukatz, Stefan Kunert, Katharina Holzer +3 more
2018Scientific Reports34 citations Open access
Semantic Scholar
Specificity of the SUV4-20H1 and SUV4-20H2 protein lysine methyltransferases and methylation of novel substrates.
Sara Weirich, Srikanth Kudithipudi, A. Jeltsch
2016Journal of Molecular Biology33 citations
Semantic Scholar
Substrate Specificity of the HEMK2 Protein Glutamine Methyltransferase and Identification of Novel Substrates*
Denis Kušević, Srikanth Kudithipudi, A. Jeltsch
2016Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Genome-wide investigation of the dynamic changes of epigenome modifications after global DNA methylation editing
Julian Broche, G. Kungulovski, P. Bashtrykov, Philipp Rathert +1 more
2020Nucleic Acids Research31 citations Open access
Semantic Scholar
The SUV39H1 Protein Lysine Methyltransferase Methylates Chromatin Proteins Involved in Heterochromatin Formation and VDJ Recombination.
Srikanth Kudithipudi, Maren Kirstin Schuhmacher, A. Kebede, A. Jeltsch
2017ACS Chemical Biology31 citations
Semantic Scholar
DNA methyltransferase DNMT3A forms interaction networks with the CpG site and flanking sequence elements for efficient methylation
Michael Dukatz, M. Dittrich, E. Stahl, Sabrina Adam +3 more
2022Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors
L. Halby, N. Marechal, Dany Pechalrieu, V. Cura +15 more
2018Philosophical Transactions of the Royal Society B: Biological Sciences29 citations Open access
Semantic Scholar
DNA Methyltransferases - Role and Function
A. Jeltsch, R. Jurkowska
2016Advances in Experimental Medicine and Biology27 citations
Semantic Scholar
Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase
Michael Dukatz, Sabrina Adam, Mahamaya Biswal, Ji-Kui Song +2 more
2020Nucleic Acids Research26 citations Open access
Semantic Scholar
CYCLIN D1 INTEGRATES G9a-MEDIATED HISTONE METHYLATION
Zhi-Ping Li, X. Jiao, G. Di Sante, A. Ertel +10 more
2019Oncogene26 citations Open access
Semantic Scholar
Biotechnological Applications of MBD Domain Proteins for DNA Methylation Analysis.
A. Jeltsch, Julian Broche, Cristiana Lungu, P. Bashtrykov
2020Journal of Molecular Biology24 citations
Semantic Scholar
TRAIL receptor signaling: From the basics of canonical signal transduction toward its entanglement with ER stress and the unfolded protein response.
D. Stöhr, A. Jeltsch, M. Rehm
2020International Review of Cell and Molecular Biology24 citations
Semantic Scholar
A functional LSD1 coregulator screen reveals a novel transcriptional regulatory cascade connecting R-loop homeostasis with epigenetic regulation
Sabine Pinter, Franziska Knodel, Michel Choudalakis, P. Schnee +9 more
2021Nucleic Acids Research22 citations Open access
Semantic Scholar
Deep enzymology studies on DNA methyltransferases reveal novel connections between flanking sequences and enzyme activity.
A. Jeltsch, Sabrina Adam, Michael Dukatz, Max Emperle +1 more
2021Journal of Molecular Biology22 citations
Semantic Scholar
Approaches and Guidelines for the Identification of Novel Substrates of Protein Lysine Methyltransferases.
Srikanth Kudithipudi, A. Jeltsch
2016Cell Chemical Biology22 citations Open access
Semantic Scholar
Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns
Sabrina Adam, J. Bräcker, Viviane Klingel, Bernd Osteresch +4 more
2022Communications Biology21 citations Open access
Semantic Scholar
A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin β-cluster genes in the developing brain
S. Balan, Y. Iwayama, T. Ohnishi, Mikiko Fukuda +24 more
2021Molecular Psychiatry21 citations
Semantic Scholar
Editing the Epigenome: Overview, Open Questions, and Directions of Future Development.
M. Rots, A. Jeltsch
2018Methods in molecular biology21 citations
Semantic Scholar

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G. Kungulovski×6

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