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D. Thakker · SciRah

Researcher profile · Semantic Scholar

D. Thakker

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D. Thakker — researcher profile on SciRah

h-index: 48
Works: 210
Citations: 7,234

Most-cited papers

Enhancing paracellular permeability by modulating epithelial tight junctions.
Peter D. Ward, Tim K. Tippin, D. Thakker
2000Pharmaceutical science & technology today236 citations
Semantic Scholar
Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium
L. Gan, D. Thakker
1997167 citations
Semantic Scholar
Novel Experimental Parameters to Quantify the Modulation of Absorptive and Secretory Transport of Compounds by P-Glycoprotein in Cell Culture Models of Intestinal Epithelium
M. Troutman, D. Thakker
2003Pharmaceutical Research165 citations
Semantic Scholar
Efflux Ratio Cannot Assess P-Glycoprotein-Mediated Attenuation of Absorptive Transport: Asymmetric Effect of P-Glycoprotein on Absorptive and Secretory Transport Across Caco-2 Cell Monolayers
M. Troutman, D. Thakker
2003Pharmaceutical Research156 citations
Semantic Scholar
CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells.
Ls Gan, M. Moseley, B. Khosla, P. Augustijns +3 more
1996Drug Metabolism And Disposition151 citations
Semantic Scholar
Rhodamine 123 Requires Carrier-Mediated Influx for Its Activity as a P-Glycoprotein Substrate in Caco-2 Cells
M. Troutman, D. Thakker
2003Pharmaceutical Research142 citations
Semantic Scholar
Mechanisms Underlying Saturable Intestinal Absorption of Metformin
W. Proctor, D. Bourdet, D. Thakker
2008Drug Metabolism And Disposition139 citations
Semantic Scholar
In Vitro Hepatic Metabolism Explains Higher Clearance of Voriconazole in Children versus Adults: Role of CYP2C19 and Flavin-Containing Monooxygenase 3
Souzan B. Yanni, P. Annaert, P. Augustijns, J. Ibrahim +2 more
2010Drug Metabolism And Disposition135 citations Open access
Semantic Scholar
High-throughput screening for stability and inhibitory activity of compounds toward cytochrome P450-mediated metabolism.
J. Ansede, D. Thakker
2004Journal of Pharmacy and Science120 citations
Semantic Scholar
Four Cation-Selective Transporters Contribute to Apical Uptake and Accumulation of Metformin in Caco-2 Cell Monolayers
T. Han, W. Proctor, Chester Costales, Hao Cai +2 more
2015Journal of Pharmacology and Experimental Therapeutics114 citations Open access
Semantic Scholar
Differential Substrate and Inhibitory Activities of Ranitidine and Famotidine toward Human Organic Cation Transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3)
D. Bourdet, J. B. Pritchard, D. Thakker
2005Journal of Pharmacology and Experimental Therapeutics113 citations
Semantic Scholar
Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers.
Dong-Zhou J. Liu, E. LeCluyse, D. Thakker
1999Journal of Pharmacy and Science102 citations
Semantic Scholar
Prodrugs of anticancer agents
A. Sinhababu, D. Thakker
1996102 citations
Semantic Scholar
Organic Cation Transporter 1 (OCT1/mOct1) Is Localized in the Apical Membrane of Caco-2 Cell Monolayers and Enterocytes
T. Han, R. Everett, W. Proctor, C. Ng +3 more
2013Molecular Pharmacology100 citations Open access
Semantic Scholar
Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters
Ming Xin, Wujian Ju, Huali Wu, R. Tidwell +2 more
2009Drug Metabolism And Disposition96 citations
Semantic Scholar
P-glycoprotein-mediated in vitro biliary excretion in sandwich-cultured rat hepatocytes.
P. Annaert, R. Turncliff, Catherine Booth, D. Thakker +1 more
2001Drug Metabolism And Disposition96 citations
Semantic Scholar
Role of Flavin-Containing Monooxygenase in Oxidative Metabolism of Voriconazole by Human Liver Microsomes
Souzan B. Yanni, P. Annaert, P. Augustijns, Arlene S. Bridges +3 more
2008Drug Metabolism And Disposition89 citations Open access
Semantic Scholar
Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters.
Ming Xin, B. Knight, D. Thakker
2011Molecular Pharmaceutics77 citations
Semantic Scholar
Direct Activation of Human Phospholipase C by Its Well Known Inhibitor U73122*
Ryan R. Klein, D. M. Bourdon, Chester Costales, C. Wagner +5 more
2011Journal of Biological Chemistry74 citations Open access
Semantic Scholar
A Physiologically Based Pharmacokinetic Model for Voriconazole Disposition Predicts Intestinal First-pass Metabolism in Children
Nicole R. Zane, D. Thakker
2014Clinical Pharmacokinetics69 citations
Semantic Scholar
Higher clearance of micafungin in neonates compared to adults: role of age-dependent micafungin serum binding
Souzan B. Yanni, Philip B. W. Smith, Daniel K. Benjamin, P. Augustijns +2 more
2011Biopharmaceutics & drug disposition62 citations Open access
Semantic Scholar
Sorafenib Hepatobiliary Disposition: Mechanisms of Hepatic Uptake and Disposition of Generated Metabolites
B. Swift, N. Nebot, Jin Kyung Lee, T. Han +6 more
2013Drug Metabolism And Disposition60 citations Open access
Semantic Scholar
Intestinal Absorptive Transport of the Hydrophilic Cation Ranitidine: A Kinetic Modeling Approach to Elucidate the Role of Uptake and Efflux Transporters and Paracellular vs. Transcellular Transport in Caco-2 Cells
D. Bourdet, G. M. Pollack, D. Thakker
2006Pharmaceutical Research59 citations
Semantic Scholar
In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats
Souzan B. Yanni, P. Augustijns, D. Benjamin, K. Brouwer +2 more
2010Drug Metabolism And Disposition58 citations Open access
Semantic Scholar
Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil.
Ming Xin, D. Thakker
2010Biochemical Pharmacology57 citations
Semantic Scholar
Saturable transport of H2-antagonists ranitidine and famotidine across Caco-2 cell monolayers.
Kiho Lee, D. Thakker
1999Journal of Pharmacy and Science57 citations
Semantic Scholar
Cation‐selective transporters are critical to the AMPK‐mediated antiproliferative effects of metformin in human breast cancer cells
Hao Cai, Yunhui Zhang, T. Han, R. Everett +1 more
2016International Journal of Cancer49 citations Open access
Semantic Scholar
Cytochrome P450 and Flavin-containing Monooxygenase Families: Age-Dependent Differences in Expression and Functional Activity
Nicole R. Zane, Yao Chen, M. Z. Wang, D. Thakker
2017Pediatric Research48 citations Open access
Semantic Scholar
Antifungal Extraction by the Extracorporeal Membrane Oxygenation Circuit.
K. Watt, M. Cohen-Wolkowiez, Duane C. Williams, D. Bonadonna +4 more
2017The journal of extra-corporeal technology45 citations Open access
Semantic Scholar
Saturable Absorptive Transport of the Hydrophilic Organic Cation Ranitidine in Caco-2 Cells: Role of pH-Dependent Organic Cation Uptake System and P-Glycoprotein
D. Bourdet, D. Thakker
2006Pharmaceutical Research43 citations
Semantic Scholar
Secretory Transport of Ranitidine and Famotidine across Caco-2 Cell Monolayers
Kiho Lee, C. Ng, K. Brouwer, D. Thakker
2002Journal of Pharmacology and Experimental Therapeutics42 citations
Semantic Scholar
Modulation of the Tight Junctions of the Caco-2 Cell Monolayers by H2-antagonists
L. Gan, Souzan B. Yanni, D. Thakker
2004Pharmaceutical Research37 citations
Semantic Scholar
Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography/tandem mass spectrometry.
Lian-Wen Zhou, D. Thakker, R. Voyksner, M. Anbazhagan +3 more
2002Journal of Mass Spectrometry35 citations
Semantic Scholar
Enhanced Permeability of the Antimicrobial Agent 2,5-Bis(4-Amidinophenyl)Furan Across Caco-2 Cell Monolayers Via Its Methylamidoxime Prodrug
Lian-Wen Zhou, Kiho Lee, D. Thakker, D. Boykin +2 more
2002Pharmaceutical Research35 citations
Semantic Scholar
USE OF CACO-2 CELLS AS AN IN VITRO INTESTINAL ABSORPTION AND METABOLISM MODEL
L. Gan, C. Eads, T. Niederer, Avis Bridgers +4 more
199433 citations
Semantic Scholar
Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny
Yao Chen, Nicole R. Zane, D. Thakker, M. Z. Wang
2016Drug Metabolism And Disposition32 citations Open access
Semantic Scholar
Deconvoluting the effects of P-glycoprotein on intestinal CYP3A: a major challenge.
B. Knight, M. Troutman, D. Thakker
2006Current opinion in pharmacology (Print)31 citations
Semantic Scholar
Role of Phospholipase C-β in the Modulation of Epithelial Tight Junction Permeability
P. Ward, H. Ouyang, D. Thakker
2003Journal of Pharmacology and Experimental Therapeutics28 citations
Semantic Scholar
Efficacious dose of metformin for breast cancer therapy is determined by cation transporter expression in tumours
Hao Cai, R. Everett, D. Thakker
2019British Journal of Pharmacology26 citations Open access
Semantic Scholar
Why Does the Intestine Lack Basolateral Efflux Transporters for Cationic Compounds? A Provocative Hypothesis.
W. Proctor, Ming Xin, D. Bourdet, T. Han +2 more
2016Journal of Pharmacy and Science25 citations
Semantic Scholar
P-Glycoprotein Increases Portal Bioavailability of Loperamide in Mouse by Reducing First-Pass Intestinal Metabolism
M. Dufek, B. Knight, Arlene S. Bridges, D. Thakker
2013Drug Metabolism And Disposition23 citations
Semantic Scholar
Physiologically Based Pharmacokinetic Models for Adults and Children Reveal a Role of Intracellular Tubulin Binding in Vincristine Disposition
Christine M. M. Lee, Nicole R. Zane, G. Veal, D. Thakker
2019CPT: Pharmacometrics & Systems Pharmacology20 citations Open access
Semantic Scholar
Exploring the role of the pharmacist in global health.
David R. Steeb, P. Joyner, D. Thakker
2014Journal of the American Pharmacists Association18 citations
Semantic Scholar
Biorelevant refinement of the Caco-2 cell culture model to assess efficacy of paracellular permeability enhancers.
T. Tippin, D. Thakker
2008Journal of Pharmacy and Science16 citations
Semantic Scholar
Characterizing the fragmentation of 2,5-bis (4-amidinophenyl)furan-bis-O-methylamidoxime and selected metabolites using ion trap mass spectrometry.
Lian-Wen Zhou, R. Voyksner, D. Thakker, C. Stephens +4 more
2002Rapid Communications in Mass Spectrometry15 citations
Semantic Scholar
Structure-activity relationships for enhancement of paracellular permeability by 2-alkoxy-3-alkylamidopropylphosphocholines across Caco-2 cell monolayers.
Dong-Zhou J. Liu, S. Morris-Natschke, Louis S. Kucera, K. S. Ishaq +1 more
1999Journal of Pharmacy and Science15 citations
Semantic Scholar
Synthesis, hydrolytic behavior, and anti-HIV activity of selected acyloxyalkyl esters of trisodium phosphonoformate (foscarnet sodium).
R. Iyer, J. Boal, L. R. Phillips, D. Thakker +1 more
1994Journal of Pharmacy and Science11 citations
Semantic Scholar
Determination of the Androgen Receptor Inhibitor Enzalutamide and its Metabolites in Animal Plasma and Brain Homogenates Using LC-MS/MS and its Application to Pharmacokinetic Studies
Yoshiaki Ohtsu, D. Thakker, J. Gibbons, K. Tsubota +2 more
201510 citations Open access
Semantic Scholar
Structure-activity relationship for enhancement of paracellular permeability across Caco-2 cell monolayers by 3-alkylamido-2-alkoxypropylphosphocholines.
H. Ouyang, S. Morris-Natschke, K. S. Ishaq, P. Ward +3 more
2002Journal of Medicinal Chemistry10 citations
Semantic Scholar
Intestinal First-Pass Metabolism by Cytochrome P450 and Not P-Glycoprotein Is the Major Barrier to Amprenavir Absorption
M. Dufek, Arlene S. Bridges, D. Thakker
2013Drug Metabolism And Disposition9 citations
Semantic Scholar

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Souzan B. Yanni×6
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Souzan B. Yanni — researcher profile on SciRah
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D. Bourdet×5
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Nicole R. Zane — researcher profile on SciRah