Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

E. LeCluyse · SciRah

Researcher profile · Semantic Scholar

E. LeCluyse

Share profile

E. LeCluyse — researcher profile on SciRah

h-index: 61
Works: 130
Citations: 15K

Most-cited papers

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
P. Godoy, N. Hewitt, U. Albrecht, M. Andersen +89 more
2013Archives of Toxicology1,242 citations Open access
Semantic Scholar
Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies
N. Hewitt, M. J. Gómez Lechón, J. Houston, D. Hallifax +12 more
2007Drug metabolism reviews (Softcover ed.)754 citations
Semantic Scholar
CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.
G. Luo, M. Cunningham, Sean Kim, T. Burn +17 more
2002Drug Metabolism And Disposition457 citations
Semantic Scholar
In vitro models for liver toxicity testing
V. Soldatow, E. LeCluyse, L. Griffith, I. Rusyn
2012Toxicological Research441 citations Open access
Semantic Scholar
Organotypic liver culture models: Meeting current challenges in toxicity testing
E. LeCluyse, R. Witek, M. Andersen, M. Powers
2012Critical Reviews in Toxicology350 citations Open access
Semantic Scholar
Relative Activation of Human Pregnane X Receptor versus Constitutive Androstane Receptor Defines Distinct Classes of CYP2B6 and CYP3A4 Inducers
S. Faucette, Tong-Cun Zhang, Rick Moore, T. Sueyoshi +4 more
2007Journal of Pharmacology and Experimental Therapeutics316 citations Open access
Semantic Scholar
Anti-Influenza Prodrug Oseltamivir Is Activated by Carboxylesterase Human Carboxylesterase 1, and the Activation Is Inhibited by Antiplatelet Agent Clopidogrel
De-Shi Shi, Jian Yang, Dongfang Yang, E. LeCluyse +4 more
2006Journal of Pharmacology and Experimental Therapeutics288 citations Open access
Semantic Scholar
Role of Orphan Nuclear Receptors in the Regulation of Drug-Metabolising Enzymes
Hong-Bing Wang, E. LeCluyse
2003Clinical Pharmacokinetics281 citations
Semantic Scholar
Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.
D. Rotroff, B. Wetmore, D. Dix, S. Ferguson +13 more
2010Toxicological Sciences269 citations Open access
Semantic Scholar
Antiplatelet Agents Aspirin and Clopidogrel Are Hydrolyzed by Distinct Carboxylesterases, and Clopidogrel Is Transesterificated in the Presence of Ethyl Alcohol
Man Tang, Madhu Mukundan, Jian Yang, Nathan Charpentier +5 more
2006Journal of Pharmacology and Experimental Therapeutics262 citations
Semantic Scholar
Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing
B. Wetmore, J. Wambaugh, B. Allen, S. Ferguson +10 more
2015Toxicological Sciences245 citations Open access
Semantic Scholar
A Novel Distal Enhancer Module Regulated by Pregnane X Receptor/Constitutive Androstane Receptor Is Essential for the Maximal Induction of CYP2B6 Gene Expression*
Hong-Bing Wang, S. Faucette, T. Sueyoshi, Rick Moore +3 more
2003Journal of Biological Chemistry229 citations Open access
Semantic Scholar
Differential Regulation of Hepatic CYP2B6 and CYP3A4 Genes by Constitutive Androstane Receptor but Not Pregnane X Receptor
S. Faucette, T. Sueyoshi, C. Smith, M. Negishi +2 more
2006Journal of Pharmacology and Experimental Therapeutics208 citations
Semantic Scholar
Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics.
E. LeCluyse
2001Chemico-Biological Interactions207 citations
Semantic Scholar
Human CYP2C8 Is Transcriptionally Regulated by the Nuclear Receptors Constitutive Androstane Receptor, Pregnane X Receptor, Glucocorticoid Receptor, and Hepatic Nuclear Factor 4α
S. Ferguson, Yu-Ping Chen, E. LeCluyse, M. Negishi +1 more
2005Molecular Pharmacology203 citations
Semantic Scholar
Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions
G. Hamilton, Summer L Jolley, D. Gilbert, J. Coon +2 more
2001Cell and Tissue Research197 citations
Semantic Scholar
Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro–in vivo correlations
N. Hewitt, E. LeCluyse, Stephen S. Ferguson
2007Xenobiotica; the fate of foreign compounds in biological systems189 citations
Semantic Scholar
Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers.
S. Faucette, Hong-Bing Wang, G. Hamilton, Summer L Jolley +5 more
2004Drug Metabolism And Disposition189 citations
Semantic Scholar
Isolation and culture of primary human hepatocytes.
E. LeCluyse, E. Alexandre, G. Hamilton, C. Viollon-Abadie +3 more
2005Methods in molecular biology167 citations
Semantic Scholar
Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.
S. Ferguson, E. LeCluyse, M. Negishi, J. A. Goldstein
2002Molecular Pharmacology161 citations
Semantic Scholar
Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)
Jenny M. Pedersen, P. Matsson, Christel A. S. Bergström, J. Hoogstraate +3 more
2013Toxicological Sciences158 citations Open access
Semantic Scholar
P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the Hepatobiliary Disposition of a Model Opioid Peptide
Keith A. Hoffmaster, R. Turncliff, E. LeCluyse, R. B. Kim +2 more
2004Pharmaceutical Research157 citations
Semantic Scholar
Human Constitutive Androstane Receptor Mediates Induction of CYP2B6 Gene Expression by Phenytoin*
Hong-Bing Wang, S. Faucette, Rick Moore, T. Sueyoshi +2 more
2004Journal of Biological Chemistry152 citations Open access
Semantic Scholar
Isolation and culture of primary hepatocytes from resected human liver tissue.
E. LeCluyse, E. Alexandre
2010Methods in molecular biology148 citations
Semantic Scholar
Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes.
L. Richert, Delphine Binda, G. Hamilton, C. Viollon-Abadie +5 more
2002Toxicology in Vitro148 citations
Semantic Scholar
Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues.
L. Norona, Deborah G. Nguyen, D. Gerber, S. Presnell +1 more
2016Toxicological Sciences127 citations Open access
Semantic Scholar
Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes.
Jeffrey A. Sunman, R. Hawke, E. LeCluyse, A. Kashuba
2004Drug Metabolism And Disposition122 citations
Semantic Scholar
Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition.
J. Sahi, C. Black, G. Hamilton, Xianxian Zheng +5 more
2003Drug Metabolism And Disposition117 citations
Semantic Scholar
Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for In Vitro Toxicity Testing.
Jingtao Lu, S. Einhorn, L. Venkatarangan, Manda E Miller +3 more
2015Toxicological Sciences107 citations Open access
Semantic Scholar
Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro.
A. Dash, Michael B. Simmers, Tye G. Deering, D. J. Berry +6 more
2013American Journal of Physiology - Cell Physiology105 citations Open access
Semantic Scholar
A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes.
C. Smith, Christina K. Nolan, M. Edwards, J. B. Hatfield +4 more
2012Journal of Pharmacy and Science99 citations
Semantic Scholar
A map of the PPARα transcription regulatory network for primary human hepatocytes.
P. McMullen, S. Bhattacharya, C. Woods, Bin Sun +7 more
2014Chemico-Biological Interactions97 citations Open access
Semantic Scholar
Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes.
Hong-Bing Wang, S. Faucette, D. Gilbert, Summer L Jolley +3 more
2003Drug Metabolism And Disposition91 citations
Semantic Scholar
Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes.
Z. Drobnâ, S. Waters, F. Walton, E. LeCluyse +2 more
2004Toxicology and Applied Pharmacology90 citations
Semantic Scholar
The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes.
C. Lindley, G. Hamilton, J. McCune, S. Faucette +7 more
2002Drug Metabolism And Disposition89 citations
Semantic Scholar
Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes.
F. Walton, S. Waters, Summer L Jolley, E. LeCluyse +2 more
2003Chemical Research in Toxicology87 citations
Semantic Scholar
Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity
K. Rose, N. Holman, A. Green, M. Andersen +1 more
2016Journal of Pharmacy and Science84 citations Open access
Semantic Scholar
Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice.
J. Harrill, R. Hukkanen, Marie Lawson, G. D. Martin +6 more
2013Toxicology and Applied Pharmacology80 citations
Semantic Scholar
Human PXR forms a tryptophan zipper-mediated homodimer.
S. Noble, Virginia E Carnahan, L. Moore, T. Luntz +10 more
2006Biochemistry71 citations Open access
Semantic Scholar
Subtoxic Alterations in Hepatocyte-Derived Exosomes: An Early Step in Drug-Induced Liver Injury?
N. Holman, M. Mosedale, K. K. Wolf, E. LeCluyse +1 more
2016Toxicological Sciences69 citations Open access
Semantic Scholar
Induction of drug metabolizing enzymes: a survey of in vitro methodologies and interpretations used in the pharmaceutical industry--do they comply with FDA recommendations?
N. Hewitt, R. de Kanter, E. LeCluyse
2007Chemico-Biological Interactions68 citations
Semantic Scholar
Avasimibe Induces CYP3A4 and Multiple Drug Resistance Protein 1 Gene Expression through Activation of the Pregnane X Receptor
J. Sahi, M. Milad, Xianxian Zheng, K. Rose +6 more
2003Journal of Pharmacology and Experimental Therapeutics68 citations
Semantic Scholar
Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes.
Rajgopal Govindarajan, Christopher J. Endres, D. Whittington, E. LeCluyse +3 more
2008American Journal of Physiology - Gastrointestinal and Liver Physiology67 citations Open access
Semantic Scholar
Xenobiotic-Metabolizing Enzyme and Transporter Gene Expression in Primary Cultures of Human Hepatocytes Modulated by Toxcast Chemicals
D. Rotroff, Andrew Beam, D. Dix, A. Farmer +7 more
2010Journal of Toxicology and Environmental Health. Part B, Critical Reviews64 citations
Semantic Scholar
Hepatic stem cells and hepatoblasts: identification, isolation, and ex vivo maintenance.
E. Wauthier, E. Schmelzer, W. Turner, Lili Zhang +13 more
2008Methods in Cell Biology63 citations
Semantic Scholar
Evaluation of the contribution of cytochrome P450 3A4 to human liver microsomal bupropion hydroxylation.
S. Faucette, R. Hawke, Stacy S. Shord, E. LeCluyse +1 more
2001Drug Metabolism And Disposition62 citations
Semantic Scholar
Hepatic Progenitors and Strategies for Liver Cell Therapies
R. Susick, N. Moss, H. Kubota, E. LeCluyse +11 more
2001Annals of the New York Academy of Sciences61 citations
Semantic Scholar
The Human Sulfotransferase SULT1A1 Gene Is Regulated in a Synergistic Manner by Sp1 and GA Binding Protein
N. Hempel, Hong-Bing Wang, E. LeCluyse, M. McManus +1 more
2004Molecular Pharmacology51 citations
Semantic Scholar
Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes
J. Sahi, Stacy S. Shord, C. Lindley, S. Ferguson +1 more
2009Journal of biochemical and molecular toxicology46 citations
Semantic Scholar
miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model
M. Mosedale, J. Eaddy, O. J. Trask, N. Holman +8 more
2018Toxicological Sciences43 citations Open access
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

Hong-Bing Wang×11
Invite
Hong-Bing Wang — researcher profile on SciRah
Summer L Jolley×9
Invite
Summer L Jolley — researcher profile on SciRah
M. Negishi×9
Invite
M. Negishi — researcher profile on SciRah
S. Faucette×8
Invite
S. Faucette — researcher profile on SciRah

×8

Invite

S. Ferguson — researcher profile on SciRah

Invite

G. Hamilton — researcher profile on SciRah

Invite

D. Gilbert — researcher profile on SciRah

Invite

M. Andersen — researcher profile on SciRah

Invite

T. Sueyoshi — researcher profile on SciRah

Invite

B. Yan — researcher profile on SciRah

Invite

C. Lindley — researcher profile on SciRah

Invite

J. Sahi — researcher profile on SciRah