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J. E. Hall · SciRah

Researcher profile · Semantic Scholar

J. E. Hall

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J. E. Hall — researcher profile on SciRah

h-index: 36
Works: 113
Citations: 3,593

Most-cited papers

Antiparasitic Compounds That Target DNA
W. D. Wilson, F. Tanious, A. Mathis, D. Tevis +2 more
2008Biochimie211 citations Open access
Semantic Scholar
Dications that target the DNA minor groove: compound design and preparation, DNA interactions, cellular distribution and biological activity.
W. Wilson, B. Nguyen, F. Tanious, A. Mathis +3 more
2005Current Medicinal Chemistry - Anti-Cancer Agents164 citations
Semantic Scholar
New Treatment Option for Second-Stage African Sleeping Sickness: In Vitro and In Vivo Efficacy of Aza Analogs of DB289
T. Wenzler, D. Boykin, M. Ismail, J. E. Hall +2 more
2009Antimicrobial Agents and Chemotherapy135 citations Open access
Semantic Scholar
Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.
R. Tidwell, S. Jones, J. Geratz, K. Ohemeng +2 more
1990Journal of Medicinal Chemistry122 citations Open access
Semantic Scholar
Accumulation and Intracellular Distribution of Antitrypanosomal Diamidine Compounds DB75 and DB820 in African Trypanosomes
A. Mathis, J. Holman, Lisa M Sturk, M. Ismail +3 more
2006Antimicrobial Agents and Chemotherapy115 citations Open access
Semantic Scholar
Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis
C. Bell, J. E. Hall, Dennis E. Kyle, Max Grogl +3 more
1990Antimicrobial Agents and Chemotherapy103 citations Open access
Semantic Scholar
Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters
Ming Xin, Wujian Ju, Huali Wu, R. Tidwell +2 more
2009Drug Metabolism And Disposition96 citations
Semantic Scholar
CYP4F Enzymes Are the Major Enzymes in Human Liver Microsomes That Catalyze the O-Demethylation of the Antiparasitic Prodrug DB289 [2,5-Bis(4-amidinophenyl)furan-bis-O-methylamidoxime]
M. Z. Wang, Janelle Y. Saulter, E. Usuki, Yen-Ling Cheung +12 more
2006Drug Metabolism And Disposition94 citations Open access
Semantic Scholar
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
D. Boykin, Arvind Kumar, Ge Xiao, W. Wilson +4 more
1998Journal of Medicinal Chemistry91 citations
Semantic Scholar
Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan.
Syed M. Rahmathullah, J. E. Hall, B. C. Bender, Donald R. McCurdy +2 more
1999Journal of Medicinal Chemistry89 citations
Semantic Scholar
Anti-pneumocystis activity of bis-amidoximes and bis-o-alkylamidoximes prodrugs
D. Boykin, Arvind Kumar, J. E. Hall, B. C. Bender +1 more
199689 citations
Semantic Scholar
Novel Arylimidamides for Treatment of Visceral Leishmaniasis
M. Z. Wang, Xiao-Hua Zhu, A. Srivastava, Qiang Liu +14 more
2010Antimicrobial Agents and Chemotherapy83 citations Open access
Semantic Scholar
Anti-Pneumocystis Activities of Aromatic Diamidoxime Prodrugs
J. E. Hall, John E. Kerrigan, K. Ramachandran, B. C. Bender +4 more
1998Antimicrobial Agents and Chemotherapy77 citations Open access
Semantic Scholar
Targeting the minor groove of DNA: crystal structures of two complexes between furan derivatives of berenil and the DNA dodecamer d(CGCGAATTCGCG)2.
John O. Trent, G. R. Clark, Arvind Kumar, W. Wilson +5 more
1996Journal of Medicinal Chemistry77 citations
Semantic Scholar
Nucleoside analogues achieve high concentrations in seminal plasma: relationship between drug concentration and virus burden.
Arlene S. Pereira, A. Kashuba, S. Fiscus, J. E. Hall +5 more
1999Journal of Infectious Diseases76 citations Open access
Semantic Scholar
Diphenyl Furans and Aza Analogs: Effects of Structural Modification on In Vitro Activity, DNA Binding, and Accumulation and Distribution in Trypanosomes
A. Mathis, Arlene S. Bridges, M. Ismail, Arvind Kumar +11 more
2007Antimicrobial Agents and Chemotherapy74 citations Open access
Semantic Scholar
Activity of cationically substituted bis-benzimidazoles against experimental Pneumocystis carinii pneumonia
R. Tidwell, S. Jones, N. A. Naiman, Louise C. Berger +3 more
1993Antimicrobial Agents and Chemotherapy74 citations Open access
Semantic Scholar
Structure-activity relationships of pentamidine analogs against Giardia lamblia and correlation of antigiardial activity with DNA-binding affinity
C. Bell, M. Cory, T. A. Fairley, J. E. Hall +1 more
1991Antimicrobial Agents and Chemotherapy74 citations Open access
Semantic Scholar
Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
M. Ismail, Reem K. Arafa, R. Brun, T. Wenzler +6 more
2006Journal of Medicinal Chemistry69 citations
Semantic Scholar
Simultaneous determination of lamivudine and zidovudine concentrations in human seminal plasma using high-performance liquid chromatography and tandem mass spectrometry.
Arlene S. Pereira, Kathryn B. Kenney, M. Cohen, J. E. Hall +3 more
2000Journal of Chromatography B: Biomedical Sciences and Applications68 citations
Semantic Scholar
Synthesis and in vitro antiprotozoal activities of dicationic 3,5-diphenylisoxazoles.
D. A. Patrick, S. A. Bakunov, S. M. Bakunova, E. Sureshkumar +8 more
2007Journal of Medicinal Chemistry66 citations
Semantic Scholar
Human Enteric Microsomal CYP4F Enzymes O-Demethylate the Antiparasitic Prodrug Pafuramidine
M. Z. Wang, J. Q. Wu, Arlene S. Bridges, D. Zeldin +4 more
2007Drug Metabolism And Disposition61 citations Open access
Semantic Scholar
O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection.
J. Ansede, M. Anbazhagan, R. Brun, Judy D. Easterbrook +2 more
2004Journal of Medicinal Chemistry59 citations
Semantic Scholar
Novel pentamidine analogs in the treatment of experimental Pneumocystis carinii pneumonia
S. Jones, J. E. Hall, Margaret A. Allen, Sharon D. Morrison +4 more
1990Antimicrobial Agents and Chemotherapy59 citations Open access
Semantic Scholar
Synthesis and in vitro antiprotozoal activity of bisbenzofuran cations.
S. M. Bakunova, S. A. Bakunov, T. Wenzler, Todd Barszcz +4 more
2007Journal of Medicinal Chemistry56 citations
Semantic Scholar
Anti-Pneumocystis carinii pneumonia activity of dicationic carbazoles
D. A. Patrick, D. Boykin, W. Wilson, F. Tanious +6 more
199753 citations
Semantic Scholar
Inhibition of Cryptosporidium parvum in neonatal Hsd:(ICR)BR Swiss miceby polyether ionophores and aromatic amidines
B. Blagburn, C. Sundermann, David S. Lindsay, J. E. Hall +1 more
1991Antimicrobial Agents and Chemotherapy51 citations Open access
Semantic Scholar
A gel‐free MS‐based quantitative proteomic approach accurately measures cytochrome P450 protein concentrations in human liver microsomes
M. Z. Wang, J. Q. Wu, J. Dennison, Arlene S. Bridges +7 more
2008Proteomics50 citations
Semantic Scholar
Development and SAR of functionally selective allosteric modulators of GABAA receptors.
C. Alhambra, C. Becker, T. Blake, Amy Chang +19 more
2011Bioorganic & Medicinal Chemistry48 citations Open access
Semantic Scholar
UNUSUAL DEHYDROXYLATION OF ANTIMICROBIAL AMIDOXIME PRODRUGS BY CYTOCHROME b5 AND NADH CYTOCHROME b5 REDUCTASE
Janelle Y. Saulter, Joseph R. Kurian, L. Trepanier, R. Tidwell +5 more
2005Drug Metabolism And Disposition48 citations
Semantic Scholar
Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue.
Lisa M Sturk, J. L. Brock, C.Robert Bagnell, J. E. Hall +1 more
2004Acta Tropica47 citations
Semantic Scholar
Development of Pentamidine Analogues as New Agents for the Treatment of Pneumocystis carinii Pneumonia a
R. R. Tidwell, S. Jones, J. Geratz, K. Ohemeng +3 more
1990Annals of the New York Academy of Sciences46 citations
Semantic Scholar
Metabolic N-hydroxylation of pentamidine in vitro
Bradley J. Berger, R. Lombardy, G. D. Marbury, C. Bell +3 more
1990Antimicrobial Agents and Chemotherapy43 citations Open access
Semantic Scholar
Primary and secondary metabolism of pentamidine by rats
Bradley J. Berger, N. A. Naiman, J. E. Hall, J. Peggins +2 more
1992Antimicrobial Agents and Chemotherapy42 citations Open access
Semantic Scholar
Pharmacology of DB844, an Orally Active aza Analogue of Pafuramidine, in a Monkey Model of Second Stage Human African Trypanosomiasis
J. Thuita, M. Z. Wang, J. Kagira, C. Denton +8 more
2012PLoS Neglected Tropical Diseases39 citations Open access
Semantic Scholar
Efficacy of the Novel Diamidine Compound 2,5-Bis(4-Amidinophenyl)- Furan-Bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense Infection in Vervet Monkeys after Oral Administration
R. Mdachi, J. Thuita, J. Kagira, J. M. Ngotho +5 more
2008Antimicrobial Agents and Chemotherapy36 citations Open access
Semantic Scholar
In vitro metabolism of an orally active O-methyl amidoxime prodrug for the treatment of CNS trypanosomiasis
John H. Ansede, Robert D. Voyksner, M. Ismail, D. Boykin +2 more
2005Xenobiotica; the fate of foreign compounds in biological systems36 citations
Semantic Scholar
Metabolites of an orally active antimicrobial prodrug, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime, identified by liquid chromatography/tandem mass spectrometry.
Lian-Wen Zhou, D. Thakker, R. Voyksner, M. Anbazhagan +3 more
2002Journal of Mass Spectrometry35 citations
Semantic Scholar
Enhanced Permeability of the Antimicrobial Agent 2,5-Bis(4-Amidinophenyl)Furan Across Caco-2 Cell Monolayers Via Its Methylamidoxime Prodrug
Lian-Wen Zhou, Kiho Lee, D. Thakker, D. Boykin +2 more
2002Pharmaceutical Research35 citations
Semantic Scholar
Hydroxylation of pentamidine by rat liver microsomes.
Bradley J. Berger, V. V. Reddy, S. T. Le, R. Lombardy +2 more
1990Journal of Pharmacology and Experimental Therapeutics31 citations
Semantic Scholar
Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: a late-stage diversification approach to potent 5HT1B antagonists.
Carey L Horchler, J. McCauley, J. E. Hall, Dean H Snyder +3 more
2007Bioorganic & Medicinal Chemistry29 citations Open access
Semantic Scholar
Synthesis and anti-Pneumocystis carinii pneumonia activity of novel dicationic dibenzothiophenes and orally active prodrugs.
D. A. Patrick, J. E. Hall, B. C. Bender, Donald R. McCurdy +4 more
1999European journal of medicinal chemistry29 citations
Semantic Scholar
Mechanisms Underlying Differences in Systemic Exposure of Structurally Similar Active Metabolites: Comparison of Two Preclinical Hepatic Models
Grace Zhixia Yan, K. Brouwer, G. M. Pollack, M. Z. Wang +3 more
2011Journal of Pharmacology and Experimental Therapeutics26 citations Open access
Semantic Scholar
Inhibition by Dications of In Vitro Growth of Leishmania major and Leishmania tropica: Causative Agents of Old World Cutaneous Leishmaniasis
A. Rosypal, K. Werbovetz, M. Salem, C. Stephens +4 more
2008Journal of Parasitology26 citations
Semantic Scholar
Anti-Pneumocystis carinii pneumonia activity of dicationic 2,4-diarylpyrimidines.
Arvind Kumar, D. Boykin, W. Wilson, S. Jones +4 more
1996European journal of medicinal chemistry26 citations Open access
Semantic Scholar
Anti-Pneumocystis carinii pneumonia activity of dicationic diaryl methylprimidines
D. Boykin, Arvind Kumar, M. Bajić, Xiao-Fan Ge +5 more
199823 citations
Semantic Scholar
Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis
J. Thuita, K. K. Wolf, G. Murilla, Qiang Liu +12 more
2013PLoS Neglected Tropical Diseases21 citations Open access
Semantic Scholar
A Semiphysiologically Based Pharmacokinetic Modeling Approach to Predict the Dose-Exposure Relationship of an Antiparasitic Prodrug/Active Metabolite Pair
Grace Zhixia Yan, Claudia Generaux, M. Yoon, R. Goldsmith +6 more
2012Drug Metabolism And Disposition21 citations Open access
Semantic Scholar
Carbamate prodrugs of N-alkylfuramidines.
S. Rahmathullah, R. Tidwell, S. Jones, J. E. Hall +1 more
2008European journal of medicinal chemistry20 citations
Semantic Scholar
Synthesis of metabolites of the prodrug 2, 5-bis(4-O-methoxyamidinophenyl)furan
D. Boykin, M. Anbazhagan, Janelle Y. Saulter, J. E. Hall
200319 citations Open access
Semantic Scholar

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