Researcher profile · Semantic Scholar

J. Kirk

h-index: 14
Works: 34
Citations: 748

Most-cited papers

Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses
Qiuhui Li, Qu Deng, Hsueh-Ping Chao, Xin Liu +21 more
2018Nature Communications127 citations Open access
Semantic Scholar
Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer
Ding-Xiao Zhang, Qiang Hu, Xiaozhuo Liu, Yibing Ji +9 more
2020Nature Communications121 citations Open access
Semantic Scholar
Prostate Luminal Progenitor Cells in Development and Cancer
Ding-Xiao Zhang, Shu-Hong Zhao, Xin-Yun Li, J. Kirk +1 more
2018Trends in Cancer83 citations Open access
Semantic Scholar
Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer
J. Kirk, Kevin Schaarschuch, Zafardjan Dalimov, E. Lasorsa +7 more
2014OncoTarget58 citations Open access
Semantic Scholar
Prostate-Specific Antigen Modulates Genes Involved in Bone Remodeling and Induces Osteoblast Differentiation of Human Osteosarcoma Cell Line SaOS-2
N. Nadiminty, W. Lou, Soo-Ok Lee, F. Mehraein‐Ghomi +4 more
2006Clinical Cancer Research57 citations Open access
Semantic Scholar
Tumor Dormancy and Slow-Cycling Cancer Cells
John E Davis, J. Kirk, Yibing Ji, Dean G. Tang
2019Advances in Experimental Medicine and Biology53 citations Open access
Semantic Scholar
The miR-96 and RARγ signaling axis governs androgen signaling and prostate cancer progression
M. Long, P. Singh, J. R. Russell, Gerard Llimos +7 more
2018Oncogene48 citations Open access
Semantic Scholar
Systematic evaluation of RNA-Seq preparation protocol performance
Hsueh-Ping Chao, Yueping Chen, Y. Takata, M. Tomida +10 more
2019BMC Genomics37 citations Open access
Semantic Scholar
LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer
Qiuhui Li, Bigang Liu, Hsueh-Ping Chao, Yibing Ji +18 more
2019Nature Communications30 citations Open access
Semantic Scholar
Early Growth Inhibition Is Followed by Increased Metastatic Disease with Vitamin D (Calcitriol) Treatment in the TRAMP Model of Prostate Cancer
A. Ajibade, J. Kirk, E. Karasik, B. Gillard +4 more
2014PLoS ONE29 citations Open access
Semantic Scholar
Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer
M. Long, P. Singh, Gerard Llimos, Justine J. Jacobi +6 more
2020bioRxiv27 citations Open access
Semantic Scholar
Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells
J. Kirk, Jie Wang, M. Long, S. Rosario +17 more
2024Cell Stem Cell19 citations Open access
Semantic Scholar
Mitochondrial protection impairs BET bromodomain inhibitor-mediated cell death and provides rationale for combination therapeutic strategies
E. Lasorsa, M. Smonksey, J. Kirk, S. Rosario +2 more
2015Cell Death and Disease16 citations Open access
Semantic Scholar
EZH2 inhibition re-sensitizes multidrug resistant B-cell lymphomas to etoposide mediated apoptosis
Matthew T. Smonskey, E. Lasorsa, S. Rosario, J. Kirk +2 more
2016Oncoscience15 citations Open access
Semantic Scholar
Phase Ib trial of enzalutamide (Enza) with venetoclax (Ven) in metastatic castration-resistant prostate cancer (mCRPC).
S. Perimbeti, Anmbreen Jamroze, K. Attwood, Bailey K. Farmer +7 more
2023Journal of Clinical Oncology8 citations
Semantic Scholar
Phase Ib Study of Enzalutamide with Venetoclax in Patients with Metastatic Castration-Resistant Prostate Cancer
S. Perimbeti, Anmbreen Jamroze, D. Gopalakrishnan, Rohit Jain +11 more
2025medRxiv5 citations Open access
Semantic Scholar
The miR-96/RARγ signaling axis governs androgen signaling and prostate cancer progression
M. Long, P. Singh, J. R. Russell, Gerard Llimos +8 more
2017bioRxiv4 citations Open access
Semantic Scholar
Increasing Cancer Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival
Xiaozhuo Liu, Anmbreen Jamroze, Eduardo Cortes, Yibing Ji +27 more
2025bioRxiv3 citations Open access
Semantic Scholar
Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma
Jiao-Yang Zhang, Winnie W. Ong, Alexandra Rasnitsyn, R. D. Gonzalez +82 more
2026Nature2 citations Open access
Semantic Scholar
Cell-resolved high-dimensional imaging analysis, therapeutic modeling, and a Phase Ib clinical study establish BCL-2 as a target across heterogeneous CRPC subtypes
Anmbreen Jamroze, Xiaozhuo Liu, Surui Hou, Wen Li +12 more
2025bioRxiv2 citations Open access
Semantic Scholar
Phase Ib study of enzalutamide with venetoclax in patients with metastatic castration-resistant prostate cancer
S. Perimbeti, Anmbreen Jamroze, D. Gopalakrishnan, Rohit Jain +12 more
2025Cancer Chemotherapy and Pharmacology2 citations Open access
Semantic Scholar
Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer
Mark D. Long, Justine J. Jacobi, Prashant K. Singh, Gerard Llimos +11 more
2021Cell Reports2 citations Open access
Semantic Scholar
Author Correction: LRIG1 is a pleiotropic androgen receptor-regulated feedback tumor suppressor in prostate cancer
Qiuhui Li, Bigang Liu, Hsueh-Ping Chao, Yibing Ji +18 more
2020Nature Communications1 citations Open access
Semantic Scholar
Dysregulated Alternative Splicing Landscape Identifies Intron Retention as a Hallmark and Spliceosome as a Therapeutic Vulnerability in Aggressive Prostate Cancer
Ding-Xiao Zhang, Qiang Hu, Yibing Ji, Hsueh-Ping Chao +7 more
2019bioRxiv1 citations Open access
Semantic Scholar
Abstract 483: Organoids-based high-throughput drug screening identifies selective vulnerability of AR-/lo CRPC to inhibitors of neurotransmission signaling.
Shan Wu, Ruize Zhao, Xiao-Zhuo Liu, Wen Li +10 more
2026Cancer Research0 citations
Semantic Scholar
Single-cell imaging analysis, therapeutic modeling and a Phase Ib trial validate BCL-2 as a target across heterogeneous castration-resistant prostate cancer
Anmbreen Jamroze, Xiaozhuo Liu, Surui Hou, Wen (Jess) Li +15 more
2026Signal Transduction and Targeted Therapy0 citations
Semantic Scholar
Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells
J. Kirk, Jie Wang, A. Tracz, Mark D. Long +16 more
2023bioRxiv0 citations Open access
Semantic Scholar
Abstract 2601: Lrig1 is a haplo-insufficient tumor suppressor and Lrig1-expressing cells can function as cells-of-origin of tumor development
Mo Wang, Qiuhui Li, A. Tracz, J. Kirk +3 more
2023Cancer Research0 citations
Semantic Scholar
Abstract 2197: Dysregulated alternative splicing landscape identifies intron retention as a hallmark and spliceosome as a therapeutic vulnerability in aggressive prostate cancer
Ding-Xiao Zhang, Qiang Hu, Xiaozhuo Liu, Yibing Ji +8 more
2021Molecular and Cellular Biology/Genetics0 citations
Semantic Scholar
Abstract LB-097: Linking prostate cancer cell AR heterogeneity to distinct castration and Enzalutamide responses
Qiuhui Li, Xin Chen, Qu Deng, Hsueh-Ping Chao +5 more
2018Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract B10: Increased expression of EZH2 and TOP2A predicts for a poorer prognostic outcome in Genitourinary Cancers
S. Rosario, Zafardjan Dalimov, J. Kirk, K. Morrell +2 more
20160 citations
Semantic Scholar
Characterizing the in vivo mechanism of action of vitamin D in the TRAMP model: A bioinformatics based approach
J. Kirk
20120 citations
Semantic Scholar
Molecular mechanisms of osteoblastic differentiation induced by PSA in SaOS-2 osteosarcoma cells
N. Nadiminty, W. Lou, Soo-Ok Lee, J. Kirk +1 more
20060 citations
Semantic Scholar
Cell-resolved high-dimensional imaging analysis, therapeutic modeling, and a Phase Ib clinical study validate BCL-2 as a target across heterogeneous CRPC subtypes
Anmbreen Jamroze, Xiaozhuo Liu, Surui Hou, Jess Li +12 more
0 citations
Semantic Scholar

Hsueh-Ping Chao

×8

Xiaozhuo Liu×8

Qiuhui Li×7

Xin Chen×7

S. Rosario×7

Dean G. Tang×7

G. Chatta×7

Ding-Xiao Zhang×6