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C. Wells · SciRah

Researcher profile · Semantic Scholar

C. Wells

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C. Wells — researcher profile on SciRah

h-index: 24
Works: 99
Citations: 2,353

Most-cited papers

Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group.
M. Lobera, K. Madauss, D. T. Pohlhaus, Q. Wright +25 more
2013Nature Chemical Biology365 citations
Semantic Scholar
Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement
J. Vasta, Cesear R. Corona, Jennifer M. Wilkinson, C. Zimprich +24 more
2017Cell Chemical Biology244 citations Open access
Semantic Scholar
Progress towards a public chemogenomic set for protein kinases and a call for contributions
D. Drewry, C. Wells, David M. Andrews, R. Angell +20 more
2017bioRxiv148 citations Open access
Semantic Scholar
Quantifying CDK inhibitor selectivity in live cells
C. Wells, J. Vasta, Cesear R. Corona, Jennifer M. Wilkinson +13 more
2020Nature Communications105 citations Open access
Semantic Scholar
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
C. Wells, D. Drewry, J. Pickett, A. Tjaden +7 more
2020Cell Chemical Biology99 citations
Semantic Scholar
Generative and reinforcement learning approaches for the automated de novo design of bioactive compounds
M. Korshunova, Niles Huang, Stephen J. Capuzzi, Dmytro S. Radchenko +6 more
2022Communications Chemistry93 citations Open access
Semantic Scholar
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3
Jark Böttcher, D. Dilworth, Ulrich Reiser, Ralph A. Neumüller +40 more
2019Nature Chemical Biology84 citations
Semantic Scholar
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
C. Wells, H. Al-Ali, D. Andrews, C. Asquith +30 more
2019bioRxiv82 citations Open access
Semantic Scholar
WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop
Megan J. Agajanian, M. Walker, Alison D. Axtman, Roberta R. Ruela de Sousa +23 more
2019Cell Reports82 citations Open access
Semantic Scholar
Crowdsourced mapping of unexplored target space of kinase inhibitors
A. Cichońska, Balaguru Ravikumar, Robert J. Allaway, Fangping Wan +83 more
2020Nature Communications75 citations Open access
Semantic Scholar
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells
D. Foulkes, D. Byrne, Wayland Yeung, Safal Shrestha +9 more
2018Science Signaling73 citations Open access
Semantic Scholar
Donated chemical probes for open science
S. Mueller, S. Ackloo, C. Arrowsmith, M. Bauser +49 more
2018eLife72 citations Open access
Semantic Scholar
SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)
C. Asquith, Benedict-Tilman Berger, Jing Wan, J. Bennett +15 more
2018bioRxiv55 citations Open access
Semantic Scholar
E2F1 proteolysis via SCF‐cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition
Kamila Burdová, Hongbin Yang, Roberta Faedda, Samuel Hume +10 more
2019EMBO Journal51 citations Open access
Semantic Scholar
Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase
C. Asquith, T. Laitinen, J. Bennett, P. Godoi +9 more
2017bioRxiv45 citations Open access
Semantic Scholar
SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K.
C. Wells, R. Couñago, Juanita C. Limas, T. L. Almeida +14 more
2019ACS Medicinal Chemistry Letters38 citations Open access
Semantic Scholar
New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors
P. Eyers, D. Byrne, Pawin Ngamlert, Yong Li +7 more
2018bioRxiv37 citations Open access
Semantic Scholar
In Depth Analysis of Kinase Cross Screening Data to Identify CAMKK2 Inhibitory Scaffolds
Sean N O'Byrne, John W. Scott, Joseph R. Pilotte, André da S. Santiago +8 more
2020bioRxiv34 citations Open access
Semantic Scholar
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma.
C. Asquith, Kaleb M. Naegeli, Michael P. East, T. Laitinen +6 more
2019Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration
D. Drewry, J. K. Annor-Gyamfi, C. Wells, J. Pickett +4 more
2021Journal of Medicinal Chemistry30 citations Open access
Semantic Scholar
Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer
A. Schirmer, Lucy M. Driver, Megan T. Zhao, C. Wells +12 more
2021bioRxiv30 citations Open access
Semantic Scholar
Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases
A. Krahn, C. Wells, D. Drewry, L. K. Beitel +2 more
2020bioRxiv30 citations Open access
Semantic Scholar
Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations
R. Couñago, C. Allerston, P. Savitsky, H. Azevedo +8 more
2017Scientific Reports28 citations Open access
Semantic Scholar
Temozolomide-induced guanine mutations create exploitable vulnerabilities of guanine-rich DNA and RNA regions in drug-resistant gliomas
D. Tiek, Beril Erdogdu, Roham Razaghi, Lu Jin +16 more
2019bioRxiv27 citations Open access
Semantic Scholar
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes
Benjamin J. Eduful, Sean N O'Byrne, Louisa Temme, C. Asquith +20 more
2020Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses
Xuan Yang, Rebekah J. Dickmander, Armin Bayati, S. Taft-Benz +13 more
2022ACS Chemical Biology22 citations Open access
Semantic Scholar
New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors
D. Byrne, Yong Li, Krithika Ramakrishnan, I. Barsukov +12 more
2018Biochemical Journal21 citations Open access
Semantic Scholar
In depth analysis of kinase cross screening data to identify chemical starting points for inhibition of the nek family of kinases
C. Wells, Nirav R. Kapadia, R. Couñago, D. Drewry
2017bioRxiv21 citations Open access
Semantic Scholar
A Chemical Probe for Dark Kinase STK17B Derives its Potency and High Selectivity Through a Unique P-loop Conformation
A. Picado, A. Chaikuad, C. Wells, Safal Shrestha +11 more
2020Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2
Zachary W. Davis-Gilbert, Andreas Krämer, J. Dunford, S. Howell +9 more
2023ACS Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors
G. S. Profeta, C. V. dos Reis, André da S. Santiago, P. Godoi +10 more
2019Scientific Reports18 citations Open access
Semantic Scholar
Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth
Linas Krulikas, Ian M. McDonald, Benjamin Lee, D. Okumu +13 more
2018SLAS discovery : advancing life sciences R & D18 citations Open access
Semantic Scholar
Discovery of Novel Small Molecules that Activate Satellite Cell Proliferation and Enhance Repair of Damaged Muscle.
A. Billin, M. Bantscheff, G. Drewes, Sonja Ghidelli-Disse +7 more
2016ACS Chemical Biology17 citations Open access
Semantic Scholar
Towards the Development of an In vivo Chemical Probe for Cyclin G Associated Kinase (GAK)
C. Asquith, J. Bennett, Lianyong Su, T. Laitinen +6 more
2019Molecules15 citations Open access
Semantic Scholar
NEK5 activity regulates the mesenchymal and migratory phenotype in breast cancer cells
M. Matossian, S. Elliott, T. Van Hoang, H. Burks +17 more
2021Breast Cancer Research and Treatment14 citations Open access
Semantic Scholar
Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals.
Ethan J. Fritch, A. Mordant, Thomas S. K. Gilbert, C. Wells +14 more
2023Journal of Proteome Research13 citations Open access
Semantic Scholar
Design and analysis of the 4-anilino-quin(az)oline kinase inhibition profiles of GAK/SLK/STK10 using quantitative structure activity relationships
C. Asquith, T. Laitinen, J. Bennett, C. Wells +4 more
2019bioRxiv13 citations Open access
Semantic Scholar
CDK16: the pick of the understudied PCTAIRE kinases
Alison D. Axtman, D. Drewry, C. Wells
2019Nature reviews. Drug discovery13 citations
Semantic Scholar
PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor
Tigist Y. Tamir, D. Drewry, C. Wells, M. Ben Major +1 more
2020Scientific Reports12 citations Open access
Semantic Scholar
Targeting STK17B kinase activates ferroptosis and suppresses drug resistance in multiple myeloma
Zhi-Bo Yan, Zhan-Nan Han, Yihui Wang, Maja Beus +15 more
2025Blood11 citations Open access
Semantic Scholar
A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction
D. Drewry, C. Wells, W. Zuercher, T. Willson
2019SLAS discovery : advancing life sciences R & D11 citations Open access
Semantic Scholar
SGC-CAMKK2-1: A Chemical Probe for CAMKK2
C. Wells, Yixin Liang, T. Pulliam, Chenchu Lin +21 more
2022bioRxiv10 citations Open access
Semantic Scholar
New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I–Interacting Kinase (TNNi3K)
C. Asquith, T. Laitinen, C. Wells, G. Tizzard +1 more
2020Molecules9 citations Open access
Semantic Scholar
A Bag of Tricks for Automated De Novo Design of Molecules with the Desired Properties: Application to EGFR Inhibitor Discovery
M. Korshunova, Niles Huang, Stephen J. Capuzzi, Dmytro S. Radchenko +6 more
20218 citations Open access
Semantic Scholar
Targeting the water network in cyclin G associated kinase (GAK) with 4-anilino-quin(az)oline inhibitors
C. Asquith, G. Tizzard, J. Bennett, C. Wells +4 more
2020bioRxiv8 citations Open access
Semantic Scholar
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective
Wee-Ong Han, Yixin Liang, W. Richardson, Emily R. Lowry +12 more
2023ACS Chemical Neuroscience6 citations Open access
Semantic Scholar
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology
Anna M. Castano, Margaux Silvestre, C. Wells, J. Sanderson +15 more
2023eLife6 citations Open access
Semantic Scholar
Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology
F. Potjewyd, J. K. Annor-Gyamfi, J. Aubé, Shao-You Chu +21 more
2022Alzheimer's & Dementia6 citations Open access
Semantic Scholar
Targeting Never-In-Mitosis-A Related Kinase 5 in Cancer: A Review.
M. Matossian, C. Wells, W. Zuercher, B. Collins-Burow +2 more
2021Current Medicinal Chemistry6 citations
Semantic Scholar
Novel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes
M. Matossian, S. Elliott, Van T. Hoang, H. Burks +7 more
2017PLoS ONE6 citations Open access
Semantic Scholar

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