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Michael P. East · SciRah

Researcher profile · Semantic Scholar

Michael P. East

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Michael P. East — researcher profile on SciRah

h-index: 19
Works: 63
Citations: 1,683

Most-cited papers

Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins
Christine E. Larkins, Gladys D. Gonzalez Aviles, Michael P. East, R. Kahn +1 more
2011Molecular Biology of the Cell299 citations Open access
Semantic Scholar
Development of Multifunctional Nanoparticles for Targeted Drug Delivery and Non-invasive Imaging of Therapeutic Effect
H. K. Sajja, Michael P. East, H. Mao, A. Wang +2 more
2009Current Drug Discovery Technologies250 citations Open access
Semantic Scholar
Mitochondrial Protease ClpP is a Target for the Anticancer Compounds ONC201 and Related Analogues
P. Graves, Lucas J. Aponte-Collazo, Emily M. J. Fennell, Adam C Graves +13 more
2019ACS Chemical Biology179 citations Open access
Semantic Scholar
Arl13b and the exocyst interact synergistically in ciliogenesis
Cecília Seixas, Young-Choi Soo, N. Polgar, Nicole L. Umberger +10 more
2016Molecular Biology of the Cell78 citations Open access
Semantic Scholar
Models for the Functions of Arf GAPs
Michael P. East, R. Kahn
2010Seminars in Cell and Developmental Biology74 citations Open access
Semantic Scholar
FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease.
S. Garcia-Recio, A. Thennavan, Michael P. East, J. Parker +21 more
2020Journal of Clinical Investigation71 citations Open access
Semantic Scholar
ELMO Domains, Evolutionary and Functional Characterization of a Novel GTPase-activating Protein (GAP) Domain for Arf Protein Family GTPases*
Michael P. East, J. B. Bowzard, J. Dacks, Richard A. Kahn
2012Journal of Biological Chemistry62 citations Open access
Semantic Scholar
SGC-GAK-1: a chemical probe for cyclin G associated kinase (GAK)
C. Asquith, Benedict-Tilman Berger, Jing Wan, J. Bennett +15 more
2018bioRxiv55 citations Open access
Semantic Scholar
Characterization of Recombinant ELMOD (Cell Engulfment and Motility Domain) Proteins as GTPase-activating Proteins (GAPs) for ARF Family GTPases*
Anna A. Ivanova, Michael P. East, Slee L Yi, R. Kahn
2014Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase
C. Asquith, T. Laitinen, J. Bennett, P. Godoi +9 more
2017bioRxiv45 citations Open access
Semantic Scholar
PKMYT1: a forgotten member of the WEE1 family
C. Asquith, T. Laitinen, Michael P. East
2019Nature reviews. Drug discovery43 citations
Semantic Scholar
BCKDK: an emerging kinase target for metabolic diseases and cancer
Michael P. East, T. Laitinen, C. Asquith
2021Nature reviews. Drug discovery41 citations
Semantic Scholar
Design of a Cyclin G Associated Kinase (GAK)/Epidermal Growth Factor Receptor (EGFR) Inhibitor Set to Interrogate the Relationship of EGFR and GAK in Chordoma.
C. Asquith, Kaleb M. Naegeli, Michael P. East, T. Laitinen +6 more
2019Journal of Medicinal Chemistry33 citations Open access
Semantic Scholar
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies
Marwah Karim, Sirle Saul, L. Ghita, M. Sahoo +14 more
2022Antiviral Research31 citations Open access
Semantic Scholar
Irreversible JNK1-JUN inhibition by JNK-IN-8 sensitizes pancreatic cancer to 5-FU/FOLFOX chemotherapy.
Matthew B Lipner, X. Peng, C. Jin, Yi Xu +11 more
2020JCI Insight30 citations Open access
Semantic Scholar
PRM-LIVE with Trapped Ion Mobility Spectrometry and Its Application in Selectivity Profiling of Kinase Inhibitors
He-Min Zhu, Scott B. Ficarro, William M. Alexander, Laura E. Fleming +11 more
2021Analytical Chemistry27 citations Open access
Semantic Scholar
Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer
K. Collins, Timothy J. Stuhlmiller, J. Zawistowski, Michael P. East +11 more
2017bioRxiv26 citations Open access
Semantic Scholar
Kinome Profiling Identifies Druggable Targets for Novel Human Cytomegalovirus (HCMV) Antivirals*
Kyle C. Arend, Erik M Lenarcic, Heather A. Vincent, N. Rashid +8 more
2017Molecular & Cellular Proteomics25 citations Open access
Semantic Scholar
BIRC6 mediates imatinib resistance independently of Mcl-1
D. Okumu, Michael P. East, M. Levine, Laura E. Herring +5 more
2017PLoS ONE21 citations Open access
Semantic Scholar
FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036
Steven P. Angus, Timothy J. Stuhlmiller, G. Mehta, Samantha M. Bevill +26 more
2021npj Breast Cancer19 citations Open access
Semantic Scholar
Adaptive chromatin remodeling and transcriptional changes of the functional kinome in tumor cells in response to targeted kinase inhibition
Michael P. East, G. Johnson
2021Journal of Biological Chemistry18 citations Open access
Semantic Scholar
Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of Gemcitabine-Resistant Pancreatic Cancer Cell Growth
Linas Krulikas, Ian M. McDonald, Benjamin Lee, D. Okumu +13 more
2018SLAS discovery : advancing life sciences R & D18 citations Open access
Semantic Scholar
CDC42BPA/MRCKα: a kinase target for brain, ovarian and skin cancers
Michael P. East, C. Asquith
2021Nature reviews. Drug discovery17 citations
Semantic Scholar
Measuring Kinase Activity—A Global Challenge
M. Cann, Ian M. McDonald, Michael P. East, G. Johnson +1 more
2017Journal of Cellular Biochemistry17 citations Open access
Semantic Scholar
Mass spectrometry–based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells
Ian M. McDonald, Gavin D. Grant, Michael P. East, Thomas S. K. Gilbert +8 more
2020Journal of Biological Chemistry16 citations Open access
Semantic Scholar
The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis
Rachel E. Turn, Michael P. East, R. Prekeris, R. Kahn
2020Molecular Biology of the Cell15 citations Open access
Semantic Scholar
The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic
Rachel E. Turn, Yihan Hu, Skylar I. Dewees, N. Devi +9 more
2021bioRxiv14 citations Open access
Semantic Scholar
RIOK2: straddling the kinase/ATPase line
C. Asquith, Michael P. East, W. Zuercher
2019Nature reviews. Drug discovery14 citations
Semantic Scholar
PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2
Marwah Karim, Manjari Mishra, Chieh-Wen Lo, Sirle Saul +30 more
2024bioRxiv13 citations Open access
Semantic Scholar
PIP5K1A: a potential target for cancers with KRAS or TP53 mutations
Michael P. East, T. Laitinen, C. Asquith
2020Nature reviews. Drug discovery13 citations
Semantic Scholar
Small Molecule Inhibition of the Archetypal UbiB protein COQ8
Nathan H. Murray, C. Asquith, Zixiang Fang, Michael P. East +9 more
2022Nature Chemical Biology11 citations Open access
Semantic Scholar
ARF-Like (ARL) Proteins
R. Kahn, Michael P. East, Joshua W. Francis
2014Ras Superfamily Small G Proteins: Biology and Mechanisms 27 citations Open access
Semantic Scholar
Tumor-intrinsic kinome landscape of pancreatic cancer reveals new therapeutic approaches
Yi Xu, X. Peng, Michael P. East, Ian C. McCabe +17 more
2024Cancer Discovery6 citations Open access
Semantic Scholar
Synthesis and Evaluation of Novel 1,2,6-Thiadiazinone Kinase Inhibitors as Potent Inhibitors of Solid Tumors
Andreas S. Kalogirou, Michael P. East, T. Laitinen, C. Torrice +6 more
2021Molecules5 citations Open access
Semantic Scholar
Lyn regulates creatine uptake in an imatinib-resistant CML cell line
D. Okumu, Lucas J. Aponte-Collazo, B. Dewar, Nathan J. Cox +7 more
2019Biochimica et Biophysica Acta - General Subjects5 citations Open access
Semantic Scholar
Identification of 4-anilino-quin(az)oline as a cell active Protein Kinase Novel 3 (PKN3) inhibitor chemotype
C. Asquith, Louisa Temme, Michael P. East, T. Laitinen +7 more
2022ChemMedChem4 citations Open access
Semantic Scholar
WNK kinases: an untapped opportunity to modulate ion transport
Michael P. East, T. Laitinen, C. Asquith
2020Nature reviews. Drug discovery4 citations
Semantic Scholar
Kinome Reprogramming of G2/M Kinases and Repression of MYCN Contribute to Superior Efficacy of Lorlatinib in ALK-Driven Neuroblastoma
Smita Matkar, Michael P. East, Timothy J. Stuhlmiller, Gabriela M. Witek +14 more
2025Molecular Cancer Therapeutics3 citations Open access
Semantic Scholar
Kinase Plasticity in Response to Vandetanib Enhances Sensitivity to Tamoxifen in Estrogen Receptor Positive Breast Cancer
A. Whitman, Rasha T. Kakati, Santiago Haase, C. Thai +11 more
2025bioRxiv3 citations Open access
Semantic Scholar
Quantitative proteomic mass spectrometry of protein kinases to determine dynamic heterogeneity of the human kinome
Michael P. East, R. Sprung, D. Okumu, J. Olivares-Quintero +22 more
2024bioRxiv3 citations
Semantic Scholar
Discovery and optimization of narrow spectrum inhibitors of Tousled like kinase 2 (TLK2) using quantitative structure activity relationships
C. Asquith, Michael P. East, T. Laitinen, Carla Alamillo-Ferrer +8 more
2024European journal of medicinal chemistry3 citations Open access
Semantic Scholar
SMALL MOLECULE CLPP AGONISTS INDUCE SENESCENCE AND ALTER TRAIL-MEDIATED APOPTOTIC RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER CELLS
Lucas J. Aponte-Collazo, Emily M. J. Fennell, Michael P. East, Thomas S. K. Gilbert +6 more
2022bioRxiv3 citations Open access
Semantic Scholar
Correction to “Mitochondrial Protease ClpP Is a Target for the Anticancer Compounds ONC201 and Related Analogues”
P. Graves, Lucas J. Aponte-Collazo, Emily M. J. Fennell, Adam C Graves +13 more
2022ACS Chemical Biology2 citations Open access
Semantic Scholar
DRES-13. DUAL KINASE INHIBITION TO COMBAT EGFR-INHIBITOR RESISTANCE IN GLIOBLASTOMA
E. Smithberger, Abigail K. Shelton, Madison K. Butler, Alex R. Flores +9 more
2019Neuro-Oncology2 citations Open access
Semantic Scholar
Design of a GAK/EGFR inhibitor set to interrogate the relationship of EGFR and GAK in chordoma
C. Asquith, Kaleb M. Naegeli, Michael P. East, T. Laitinen +6 more
2018bioRxiv2 citations Open access
Semantic Scholar
ELMO Domains, Evolutionary and Functional Characterization of a Novel GTPase-activating Protein (GAP)
Michael P. East, J. B. Bowzard, J. Dacks, Richard A. Kahn +1 more
20122 citations
Semantic Scholar
Kinase Plasticity with Vandetanib Treatment Enhances Sensitivity to Tamoxifen in Estrogen Receptor Positive Breast Cancer
A. Whitman, Rasha T. Kakati, Santiago Haase, C. Thai +12 more
2026Molecular Cancer Therapeutics1 citations Open access
Semantic Scholar
Abstract 1857: Glioblastoma growth is suppressed dual inhibition of EGFR and CDK6 kinases
E. Smithberger, Abigail K. Shelton, R. Bash, Madison K. Butler +8 more
2022Cancer Research1 citations
Semantic Scholar
The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic.
Rachel E. Turn, Yihan Hu, Skylar I. Dewees, N. Devi +9 more
2022Molecular Biology of the Cell1 citations Open access
Semantic Scholar
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for therapy
Marwah Karim, Sirle Saul, L. Ghita, M. Sahoo +13 more
2022bioRxiv1 citations Open access
Semantic Scholar

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