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N. Brooks · SciRah

Researcher profile · Semantic Scholar

N. Brooks

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N. Brooks — researcher profile on SciRah

h-index: 16
Works: 48
Citations: 1,215

Most-cited papers

Targeting p300/CBP in lethal prostate cancer
J. Welti, A. Sharp, N. Brooks, W. Yuan +36 more
2021Cancer Discovery186 citations Open access
Semantic Scholar
The effects of the phytoestrogen genistein on the postnatal development of the rat.
Richard W. Lewis, N. Brooks, Gillian Milburn, A. Soames +3 more
2003Toxicological Sciences137 citations Open access
Semantic Scholar
Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma
Stefanie N. Meyer, C. Scuoppo, Sofija Vlasevska, E. Bal +10 more
2019Immunity135 citations Open access
Semantic Scholar
A Phase 1b Open Label Multicentre Study of AZD4547 in Patients with Advanced Squamous Cell Lung Cancers
P. Paik, R. Shen, M. Berger, D. Ferry +10 more
2017Clinical Cancer Research114 citations Open access
Semantic Scholar
Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies.
L. Nicosia, Gary J. Spencer, N. Brooks, F. Amaral +19 more
2023Cancer Cell112 citations Open access
Semantic Scholar
Effect of zinc oxide nanoparticles synthesized from Carya illinoinensis leaf extract on growth and antioxidant properties of mustard (Brassica juncea)
Addisie Geremew, Laura Carson, Selamawit Woldesenbet, Hui-Chen Wang +5 more
2023Frontiers in Plant Science74 citations Open access
Semantic Scholar
AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo
Sarah A. Loddick, Sarah J. Ross, A. Thomason, David M Robinson +21 more
2013Molecular Cancer Therapeutics70 citations Open access
Semantic Scholar
A phase 1b open-label multicenter study of AZD4547 in patients with advanced squamous cell lung cancers: Preliminary antitumor activity and pharmacodynamic data.
P. Paik, R. Shen, D. Ferry, J. Soria +6 more
201447 citations
Semantic Scholar
Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer.
R. Bradbury, N. Hales, A. Rabow, Graeme E. Walker +11 more
2011Bioorganic & Medicinal Chemistry Letters41 citations
Semantic Scholar
Influence of corticotrophin releasing factor on neuronal cell death in vitro and in vivo.
M. Craighead, H. Boutin, Kelly M. L. Middlehurst, S. Allan +3 more
2000Brain Research30 citations
Semantic Scholar
Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series.
B. Barlaam, R. Ducray, Christine Lambert-van der Brempt, P. Plé +6 more
2011Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors.
C. Bardelle, B. Barlaam, N. Brooks, T. Coleman +6 more
2010Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis
J. Diesch, Marguerite-Marie Le Pannérer, R. Winkler, R. Casquero +14 more
2021Nature Communications24 citations Open access
Semantic Scholar
A phase 1 expansion cohort of the fibroblast growth factor receptor (FGFR) inhibitor AZD4547 in patients (pts) with advanced gastric (GC) and gastroesophageal (GOJ) cancer.
H. Arkenau, M. Saggese, A. Hollebecque, A. Mathewson +5 more
201421 citations
Semantic Scholar
CCS1477: A Novel Small Molecule Inhibitor of p300/CBP Bromodomain for the Treatment of Acute Myeloid Leukaemia and Multiple Myeloma
N. Brooks, M. Raja, Barbara Young, Gary J. Spencer +2 more
2019Blood20 citations Open access
Semantic Scholar
Characterisation of CCS1477: A novel small molecule inhibitor of p300/CBP for the treatment of castration resistant prostate cancer.
N. Pegg, N. Brooks, J. Worthington, Barbara Young +8 more
201719 citations
Semantic Scholar
Exploratory biomarker analysis of a phase I study of AZD4547, an inhibitor of fibroblast growth factor receptor (FGFR), in patients with advanced solid tumors.
E. Kilgour, D. Ferry, M. Saggese, H. Arkenau +12 more
201416 citations
Semantic Scholar
Inhibitors of the Tyrosine Kinase EphB4. Part 3. Identification of Non-benzodioxole-Based Kinase Inhibitors.
C. Bardelle, B. Barlaam, N. Brooks, T. Coleman +6 more
201115 citations
Semantic Scholar
CCS1477, a Novel p300/CBP Bromodomain Inhibitor, Enhances Efficacy of Azacitidine and Venetoclax in Pre-Clinical Models of Acute Myeloid Leukaemia and Lymphoma
N. Brooks, T. Knurowski, A. Hughes, K. Clegg +5 more
2021Blood12 citations Open access
Semantic Scholar
560TiP A phase I/IIa study to evaluate the safety and efficacy of CCS1477, a first in clinic inhibitor of p300/CBP, as monotherapy in patients with selected molecular alterations
S. Crabb, R. Plummer, A. Greystoke, L. Carter +11 more
2021Annals of Oncology10 citations Open access
Semantic Scholar
An Open-Label Phase I/IIa Study to Evaluate the Safety and Efficacy of CCS1477, a First in Clinic Inhibitor of the p300/CPB Bromodomains, As Monotherapy in Patients with Advanced Haematological Malignancies
T. Knurowski, K. Clegg, N. Brooks, Fay Ashby +6 more
2019Blood8 citations Open access
Semantic Scholar
Abstract 3568: Characterization of AZD4547: An orally bioavailable, potent and selective inhibitor of FGFR tyrosine kinases 1, 2 and 3
P. Gavine, L. Mooney, E. Kilgour, A. Thomas +7 more
20118 citations
Semantic Scholar
78 ZD4054 specifically inhibits endothelin A receptor-mediated anti-apoptotic effects, but not endothelin B receptor-mediated pro-apoptotic effects
N. Curtis, Z. Howard, N. Brooks, J. Curwen
20048 citations
Semantic Scholar
Therapeutic Targeting of EP300/CBP By Bromodomain Inhibition in Acute Myeloid Leukemia
L. Nicosia, Gary J. Spencer, N. Brooks, Fabio M. R. Amaral +16 more
2022Blood6 citations Open access
Semantic Scholar
Potent Pre-Clinical and Early Phase Clinical Activity of EP300/CBP Bromodomain Inhibitor CCS1477 in Multiple Myeloma
L. Nicosia, N. Brooks, Fabio M. R. Amaral, Oliver J. Sinclair +8 more
2022Blood6 citations Open access
Semantic Scholar
Abstract 3826: CCS1477, a potent and selective p300/CBP bromodomain inhibitor, is targeted & differentiated from BET inhibitors in prostate cancer cell linesin vitro
N. Brooks, A. Prosser, Barbara Young, L. Gaughan +2 more
2019Experimental and Molecular Therapeutics6 citations
Semantic Scholar
Abstract 3848: Preclinical profile of AZD3514: A small molecule-targeting androgen receptor function with a novel mechanism of action and the potential to treat castration-resistant prostate cancer
Sarah A. Loddick, R. Bradbury, Nicola Broadbent, H. Campbell +14 more
20126 citations
Semantic Scholar
457 Preclinical pharmacology of AZD5312, a generation 2.5 antisense oligonucletotide targeting the androgen receptor with differentiated activity from enzalutamide
B. Davies, A. Thomason, Rebecca P A Ellston, H. Campbell +9 more
20145 citations
Semantic Scholar
36 POSTER The comnination of a specific endothelin A receptor antagonist ZD4054 and submaximal bisphosphonate pamidronate prevents bone metastasis
E. Williams, E. Thompson, D. Sreedharan, N. Brooks
20065 citations
Semantic Scholar
Abstract 1345: p300/CBP bromodomain inhibitor CCS1477 enhances the efficacy of immune checkpoint blockade therapy in cancer treatment
Jing-Hui Liu, Xinyi Wang, Katelyn Jones, N. Brooks +2 more
2022Cancer Research4 citations
Semantic Scholar
The combination of a specific endothelin A receptor antagonist ZD4054 and submaximal bisphosphonate pamidronate prevents bone metastasis
E. Williams, E. Thompson, D. Sreedharan, N. Brooks
20064 citations
Semantic Scholar
A Phase 1b Open Label Multicentre Study of AZD4547 in Patients with Advanced Squamous Cell Lung Cancers
P. Paik, Rong-Rong Shen, M. Berger, D. Ferry +11 more
20173 citations
Semantic Scholar
A novel small molecule inhibitor of p300/CBP for the treatment of castration-resistant prostate cancer: Preclinical evaluation.
N. Brooks, N. Pegg, J. Worthington, Barbara Young +6 more
20173 citations
Semantic Scholar
Abstract 3991: Novel small molecule inhibitors of p300/CBP down-regulate androgen receptor (AR) and c-Myc for the treatment of prostate cancer and beyond
N. Pegg, J. Worthington, Barbara Young, A. Prosser +6 more
2018Experimental and Molecular Therapeutics2 citations
Semantic Scholar
Abstract 3912: The discovery of AZD4547: An orally bioavailable, potent and selective N-(5-Pyrazolyl)benzamide FGFR1-3 inhibitor
A. Thomas, M. Theoclitou, D. Buttar, Linette Ruston +9 more
20122 citations
Semantic Scholar
The combination of the specific endothelin A receptor antagonist ZD4054 and submaximal bisphosphonate pamidronate prevents soft-tissue metastasis
E. Williams, E. Thompson, D. Sreedharan, N. Brooks +2 more
20072 citations
Semantic Scholar
Abstract 1575: Novel small molecule inhibitors of p300/CBP down-regulate AR and c-Myc for the treatment of castrate resistant prostate cancer
N. Brooks, N. Pegg, J. Worthington, Barbara Young +7 more
20171 citations
Semantic Scholar
Abstract B107: Characterization of a small molecule selective androgen receptor downregulator: A novel approach for the treatment of castration-resistant prostate cancer.
Sarah A. Loddick, S. Brave, H. Campbell, L. Gaughan +10 more
20111 citations
Semantic Scholar
Abstract B074: Targeting CBP/p300 and its downstream transcriptional machinery in advanced PCa
Sumaira Sardar, L. Ravindranath, C. McNair, Saswati N. Chand +12 more
2023Cancer Research0 citations
Semantic Scholar
Abstract 1449: Targeting CBP/p300 and its downstream transcriptional machinery in advanced prostate cancer
Sumaira Sardar, L. Ravindranath, C. McNair, Saswati N. Chand +12 more
2023Cancer Research0 citations
Semantic Scholar
Targeting p300/CBP in lethal prostate cancer
J. Welti, A. Sharp, N. Brooks, W. Yuan +38 more
20200 citations
Semantic Scholar
Abstract 1019: P300/CBP inhibitor CCS1477 targets 22Rv1 prostate tumor AR and c-myc gene expressionin vivo
P. Elvin, N. Pegg, Simone Daminelli, I. Edén +4 more
2019Endocrinology0 citations
Semantic Scholar
Abstract A091: Therapeutic targeting of the p300/CBP bromodomain for the treatment of castration-resistant prostate cancer
N. Brooks, N. Pegg, J. Worthington, Barbara Young +1 more
2018Oral Presentations - Proffered Abstracts0 citations
Semantic Scholar
Abstract DDT01-01: Preclinical profile of AZD4547: A selective inhibitor of FGF-receptors 1, 2, and 3
N. Brooks
20110 citations
Semantic Scholar
1293 A NOVEL ANTI-ANDROGEN ARD1 DOWN-REGULATES ANDROGEN RECEPTOR LEVELS AND ACTIVITY AND SUPPRESSES PROSTATE CANCER LNCAP CELL GROWTH IN VITRO AND IN VIVO
H. Kuruma, K. Gust, H. Matsumoto, A. Zoubeidi +4 more
20100 citations
Semantic Scholar
Tu-P7:196 Co-existent obesity, hyperlipidemia and systemic inflammation in a rodent model of atherosclerosis
S. Filippov, B. Goetz, C. Whitinger, N. Brooks +2 more
20060 citations
Semantic Scholar
Research report Influence of corticotrophin releasing factor on neuronal cell death in vitro and in vivo
M. Craighead, H. Boutin, S. Allan, N. Brooks +2 more
20000 citations
Semantic Scholar
Frontiers in reproductive biology : symposium to honour Professor G. E. Lamming OBE on the occasion of his 65th birthday, held at the University of Nottingham School of Agriculture, Sutton Bonington 12th and 13th July 1992
N. Brooks
19920 citations
Semantic Scholar

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K. Knudsen — researcher profile on SciRah

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E. Kilgour — researcher profile on SciRah

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