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P. Gavine · SciRah

Researcher profile · Semantic Scholar

P. Gavine

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P. Gavine — researcher profile on SciRah

h-index: 20
Works: 45
Citations: 1,910

Most-cited papers

AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family.
P. Gavine, L. Mooney, E. Kilgour, A. Thomas +8 more
2012Cancer Research472 citations Open access
Semantic Scholar
FGFR2 Gene Amplification in Gastric Cancer Predicts Sensitivity to the Selective FGFR Inhibitor AZD4547
Liang Xie, Xinying Su, Lin Zhang, Xiao-Lu Yin +15 more
2013Clinical Cancer Research221 citations
Semantic Scholar
Translating the Therapeutic Potential of AZD4547 in FGFR1-Amplified Non–Small Cell Lung Cancer through the Use of Patient-Derived Tumor Xenograft Models
Jingchuan Zhang, Lin Zhang, Xinying Su, Ming X. Li +17 more
2012Clinical Cancer Research151 citations
Semantic Scholar
Tumour cell responses to new fibroblast growth factor receptor tyrosine kinase inhibitors and identification of a gatekeeper mutation in FGFR3 as a mechanism of acquired resistance
V. Chell, K. Balmanno, A. S. Little, M. Wilson +5 more
2013Oncogene146 citations Open access
Semantic Scholar
Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically
Lucy C. Riches, A. G. Trinidad, Gareth D. Hughes, Gemma N. Jones +17 more
2019Molecular Cancer Therapeutics136 citations
Semantic Scholar
HER2, MET and FGFR2 oncogenic driver alterations define distinct molecular segments for targeted therapies in gastric carcinoma
Yuan-Jie Liu, D. Shen, Xiao-Lu Yin, P. Gavine +12 more
2014British Journal of Cancer107 citations Open access
Semantic Scholar
Establishment of patient-derived non-small cell lung cancer xenograft models with genetic aberrations within EGFR, KRAS and FGFR1: useful tools for preclinical studies of targeted therapies
Xu-Chao Zhang, Jingchuan Zhang, Ming X. Li, Xiao-sui Huang +12 more
2013Journal of Translational Medicine78 citations Open access
Semantic Scholar
PD-L1 expression and its relationship with oncogenic drivers in non-small cell lung cancer (NSCLC)
Li-Yan Jiang, Xinying Su, Tian-wei Zhang, Xiao-Lu Yin +17 more
2017OncoTarget58 citations Open access
Semantic Scholar
Targeting fibroblast growth factor receptor signaling inhibits prostate cancer progression
Shu Feng, Long-Jiang Shao, Wendong Yu, P. Gavine +1 more
2012Clinical Cancer Research48 citations Open access
Semantic Scholar
Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation.
Jing Zhang, Li-Qiang Fu, B. Shen, Ying-Tao Liu +20 more
2020Cell Chemical Biology44 citations Open access
Semantic Scholar
Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models
Xian-hua Wu, Jingchuan Zhang, Ruheng Zhen, Jing Lv +16 more
2012Journal of Translational Medicine44 citations Open access
Semantic Scholar
Assessment and prognostic analysis of EGFR, HER2, and HER3 protein expression in surgically resected gastric adenocarcinomas
Daoqiang Tang, C. Liu, D. Shen, Shuqiong Fan +4 more
2014OncoTargets and Therapy40 citations Open access
Semantic Scholar
Longitudinal high-dimensional analysis identifies immune features associating with response to anti-PD-1 immunotherapy
E. Leung, Run-Ze Li, Xing-Xing Fan, L. Wang +16 more
2023Nature Communications33 citations Open access
Semantic Scholar
Establishment and characterization of esophageal squamous cell carcinoma patient-derived xenograft mouse models for preclinical drug discovery
Jingchuan Zhang, Dong-Xian Jiang, Xiao-Jing Li, Jing Lv +12 more
2014Laboratory Investigation33 citations Open access
Semantic Scholar
Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma
P. Gavine, Mei Wang, D. Yu, Eva Hu +12 more
2015BMC Cancer32 citations Open access
Semantic Scholar
Intra-Tumoral Heterogeneity of HER2, FGFR2, cMET and ATM in Gastric Cancer: Optimizing Personalized Healthcare through Innovative Pathological and Statistical Analysis
Peng Ye, Mei-Zhuo Zhang, Shuqiong Fan, Tian-wei Zhang +5 more
2015PLoS ONE32 citations Open access
Semantic Scholar
Frequency, characterization, and prognostic analysis of PIK3CA gene mutations in Chinese esophageal squamous cell carcinoma.
Jun Hou, Dong-Xian Jiang, Jingchuan Zhang, P. Gavine +10 more
2014Human Pathology32 citations
Semantic Scholar
Patient-Derived Gastric Carcinoma Xenograft Mouse Models Faithfully Represent Human Tumor Molecular Diversity
Tian-wei Zhang, Lin Zhang, Shuqiong Fan, Mei-Zhuo Zhang +10 more
2015PLoS ONE31 citations Open access
Semantic Scholar
Relationships between Chromosome 7 Gain, MET Gene Copy Number Increase and MET Protein Overexpression in Chinese Papillary Renal Cell Carcinoma Patients
Xiao-Lu Yin, Tian-wei Zhang, Xinying Su, Yan Ji +6 more
2015PLoS ONE21 citations Open access
Semantic Scholar
Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL.
Li-Qiang Fu, Jing Zhang, Bin-Jon Shen, L. Kong +17 more
2021Journal of Medicinal Chemistry20 citations Open access
Semantic Scholar
An evaluation and recommendation of the optimal methodologies to detect RET gene rearrangements in papillary thyroid carcinoma
Tian-wei Zhang, Ya-Chao Lu, Qingqing Ye, Mei-Zhuo Zhang +7 more
2015Genes, Chromosomes and Cancer18 citations
Semantic Scholar
Establishment of patient-derived non-small cell lung cancer xenograft models with genetic aberrations within EGFR, KRAS and FGFR1: useful tools for preclinical studies of targeted therapies
Xu-Chao Zhang, Jingchuan Zhang, Ming X. Li, Xiao-sui Huang +12 more
2013Journal of Translational Medicine18 citations Open access
Semantic Scholar
Protein stabilization: a common consequence of mutations in independently derived v-Myc alleles
P. Gavine, J. Neil, D. Crouch
1999Oncogene17 citations Open access
Semantic Scholar
Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site
Hong-Ming Chen, Julie A. Tucker, Xiao-Tao Wang, P. Gavine +6 more
2016Acta Crystallographica Section D: Structural Biology15 citations Open access
Semantic Scholar
Evaluation of Trastuzumab Anti-Tumor Efficacy and its Correlation with HER-2 Status in Patient-Derived Gastric Adenocarcinoma Xenograft Models
Hao Chen, Qingqing Ye, Jing Lv, Peng Ye +5 more
2015Pathology and Oncology Research11 citations Open access
Semantic Scholar
Prevalence and prognostic significance of FGF receptor 2 (FGFR2) gene amplification in Caucasian and Korean gastric cancer cohorts.
E. Kilgour, Xinying Su, P. Zhan, P. Gavine +7 more
201211 citations
Semantic Scholar
Structure-activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: part 2.
Bénédicte Delouvrié, K. Al-Kadhimi, J. Arnould, S. Barry +17 more
2012Bioorganic & Medicinal Chemistry Letters9 citations Open access
Semantic Scholar
Abstract 3568: Characterization of AZD4547: An orally bioavailable, potent and selective inhibitor of FGFR tyrosine kinases 1, 2 and 3
P. Gavine, L. Mooney, E. Kilgour, A. Thomas +7 more
20118 citations
Semantic Scholar
Structure-activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: part 1.
Bénédicte Delouvrié, K. Al-Kadhimi, J. Arnould, S. Barry +17 more
2012Bioorganic & Medicinal Chemistry Letters6 citations
Semantic Scholar
Abstract 3114: Targeting MET in preclinical models to support the clinical development of Volitinib in NSCLC
C. D'Cruz, M. Frigault, Ammar Adam, Minhui Shen +10 more
20145 citations
Semantic Scholar
Abstract C60: Pre-clinical efficacy of the ATR inhibitor AZD6738 in combination with the PARP inhibitor olaparib
A. Lau, E. Brown, A. Thomason, R. Odedra +6 more
20153 citations
Semantic Scholar
Predictive Biomarkers and Personalized Medicine FGFR 2 Gene Ampli fi cation in Gastric Cancer Predicts Sensitivity to the Selective FGFR Inhibitor AZD 4547
Liang Xie, Xinying Su, Lin Zhang, Xiao-Lu Yin +15 more
20132 citations
Semantic Scholar
Therapeutics , Targets , and Chemical Biology AZD 4547 : An Orally Bioavailable , Potent , and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family
P. Gavine, L. Mooney, E. Kilgour, A. Thomas +8 more
20122 citations
Semantic Scholar
Abstract 3912: The discovery of AZD4547: An orally bioavailable, potent and selective N-(5-Pyrazolyl)benzamide FGFR1-3 inhibitor
A. Thomas, M. Theoclitou, D. Buttar, Linette Ruston +9 more
20122 citations
Semantic Scholar
JNJ-79032421, a Novel Membrane-Restricted Mesothelin-Targeting T Cell–Engaging Bispecific Antibody for the Treatment of Mesothelin-Positive Cancers
K. Smans, T. Nesspor, S. de Breucker, E. V. van Heerde +19 more
2026Molecular Cancer Therapeutics1 citations Open access
Semantic Scholar
The class A repeats of LRP5 are required for normal development of bone, retinal vasculature and mammary gland in vivo
Cassandra R. Diegel, Megan N. Michalski, J. Ubels, Gabrielle Foxa Wiartalla +10 more
2025Disease Models & Mechanisms1 citations Open access
Semantic Scholar
Abstract 189: Developing a patient-derived organoid biobank, suitable for large scale drug screenings
L. Fielmich, Annemarie Buijs, Daniele Mori, B. Viergever +13 more
2023Cancer Research1 citations
Semantic Scholar
Abstract 5140: PD-L1 expression and its relationship with other driver genes in non-small cell lung cancer (NSCLC)
Li-Yan Jiang, Xinying Su, Tian-wei Zhang, Xiao-Lu Yin +16 more
20161 citations
Semantic Scholar
Abstract 2923: Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma
P. Gavine, Mei Wang, Dehua Yu, Eva Hu +14 more
20141 citations
Semantic Scholar
Abstract 928: Volitinib (HMPL504), a novel, selective and potent cMET inhibitor, is efficacious in primary tumor models of cMET-driven gastric cancer.
P. Gavine, S. Fan, Haihua Fu, Lu Han +14 more
20131 citations
Semantic Scholar
Longitudinal High-Dimensional Analysis Identifies Biomarkers of Response to Anti-PD-1 Immunotherapy
Run-Ze Li, Xing-Xing Fan, Ze-Bo Jiang, Ju-Min Huang +15 more
2021Social Science Research Network0 citations Open access
Semantic Scholar
Relationships between Chromosome 7 Gain, MET GCN Increase and MET Protein Overexpression in Chinese PRCC
Xiao-Lu Yin, Tian-wei Zhang, Xinying Su, Yan Ji +6 more
20160 citations
Semantic Scholar
Abstract 2090: Targeting HER family signaling in gastric cancer: The selective and equipotent EGFR, HER2 and HER3 signaling inhibitor, AZD8931, is efficacious in primary models of HER family driven disease.
P. Gavine, Liang Xie, Lin Zhang, Jing Lv +6 more
20130 citations
Semantic Scholar
Abstract 1917: Translating the therapeutic potential of AZD4547 in FGFR1-amplified non-small cell lung cancer through the use of primary lung explant models
Jingchuan Zhang, Lin Zhang, Xinying Su, Ming X. Li +10 more
20120 citations
Semantic Scholar
Abstract 3758: Activity of AZD4547, a potent and selective FGF-receptor inhibitor, alone and in combination with chemotherapy in standard xenograft and human primary explant models of FGF-receptor 2 amplified gastric cancer
Jingchuan Zhang, Lin Zhang, Xiao-Lu Yin, Yan-Ping Xu +7 more
20120 citations
Semantic Scholar

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Xinying Su×23
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Xinying Su — researcher profile on SciRah
Xiao-Lu Yin×18
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Xiao-Lu Yin — researcher profile on SciRah
Jingchuan Zhang×12
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Liang Xie×11
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Tian-wei Zhang — researcher profile on SciRah

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E. Kilgour — researcher profile on SciRah

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Lin Zhang — researcher profile on SciRah

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Q. Ji — researcher profile on SciRah

Shuqiong Fan×9

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Guanshan Zhu×8

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Guanshan Zhu — researcher profile on SciRah

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Li Zheng — researcher profile on SciRah

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Yan-Ping Xu — researcher profile on SciRah