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L. Gaughan · SciRah

Researcher profile · Semantic Scholar

L. Gaughan

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L. Gaughan — researcher profile on SciRah

h-index: 32
Works: 81
Citations: 3,999

Most-cited papers

Upregulation and Nuclear Recruitment of HDAC1 in Hormone Refractory Prostate Cancer
K. Halkidou, L. Gaughan, Susan Cook, H. Y. Leung +2 more
2004The Prostate525 citations
Semantic Scholar
Tip60 and Histone Deacetylase 1 Regulate Androgen Receptor Activity through Changes to the Acetylation Status of the Receptor*
L. Gaughan, I. R. Logan, Susan Cook, D. Neal +1 more
2002Journal of Biological Chemistry311 citations Open access
Semantic Scholar
Tip60 Is a Nuclear Hormone Receptor Coactivator*
M. Brady, D. Ozanne, L. Gaughan, Ian S. Waite +3 more
1999Journal of Biological Chemistry271 citations Open access
Semantic Scholar
The RNA helicase p68 is a novel Androgen Receptor Co-Activator involved in splicing and is over-expressed in Prostate Cancer
E. Clark, A. Coulson, Caroline Dalgliesh, P. Rajan +8 more
2008Cancer Research199 citations Open access
Semantic Scholar
Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation
L. Gaughan, I. R. Logan, D. Neal, C. Robson
2005Nucleic Acids Research187 citations Open access
Semantic Scholar
Androgen receptor nuclear translocation is facilitated by the f-actin cross-linking protein filamin.
D. Ozanne, M. Brady, Susan Cook, L. Gaughan +2 more
2000Molecular Endocrinology179 citations Open access
Semantic Scholar
2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer
A. Blomme, Catriona A. Ford, E. Mui, Rachana Patel +21 more
2020Nature Communications157 citations Open access
Semantic Scholar
Regulation of the androgen receptor by SET9-mediated methylation
L. Gaughan, J. Stockley, Nan Wang, S. McCracken +8 more
2010Nucleic Acids Research126 citations Open access
Semantic Scholar
The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover
Kelly Coffey, L. Rogerson, Claudia A. Ryan-Munden, Dhuha Alkharaif +10 more
2013Nucleic Acids Research120 citations Open access
Semantic Scholar
This Work Is Licensed under a Creative Commons Attribution 4.0 International License Date Deposited: the Histone Demethylase Enzyme Kdm3a Is a Key Estrogen Receptor Regulator in Breast Cancer
Wade Ma, J. D, W. L, Stockley J +10 more
103 citations
Semantic Scholar
Human PIRH2 Enhances Androgen Receptor Signaling through Inhibition of Histone Deacetylase 1 and Is Overexpressed in Prostate Cancer
I. R. Logan, L. Gaughan, S. McCracken, Vasileia Sapountzi +2 more
2006Molecular and Cellular Biology99 citations Open access
Semantic Scholar
Tip60 Is a Co-activator Specific for Class I Nuclear Hormone Receptors*
L. Gaughan, M. Brady, Susan Cook, D. Neal +1 more
2001Journal of Biological Chemistry95 citations Open access
Semantic Scholar
Deubiquitinating Enzyme Usp12 Is a Novel Co-activator of the Androgen Receptor*
Urszula L. Burska, V. Harle, Kelly Coffey, S. Darby +5 more
2013Journal of Biological Chemistry84 citations Open access
Semantic Scholar
The RNA‐binding and adaptor protein Sam68 modulates signal‐dependent splicing and transcriptional activity of the androgen receptor
P. Rajan, L. Gaughan, Caroline Dalgliesh, A. El-Sherif +3 more
2008Journal of Pathology79 citations Open access
Semantic Scholar
KDM4B is a Master Regulator of the Estrogen Receptor Signalling Cascade
L. Gaughan, J. Stockley, Kelly Coffey, Daniel J O'Neill +7 more
2013Nucleic Acids Research78 citations Open access
Semantic Scholar
Control of Human PIRH2 Protein Stability
I. R. Logan, Vasileia Sapountzi, L. Gaughan, D. Neal +1 more
2004Journal of Biological Chemistry77 citations Open access
Semantic Scholar
Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors
I. Mills, L. Gaughan, C. Robson, T. S. Ross +3 more
2005Journal of Cell Biology75 citations Open access
Semantic Scholar
FUS/TLS is a novel mediator of androgen-dependent cell-cycle progression and prostate cancer growth.
G. Brooke, Rachel Culley, D. A. Dart, D. Mann +10 more
2011Cancer Research74 citations Open access
Semantic Scholar
Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity.
Andrew Axon, F. May, L. Gaughan, F. Williams +2 more
2012Toxicology73 citations Open access
Semantic Scholar
A Human T-Cell Lymphotropic Virus Type 1 Enhancer of Myc Transforming Potential Stabilizes Myc-TIP60 Transcriptional Interactions
Soumya Awasthi, Anima Sharma, Kasuen Wong, Junyu Zhang +16 more
2005Molecular and Cellular Biology71 citations Open access
Semantic Scholar
AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo
Sarah A. Loddick, Sarah J. Ross, A. Thomason, David M Robinson +21 more
2013Molecular Cancer Therapeutics70 citations Open access
Semantic Scholar
Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer
C. Fletcher, E. Sulpice, S. Combe, A. Shibakawa +18 more
2019Oncogene68 citations Open access
Semantic Scholar
Targeting the DNA Double Strand Break Repair Machinery in Prostate Cancer
Fadhel S. Shaheen, P. Znojek, A. Fisher, M. Webster +6 more
2011PLoS ONE68 citations Open access
Semantic Scholar
Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway
U. McClurg, Emma E. Summerscales, V. Harle, L. Gaughan +1 more
2014OncoTarget56 citations Open access
Semantic Scholar
AGE‐modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival
M. Rodríguez-Teja, Julian H. Gronau, Claudia Breit, Yu-Zhi Zhang +11 more
2015Journal of Pathology53 citations Open access
Semantic Scholar
A novel CRISPR-engineered prostate cancer cell line defines the AR-V transcriptome and identifies PARP inhibitor sensitivities
E. Kounatidou, S. Nakjang, S. McCracken, S. Dehm +3 more
2019Nucleic Acids Research44 citations Open access
Semantic Scholar
FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer
Dominic Jones, M. Wade, S. Nakjang, Lewis Chaytor +3 more
2015OncoTarget44 citations Open access
Semantic Scholar
Identification of Novel Androgen-Regulated Pathways and mRNA Isoforms through Genome-Wide Exon-Specific Profiling of the LNCaP Transcriptome
P. Rajan, Caroline Dalgliesh, Phillippa J. Carling, T. Buist +11 more
2011PLoS ONE43 citations Open access
Semantic Scholar
Aurora A regulates expression of AR-V7 in models of castrate resistant prostate cancer
Dominic Jones, M. Noble, S. Wedge, C. Robson +1 more
2017Scientific Reports39 citations Open access
Semantic Scholar
ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1) synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer
R. Garnham, D. Geh, Ryan Nelson, E. Ramon‐Gil +20 more
2024Communications Biology37 citations Open access
Semantic Scholar
SETD6 controls the expression of estrogen-responsive genes and proliferation of breast carcinoma cells
Daniel J O'Neill, S. Williamson, Dhuha Alkharaif, I. Monteiro +5 more
2014Epigenetics37 citations Open access
Semantic Scholar
The co‐chaperone p23 promotes prostate cancer motility and metastasis
Laia Querol Cano, Derek N. Lavery, Soraya Sin, E. Spanjaard +10 more
2014Molecular Oncology35 citations Open access
Semantic Scholar
Propagation of human prostate tissue from induced pluripotent stem cells
A. Hepburn, Emma L. Curry, M. Moad, R. Steele +10 more
2020Stem Cells Translational Medicine32 citations Open access
Semantic Scholar
Regulation of gene expression by the RNA-binding protein Sam68 in cancer.
P. Rajan, L. Gaughan, Caroline Dalgliesh, A. El-Sherif +3 more
2008Biochemical Society Transactions32 citations Open access
Semantic Scholar
IKBKE activity enhances AR levels in advanced prostate cancer via modulation of the Hippo pathway
A. Bainbridge, Scott Walker, Joseph Smith, Kathryn Patterson +12 more
2020Nucleic Acids Research31 citations Open access
Semantic Scholar
AR alterations inform circulating tumor DNA detection in metastatic castration resistant prostate cancer patients
Todd P. Knutson, Bin Luo, Anna Kobilka, Jacqueline Lyman +12 more
2024Nature Communications30 citations Open access
Semantic Scholar
Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity
U. McClurg, D. Cork, S. Darby, Claudia A. Ryan-Munden +5 more
2016Nucleic Acids Research29 citations Open access
Semantic Scholar
Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy
Daniel J O'Neill, Dominic Jones, M. Wade, James Grey +7 more
2015OncoTarget29 citations Open access
Semantic Scholar
SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer
R. S. Martinez, M. Salji, L. Rushworth, C. Ntala +18 more
2021Cancer Research25 citations Open access
Semantic Scholar
Survival Outcome and EMT Suppression Mediated by a Lectin Domain Interaction of Endo180 and CD147
M. Rodríguez-Teja, J. Gronau, Ai Minamidate, S. Darby +5 more
2014Molecular Cancer Research24 citations Open access
Semantic Scholar
The Histone Demethylase Enzymes KDM3A and KDM4B Co-Operatively Regulate Chromatin Transactions of the Estrogen Receptor in Breast Cancer
Dominic Jones, L. Wilson, H. Thomas, L. Gaughan +1 more
2019Cancers23 citations Open access
Semantic Scholar
The methyltransferase SET9 regulates TGFB1 activation of renal fibroblasts via interaction with SMAD3
V. Shuttleworth, L. Gaughan, L. Nawafa, Caitlin A. Mooney +3 more
2018Journal of Cell Science22 citations Open access
Semantic Scholar
Engineering prostate cancer in vitro: what does it take?
A. Buskin, E. Scott, Ryan Nelson, L. Gaughan +3 more
2023Oncogene19 citations Open access
Semantic Scholar
Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
U. McClurg, V. Harle, A. Nabbi, Amanda Batalha-Pereira +5 more
2015OncoTarget17 citations Open access
Semantic Scholar
The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer
Beth Adamson, Nicholas Brittain, Laura Walker, Ruaridh Duncan +18 more
2023Journal of Clinical Investigation16 citations Open access
Semantic Scholar
The Pioneering Role of GATA2 in Androgen Receptor Variant Regulation Is Controlled by Bromodomain and Extraterminal Proteins in Castrate-Resistant Prostate Cancer
Lewis Chaytor, Matthew Simcock, S. Nakjang, Richard Heath +4 more
2019Molecular Cancer Research16 citations Open access
Semantic Scholar
Differential regulation of the androgen receptor by protein phosphatase regulatory subunits
James Grey, Dominic Jones, L. Wilson, S. Nakjang +5 more
2017OncoTarget9 citations Open access
Semantic Scholar
Defining Splicing Factor Requirements for Androgen Receptor Variant Synthesis in Advanced Prostate Cancer
Laura Walker, Ruaridh Duncan, Beth Adamson, Hannah Kendall +8 more
2024Molecular Cancer Research8 citations Open access
Semantic Scholar
Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation
Rebecca J. Harris, Maninder Heer, M. Levasseur, T. Cartwright +7 more
2023bioRxiv8 citations Open access
Semantic Scholar
Regulation of the androgen receptor by SET9-mediated methylation
L. Gaughan, J. Stockley, Nan Wang, S. McCracken +8 more
2013Nucleic Acids Research8 citations Open access
Semantic Scholar

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