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V. Tkachev · SciRah

Researcher profile · Semantic Scholar

V. Tkachev

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V. Tkachev — researcher profile on SciRah

h-index: 21
Works: 84
Citations: 4,332

Most-cited papers

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
Carly G. K. Ziegler, Samuel J. Allon, Sarah K. Nyquist, I. Mbano +111 more
2020Cell2,176 citations Open access
Semantic Scholar
Innovations present in the primate interneuron repertoire
F. Krienen, Melissa Goldman, Qiang-Ge Zhang, Ricardo C. H. del Rosario +28 more
2020Nature321 citations Open access
Semantic Scholar
Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD
Benjamin K. Watkins, M. Qayed, Courtney Mccracken, Brandi Bratrude +42 more
2021Journal of Clinical Oncology198 citations Open access
Semantic Scholar
Chimeric Antigen Receptor T Cell-Mediated Neurotoxicity in Non-Human Primates
A. Taraseviciute, V. Tkachev, R. Ponce, C. Turtle +19 more
2018Cancer Discovery198 citations Open access
Semantic Scholar
Current Concepts and Advances in Graft-Versus-Host Disease Immunology
G. Hill, B. Betts, V. Tkachev, L. Kean +1 more
2021Annual Review of Immunology168 citations Open access
Semantic Scholar
The IL-33/ST2 axis augments effector T-cell responses during acute GVHD.
D. Reichenbach, V. Schwarze, B. Matta, V. Tkachev +23 more
2015Blood168 citations Open access
Semantic Scholar
Effector T cells require fatty acid metabolism during murine graft-versus-host disease.
C. Byersdorfer, V. Tkachev, A. Opipari, Stefanie Goodell +4 more
2013Blood137 citations Open access
Semantic Scholar
Programmed death-1 controls T cell survival by regulating oxidative metabolism
V. Tkachev, Stefanie Goodell, A. Opipari, Ling-Yang Hao +4 more
2015Journal of Immunology117 citations Open access
Semantic Scholar
Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.
A. Saha, Roddy S. O'Connor, G. Thangavelu, S. Lovitch +31 more
2016Journal of Clinical Investigation86 citations Open access
Semantic Scholar
Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant
V. Tkachev, Scott N. Furlan, Benjamin K. Watkins, Daniel J. Hunt +14 more
2017Science Translational Medicine74 citations Open access
Semantic Scholar
Anaplerotic Metabolism of Alloreactive T Cells Provides a Metabolic Approach To Treat Graft-Versus-Host Disease
G. Glick, R. Rossignol, C. Lyssiotis, D. Wahl +11 more
2014Journal of Pharmacology and Experimental Therapeutics73 citations Open access
Semantic Scholar
SARS-CoV-2 Receptor ACE2 is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Enriched in Specific Cell Subsets Across Tissues
Carly G. K. Ziegler, Samuel J. Allon, Sarah K. Nyquist, I. Mbano +42 more
2020Social Science Research Network70 citations
Semantic Scholar
Transcriptome Analysis of GVHD Reveals Aurora Kinase A as a Targetable Pathway for Disease Prevention
Scott N. Furlan, Benjamin K. Watkins, V. Tkachev, R. Flynn +17 more
2015Science Translational Medicine57 citations Open access
Semantic Scholar
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident donor CD8+ memory T cells drive gastrointestinal acute graft-versus-host disease
V. Tkachev, J. Kaminski, E. L. Potter, Scott N. Furlan +24 more
2021Science Translational Medicine52 citations Open access
Semantic Scholar
CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates
Benjamin K. Watkins, V. Tkachev, Scott N. Furlan, Daniel J. Hunt +20 more
2018Journal of Clinical Investigation51 citations Open access
Semantic Scholar
Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells.
Scott N. Furlan, Benjamin K. Watkins, V. Tkachev, S. Cooley +12 more
2016Blood40 citations Open access
Semantic Scholar
IL2 enhances ex-vivo expanded regulatory T cell persistence after adoptive transfer
Scott N. Furlan, Karnail Singh, Christina Lopez, V. Tkachev +6 more
2019bioRxiv38 citations Open access
Semantic Scholar
Chronic GvHD NIH Consensus Project Biology Task Force: evolving path to personalized treatment of chronic GvHD
N. Buxbaum, G. Socié, Geoffrey R. Hill, K. Macdonald +12 more
2022Blood Advances37 citations Open access
Semantic Scholar
Innovations in Primate Interneuron Repertoire
F. Krienen, Melissa Goldman, Qiang-Ge Zhang, Ricardo C. H. del Rosario +28 more
2019bioRxiv36 citations Open access
Semantic Scholar
Human OX40L–CAR-Tregs target activated antigen-presenting cells and control T cell alloreactivity
Xianliang Rui, Francesca Alvarez Calderon, Holly Wobma, U. Gerdemann +8 more
2024Science Translational Medicine33 citations Open access
Semantic Scholar
Measurement of leukocyte trafficking kinetics in macaques by serial intravascular staining
E. L. Potter, H. Gideon, V. Tkachev, G. Fabozzi +8 more
2021Science Translational Medicine25 citations
Semantic Scholar
Engineering T cells to suppress acute GvHD and leukemia relapse after allogeneic hematopoietic stem cell transplantation.
Fei-Yan Mo, N. Watanabe, Kayleigh Ingersoll Omdahl, Phillip M Burkhardt +9 more
2022Blood21 citations Open access
Semantic Scholar
The Knife’s Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism But With A Significant Risk of CMV Reactivation and Disease in Rhesus Macaques
H. Zheng, Benjamin K. Watkins, V. Tkachev, Shan Yu +15 more
2016American Journal of Transplantation21 citations Open access
Semantic Scholar
B-cell-directed CAR-T cell therapy activates CD8+ cytotoxic CARneg bystander T-cells in non-human primates and patients.
J. Kaminski, R. Fleming, Francesca Alvarez-Calderon, Marlana B. Winschel +17 more
2024Blood19 citations Open access
Semantic Scholar
Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation
Lucrezia Colonna, C. Peterson, John B. Schell, Judith M Carlson +35 more
2018Nature Communications17 citations Open access
Semantic Scholar
DNA methylation and chromatin accessibility predict age in the domestic dog
Kelly Jin, Brianah M. McCoy, Elisabeth A. Goldman, Viktoria Usova +8 more
2024Aging Cell14 citations Open access
Semantic Scholar
Notch signaling drives intestinal graft-versus-host disease in mice and non-human primates
V. Tkachev, A. Vanderbeck, E. Perkey, Scott N. Furlan +27 more
2023Science Translational Medicine14 citations Open access
Semantic Scholar
Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade
H. Zheng, Ben A. Doran, Kyle J. Kimler, Alison Yu +42 more
2026eLife13 citations Open access
Semantic Scholar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice.
A. Saha, R. Palchaudhuri, Leanne Lanieri, Sharon L. Hyzy +18 more
2024Blood11 citations Open access
Semantic Scholar
Preclinical testing of anti-human CD28 Fab’ antibody in a novel nonhuman primate (NHP) small animal rodent model of xenogenic graft-versus-host disease (GVHD)
K. Hippen, Benjamin K. Watkins, V. Tkachev, Amanda M. Lemire +8 more
2016Transplantation11 citations Open access
Semantic Scholar
Identification and Tracking of Alloreactive T Cell Clones in Rhesus Macaques Through the RM-scTCR-Seq Platform
U. Gerdemann, R. Fleming, J. Kaminski, C. McGuckin +7 more
2021bioRxiv7 citations Open access
Semantic Scholar
Organ-specific microenvironments drive divergent T cell evolution in acute graft-versus-host disease
K. Omdahl, R. Bermea, R. Fleming, Kyle J. Kimler +10 more
2025Science Translational Medicine6 citations
Semantic Scholar
A single dose of a CD137 antibody–drug conjugate protects rhesus macaque allogeneic HCT recipients against acute GVHD
U. Gerdemann, Kyle J. Kimler, Matthew Warren, C. McGuckin +21 more
2025Blood6 citations Open access
Semantic Scholar
Author Correction: Innovations present in the primate interneuron repertoire
F. Krienen, Melissa Goldman, Qiang-Ge Zhang, Ricardo C. H. del Rosario +28 more
2020Nature6 citations Open access
Semantic Scholar
A Treatment-Naive Cellular Atlas of Pediatric Crohn's Disease Predicts Disease Severity and Therapeutic Response
H. Zheng, Ben A. Doran, Kyle J. Kimler, Alison Yu +26 more
2021medRxiv5 citations Open access
Semantic Scholar
Enhanced costimulation blockade with αCD154, αCD2 and αCD28 to promote heart allograft tolerance in nonhuman primates
Ryan Chaban, I. Ileka, K. Kinoshita, Gannon McGrath +9 more
2025Transplantation4 citations
Semantic Scholar
Refined design of a CD117 antibody-drug conjugate safely and effectively conditions non-human primates for autologous transplant-based gene therapy
Lev Gorfinkel, Boya Liu, Yi Liu, Madhura Panditrao +18 more
2025Blood3 citations
Semantic Scholar
A Novel Human OX40L-CAR-Treg Specifically Targets Activated Antigen-Presenting Cells and Effectively Controls T Cell Alloreactivity and Xeno-GvHD
Xianliang Rui, Francesca Alvarez Calderon, U. Gerdemann, C. McGuckin +4 more
2022Blood2 citations
Semantic Scholar
Pharmacologic Blockade of Notch/Delta-like Ligand 4 Signaling Protects from Gastrointestinal Acute Graft-Versus-Host Disease in Non-Human Primates
V. Tkachev, F. Kuhnert, Scott N. Furlan, H. Zheng +14 more
2018Blood2 citations Open access
Semantic Scholar
Delineating tissue-specific alloimmunity during acute GVHD
V. Tkachev, Scott N. Furlan, E. L. Potter, B. Zheng +13 more
2018Journal of Immunology2 citations
Semantic Scholar
Enhanced T Cell Function of PTPN2 Deleted CAR-T Cells Comes at a Cost: PTPN2 Knockout CAR-Ts Secrete More Cytokines and Demonstrate Increased Cytotoxicity, but Exhibit More Severe CRS and Icans in a Non-Human Primate Model
Francesca Alvarez Calderon, R. Fleming, Lev Gorfinkel, Katherine A. Michaelis +10 more
2023Blood1 citations Open access
Semantic Scholar
Acute GVHD in liver and lungs is mediated by phenotypically-analogous but transcriptionally unique T cells.
K. Omdahl, R. Bermea, C. McGuckin, J. Kaminski +3 more
2022Journal of Immunology1 citations
Semantic Scholar
Predicting Immune Pathology after Hematopoietic Stem Cell Transplant (HCT) with Day 100 Transcriptomics: Naïve CD4 T Cell Expansion Versus Regulatory Programming Predicts Patients Who Develop De Novo Chronic Gvhd (CGVHD) Versus Those Displaying Operational Immune Tolerance
Benjamin K. Watkins, J. Kaminski, V. Tkachev, Yvonne Suessmuth +6 more
20211 citations Open access
Semantic Scholar
T Stem Cell Memory Dynamics during Acute Graft-Versus-Host Disease
V. Tkachev, Scott N. Furlan, Benjamin K. Watkins, A. Panoskaltsis-Mortari +2 more
20151 citations
Semantic Scholar
Refined Design of a CD117 Antibody-Drug Conjugate Safely and Effectively Conditions Non-Human Primates for Autologous Transplant-Based Gene Therapy
Lev Gorfinkel, Boya Liu, Yi Liu, Madhura Panditrao +18 more
2026Transplantation and Cellular Therapy0 citations
Semantic Scholar
PTPN2 Deletion Enhances CAR-T Effector Function and CNS Trafficking in a Non-Human Primate Model.
Francesca Alvarez-Calderon, R. Fleming, Marlana B. Winschel, Lev Gorfinkel +10 more
2026Blood Advances0 citations Open access
Semantic Scholar
Steroid Refractory GI Acute GVHD Is Associated with Distinct Immune Cell Infiltrates and Gene Expression Profiles
Cameron McDonald-Hyman, Julie R. Boiko, Michael C. Zaiken, G. Thangavelu +11 more
2026Transplantation and Cellular Therapy0 citations
Semantic Scholar
Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies
Holly Wobma, Francesca Alvarez Calderon, Jiayi Dong, K. Omdahl +16 more
2025bioRxiv0 citations
Semantic Scholar
PTPN2-KO CAR-T Cells Demonstrate Enhanced Effector Function, CNS Infiltration, and Toxicity in a Non-Human Primate CAR-T Model
Francesca Alvarez Calderon, R. Fleming, Marlana B. Winschel, Lev Gorfinkel +10 more
2025bioRxiv0 citations Open access
Semantic Scholar
Organ-specific microenvironments drive divergent T cell evolution in acute Graft-Versus-Host Disease 3176
K. Omdahl, R. Bermea, R. Fleming, Kyle J. Kimler +10 more
2025Journal of Immunology0 citations
Semantic Scholar

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