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F. Jean-Alphonse · SciRah

Researcher profile · Semantic Scholar

F. Jean-Alphonse

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F. Jean-Alphonse — researcher profile on SciRah

h-index: 23
Works: 40
Citations: 2,006

Most-cited papers

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release
Y. Suofu, Wei Li, F. Jean-Alphonse, J. Jia +32 more
2017Proceedings of the National Academy of Sciences of the United States of America393 citations Open access
Semantic Scholar
Endosomal generation of cAMP in GPCR signaling
Jean-Pierre Vilardaga, F. Jean-Alphonse, T. Gardella
2014Nature Chemical Biology217 citations Open access
Semantic Scholar
Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein
L.-H. Zhao, S. Ma, I. Sutkeviciute, D.-D. Shen +17 more
2019115 citations
Semantic Scholar
Spatially Restricted G Protein-coupled Receptor Activity via Divergent Endocytic Compartments
F. Jean-Alphonse, S. Bowersox, Stanford Chen, Gemma Beard +2 more
2013Journal of Biological Chemistry115 citations Open access
Semantic Scholar
Structure and dynamics of the active human parathyroid hormone receptor-1
Li-Hua Zhao, Shanshan Ma, Ieva Sutkeviciute, D. Shen +20 more
2019Science104 citations Open access
Semantic Scholar
Regulation of GPCR signal networks via membrane trafficking.
F. Jean-Alphonse, A. Hanyaloglu
2011Molecular and Cellular Endocrinology101 citations
Semantic Scholar
Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus.
F. Jean-Alphonse, S. Perkovska, Marie-Céline Frantz, T. Durroux +7 more
2009Journal of the American Society of Nephrology95 citations Open access
Semantic Scholar
Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms
Silvia Sposini, F. Jean-Alphonse, M. Ayoub, Affiong I. Oqua +5 more
2017Cell Reports92 citations Open access
Semantic Scholar
Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
Alexandre Gidon, M. Al-Bataineh, F. Jean-Alphonse, Hilary P. Stevenson +7 more
2014Nature Chemical Biology90 citations Open access
Semantic Scholar
Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation
A. White, Karina A. Peña, L. Clark, Christian Santa Maria +15 more
2021Science Signaling80 citations Open access
Semantic Scholar
Actin-Sorting Nexin 27 (SNX27)-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling*
Jennifer C. Mcgarvey, K. Xiao, Shanna L. Bowman, Tatyana Mamonova +8 more
2016Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Design and validation of the first cell‐impermeant melatonin receptor agonist
F. Gbahou, E. Cecon, G. Viault, R. Gerbier +8 more
2017British Journal of Pharmacology54 citations Open access
Semantic Scholar
β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ
F. Jean-Alphonse, V. Wehbi, Jingming Chen, Masaki Noda +3 more
2016Nature Chemical Biology50 citations Open access
Semantic Scholar
Gq/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR
A. White, F. Jean-Alphonse, Fei Fang, Karina A. Peña +8 more
2020Proceedings of the National Academy of Sciences of the United States of America47 citations Open access
Semantic Scholar
Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation
L. Clark, James M. Krieger, A. White, V. Bondarenko +13 more
2020Nature Chemical Biology47 citations Open access
Semantic Scholar
Ca2+ allostery in PTH-receptor signaling
A. White, Fei Fang, F. Jean-Alphonse, L. Clark +8 more
2019Proceedings of the National Academy of Sciences of the United States of America46 citations Open access
Semantic Scholar
Biased Signaling and Allosteric Modulation at the FSHR
Flavie Landomiel, F. De Pascali, Pauline Raynaud, F. Jean-Alphonse +7 more
2019Frontiers in Endocrinology44 citations Open access
Semantic Scholar
Past, present and future of vasopressin and oxytocin receptor oligomers, prototypical GPCR models to study dimerization processes.
M. Cottet, L. Albizu, S. Perkovska, F. Jean-Alphonse +7 more
2010Current opinion in pharmacology (Print)41 citations
Semantic Scholar
PTH Hypersecretion Triggered by a GABAB1 and Ca2+-sensing Receptor Heterocomplex in Hyperparathyroidism
Wen-Han Chang, C. Tu, F. Jean-Alphonse, A. Herberger +14 more
2020Nature Metabolism35 citations Open access
Semantic Scholar
The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking.
Yaoxian Xu, Andrew J. Streets, A. Hounslow, Uyen Tran +6 more
2016Journal of the American Society of Nephrology29 citations Open access
Semantic Scholar
Use of Backbone Modification to Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism
Shi Liu, F. Jean-Alphonse, A. White, D. Wootten +4 more
2019Journal of the American Chemical Society27 citations Open access
Semantic Scholar
Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport
Qiangmin Zhang, K. Xiao, J. M. Paredes, Tatyana Mamonova +11 more
2019Journal of Biological Chemistry25 citations Open access
Semantic Scholar
Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential
E. Nikolopoulou, G. Papacleovoulou, F. Jean-Alphonse, Giulia Grimaldi +3 more
2014Journal of Lipid Research25 citations Open access
Semantic Scholar
Biased GPCR signaling by the native parathyroid hormone–related protein 1 to 141 relative to its N-terminal fragment 1 to 36
Karina A. Peña, A. White, S. Savransky, I. Castillo +4 more
2022Journal of Biological Chemistry14 citations Open access
Semantic Scholar
Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor
F. De Pascali, M. Ayoub, R. Benevelli, Silvia Sposini +20 more
2021International Journal of Molecular Sciences13 citations Open access
Semantic Scholar
Cdc42 activation couples fluid shear stress to apical endocytosis in proximal tubule cells
Sohinee Bhattacharyya, F. Jean-Alphonse, Venkatesan Raghavan, Jennifer C. Mcgarvey +4 more
2017Physiological Reports12 citations Open access
Semantic Scholar
Intracellular VHHs to monitor and modulate GPCR signaling
Pauline Raynaud, Camille Gauthier, V. Jugnarain, F. Jean-Alphonse +3 more
2022Frontiers in Endocrinology11 citations Open access
Semantic Scholar
Ca2+ allostery in PTH‐receptor signaling
A. White, Ieva Sutkeviciute, F. Jean-Alphonse, K. Xiao +1 more
2019The FASEB Journal8 citations
Semantic Scholar
Design and synthesis of cyclic and linear peptide-agarose tools for baiting interacting protein partners of GPCRs.
S. Granier, F. Jean-Alphonse, H. Déméné, G. Guillon +2 more
2006Bioorganic & Medicinal Chemistry Letters8 citations
Semantic Scholar
Confocal and TIRF microscopy based approaches to visualize arrestin trafficking in living cells.
F. Jean-Alphonse, Silvia Sposini
2021Methods in Cell Biology4 citations
Semantic Scholar
The multifunctional protein GC1q-R interacts specifically with the i3 loop arginine cluster of the vasopressin V2 receptor.
S. Granier, F. Jean-Alphonse, D. Bacqueville, A. Monteil +9 more
2008Regulatory Peptides4 citations
Semantic Scholar
Highly-Sensitive In Vitro Bioassays for FSH, TSH, PTH, Kp, and OT in Addition to LH in Mouse Leydig Tumor Cell
Danièle Klett, Lucie P. Pellissier, D. Lomet, F. Derouin-Tochon +9 more
2023International Journal of Molecular Sciences2 citations Open access
Semantic Scholar
Endosomal PTH Receptor Signaling Through cAMP and Its Consequence for Human Medicine
Ieva Sutkeviciute, F. Jean-Alphonse, Jean-Pierre Vilardaga
20172 citations
Semantic Scholar
β-Arrestins and Endocrine-Related GPCRs
F. De Pascali, Pauline Raynaud, F. Jean-Alphonse, Shifa Tahir +7 more
20210 citations
Semantic Scholar
Location Bias in cAMP Signaling and its effects on Parathyroid Hormone Receptor Biological Effectiveness
Karina A. Peña, A. White, L. Clark, Shi Liu +7 more
2021The FASEB Journal0 citations Open access
Semantic Scholar
MON-538 Ca2+Allostery in PTH-Receptor Signaling
Alex White, Ieva Sutkeviciute, F. Jean-Alphonse, K. Xiao +1 more
2019Journal of the Endocrine Society0 citations Open access
Semantic Scholar
Disease‐associated mutation in PTH reveals molecular mechanisms in endosomal GPCR signaling
F. Jean-Alphonse, Ieva Sutkeviciute, K. Xiao, Jean-Pierre Vilardaga
20180 citations
Semantic Scholar
Decoding gonadotrophin receptor signalling via spatial regulation of the LH receptor
Silvia Sposini, F. Jean-Alphonse, A. Hanyaloglu
20150 citations
Semantic Scholar
Post-endocytic sorting of the LH receptor is mediated by a novel APPL1 dependent mechanism
Silvia Sposini, F. Jean-Alphonse, Ashley A. Newcombe, A. Hanyaloglu
20140 citations
Semantic Scholar
Identification of very early sorting endosomes that spatially program gonadotrophin hormone receptor signalling
F. Jean-Alphonse, S. Bowersox, Stanford Chen, Gemma Beard +2 more
20130 citations
Semantic Scholar

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