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Paolo Mellini · SciRah

Researcher profile · Semantic Scholar

Paolo Mellini

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Paolo Mellini — researcher profile on SciRah

h-index: 15
Works: 21
Citations: 698

Most-cited papers

Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.
D. Rotili, D. Tarantino, A. Nebbioso, C. Paolini +15 more
2012Journal of Medicinal Chemistry92 citations Open access
Semantic Scholar
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells.
S. Valente, Paolo Mellini, Francesco Spallotta, V. Carafa +18 more
2016Journal of Medicinal Chemistry66 citations
Semantic Scholar
Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, “selectivity pocket” and NAD+-binding site
Paolo Mellini, Yukihiro Itoh, H. Tsumoto, Ying Li +7 more
2017Chemical Science62 citations Open access
Semantic Scholar
SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant‐like action
M. Erburu, I. Muñoz-Cobo, T. Díaz-Perdigon, Paolo Mellini +3 more
2017Neuropharmacology62 citations
Semantic Scholar
Sirtuin modulators: an updated patent review (2012 – 2014)
Paolo Mellini, S. Valente, A. Mai
2015Expert Opinion on Therapeutic Patents53 citations
Semantic Scholar
Studying SIRT6 regulation using H3K56 based substrate and small molecules.
Piia Kokkonen, M. Rahnasto-Rilla, Paolo Mellini, Elina M. Jarho +2 more
2014European Journal of Pharmaceutical Sciences52 citations
Semantic Scholar
Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines
T. Kozako, Paolo Mellini, T. Ohsugi, Akiyoshi Aikawa +3 more
2018BMC Cancer45 citations Open access
Semantic Scholar
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells
E. Miele, S. Valente, Vincenzo Alfano, M. Silvano +16 more
2017OncoTarget44 citations Open access
Semantic Scholar
Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach.
M. Prakash, Yukihiro Itoh, Yoshie Fujiwara, Yukari Takahashi +15 more
2021Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells.
Paolo Mellini, T. Kokkola, T. Suuronen, Heikki S. Salo +4 more
2013Journal of Medicinal Chemistry39 citations Open access
Semantic Scholar
Synthesis and antifungal activity of a new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives.
D. de Vita, L. Scipione, S. Tortorella, Paolo Mellini +7 more
2012European journal of medicinal chemistry38 citations
Semantic Scholar
Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators.
Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo +13 more
2016Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site.
Paolo Mellini, Yukihiro Itoh, Elghareeb E. Elboray, H. Tsumoto +11 more
2019Journal of Medicinal Chemistry23 citations Open access
Semantic Scholar
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells
Paolo Mellini, B. Marrocco, D. Borovika, Lucia Polletta +9 more
2018Philosophical Transactions of the Royal Society B: Biological Sciences22 citations Open access
Semantic Scholar
Carprofen Analogues as Sirtuin Inhibitors: Enzyme and Cellular Studies
Paolo Mellini, V. Carafa, B. Di Rienzo, D. Rotili +8 more
2012ChemMedChem15 citations Open access
Semantic Scholar
Quantitative insights for the design of substrate-based SIRT1 inhibitors.
Piia Kokkonen, Paolo Mellini, O. Nyrhilä, M. Rahnasto-Rilla +6 more
2014European Journal of Pharmaceutical Sciences10 citations
Semantic Scholar
Efficient Synthesis of 3,5‐Dicarbamoyl‐1,4‐dihydropyridines from Pyridinium Salts: Key Molecules in Understanding NAD(P)+/NAD(P)H Pathways
Paolo Mellini, D. de Vita, B. Di Rienzo, S. La Rosa +4 more
20154 citations Open access
Semantic Scholar
Activity of Drugs Against Dormant Mycobacterium tuberculosis
Giovanni Piccaro, P. Filippini, F. Giannoni, L. Scipione +4 more
2011Journal of chemotherapy4 citations
Semantic Scholar
Correction to ‘Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells’
Paolo Mellini, B. Marrocco, D. Borovika, Lucia Polletta +9 more
2018Philosophical Transactions of the Royal Society B: Biological Sciences3 citations Open access
Semantic Scholar
Crystal structure of human Sirtuin 2 in complex with a selective inhibitor
Paolo Mellini, Yukihiro Itoh, H. Tsumoto, Ying Li +7 more
20171 citations
Semantic Scholar
Facile and Efficient Synthesisof 4-Alkyl Derivatives of 3-Carbamoyl- and 3,5-Dicarbamoylpyridinesas Nicotinamide Mimetics
L. Scipione, B. Di Rienzo, Paolo Mellini, S. Tortorella +1 more
20101 citations
Semantic Scholar

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