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R. Palacharla · SciRah

Researcher profile · Semantic Scholar

R. Palacharla

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R. Palacharla — researcher profile on SciRah

h-index: 11
Works: 20
Citations: 256

Most-cited papers

Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease.
R. Nirogi, A. Shinde, R. Kambhampati, A. R. Mohammed +13 more
2017Journal of Medicinal Chemistry35 citations Open access
Semantic Scholar
Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays
R. Nirogi, R. Palacharla, Venkatesham Uthukam, Arunkumar Manoharan +6 more
2015Xenobiotica; the fate of foreign compounds in biological systems34 citations
Semantic Scholar
Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions
R. Nirogi, V. Kandikere, R. Palacharla, G. Bhyrapuneni +3 more
2014Xenobiotica; the fate of foreign compounds in biological systems28 citations
Semantic Scholar
Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane hydrochloride (SUVN-911): A Novel, Potent, Selective and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression.
R. Nirogi, A. R. Mohammed, A. Shinde, S. Ravella +9 more
2020Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Synthesis, Structure-Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5-HT4 Receptor Partial Agonists.
R. Nirogi, A. R. Mohammed, A. Shinde, Shankar Reddy Gagginapally +11 more
2018Journal of Medicinal Chemistry21 citations Open access
Semantic Scholar
Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Active Histamine H3 Receptor Inverse Agonist with Robust Wake-Promoting Activity.
R. Nirogi, A. Shinde, A. R. Mohammed, R. Badange +13 more
2019Journal of Medicinal Chemistry17 citations Open access
Semantic Scholar
Quantitative in vitro phenotyping and prediction of drug interaction potential of CYP2B6 substrates as victims
R. Palacharla, R. Nirogi, Venkatesham Uthukam, Arunkumar Manoharan +2 more
2018Xenobiotica; the fate of foreign compounds in biological systems17 citations Open access
Semantic Scholar
Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010): A Potent, Selective 5-HT4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer's Disease.
R. Nirogi, A. R. Mohammed, A. Shinde, Shankar Reddy Gagginapally +19 more
2021Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro – in vivo extrapolation of hepatic clearance
R. Palacharla, Venkatesham Uthukam, Arunkumar Manoharan, R. Ponnamaneni +5 more
2017European Journal of Pharmaceutical Sciences15 citations
Semantic Scholar
Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole
R. Palacharla, Parusharamulu Molgara, Hanumanth Rao Panthangi, R. Boggavarapu +4 more
2019Xenobiotica; the fate of foreign compounds in biological systems12 citations
Semantic Scholar
Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction.
R. Nirogi, R. Palacharla, A. R. Mohammed, Arunkumar Manoharan +2 more
2015Chemico-Biological Interactions12 citations
Semantic Scholar
Effect of Dimethyl Sulfoxide on In Vitro Cytochrome P4501A2 Mediated Phenacetin O-Deethylation in Human Liver Microsomes
R. Nirogi, V. Kandikere, G. Bhyrapuneni, R. Ponnamaneni +2 more
2011Drug Metabolism And Disposition11 citations
Semantic Scholar
Safety, Tolerability and Pharmacokinetics of the Serotonin 5-HT6 Receptor Antagonist, SUVN-502, in Healthy Young Adults and Elderly Subjects
R. Nirogi, K. Mudigonda, G. Bhyrapuneni, N. Muddana +3 more
2018Clinical drug investigation8 citations
Semantic Scholar
Simultaneous in-vivo receptor occupancy assays for serotonin 1A, 2A, and dopamine 2 receptors with the use of non-radiolabelled tracers: Proposed method in screening antipsychotics.
Jagadeesh Babu Thentu, R. Nirogi, G. Bhyrapuneni, D. Ajjala +2 more
2017Journal of pharmacological and toxicological methods4 citations
Semantic Scholar
004 Samelisant (SUVN-G3031), Differentiating features over current treatments of narcolepsy
A. Shinde, R. Subramanian, R. Palacharla, V. Benade +6 more
20211 citations Open access
Semantic Scholar
The use of bovine serum albumin in phenotyping experiments by substrate depletion approach to determine f m, cyp : Application to CYP2B6 substrates with emphasis on bupropion
R. Palacharla, Venkatesham Uthukam, Arunkumar Manoharan, I. Kalaikadhiban +3 more
20181 citations
Semantic Scholar
LC–MS/MS method for the simultaneous quantification of artemether, dihydroartemisinin and lumefantrine in rabbit plasma and its application to a PK study
N. Padala, R. Boggavarapu, Praveen Kunduru, R. Palacharla +2 more
20180 citations
Semantic Scholar
Evaluation of methoxsalen as a PAN-CYP450 direct and time dependent inhibitor in human liver microsomes: Comparison with ABT as a tool for in vitro phenotyping studies
R. Palacharla, Parusharamulu Molgara, Arunkumar Manoharan, I. Kalaikadhiban +3 more
20180 citations
Semantic Scholar
Sensitive LC–MS/MS method for quantification of vitamin B 12 in rat serum: Application to pharmacokinetic study
R. Aleti, L. Rayapati, Prathyusha Chunduru, R. Palacharla +2 more
20180 citations
Semantic Scholar
Effect of Dimethyl Sulfoxide on In Vitro Cytochrome P 4501 A 2 Mediated Phenacetin O-Deethylation in Human Liver Microsomes
R. Nirogi, V. Kandikere, G. Bhyrapuneni, R. Ponnamaneni +2 more
20110 citations
Semantic Scholar

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