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R. Nirogi · SciRah

Researcher profile · Semantic Scholar

R. Nirogi

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R. Nirogi — researcher profile on SciRah

h-index: 26
Works: 314
Citations: 2,632

Most-cited papers

Progress in Investigational Agents Targeting Serotonin-6 Receptors for the Treatment of Brain Disorders
R. Nirogi, P. Jayarajan, A. Shinde, A. R. Mohammed +6 more
2023Biomolecules42 citations Open access
Semantic Scholar
SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization
R. Nirogi, Renny Abraham, V. Benade, R. Medapati +8 more
2019Behavioural Pharmacology33 citations
Semantic Scholar
Effect of masupirdine (SUVN‐502) on cognition in patients with moderate Alzheimer's disease: A randomized, double‐blind, phase 2, proof‐of‐concept study
R. Nirogi, J. Ieni, V. Goyal, J. Ravula +9 more
2022Alzheimer's & Dementia24 citations Open access
Semantic Scholar
Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane hydrochloride (SUVN-911): A Novel, Potent, Selective and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression.
R. Nirogi, A. R. Mohammed, A. Shinde, S. Ravella +9 more
2020Journal of Medicinal Chemistry24 citations Open access
Semantic Scholar
Discovery and Preclinical Characterization of Usmarapride (SUVN-D4010): A Potent, Selective 5-HT4 Receptor Partial Agonist for the Treatment of Cognitive Deficits Associated with Alzheimer's Disease.
R. Nirogi, A. R. Mohammed, A. Shinde, Shankar Reddy Gagginapally +19 more
2021Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
Potential beneficial effects of masupirdine (SUVN‐502) on agitation/aggression and psychosis in patients with moderate Alzheimer's disease: Exploratory post hoc analyses
R. Nirogi, P. Jayarajan, V. Benade, A. Shinde +12 more
2022International Journal of Geriatric Psychiatry15 citations Open access
Semantic Scholar
Samelisant (SUVN-G3031), a potent, selective and orally active histamine H3 receptor inverse agonist for the potential treatment of narcolepsy: pharmacological and neurochemical characterisation
R. Nirogi, V. Benade, S. Daripelli, R. Subramanian +9 more
2021Psychopharmacology13 citations
Semantic Scholar
Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole
R. Palacharla, Parusharamulu Molgara, Hanumanth Rao Panthangi, R. Boggavarapu +4 more
2019Xenobiotica; the fate of foreign compounds in biological systems12 citations
Semantic Scholar
Absorption, Distribution, Metabolism, Excretion (ADME), Drug-drug interaction potential and Prediction of Human Pharmacokinetics of SUVN-G3031, a Novel Histamine 3 Receptor (H3R) inverse agonist in Clinical development for the treatment of Narcolepsy.
R. Nirogi, G. Bhyrapuneni, N. Muddana, Arunkumar Manoharan +6 more
2020European Journal of Pharmaceutical Sciences11 citations
Semantic Scholar
Usmarapride (SUVN-D4010), a 5-HT4 receptor partial agonist for the potential treatment of Alzheimer's disease: Behavioural, neurochemical and pharmacological profiling.
R. Nirogi, Venkata Ramalingayya Grandhi, R. Medapati, Narender Ganuga +11 more
2023European Journal of Pharmacology10 citations
Semantic Scholar
Samelisant (SUVN-G3031), a histamine 3 receptor inverse agonist: Results from the phase 2 double-blind randomized placebo-controlled study for the treatment of excessive daytime sleepiness in adult patients with narcolepsy.
R. Nirogi, A. Shinde, V. Goyal, J. Ravula +12 more
2024Sleep Medicine8 citations
Semantic Scholar
Ropanicant (SUVN-911), an α4β2 nicotinic acetylcholine receptor antagonist intended for the treatment of depressive disorders: pharmacological, behavioral, and neurochemical characterization
R. Nirogi, Renny Abraham, P. Jayarajan, Venkatesh Goura +12 more
2022Psychopharmacology8 citations
Semantic Scholar
Histamine 3 receptor inverse agonist Samelisant (SUVN-G3031): Pharmacological characterization of an investigational agent for the treatment of cognitive disorders
R. Nirogi, Venkata Ramalingayya Grandhi, R. Medapati, Narender Ganuga +11 more
2021Journal of Psychopharmacology8 citations
Semantic Scholar
Effect of Concurrent Use of Memantine on the Efficacy of Masupirdine (SUVN-502): A Post Hoc Analysis of a Phase 2 Randomized Placebo-Controlled Study
R. Nirogi, V. Goyal, V. Benade, R. Subramanian +7 more
2022Neurological Therapeutics6 citations Open access
Semantic Scholar
Safety, Tolerability, and Pharmacokinetics of SUVN-G3031, a Novel Histamine-3 Receptor Inverse Agonist for the Treatment of Narcolepsy, in Healthy Human Subjects Following Single and Multiple Oral Doses
R. Nirogi, K. Mudigonda, G. Bhyrapuneni, N. Muddana +7 more
2020Clinical drug investigation6 citations
Semantic Scholar
First-in-Human Studies to Evaluate the Safety, Tolerability, and Pharmacokinetics of a Novel 5-HT4 Partial Agonist, SUVN-D4010, in Healthy Adult and Elderly Subjects
R. Nirogi, G. Bhyrapuneni, N. Muddana, V. Goyal +5 more
2021Clinical drug investigation5 citations
Semantic Scholar
Hits and misses with animal models of narcolepsy and the implications for drug discovery
R. Nirogi, P. Jayarajan, V. Benade, Renny Abraham +1 more
2024Expert Opinion on Drug Discovery4 citations
Semantic Scholar
Review on 505(b)(2) drug products approved by USFDA from 2010 to 2020 emphasizing intellectual property and regulatory considerations for reformulations and new combinations.
Jyosna Devi Ravula, R. Nirogi, M. Janodia
2023Journal of Pharmacy and Science4 citations
Semantic Scholar
Safety, Tolerability, and Pharmacokinetics of Ropanicant (SUVN-911), a Novel Alpha4 Beta2 Nicotinic Acetylcholine Receptor (α4β2 nAChR) Antagonist, in Healthy Adult and Elderly Subjects
R. Nirogi, V. Benade, V. Goyal, S. Pandey +6 more
2022Clinical drug investigation4 citations
Semantic Scholar
Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes)
Veera Raghava Chowdary Palacharla, Prathyusha Chunduru, D. Ajjala, G. Bhyrapuneni +2 more
2019Drug Metabolism And Disposition4 citations Open access
Semantic Scholar
Resveratrol, a calorie restriction mimetic, protects AlCl3-induced neurotoxicity and cognitive deficits in rats via inhibition of oxidative stress
V. Benade, P. Jayarajan, N. Krishnadas, R. Nirogi
2025Naunyn-Schmiedeberg's Archives of Pharmacology3 citations
Semantic Scholar
Determination of Intrinsic Clearance and Fraction Unbound in Human Liver Microsomes and In Vitro-In Vivo Extrapolation of Human Hepatic Clearance for Marketed Central Nervous System Drugs
Veera Raghava Chowdary Palacharla, R. Nirogi, Nitesh Kumar, K. Nandakumar
2024European journal of drug metabolism and pharmacokinetics3 citations
Semantic Scholar
0609 Samelisant, Histamine 3 Receptor Agonist for the Potential Treatment of Excessive Daytime Sleepiness in Patients with Narcolepsy
R. Nirogi, J. Ravula, P. Jayarajan, V. Goyal +3 more
2023Sleep3 citations Open access
Semantic Scholar
Metformin, a calorie restriction mimetic for the treatment of Alzheimer’s disease: A preclinical investigation
V. Benade, P. Jayarajan, N. Krishnadas, Venkatesh Kamuju +2 more
2021Alzheimer's & Dementia3 citations
Semantic Scholar
1‐[2‐(1‐Cyclobutylpiperidin‐4‐yloxy)‐6,7‐dihydro‐4H‐thiazolo[5,4‐c]pyridin‐5‐yl]propan‐1‐one: a Histamine H3 Receptor Inverse Agonist with Efficacy in Animal Models of Cognition
R. Nirogi, A. Shinde, R. Badange, V. Reballi +14 more
2021ChemMedChem3 citations
Semantic Scholar
Potential benefits of Masupirdine (SUVN-502) on Behavioral and Psychological symptoms in patients with moderate Alzheimer’s Disease (5090)
R. Nirogi, A. Shinde, P. Jayarajan, V. Goyal +5 more
2020Neurology3 citations
Semantic Scholar
LC-MS/MS method for the quantification of SUVN-G3031, a novel H3 receptor inverse agonist for narcolepsy treatment.
R. Nirogi, D. Ajjala, Naga Surya Prakash Padala, I. Kalaikadhiban +3 more
2020Bioanalysis3 citations
Semantic Scholar
Masupirdine (SUVN‐502): Novel treatment option for the management of behavioral and psychological symptoms in patients with Alzheimer’s disease
R. Nirogi, P. Jayarajan, A. Shinde, Renny Abraham +4 more
2020Alzheimer's & Dementia3 citations Open access
Semantic Scholar
Short-term toxicity study of 1-aminobenzotraizole, a CYP inhibitor, in Wistar rats
S. Pandey, Harish Nakka, S. Ambhore, S. Londhe +2 more
2020Drug and chemical toxicology (New York, N.Y. 1978)3 citations
Semantic Scholar
0120 SUVN-G3031, a Novel, Potent and Selective Histamine H3 Receptor Inverse Agonist for the Treatment of Narcolepsy: Preclinical Characterization
G. Bhayrapuneni, Venkatesh Kamuju, Sudhakar Gandipudi, P. Jayarajan +5 more
2019Sleep3 citations
Semantic Scholar
LC-MS/MS method for quantification of 3,4-dihydroxyphenylglycol, a norepinephrine metabolite in plasma and brain regions.
N. Padala, D. Ajjala, R. Boggavarapu, Hanumanth Rao Pantangi +3 more
2019Bioanalysis3 citations
Semantic Scholar
0054 SUVN-G3031, a Histamine H3 Receptor Inverse Agonist Produces Wake Promoting Effect in Orexin-2-saporin Lesioned Rats
V. Benade, S. Daripelli, Chaitanya Tirumalasetty, R. Subramanian +3 more
2019Sleep3 citations
Semantic Scholar
Masupirdine (SUVN-502): An Update on the Phase-3 Clinical Development Program Targeting Agitation in Patients with Dementia of Alzheimer’s Type (P1-3.020)
R. Nirogi, J. Ravula, S. Jetta, V. Goyal +9 more
2025Neurology2 citations
Semantic Scholar
Evaluation of monoamine oxidase A and B type enzyme occupancy using non-radiolabelled tracers in rat brain.
Jagadeesh Babu Thentu, G. Bhyrapuneni, N. Padala, Prathyusha Chunduru +2 more
2021Neurochemistry International2 citations
Semantic Scholar
Masupirdine in combination with donepezil and memantine in patients with moderate Alzheimer's disease: Subgroup analyses of memantine regimen, plasma concentrations and duration of treatment
R. Nirogi, V. Goyal, G. Bhyrapuneni, Veera Raghava Chowdary Palacharla +3 more
2020Alzheimer's & Dementia2 citations Open access
Semantic Scholar
0053 SUVN-G3031: Safety, Tolerability and Pharmacokinetics of a Potent and Selective Histamine H3 Receptor Inverse Agonist - Single and Multiple Ascending Doses in Healthy Subjects
R. Nirogi, A. Shinde, K. Mudigonda, G. Bhyrapuneni +7 more
2019Sleep2 citations
Semantic Scholar
Determination of Clastogenic and Anticlastogenic Potential of Cuminum Cyminum Seed Oil Using in Vitro Micronucleus Assay in CHO-K1 Cells
V. Goyal, Sthevaan Vincent, S. Pandey, R. Nirogi
2019Journal of Herbs, Spices & Medicinal Plants2 citations
Semantic Scholar
Samelisant (SUVN-G3031), a histamine H3 receptor inverse agonist, as a potential treatment for narcolepsy: a phase-2 drug evaluation
R. Nirogi, A. Shinde, R. Subramanian, Veera Raghava Chowdary Palacharla +4 more
2026Expert Opinion on Investigational Drugs1 citations
Semantic Scholar
Samelisant (SUVN-G3031): Positive Results from Phase-2 Proof-of-concept, Double-blind, Placebo-controlled Study in Patients with Narcolepsy and an Update on Further Clinical Development (S6.004)
R. Nirogi, J. Ravula, S. Jetta, V. Goyal +9 more
2025Neurology1 citations
Semantic Scholar
Analysis of patentability factors and its impact on claim protection and prosecution timelines for pharmaceutical patents
Jyosna Devi Ravula, R. Nirogi, M. Janodia
2025World Patent Information1 citations
Semantic Scholar
Update on the Development of SUVN‐I6107: A True Positive Allosteric Modulator of the Muscarinic M1 Acetylcholine Receptor for the Treatment of Dementia
V. Benade, A. Shinde, R. Badange, Mohammed Abdul Rasheed +10 more
2025Alzheimer's & Dementia1 citations Open access
Semantic Scholar
Samelisant (SUVN-G3031) - Topline Results from the Phase-2 Proof-of-Concept Double-blind, Placebo-controlled Study in Patients with Narcolepsy (P10-9.002)
R. Nirogi, P. Jayarajan, V. Benade, V. Goyal +4 more
2024Neurology1 citations
Semantic Scholar
Bioequivalence, food effect and comparative pharmacokinetics of SUVN-1105, a novel granule formulation of abiraterone acetate, to Zytiga in healthy male subjects
R. Nirogi, J. Ravula, V. Benade, V. Goyal +6 more
2023Cancer Chemotherapy and Pharmacology1 citations
Semantic Scholar
0051 Samelisant, a H3 Receptor Inverse Agonist for the Potential Treatment of Excessive Daytime Sleepiness in Parkinson’s Disease
R. Nirogi, V. Benade, Renny Abraham, Jagadeesh Babu Thentu +5 more
2023Sleep1 citations Open access
Semantic Scholar
Masupirdine (SUVN‐502) for the Potential Treatment of Agitation in Patients with Dementia of the Alzheimer’s Type: Preliminary Efficacy and Phase‐3 Study Design
R. Nirogi, Renny Abraham, J. Ravula, S. Jetta +8 more
2023Alzheimer's & Dementia1 citations Open access
Semantic Scholar
Effects of Masupirdine (SUVN‐502) on Agitation/Aggression and Psychosis in Patients with Probable Alzheimer’s Disease: A Post Hoc Analysis
R. Nirogi, P. Jayarajan, Renny Abraham, Jayaprakash Tadiparthi +9 more
2022Alzheimer's & Dementia1 citations
Semantic Scholar
Development, validation, and application of an ultra-high performance liquid chromatography-tandem mass spectrometry method for the estimation of Ropanicant in human plasma and urine
R. Nirogi, I. Kalaikadhiban, L. Rayapati, Hanumanth Rao Pantangi +4 more
2022Journal of Chromatography Open1 citations Open access
Semantic Scholar
A selective and accurate liquid chromatography-tandem mass spectrometry method for the quantitation of the novel 5-HT4 receptor partial agonist SUVN-D4010 (Usmarapride) in human plasma and urine.
R. Nirogi, I. Kalaikadhiban, N. Padala, Hanumanth Rao Pantangi +2 more
2022Journal of Pharmaceutical and Biomedical Analysis1 citations
Semantic Scholar
004 Samelisant (SUVN-G3031), Differentiating features over current treatments of narcolepsy
A. Shinde, R. Subramanian, R. Palacharla, V. Benade +6 more
20211 citations Open access
Semantic Scholar
Masupirdine (SUVN‐502): A promising clinical candidate for the management of agitation in Alzheimer’s dementia
R. Nirogi, P. Jayarajan, Jayaprakash Tadiparthi, A. Shinde +7 more
2021Alzheimer's & Dementia1 citations
Semantic Scholar

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V. Goyal×27
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A. R. Mohammed×18

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Veera Raghava Chowdary Palacharla×14

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