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M. Cryle · SciRah

Researcher profile · Semantic Scholar

M. Cryle

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M. Cryle — researcher profile on SciRah

h-index: 36
Works: 167
Citations: 3,765

Most-cited papers

X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis
K. Haslinger, Madeleine Peschke, Clara Brieke, E. Maximowitsch +1 more
2015Nature182 citations
Semantic Scholar
Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism.
Anja Greule, J. E. Stok, J. D. De Voss, M. Cryle
2018Natural product reports (Print)158 citations Open access
Semantic Scholar
Structural aspects of phenylglycines, their biosynthesis and occurrence in peptide natural products.
Rashed S. Al Toma, Clara Brieke, M. Cryle, R. Süssmuth
2015Natural product reports (Print)74 citations Open access
Semantic Scholar
Diversity of nature's assembly lines - recent discoveries in non-ribosomal peptide synthesis.
Jennifer A. E. Payne, M. Schoppet, M. H. Hansen, M. Cryle
2016Molecular Biosystems70 citations
Semantic Scholar
Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity
T. Izoré, Y. T. Candace Ho, J. Kaczmarski, A. Gavriilidou +11 more
2021Nature Communications69 citations Open access
Semantic Scholar
Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics
Anja Greule, T. Izoré, Dumitrita Iftime, J. Tailhades +15 more
2019Nature Communications59 citations Open access
Semantic Scholar
The many faces and important roles of protein-protein interactions during non-ribosomal peptide synthesis.
T. Izoré, M. Cryle
2018Natural product reports (Print)59 citations Open access
Semantic Scholar
Regulation of the P450 Oxygenation Cascade Involved in Glycopeptide Antibiotic Biosynthesis.
Madeleine Peschke, K. Haslinger, Clara Brieke, J. Reinstein +1 more
2016Journal of the American Chemical Society54 citations
Semantic Scholar
Understanding the crucial interactions between Cytochrome P450s and non-ribosomal peptide synthetases during glycopeptide antibiotic biosynthesis.
Madeleine Peschke, M. Gonsior, R. Süssmuth, M. Cryle
2016Current Opinion in Structural Biology51 citations Open access
Semantic Scholar
Sequential In Vitro Cyclization by Cytochrome P450 Enzymes of Glycopeptide Antibiotic Precursors Bearing the X-Domain from Nonribosomal Peptide Biosynthesis.
Clara Brieke, Madeleine Peschke, K. Haslinger, M. Cryle
2015Angewandte Chemie47 citations
Semantic Scholar
Cytochrome P450Blt Enables Versatile Peptide Cyclisation to Generate Histidine‐ and Tyrosine‐Containing Crosslinked Tripeptide Building Blocks
Yong-Wei Zhao, Edward Marschall, Maxine Treisman, Alasdair I. McKay +7 more
2022Angewandte Chemie46 citations Open access
Semantic Scholar
Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis
Tiia Kittilä, C. Kittel, J. Tailhades, Diane Butz +9 more
2017Chemical Science45 citations Open access
Semantic Scholar
New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis
Tiia Kittilä, Aurelio Mollo, Louise K. Charkoudian, M. Cryle
2016Angewandte Chemie45 citations Open access
Semantic Scholar
Molecular basis for control of antibiotic production by a bacterial hormone
Shanshan Zhou, Hussain Bhukya, Nicolas Malet, P. J. Harrison +11 more
2021Nature37 citations Open access
Semantic Scholar
Structural diversity, biosynthesis, and biological functions of lipopeptides from Streptomyces.
Songya Zhang, Yun-Liang Chen, Jing Zhu, Qiujie Lu +3 more
2022Natural product reports (Print)36 citations
Semantic Scholar
Two uptake hydrogenases differentially interact with the aerobic respiratory chain during mycobacterial growth and persistence
P. R. Cordero, R. Grinter, Kiel Hards, M. Cryle +3 more
2019Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Online Pyrophosphate Assay for Analyzing Adenylation Domains of Nonribosomal Peptide Synthetases
Tiia Kittilä, M. Schoppet, M. Cryle
2016ChemBioChem36 citations
Semantic Scholar
A proof-reading mechanism for non-proteinogenic amino acid incorporation into glycopeptide antibiotics
Milda Kaniusaite, J. Tailhades, Edward Marschall, R. Goode +2 more
2019Chemical Science34 citations Open access
Semantic Scholar
F-O-G Ring Formation in Glycopeptide Antibiotic Biosynthesis is Catalysed by OxyE
Madeleine Peschke, Clara Brieke, M. Cryle
2016Scientific Reports34 citations Open access
Semantic Scholar
Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides
Mathias H. Hansen, Martina Adamek, Dumitrita Iftime, D. Petráš +5 more
2023Nature Communications33 citations Open access
Semantic Scholar
Beyond vancomycin: recent advances in the modification, reengineering, production and discovery of improved glycopeptide antibiotics to tackle multidrug-resistant bacteria.
M. H. Hansen, E. Stegmann, M. Cryle
2022Current Opinion in Biotechnology32 citations Open access
Semantic Scholar
Structural Insights into a Side Chain Cross-Linking Biarylitide P450 from RiPP Biosynthesis
Mathias H. Hansen, Angus Keto, Maxine Treisman, V. M. Sasi +13 more
2024ACS Catalysis30 citations Open access
Semantic Scholar
A chemoenzymatic approach to the synthesis of glycopeptide antibiotic analogues.
M. Cryle, J. Tailhades, Yong-Wei Zhao, C. Ho +7 more
2020Angewandte Chemie30 citations Open access
Semantic Scholar
Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain
T. Izoré, J. Tailhades, M. H. Hansen, J. Kaczmarski +2 more
2019Proceedings of the National Academy of Sciences of the United States of America30 citations Open access
Semantic Scholar
Biological, chemical, and biochemical strategies for modifying glycopeptide antibiotics
Edward Marschall, M. Cryle, J. Tailhades
2019Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics.
Clara Brieke, Veronika Kratzig, K. Haslinger, A. Winkler +1 more
2015Organic and biomolecular chemistry28 citations
Semantic Scholar
Communication Breakdown: Dissecting the COM Interfaces between the Subunits of Nonribosomal Peptide Synthetases
C. Fage, Simone Kosol, M. Jenner, Carl Öster +8 more
2021ACS Catalysis27 citations Open access
Semantic Scholar
Antibiotic-chemoattractants enhance neutrophil clearance of Staphylococcus aureus
Jennifer A. E. Payne, J. Tailhades, F. Ellett, Xenia Kostoulias +12 more
2021Nature Communications26 citations Open access
Semantic Scholar
Chlorinated Glycopeptide Antibiotic Peptide Precursors Improve Cytochrome P450-Catalyzed Cyclization Cascade Efficiency.
Madeleine Peschke, Clara Brieke, R. Goode, R. Schittenhelm +1 more
2017Biochemistry25 citations
Semantic Scholar
Structure of the terminal PCP domain of the non‐ribosomal peptide synthetase in teicoplanin biosynthesis
K. Haslinger, C. Redfield, M. Cryle
2015Proteins: Structure, Function, and Bioinformatics24 citations
Semantic Scholar
An Engineered Biarylitide Cross-Linking P450 from RiPP Biosynthesis Generates Alternative Cyclic Peptides
Maxine Treisman, Laura J. Coe, Yong-Wei Zhao, V. M. Sasi +12 more
2024Organic Letters23 citations
Semantic Scholar
More than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaH.
V. Ulrich, Madeleine Peschke, Clara Brieke, M. Cryle
2016Molecular Biosystems21 citations
Semantic Scholar
A route to diastereomerically pure phenylglycine thioester peptides: crucial intermediates for investigating glycopeptide antibiotic biosynthesis.
J. Tailhades, M. Schoppet, Anja Greule, Madeleine Peschke +2 more
2018Chemical Communications20 citations Open access
Semantic Scholar
The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis
M. Schoppet, Madeleine Peschke, Anja Kirchberg, Vincent Wiebach +3 more
2018Chemical Science20 citations Open access
Semantic Scholar
Understanding the early stages of peptide formation during the biosynthesis of teicoplanin and related glycopeptide antibiotics
Milda Kaniusaite, J. Tailhades, Tiia Kittilä, C. Fage +3 more
2020The FEBS Journal19 citations Open access
Semantic Scholar
Exploring modular reengineering strategies to redesign the teicoplanin non-ribosomal peptide synthetase
Milda Kaniusaite, R. Goode, J. Tailhades, R. Schittenhelm +1 more
2020Chemical Science19 citations Open access
Semantic Scholar
Enzymatic Cascade To Evaluate the Tricyclization of Glycopeptide Antibiotic Precursor Peptides as a Prequel to Biosynthetic Redesign.
J. Tailhades, Yong-Wei Zhao, M. Schoppet, Anja Greule +4 more
2019Organic Letters19 citations Open access
Semantic Scholar
Uncovering protein–protein interactions through a team-based undergraduate biochemistry course
D. Cookmeyer, Emily S Winesett, Bashkim Kokona, Adam R. Huff +18 more
2017PLoS Biology18 citations Open access
Semantic Scholar
Structure of OxyAtei: completing our picture of the glycopeptide antibiotic producing Cytochrome P450 cascade
K. Haslinger, M. Cryle
2016FEBS Letters18 citations Open access
Semantic Scholar
Exploring the tetracyclization of teicoplanin precursor peptides through chemoenzymatic synthesis.
Yong-Wei Zhao, R. Goode, R. Schittenhelm, J. Tailhades +1 more
2019Journal of Organic Chemistry17 citations Open access
Semantic Scholar
The Thioesterase Domain in Glycopeptide Antibiotic Biosynthesis Is Selective for Cross-Linked Aglycones.
Madeleine Peschke, Clara Brieke, M. Heimes, M. Cryle
2017ACS Chemical Biology17 citations Open access
Semantic Scholar
Understanding the Glycopeptide Antibiotic Crosslinking Cascade: In Vitro Approaches Reveal the Details of a Complex Biosynthesis Pathway
Yong-Wei Zhao, Y. T. Candace Ho, J. Tailhades, M. Cryle
2020ChemBioChem16 citations
Semantic Scholar
Precursor Manipulation in Glycopeptide Antibiotic Biosynthesis: Are β-Amino Acids Compatible with the Oxidative Cyclization Cascade?
M. Schoppet, J. Tailhades, Ketav Kulkarni, M. Cryle
2018Journal of Organic Chemistry16 citations
Semantic Scholar
Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation
Terry C. C. Lim Kam Sian, Saranjah Indumathy, H. Halim, Anja Greule +6 more
2019Journal of Biological Chemistry14 citations Open access
Semantic Scholar
REASSIGNMENT OF THE STRUCTURE OF A TRYPTOPHAN-CONTAINING CYCLIC TRIPEPTIDE PRODUCED BY THE BIARYLITIDE CROSSLINKING CYTOCHROME P450BLT.
Laura J. Coe, Yong-Wei Zhao, Leo Padva, Angus Keto +7 more
2024Chemistry13 citations Open access
Semantic Scholar
Metabolic engineering of the shikimate pathway in Amycolatopsis strains for optimized glycopeptide antibiotic production.
Valentina Goldfinger, M. Spohn, Jens-Peter Rodler, Melanie Sigle +6 more
2023Metabolic Engineering13 citations
Semantic Scholar
Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria
R. Grinter, Blair Ney, Rajini Brammananth, Christopher K. Barlow +16 more
2020mSystems13 citations Open access
Semantic Scholar
The Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis
Milda Kaniusaite, R. Goode, R. Schittenhelm, Thomas M. Makris +1 more
2019ACS Chemical Biology13 citations Open access
Semantic Scholar
Biochemical and structural characterisation of the second oxidative crosslinking step during the biosynthesis of the glycopeptide antibiotic A47934
V. Ulrich, Clara Brieke, M. Cryle
2016Beilstein Journal of Organic Chemistry13 citations Open access
Semantic Scholar
Staphylococcus aureus entanglement in self-assembling β-peptide nanofibres decorated with vancomycin
Jennifer A. E. Payne, Ketav Kulkarni, T. Izoré, A. Fulcher +4 more
2021Nanoscale Advances12 citations Open access
Semantic Scholar

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