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S. Musto · SciRah

Researcher profile · Semantic Scholar

S. Musto

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S. Musto — researcher profile on SciRah

h-index: 20
Works: 37
Citations: 1,516

Most-cited papers

Tumor Cells Chronically Treated with a Trastuzumab–Maytansinoid Antibody–Drug Conjugate Develop Varied Resistance Mechanisms but Respond to Alternate Treatments
F. Loganzo, X. Tan, Matthew S. Sung, G. Jin +18 more
2015Molecular Cancer Therapeutics239 citations Open access
Semantic Scholar
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules
M. Hari, F. Loganzo, T. Annable, X. Tan +5 more
2006Molecular Cancer Therapeutics150 citations Open access
Semantic Scholar
HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.
F. Loganzo, C. Discafani, T. Annable, C. Beyer +15 more
2003Cancer Research133 citations
Semantic Scholar
Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.
A. Maderna, M. Doroski, C. Subramanyam, A. Porte +17 more
2014Journal of Medicinal Chemistry106 citations
Semantic Scholar
Human erythrocyte protein 4.2 deficiency associated with hemolytic anemia and a homozygous 40glutamic acid-->lysine substitution in the cytoplasmic domain of band 3 (band 3Montefiore).
A. C. Rybicki, J.-J.-H. Qiu, S. Musto, Norman L. Rosen +2 more
1993Blood86 citations
Semantic Scholar
Synthesis, molecular editing, and biological assessment of the potent cytotoxin leiodermatolide.
Damien Mailhol, Jens Willwacher, Nina Kausch-Busies, E. Rubitski +7 more
2014Journal of the American Chemical Society73 citations
Semantic Scholar
MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo.
D. Sampath, C. Discafani, F. Loganzo, C. Beyer +7 more
2003Molecular Cancer Therapeutics69 citations
Semantic Scholar
Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates
L. Tumey, Fengping Li, Brian Rago, Xiaogang Han +15 more
2017AAPS Journal67 citations
Semantic Scholar
Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism
L. Tumey, C. Leverett, B. Vetelino, Fengping Li +21 more
2016ACS Medicinal Chemistry Letters63 citations Open access
Semantic Scholar
Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads.
S. Puthenveetil, F. Loganzo, Hai-Yin He, K. Dirico +18 more
2016Bioconjugate chemistry62 citations
Semantic Scholar
2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as covalent-binding, irreversible inhibitors of the kinase domain of vascular endothelial growth factor receptor-2.
A. Wissner, M. Floyd, Bernard D. Johnson, Heidi L. Fraser +13 more
2005Journal of Medicinal Chemistry59 citations Open access
Semantic Scholar
Development of Solid-Phase Site-Specific Conjugation and Its Application toward Generation of Dual Labeled Antibody and Fab Drug Conjugates.
S. Puthenveetil, S. Musto, F. Loganzo, L. Tumey +2 more
2016Bioconjugate chemistry50 citations
Semantic Scholar
Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.
F. Loganzo, M. Hari, T. Annable, X. Tan +10 more
2004Molecular Cancer Therapeutics38 citations
Semantic Scholar
Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).
A. Zask, G. Birnberg, Katherine Cheung, Joshua A. Kaplan +18 more
2004Journal of Medicinal Chemistry36 citations Open access
Semantic Scholar
Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.
C. Leverett, S. C. K. Sukuru, B. Vetelino, S. Musto +12 more
2016ACS Medicinal Chemistry Letters32 citations Open access
Semantic Scholar
Discovery of Cytotoxic Dolastatin 10 Analogues with N-Terminal Modifications
A. Maderna, M. Doroski, C. Subramanyam, P. Michael +17 more
201529 citations
Semantic Scholar
Two Photoaffinity Analogues of the Tripeptide, Hemiasterlin, Exclusively Label α-Tubulin
Maria Nunes, Joshua A. Kaplan, J. Wooters, M. Hari +11 more
200526 citations
Semantic Scholar
Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.
A. Yamashita, Emily B. Norton, Joshua A. Kaplan, Chuan-Sheng Niu +8 more
2004Bioorganic & Medicinal Chemistry Letters25 citations
Semantic Scholar
Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate
S. Puthenveetil, Haiying He, F. Loganzo, S. Musto +10 more
2017PLoS ONE24 citations Open access
Semantic Scholar
Hybrids of the hemiasterlin analogue taltobulin and the dolastatins are potent antimicrotubule agents.
A. Zask, Joshua A. Kaplan, S. Musto, F. Loganzo
2005Journal of the American Chemical Society24 citations
Semantic Scholar
Establishing in vitro–in vivo correlation for antibody drug conjugate efficacy: a PK/PD modeling approach
D. Shah, F. Loganzo, N. Haddish-Berhane, S. Musto +6 more
2018Journal of Pharmacokinetics and Pharmacodynamics20 citations
Semantic Scholar
Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates.
Anokha S. Ratnayake, Li-Ping Chang, L. Tumey, F. Loganzo +16 more
2018Bioconjugate chemistry18 citations
Semantic Scholar
New cytotoxic benzosuberene analogs. Synthesis, molecular modeling and biological evaluation.
Ze-Cheng Chen, A. Maderna, S. C. K. Sukuru, M. Wagenaar +4 more
2013Bioorganic & Medicinal Chemistry Letters16 citations
Semantic Scholar
Development of Fluorophore-Labeled Thailanstatin Antibody-Drug Conjugates for Cellular Trafficking Studies.
C. Kulkarni, J. E. Finley, A. J. Bessire, Xiao-Tian Zhong +2 more
2017Bioconjugate chemistry15 citations
Semantic Scholar
Abstract 4629: Tumor cells selected for resistance to an antibody-drug conjugate retain sensitivity to ADCs with modified linkers and payloads.
X. Tan, G. Jin, Jeremy S. Myers, Veronica Diesl +14 more
201314 citations
Semantic Scholar
Decreased content of protein 4.2 in ankyrin-deficient normoblastosis (nb/nb) mouse red blood cells: evidence for ankyrin enhancement of protein 4.2 membrane binding.
A. C. Rybicki, S. Musto, Robert S. Schwartz
1995Blood12 citations
Semantic Scholar
Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.
Dahui Zhou, Jeffrey M. Casavant, Edmund I. Graziani, Hai-Yin He +6 more
2019Bioorganic & Medicinal Chemistry Letters10 citations
Semantic Scholar
Portraiture, revolutionary, identity and subjucation: Anne-Louis Girodet’s citizen Belley
S. Musto
19937 citations
Semantic Scholar
Abstract 1830: Antibody-drug conjugates with modified linker-payloads overcome resistance to a trastuzumab-maytansinoid conjugate in multiple cultured tumor cell models
X. Tan, Bing-Wen Lu, G. Jin, Fang Wang +8 more
20143 citations
Semantic Scholar
Abstract 4837: Extracellular proteolytic cleavage of peptide-linked antibody-drug conjugates promotes bystander killing of cancer cells
My-Hanh Lam, J. Lucas, A. Maderna, H. Wald +10 more
20143 citations
Semantic Scholar
Hemiasterlin analogs exclusively label α-tubulin at the interdimer region and specifically block subtilisin digestion of α-tubulin
M. Hari, Maria Nunes, A. Zask, Joshua A. Kaplan +10 more
20043 citations
Semantic Scholar
Two photoaffinity analogues of the tripeptide, hemiasterlin, exclusively label alpha-tubulin.
Maria Nunes, Joshua A. Kaplan, J. Wooters, M. Hari +11 more
2005Biochemistry2 citations
Semantic Scholar
Discovery of new auristatins for the use on antibody drug conjugates for the treatment of cancer
A. Maderna, M. Doroski, H. Risley, P. Michael +36 more
20131 citations
Semantic Scholar
524 MST-997: a novel taxane with superior efficacy that overcomes paclitaxel and docetaxel resistance in vitro and in vivo
D. Sampath, C. Discafani, C. Beyer, Hao Liu +6 more
20041 citations
Semantic Scholar
Social crisis and the imaging of England’s history : representing medieval Norfolk in the early 19th century
S. Musto
20011 citations
Semantic Scholar
Abstract C161: Tumor cells selected for resistance to an antibody-drug conjugate modulate protein trafficking and signaling pathways.
X. Tan, Lauren Whitney, G. Jin, Jeremy S. Myers +8 more
20110 citations
Semantic Scholar
Identification of Plk1 kinase inhibitors in enzyme and cell-based assays by monitoring phosphorylation of T495-Myt1
X. Tan, S. Musto, Lauren Whitney, W. Ding +2 more
20070 citations
Semantic Scholar

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