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Xiao-Tian Zhong · SciRah

Researcher profile · Semantic Scholar

Xiao-Tian Zhong

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Xiao-Tian Zhong — researcher profile on SciRah

h-index: 21
Works: 47
Citations: 1,113

Most-cited papers

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5
L. Mosyak, K. E. Georgiadis, T. Shane, K. Svenson +18 more
2008Protein Science133 citations Open access
Semantic Scholar
The Structure of the Lingo-1 Ectodomain, a Module Implicated in Central Nervous System Repair Inhibition*
L. Mosyak, A. Wood, Brian Dwyer, M. Buddha +15 more
2006Journal of Biological Chemistry91 citations Open access
Semantic Scholar
Interactions of dedicated export membrane proteins of the colicin V secretion system: CvaA, a member of the membrane fusion protein family, interacts with CvaB and TolC
Jaiweon Hwang, Xiao-Tian Zhong, Phang C. Tai
1997Journal of Bacteriology73 citations Open access
Semantic Scholar
N‐linked glycosylation of platelet P2Y12 ADP receptor is essential for signal transduction but not for ligand binding or cell surface expression
Xiao-Tian Zhong, R. Kriz, J. Seehra, Ravindra Kumar
2004FEBS Letters51 citations
Semantic Scholar
Biological Insights into Therapeutic Protein Modifications throughout Trafficking and Their Biopharmaceutical Applications
Xiao-Tian Zhong, Jill F. Wright
2013International Journal of Cell Biology49 citations Open access
Semantic Scholar
Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design
James R. Apgar, A. Tam, R. Sorm, Sybille Moesta +13 more
2020PLoS ONE46 citations Open access
Semantic Scholar
Transient CHO expression platform for robust antibody production and its enhanced N‐glycan sialylation on therapeutic glycoproteins
Xiao-Tian Zhong, Wei-Jun Ma, Caryl L Meade, A. Tam +20 more
2018Biotechnology progress (Print)44 citations
Semantic Scholar
H6PDH interacts directly with 11beta-HSD1: implications for determining the directionality of glucocorticoid catalysis.
Yan-Ling Zhang, Xiao-Tian Zhong, Zheni Gjoka, Yuanhong Li +6 more
2009Archives of Biochemistry and Biophysics42 citations
Semantic Scholar
Regulation of Secreted Frizzled-related Protein-1 by Heparin*
Xiao-Tian Zhong, T. Desilva, Laura Lin, P. Bodine +5 more
2007Journal of Biological Chemistry41 citations Open access
Semantic Scholar
Mammalian Plasma Membrane Ecto-nucleoside Triphosphate Diphosphohydrolase 1, CD39, Is Not Active Intracellularly
Xiao-Tian Zhong, R. Malhotra, Rachel V. Woodruff, G. Guidotti
2001Journal of Biological Chemistry40 citations Open access
Semantic Scholar
Recent Advances in the Molecular Design and Applications of Multispecific Biotherapeutics
Xiao-Tian Zhong, A. D'Antona
2021Antibodies39 citations Open access
Semantic Scholar
A Yeast Golgi E-type ATPase with an Unusual Membrane Topology*
Xiao-Tian Zhong, G. Guidotti
1999Journal of Biological Chemistry38 citations Open access
Semantic Scholar
ATP Uptake in the Golgi and Extracellular Release Require Mcd4 Protein and the Vacuolar H+-ATPase*
Xiao-Tian Zhong, R. Malhotra, G. Guidotti
2003Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Engineering novel Lec1 glycosylation mutants in CHO–DUKX cells: Molecular insights and effector modulation of N‐acetylglucosaminyltransferase I
Xiao-Tian Zhong, Cecilia Cooley, N. Seth, Z. Sean Juo +8 more
2012Biotechnology and Bioengineering35 citations
Semantic Scholar
Regulation of Yeast Ectoapyrase Ynd1p Activity by Activator Subunit Vma13p of Vacuolar H+-ATPase*
Xiao-Tian Zhong, R. Malhotra, G. Guidotti
2000Journal of Biological Chemistry35 citations Open access
Semantic Scholar
CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery
B. Fennell, Barry McDonnell, A. Tam, Lijun Chang +32 more
2013mAbs33 citations Open access
Semantic Scholar
Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease
Xiao-Tian Zhong, S. Jagarlapudi, Yan Weng, Mellisa Ly +27 more
2020Journal of Biological Chemistry28 citations Open access
Semantic Scholar
Processing of Colicin V-1, a Secretable Marker Protein of a Bacterial ATP Binding Cassette Export System, Requires Membrane Integrity, Energy, and Cytosolic Factors*
Xiao-Tian Zhong, R. Kolter, P. Tai
1996Journal of Biological Chemistry28 citations Open access
Semantic Scholar
Cysteine metabolic engineering and selective disulfide reduction produce superior antibody-drug-conjugates
Renée Procopio-Melino, Frank W. Kotch, Amar S. Prashad, J. M. Gomes +14 more
2022Scientific Reports24 citations Open access
Semantic Scholar
Mechanistic understanding of the cysteine capping modifications of antibodies enables selective chemical engineering in live mammalian cells.
Xiao-Tian Zhong, Tao He, Amar S. Prashad, Wen-Ge Wang +15 more
2017Journal of Biotechnology23 citations
Semantic Scholar
When an ATPase Is Not an ATPase: at Low Temperatures the C-Terminal Domain of the ABC Transporter CvaB Is a GTPase
Xiao-Tian Zhong, P. Tai
1998Journal of Bacteriology22 citations Open access
Semantic Scholar
Pyroglutamate and O-Linked Glycan Determine Functional Production of Anti-IL17A and Anti-IL22 Peptide-Antibody Bispecific Genetic Fusions
Xiao-Tian Zhong, E. Kieras, Eric A. Sousa, A. D'Antona +11 more
2012Journal of Biological Chemistry19 citations Open access
Semantic Scholar
Development of Fluorophore-Labeled Thailanstatin Antibody-Drug Conjugates for Cellular Trafficking Studies.
C. Kulkarni, J. E. Finley, A. J. Bessire, Xiao-Tian Zhong +2 more
2017Bioconjugate chemistry15 citations
Semantic Scholar
Distinctive roles of endoplasmic reticulum and golgi glycosylation in functional surface expression of mammalian E-NTPDase1, CD39.
Xiao-Tian Zhong, R. Kriz, Ravindra Kumar, G. Guidotti
2005Biochimica et Biophysica Acta14 citations
Semantic Scholar
New Opportunities in Glycan Engineering for Therapeutic Proteins
Xiao-Tian Zhong, A. D'Antona, John J. Scarcelli, J. Rouse
2022Antibodies13 citations Open access
Semantic Scholar
Mission possible: managing innovation in drug discovery
Xiao-Tian Zhong, George B Moseley
2007Nature Biotechnology13 citations
Semantic Scholar
Recent Advances in Biotherapeutics Drug Discovery and Development
Xiao-Tian Zhong, P. Neumann, M. Corbo, E. Loh
201112 citations Open access
Semantic Scholar
Exploring Parametric and Mechanistic Differences between Expi293FTM and ExpiCHO-STM Cells for Transient Antibody Production Optimization
Jing Zhou, G. Yan, David Cluckey, Caryl L Meade +8 more
2023Antibodies11 citations Open access
Semantic Scholar
Parallel loading and complete automation of a 3-step mAb purification process for multiple samples using a customized preparative chromatography instrument with networked pumps.
Darren E. Ferguson, Evan R Mahan, Wei-Jun Ma, Gabrielle Bitzas +3 more
2018Journal of Chromatography A11 citations
Semantic Scholar
Recent Advances in Glycosylation Modifications in the Context of Therapeutic Glycoproteins
Xiao-Tian Zhong, W. Somers
201211 citations Open access
Semantic Scholar
A potential antibody repertoire diversification mechanism through tyrosine sulfation for biotherapeutics engineering and production
Xiao-Tian Zhong, A. D'Antona
2022Frontiers in Immunology10 citations Open access
Semantic Scholar
Pharmacokinetics of anti-IL17A and anti-IL22 peptide-antibody bispecific genetic fusions in mice.
Y. Vugmeyster, Yiqun Zhang, Xiao-Tian Zhong, Jill F. Wright +1 more
2014International Immunopharmacology10 citations
Semantic Scholar
Swift residue‐screening identifies key N‐glycosylated asparagines sufficient for surface expression of neuroglycoprotein Lingo‐1
Xiao-Tian Zhong, J. Pocas, Yan Liu, Paul W. Wu +3 more
2009FEBS Letters6 citations Open access
Semantic Scholar
A eukaryotic carboxyl‐terminal signal sequence translocating large hydrophilic domains across membranes
Xiao-Tian Zhong, R. Malhotra, G. Guidotti
2005FEBS Letters5 citations
Semantic Scholar
Large-Scale Transient Production in ExpiCHO-S™ with Enhanced N-Galactosylation-Sialylation and PEI-Based Transfection.
Xiao-Tian Zhong, Ashley M. Schwab, Wei-Jun Ma, Caryl L Meade +4 more
2021Methods in molecular biology4 citations
Semantic Scholar
Impacts of fast production of afucosylated antibodies and Fc mutants in ExpiCHO-S™ for enhancing FcγRIIIa binding and NK cell activation.
Xiao-Tian Zhong, Jennifer Schenk, P. Sakorafas, J. Chamberland +22 more
2022Journal of Biotechnology3 citations Open access
Semantic Scholar
Expression, purification and crystallization of the ecto-enzymatic domain of rat E-NTPDase1 CD39.
Xiao-Tian Zhong, M. Buddha, G. Guidotti, R. Kriz +2 more
2008Acta Crystallographica. Section F : Structural Biology and Crystallization Communications3 citations Open access
Semantic Scholar
Paying for a Long-Fighting War
Xiao-Tian Zhong
2010Pharmaceutical Medicine2 citations
Semantic Scholar
Developing Stable Cell Lines for the Production of Vaccine Antigens
Xiao-Tian Zhong, Zhijian Lu, R. Zollner, Ji-Min Zhang +3 more
20111 citations
Semantic Scholar
A Surprising Benefit of Cysteine Capping for Antibody Drug Conjugates
Xiao-Tian Zhong, A. D'Antona, K. Dutta
2022Journal of cancer immunology0 citations Open access
Semantic Scholar
involvement of furin and proprotein convertase 5 6 in proteolytic processing of factor viii albumin fusion protein
Wei-Jun Ma, D. Pittman, M. Stahl, R. Kriz +2 more
20180 citations
Semantic Scholar
抗体のシステインキャッピング修飾の機構的理解は生きているほ乳類細胞における選択的化学工学を可能にする【Powered by NICT】
Xiao-Tian Zhong, He Tao, Sreelakshmi P. Amar, Wen-Ge Wang +15 more
20170 citations
Semantic Scholar
End-blocking and uncapped antibody cysteine, and its purposes in antibody drug is conjugated
Xiao-Tian Zhong, A.S.普拉沙, R.W.克里斯, Tao He +3 more
20160 citations
Semantic Scholar
wo guo nei bu kong zhi shen ji zhi chi ti xi yan jiu ji yu mei guo jing yan de qi shi
Shu-Ren Zuo, Xiao-Tian Zhong, Zuo Li
20110 citations
Semantic Scholar
Expression and Purification of Mammalian PCSK9 and Characterization of its Prodomain for Extracellular Trafficking.
Xiao-Tian Zhong, Lora Cameron-Landis, W. Stochaj, T. Awad +3 more
20090 citations
Semantic Scholar
Cell‐type Specific Regulation of Recombinant Secreted Frizzled Related‐1 Production by Heparin and Fibroblast Growth Factor
Xiao-Tian Zhong, M. Stahl, T. Desilva, Laura Lin +5 more
20070 citations
Semantic Scholar
Systems and procedures protein production
Yijie Gao, N. Piché, M. Geng, S. Herrmann +3 more
20050 citations
Semantic Scholar

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