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L. Hoekman · SciRah

Researcher profile · Semantic Scholar

L. Hoekman

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L. Hoekman — researcher profile on SciRah

h-index: 17
Works: 51
Citations: 883

Most-cited papers

Endogenous androgen receptor proteomic profiling reveals genomic subcomplex involved in prostate tumorigenesis
S. Stelloo, E. Nevedomskaya, Y. Kim, L. Hoekman +7 more
2018Oncogene95 citations Open access
Semantic Scholar
Hemidesmosomes modulate force generation via focal adhesions
Wei Wang, Alba Zuidema, Lisa Te Molder, L. Nahidiazar +4 more
2020Journal of Cell Biology84 citations Open access
Semantic Scholar
Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer
S. Preković, K. Schuurman, I. Mayayo-Peralta, A. G. Manjón +26 more
2021Nature Communications75 citations Open access
Semantic Scholar
The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism
M. S. van Ruiten, Démi van Gent, Ángela Sedeño Cacciatore, Astrid Fauster +8 more
2022Nature Structural & Molecular Biology64 citations Open access
Semantic Scholar
Drug-induced epigenomic plasticity reprograms circadian rhythm regulation to drive prostate cancer towards androgen-independence
S. Linder, M. Hoogstraat, S. Stelloo, Nils Eickhoff +32 more
2021medRxiv62 citations Open access
Semantic Scholar
H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2
M. Simonetta, I. de Krijger, Judit Serrat, N. Moatti +5 more
2018Cell Cycle53 citations Open access
Semantic Scholar
Mechanisms of integrin αVβ5 clustering in flat clathrin lattices
Alba Zuidema, Wei Wang, Maaike Kreft, Lisa Te Molder +5 more
2018Journal of Cell Science50 citations Open access
Semantic Scholar
MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair
I. de Krijger, Bastian Föhr, S. Pérez, Estelle Vincendeau +11 more
2021Nature Communications35 citations Open access
Semantic Scholar
Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L‐dose dependency in HDAC1‐deficient thymic lymphoma
H. Vlaming, C. McLean, T. Korthout, M. F. Alemdehy +13 more
2019EMBO Journal35 citations Open access
Semantic Scholar
Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation
Joana Silva, F. Alkan, S. Ramalho, Goda Snieckute +11 more
2022Nature Communications32 citations Open access
Semantic Scholar
P-stalk ribosomes act as master regulators of cytokine-mediated processes
A. Dopler, F. Alkan, Y. Malka, Rob van der Kammen +18 more
2024Cell31 citations Open access
Semantic Scholar
Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1
H. Vlaming, Thom M. Molenaar, T. van Welsem, D. W. Poramba-Liyanage +7 more
2016eLife27 citations Open access
Semantic Scholar
NASP modulates histone turnover to drive PARP inhibitor resistance
S. Moser, Anna Khalizieva, Josef Roehsner, Elisabeth Pottendorfer +25 more
2025Nature22 citations Open access
Semantic Scholar
Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity
S. Preković, Theofilos Chalkiadakis, Merel Roest, D. Roden +21 more
2023EMBO Molecular Medicine22 citations Open access
Semantic Scholar
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer
J. Bhin, Julia Yemelyanenko, Xue Chao, S. Klarenbeek +20 more
2023Journal of Experimental Medicine21 citations Open access
Semantic Scholar
Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness
Chun-Pu Lin, Pierre L. Levy, A. Alflen, Georgi Apriamashvili +30 more
2024Cancer Cell18 citations Open access
Semantic Scholar
PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins
Alba Zuidema, P. Atherton, Maaike Kreft, L. Hoekman +5 more
2022Journal of Cell Biology18 citations Open access
Semantic Scholar
Molecular determinants of αVβ5 localization in flat clathrin lattices – role of αVβ5 in cell adhesion and proliferation
Alba Zuidema, Wei Wang, Maaike Kreft, Onno B. Bleijerveld +5 more
2022Journal of Cell Science15 citations Open access
Semantic Scholar
An antibiotic that mediates immune destruction of senescent cancer cells
Gabriele Casagrande Raffi, Jian Chen, Xuezhao Feng, Zhen Chen +14 more
2024bioRxiv13 citations Open access
Semantic Scholar
PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription
I. Mayayo-Peralta, S. Gregoricchio, K. Schuurman, Selçuk Yavuz +15 more
2022bioRxiv13 citations Open access
Semantic Scholar
Targeting DOT1L and EZH2 synergizes in breaking the germinal center identity of Diffuse Large B-cell Lymphoma.
Camiel Göbel, Rachele Niccolai, M. D. de Groot, Jayashree Jayachandran +16 more
2025Blood12 citations Open access
Semantic Scholar
PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription
I. Mayayo-Peralta, S. Gregoricchio, K. Schuurman, Selçuk Yavuz +15 more
2023Nucleic Acids Research11 citations Open access
Semantic Scholar
Comparative interactomics analysis reveals potential regulators of α6β4 distribution in keratinocytes
Lisa Te Molder, L. Hoekman, Maaike Kreft, Onno B. Bleijerveld +1 more
2020Biology Open11 citations Open access
Semantic Scholar
Systemic LRG1 Expression in Melanoma is Associated with Disease Progression and Recurrence
E. Hoefsmit, Franziska Völlmy, E. Rozeman, I. Reijers +8 more
2023Cancer Research Communications10 citations Open access
Semantic Scholar
NAC regulates metabolism and cell fate in intestinal stem cells
Sofia Ramalho, F. Alkan, S. Preković, Katarzyna Jastrzebski +13 more
2025Science Advances9 citations Open access
Semantic Scholar
UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168
Zeliha Yalçin, Shiu-Yeung Lam, Marieke H. Peuscher, J. van der Torre +12 more
2024Nature Communications7 citations Open access
Semantic Scholar
Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA Polymerase III assembly
M. V. van Breugel, Ila van Kruijsbergen, Chitvan Mittal, C. Lieftink +13 more
2023Molecules and Cells7 citations Open access
Semantic Scholar
Ribociclib Induces Broad Chemotherapy Resistance and EGFR Dependency in ESR1 Wildtype and Mutant Breast Cancer
I. Mayayo-Peralta, Beatrice Faggion, L. Hoekman, B. Morris +10 more
2021Cancers7 citations Open access
Semantic Scholar
Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility
Wei Wang, P. Atherton, Maaike Kreft, Lisa Te Molder +7 more
2024bioRxiv5 citations Open access
Semantic Scholar
Histone methyltransferase DOT1L maintains cell state and restricts cytotoxic potential of CD8 T cells
Muddassir Malik, W. de Leeuw, M. A. Aslam, E. M. Kwesi-Maliepaard +12 more
2025Science Advances4 citations Open access
Semantic Scholar
Glucocorticoids regulate cancer cell dormancy
S. Preković, K. Schuurman, A. G. Manjón, M. Buijs +22 more
2019bioRxiv4 citations Open access
Semantic Scholar
Arginine Deprivation of ASS1-Deficient Cancers Drives Mistranslation and Shared Neoepitope Production
Remco Nagel, Adva Kochavi, K. Flem-Karlsen, Mrittika Adhikary +16 more
2026Cancer Research3 citations Open access
Semantic Scholar
SRBD1, a highly conserved gene required for chromosome individualization.
J. Raaijmakers, L. M. Janssen, A. Mazouzi, Amber L.H. Hondema +20 more
2025Cell Reports3 citations Open access
Semantic Scholar
TRIM33 loss reduces androgen receptor transcriptional output and H2BK120 ubiquitination
Nils Eickhoff, Janina Janetzko, Nuno Padrão, S. Gregoricchio +6 more
2025bioRxiv2 citations Open access
Semantic Scholar
Assessment of the primary cancer cell secretome using amino acid-analog labeling.
Annemieke C. Bouwman, A. van Weverwijk, O. Bleijerveld, L. Hoekman +3 more
2025Methods in Cell Biology2 citations Open access
Semantic Scholar
A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator
Anniek Zaalberg, Emma Minnee, I. Mayayo-Peralta, K. Schuurman +13 more
2023bioRxiv2 citations Open access
Semantic Scholar
Histidine to glutamine substitutants, a regulated process that impacts cell survival and suggests histidine shortage in cancer
Domenica Lovecchio, Pierré-René Körner, Lorenzo Valcanover, Onno B. Bleijerveld +13 more
2026Cell Death Discovery1 citations Open access
Semantic Scholar
Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair
R. Shah, M. A. Aslam, A. Spanjaard, Daniël C. de Groot +7 more
2024PNAS Nexus1 citations Open access
Semantic Scholar
NAC-mediated ribosome localization regulates cell fate and metabolism in intestinal stem cells
Sofia Ramalho, F. Alkan, S. Preković, Katarzyna Jastrzebski +8 more
2024bioRxiv1 citations Open access
Semantic Scholar
DOT1L shapes ncPRC1 target gene repression to maintain germinal center B-cell identity in diffuse large B-cell lymphoma
Camiel Göbel, Rachele Niccolai, S. Gregoricchio, M. D. de Groot +11 more
2026Blood0 citations Open access
Semantic Scholar
O13.03 Cancer cell–intrinsic rewiring of the secretome in immune-excluded colorectal cancer
M. Witsen, T. Foskolos, J. Dijkstra, M. Parra-Martínez +15 more
2026Oral Presentations0 citations Open access
Semantic Scholar
A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator
Anniek Zaalberg, Audrey Lacoste, Emma Minnee, I. Mayayo-Peralta +17 more
2026Oncogene0 citations Open access
Semantic Scholar
Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by regulating expression of AP-1 transcription factors and their target genes
Sanne C. Lith, S. Gregoricchio, C. V. van Tiel, I. van der Made +9 more
2026Nucleic Acids Research0 citations Open access
Semantic Scholar
Global and specific mechanisms stimulate mistranslation in cancer.
Demi Wernaart, Amos Fumagalli, Mrittika Adhikary, Xiao-Dong Feng +19 more
2026Nature Cell Biology0 citations Open access
Semantic Scholar
DEprot: a comprehensive R-package for the analysis of label-free quantitation mass spectrometry data
Nils Eickhoff, L. Hoekman, Onno B. Bleijerveld, A. Bergman +2 more
2026NAR Genomics and Bioinformatics0 citations Open access
Semantic Scholar
Loss of ribosomal protein uL14 enables tumor escape from T cell immunosurveillance
A. Dopler, Edwin S. Kyei-Baffour, Mandy Kerkhoff, F. Alkan +10 more
2025NAR Cancer0 citations Open access
Semantic Scholar
354P Intrinsic dysregulation of the colorectal cancer secretome
M. Witsen, T. Foskolos, J. Catsman, M. Martinez +8 more
2025Immuno-Oncology and Technology0 citations Open access
Semantic Scholar
Histone methyltransferase DOT1L maintains identity and restricts cytotoxic potential of CD8 T cells
Muddassir Malik, W. de Leeuw, M. A. Aslam, E. M. Kwesi-Maliepaard +10 more
2025bioRxiv0 citations Open access
Semantic Scholar
An “alert state” ribosome population acts as a master regulator of cytokine-mediated processes
A. Dopler, F. Alkan, Y. Malka, K. Hoefakker +11 more
2023bioRxiv0 citations Open access
Semantic Scholar
Evolutionarily-conserved chromatin crosstalk generates a DOT1L-dose dependency in thymic lymphoma caused by loss of HDAC1
H. Vlaming, C. McLean, T. Korthout, M. F. Alemdehy +13 more
2019bioRxiv0 citations Open access
Semantic Scholar

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