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T. Sewastianik · SciRah

Researcher profile · Semantic Scholar

T. Sewastianik

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T. Sewastianik — researcher profile on SciRah

h-index: 20
Works: 60
Citations: 1,310

Most-cited papers

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma
S. McBrayer, Jared R. Mayers, G. Dinatale, Diana D. Shi +23 more
2018Cell319 citations Open access
Semantic Scholar
Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy
P. P. Guimaraes, Stephanie Gaglione, T. Sewastianik, R. Carrasco +2 more
2018ACS Nano129 citations Open access
Semantic Scholar
Bortezomib induces anti-multiple myeloma immune response mediated by cGAS/STING pathway activation
A. Gullà, E. Morelli, M. Samur, C. Botta +14 more
2021Cancer Discovery123 citations Open access
Semantic Scholar
FOXO1 activation is an effector of SYK and AKT inhibition in tonic BCR signal-dependent diffuse large B-cell lymphomas.
M. Szydłowski, P. Kiliszek, T. Sewastianik, E. Jabłońska +12 more
2016Blood68 citations
Semantic Scholar
MYC deregulation in lymphoid tumors: molecular mechanisms, clinical consequences and therapeutic implications.
T. Sewastianik, M. Prochorec-Sobieszek, B. Chapuy, P. Juszczyński
2014Biochimica et Biophysica Acta60 citations
Semantic Scholar
Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of resting human T cells.
Zbigniew Korwek, T. Sewastianik, A. Bielak-Zmijewska, G. Mosieniak +4 more
2012DNA Repair60 citations Open access
Semantic Scholar
In vivo bone marrow microenvironment siRNA delivery using lipid–polymer nanoparticles for multiple myeloma therapy
P. P. Guimaraes, Christian G. Figueroa-Espada, Rachel S. Riley, Ning-Qiang Gong +14 more
2023Proceedings of the National Academy of Sciences of the United States of America44 citations Open access
Semantic Scholar
A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation
Grégory Lazarian, Shanye Yin, E. ten Hacken, T. Sewastianik +25 more
2021Cancer Cell44 citations Open access
Semantic Scholar
BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins
Meng Jiang, Yue Kang, T. Sewastianik, Jiao Wang +13 more
2020Nature Communications42 citations Open access
Semantic Scholar
FOXO1 is a TXN- and p300-dependent sensor and effector of oxidative stress in diffuse large B-cell lymphomas characterized by increased oxidative metabolism
T. Sewastianik, M. Szydłowski, E. Jabłońska, E. Białopiotrowicz +11 more
2016Oncogene42 citations
Semantic Scholar
A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer
Helen Tanton, T. Sewastianik, H. Seo, David Remillard +14 more
2022Science Advances39 citations Open access
Semantic Scholar
Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma.
M. Szydłowski, M. Prochorec-Sobieszek, A. Szumera-Ciećkiewicz, E. Derezińska +14 more
2015Blood39 citations
Semantic Scholar
MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy
A. Polak, P. Kiliszek, T. Sewastianik, M. Szydłowski +13 more
2016PLoS ONE34 citations Open access
Semantic Scholar
A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia
W. Czardybon, R. Windak, A. Gołas, M. Gałęzowski +28 more
2018OncoTarget32 citations Open access
Semantic Scholar
In vivo modeling of CLL transformation to Richter's syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities.
E. ten Hacken, T. Sewastianik, Shanye Yin, Gabriela Brunsting Hoffmann +36 more
2022Blood Cancer Discovery25 citations Open access
Semantic Scholar
Human MYD88L265P is insufficient by itself to drive neoplastic transformation in mature mouse B cells.
T. Sewastianik, M. Guerrera, Keith Adler, Peter S. Dennis +17 more
2019Blood Advances23 citations Open access
Semantic Scholar
Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma.
Ting Du, Yan Song, A. Ray, Yao Yao +12 more
2023Blood22 citations Open access
Semantic Scholar
ERK signaling mediates resistance to immunomodulatory drugs in the bone marrow microenvironment
Jiye Liu, T. Hideshima, L. Xing, Sui-Zhao Wang +16 more
2021Science Advances22 citations Open access
Semantic Scholar
Multicenter phase 2 study of daratumumab monotherapy in patients with previously treated Waldenström macroglobulinemia.
J. Castillo, E. Libby, S. Ansell, M. Palomba +11 more
2020Blood Advances21 citations
Semantic Scholar
Microenvironment‐induced PIM kinases promote CXCR4‐triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration
E. Białopiotrowicz, P. Górniak, Monika Noyszewska-Kania, B. Puła +18 more
2018Journal of Cellular and Molecular Medicine20 citations Open access
Semantic Scholar
miR-15a/16-1 deletion in activated B-cells promotes plasma cell and mature B-cell neoplasms.
T. Sewastianik, J. Straubhaar, Jian-Jun Zhao, M. Samur +21 more
2020Blood18 citations Open access
Semantic Scholar
MiR-17-92 represses PTPROt and PP2A phosphatases and amplifies tonic BCR signaling in DLBCL cells.
E. Jabłońska, P. Górniak, M. Szydłowski, T. Sewastianik +4 more
2017Experimental Hematology17 citations Open access
Semantic Scholar
ROBO1 Promotes Homing, Dissemination, and Survival of Multiple Myeloma within the Bone Marrow Microenvironment
G. Bianchi, P. Czarnecki, M. Ho, A. Roccaro +16 more
2021Cancer Discovery13 citations Open access
Semantic Scholar
Constitutive Ras signaling and Ink4a/Arf inactivation cooperate during the development of B-ALL in mice.
T. Sewastianik, Meng Jiang, K. Sukhdeo, Sanjay S. Patel +16 more
2017Blood Advances10 citations Open access
Semantic Scholar
SIRT1 and HSP90α feed-forward circuit safeguards chromosome segregation integrity in diffuse large B cell lymphomas
Emilia Białopiotrowicz-Data, Monika Noyszewska-Kania, Ewa Jabłońska, T. Sewastianik +8 more
2023Cell Death and Disease9 citations Open access
Semantic Scholar
MiR-155 Amplifies AKT and NFkB Signaling By Targeting Multiple Regulators of BCR Signal in DLBCL
E. Jabłońska, P. Górniak, Weronika Prusisz, P. Kiliszek +8 more
20158 citations
Semantic Scholar
Downregulation of Deptor By MiR-155 Promotes Cell Survival through Activation of PI3K/AKT and NFkB Signaling in ABC-Type Diffuse Large B-Cell Lymphomas
E. Jabłońska, P. Górniak, Weronika Prusisz, P. Kiliszek +8 more
20165 citations
Semantic Scholar
Microenvironment-Induced Expression of PIM Kinases Supports Chronic Lymphocytic Leukemia Cells Survival and Promotes CXCR4-mTOR Pathway Dependent Migration
E. Białopiotrowicz, P. Górniak, B. Puła, Monika Noyszewska-Kania +16 more
20164 citations
Semantic Scholar
Abstract 1749: Preclinical characterization of SEL24-B489, a dual PIM/FLT3 inhibitor for the treatment of hematological malignancies
W. Czardybon, R. Windak, I. Dolata, M. Salwińska +9 more
20143 citations
Semantic Scholar
Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability
Catherine Gutierrez, M. Kwok, Neil G. Ruthen, Peyton Waddicor +40 more
2026Nature Communications2 citations Open access
Semantic Scholar
CD47 blockade-driven necroptosis complements BCL-2 inhibition-driven apoptosis in lymphoid malignancies
Stephen J. F. Chong, Rebecca Valentin, Jing Wang, Fengfang Zhu +30 more
2026Journal of Hematology & Oncology2 citations Open access
Semantic Scholar
Aggressive CD4/CD8 Double-Negative Primary Cutaneous T-Cell Lymphoma With Dural Invasion: A Rare Presentation of Mycosis Fungoides?
K. Haghayeghi, L. Robinson-Bostom, A. Olszewski, C. Jackson +5 more
2020American journal of dermatopathology2 citations
Semantic Scholar
A Novel Pan-PIM Kinase Inhibitor, SEL24-B489, Induces Apoptosis and Inhibits Proliferation of Diffuse Large B-Cell Lymphoma Cells through Inhibition of Protein Translation and Attenuation of Myc and NFkB Activity
E. Jabłońska, M. Szydłowski, E. Białopiotrowicz, P. Kiliszek +9 more
20152 citations
Semantic Scholar
Corrigendum to “Inhibition of ATM blocks the etoposide-induced DNA damage response and apoptosis of human resting T cells” [DNA Repair 11 (11) (2012) 864–873]
Zbigniew Korwek, T. Sewastianik, A. Bielak-Zmijewska, G. Mosieniak +4 more
20132 citations
Semantic Scholar
Atypical Stem Cell, Pre-B-Cell, T-Cell and Myeloid Gene Expression Characterizes Early Waldenstrom's Macroglobulinemia Clones Which Diminishes with Advancing Disease and Has Therapeutic Implications
Z. Hunter, M. Guerrera, R. Carrasco, N. Tsakmaklis +16 more
2023Blood1 citations Open access
Semantic Scholar
Abstract A009: AFNT-111: A novel TCR-engineered T cell therapy targeting the oncogenic driver KRAS G12V
Michele M. Hoffmann, Xingyue He, C. Black, J. Francis +16 more
2023Molecular Cancer Research1 citations
Semantic Scholar
Super-Enhancer-Driven PIM Kinase Upregulation in Multiple Myeloma Maintains the Plasma Cell-Specific Oncogenic and Microenvironmental Circuits, and Can be Efficiently Targeted By the Pan-PIM Inhibitor MEN1703
F. Garbicz, Sonia Dębek, A. Szumera-Ciećkiewicz, J. Barankiewicz +24 more
2022Blood1 citations Open access
Semantic Scholar
Dissecting Richter's Syndrome in a Multiplexed CRISPR-Based Mouse Model Reveals Key Changes in MYC, Interferon and BCR Signaling Underlying Transformation
E. ten Hacken, Shanye Yin, T. Sewastianik, L. Penter +19 more
2021Blood1 citations Open access
Semantic Scholar
Multiplexed CRISPR In Vivo Editing of CLL Loss-of-Function Lesions Models Transformation of Chronic Lymphocytic Leukemia into Richter's Syndrome
E. ten Hacken, T. Sewastianik, R. Redd, G. Fell +16 more
20201 citations
Semantic Scholar
SIRT1 and HSP90alpha Are Functionally Linked and Control Mitotic Chromosome Segregation and Cell Viability in a Subset of Dlbcls
E. Białopiotrowicz, Monika Noyszewska-Kania, E. Jabłońska, T. Sewastianik +10 more
20201 citations Open access
Semantic Scholar
B Cell Restricted Expression of Mutated IKZF3 modulates BCR Signaling and Homing Pathways in a Mouse Model of CLL
Grégory Lazarian, Shanye Yin, E. ten Hacken, T. Sewastianik +9 more
2019Blood1 citations Open access
Semantic Scholar
Functional Link Between Heat Shock Protein HSP90alpha and Sirtuin 1 (SIRT1) in the Pathogenesis of Diffuse Large B Cell Lymphoma
E. Białopiotrowicz, T. Sewastianik, Monika Noyszewska-Kania, M. Szydłowski +6 more
20161 citations
Semantic Scholar
MEK1 Inhibitor Selumetinib Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia Cells (B-ALL) to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy
A. Polak, P. Kiliszek, T. Sewastianik, M. Szydłowski +12 more
20151 citations Open access
Semantic Scholar
FOXO1-p300-Txn Circuit Regulates Oxidative Stress Responses in Diffuse Large B-Cell Lymphomas Characterized By Enhanced Oxidative Phosphorylation
T. Sewastianik, M. Szydłowski, E. Białopiotrowicz, E. Jabłońska +11 more
20151 citations
Semantic Scholar
Abstract 5394: First-in-class dual PIM/FLT3 kinase inhibitor SEL24-B489 for the treatment of hematological malignancies
K. Brzózka, W. Czardybon, A. Gołas, R. Windak +11 more
20151 citations
Semantic Scholar
Abstract 5177: Modeling 6q deletion and MYD88L265P-driven B-cell lymphomas in mice reveals early lymphomagenesis mechanisms and identifies the putative cell of origin
Filip Garbicz, Johany Peñailillo, Senthilkumar Muthiah, Fernanda Cuevas +12 more
2025Cancer Research0 citations
Semantic Scholar
CD47-blockade induces programmed necroptosis and complements the effects of BCL-2 inhibition in lymphoid malignancies
S. Chong, Rebecca Valentin, Jing Wang, Fengfang Zhu +27 more
2025Blood0 citations
Semantic Scholar
The ERK1/2 Regulator WNK2 Shows Novel Alternative Splicing Aberrations That Support Tumor Growth in MYD88 Mutated Waldenström's Macroglobulinemia
M. Guerrera, Xia Liu, E. Morelli, Kris Richardson +21 more
2022Blood0 citations Open access
Semantic Scholar
244 AFNT-111, a safe and effective TCR-engineered T cell therapy targeting the oncogenic driver KRAS G12V mutation
H. Lam, Xingyue He, C. Black, Michele M. Hoffmann +16 more
2022Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
The ERK1/2 Regulator WNK2 Shows Differential Expression and Isoform Usage, Primarily Driven By Aberrant Methylation, in MYD88 Mutated Waldenström's Macroglobulinemia
M. Guerrera, Guang Yang, Xia Liu, N. Tsakmaklis +14 more
2021Blood0 citations
Semantic Scholar

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