Skip to content

Home Search Authors Pakistan News Saved

SciRah

SciRah does not host or store research papers. Results come live from free, official scholarly APIs, and every paper links back to its original source.

Data sources

OpenAlex
Semantic Scholar
Crossref
CORE
arXiv
PubMed

Privacy policy Terms of service

C. Cherian · SciRah

Researcher profile · Semantic Scholar

C. Cherian

Share profile

C. Cherian — researcher profile on SciRah

h-index: 17
Works: 49
Citations: 988

Most-cited papers

The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T- cell acute lymphoblastic leukemia: A report from the Children's Oncology Group
A. Gedman, Qing Chen, S. Desmoulin, Y. Ge +7 more
2009Leukemia144 citations Open access
Semantic Scholar
Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry
Yi-Jun Deng, Xilin Zhou, S. Desmoulin, Jian-Mei Wu +4 more
2009Journal of Medicinal Chemistry86 citations Open access
Semantic Scholar
Synthesis and Discovery of High Affinity Folate Receptor-Specific Glycinamide Ribonucleotide Formyltransferase Inhibitors With Antitumor Activity
Yi-Jun Deng, Yiqiang Wang, C. Cherian, Z. Hou +3 more
2008Journal of Medicinal Chemistry80 citations Open access
Semantic Scholar
Synthesis, biological and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase
Lei Wang, S. Desmoulin, C. Cherian, L. Polin +10 more
2011Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
Therapeutic Targeting of a Novel 6-Substituted Pyrrolo [2,3-d]pyrimidine Thienoyl Antifolate to Human Solid Tumors Based on Selective Uptake by the Proton-Coupled Folate Transporter
Sita Kugel Desmoulin, Lei Wang, Eric C. Hales, L. Polin +7 more
2011Molecular Pharmacology66 citations Open access
Semantic Scholar
Synthesis and biological activity of a novel series of 6-substituted pyrrolo[2,3- d ]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry
Lei Wang, C. Cherian, S. Desmoulin, L. Polin +8 more
201064 citations
Semantic Scholar
Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors
S. Desmoulin, Yiqiang Wang, Jian-Mei Wu, M. Stout +7 more
2010Molecular Pharmacology55 citations Open access
Semantic Scholar
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes
Si-Wei Chen, B. Abou-Khalil, Z. Afawi, Q. Z. Ali +332 more
2024Nature Neuroscience50 citations Open access
Semantic Scholar
Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier
Lei Wang, C. Cherian, S. Desmoulin, S. Mitchell-Ryan +3 more
2012Journal of Medicinal Chemistry48 citations Open access
Semantic Scholar
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes
Si-Wei Chen, B. Abou-Khalil, Z. Afawi, Q. Z. Ali +332 more
2023medRxiv44 citations Open access
Semantic Scholar
Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carbo
S. Mitchell-Ryan, Yiqiang Wang, Sudhir Raghavan, M. Ravindra +6 more
2013Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Identification and Functional Impact of Homo-oligomers of the Human Proton-coupled Folate Transporter*
Z. Hou, Sita Kugel Desmoulin, Erika Etnyre, M. Olive +5 more
2011Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Functional Loss of the Reduced Folate Carrier Enhances the Antitumor Activities of Novel Antifolates with Selective Uptake by the Proton-Coupled Folate Transporter
S. Desmoulin, Lei Wang, L. Polin, Kathryn White +6 more
2012Molecular Pharmacology30 citations Open access
Semantic Scholar
Tumor-Targeting with Novel Non-Benzoyl 6-Substituted Straight Chain Pyrrolo[2,3-d]pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and Inhibition of de novo Purine Nucleotide Biosynthesis
Yiqiang Wang, C. Cherian, Steven M. Orr, S. Mitchell-Ryan +4 more
2013Journal of Medicinal Chemistry26 citations Open access
Semantic Scholar
Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-D]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter
C. Cherian, S. Desmoulin, Lei Wang, L. Polin +6 more
2013Cancer Chemotherapy and Pharmacology25 citations Open access
Semantic Scholar
Intestinal Transport of Aminopterin Enantiomers in Dogs and Humans with Psoriasis Is Stereoselective: Evidence for a Mechanism Involving the Proton-Coupled Folate Transporter
A. Menter, Breck Thrash, C. Cherian, L. Matherly +7 more
2012Journal of Pharmacology and Experimental Therapeutics22 citations Open access
Semantic Scholar
Role of Lysine 411 in Substrate Carboxyl Group Binding to the Human Reduced Folate Carrier, as Determined by Site-Directed Mutagenesis and Affinity Inhibition
Yi-Jun Deng, Z. Hou, Lei Wang, C. Cherian +3 more
2008Molecular Pharmacology21 citations Open access
Semantic Scholar
Synthesis and biological activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry†
Lei Wang, C. Cherian, S. Desmoulin, Lisa Polin +7 more
2010Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Identification of the Minimal Functional Unit of the Homo-oligomeric Human Reduced Folate Carrier*
Z. Hou, C. Cherian, J. Drews, Jian-Mei Wu +1 more
2009Journal of Biological Chemistry15 citations Open access
Semantic Scholar
A humanized mouse model for the reduced folate carrier.
D. Patterson, C. Graham, C. Cherian, L. Matherly
2008Molecular Genetics and Metabolism14 citations Open access
Semantic Scholar
The phenotypic spectrum of KCNT1: a new family with variable epilepsy syndromes including mild focal epilepsy
C. Cherian, J. Appendino, S. Ashtiani, P. Federico +5 more
2021Journal of Neurology12 citations
Semantic Scholar
Open flower segregants selected from Cajanus platycarpus crosses.
C. Cherian, N. Mallikarjuna, D. Jadhav, K. Saxena
200611 citations
Semantic Scholar
Substrate-specific binding and conformational changes involving Ser313 and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking
Z. Hou, Jian-Mei Wu, Jun Ye, C. Cherian +1 more
2010Biochemical Journal8 citations Open access
Semantic Scholar
Trends in Carbapenem Susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae Isolates From Long-Term Acute Care Hospitals Across the United States-An Analysis of Antibiograms
Sukhesh Sudan, C. Cherian, Ellie J. C. Goldstein, David W. Hines +2 more
2015Open Forum Infectious Diseases2 citations Open access
Semantic Scholar
Abstract 5493: Tumor-targeting with novel non-benzoyl 6-substituted pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition ofde novopurine nucleotide biosynthesis.
C. Cherian, Yiqiang Wang, S. Mitchell-Ryan, Steven M. Orr +3 more
20132 citations
Semantic Scholar
Abstract 4546: Expression profiling of the major folate facilitative transporters in human tumors and normal tissues
Sita Kugel-Desmoulin, Lei Wang, L. Tait, Z. Hou +3 more
20102 citations
Semantic Scholar
Abstract 873: Acute regulation of human reduced folate carrier by folates as a novel adaptive mechanism to folate deprivation.
Z. Hou, Steven M. Orr, Erika Etnyre, C. Cherian +1 more
20131 citations
Semantic Scholar
Abstract 4765: Synthesis and evaluation of nonclassical 6-substituted pyrrolo[2,3-d]pyrimidine antifolates: Role of terminal amino acid moiety in membrane transport and antitumor activity.
A. Gangjee, L. Kumar, C. Cherian, Steven M. Orr +2 more
20121 citations
Semantic Scholar
Abstract 2706: Tumor-targeting with novel pyridyl 6-substituted pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor (FR) α and the proton-coupled folate transporter (PCFT) and inhibition ofde novopurine nucleotide biosynthesis
C. Cherian, Lei Wang, Adrianne Wallace, Steven M. Orr +3 more
20140 citations
Semantic Scholar
Abstract 1620: Synthesis and preclinical evaluation of novel 6-substituted pyrrolo[2,3-d]pyrimidines as targeted antifolates
Lalit K. Golani, A. Gangjee, C. Cherian, Steven M. Orr +4 more
20140 citations
Semantic Scholar
Abstract 4591: The folate receptor-targeted agents, vintafolide and etarfolatide, are not substrates for the reduced folate carrier or the proton-coupled folate transporter
Nikki Parker, C. Cherian, L. Matherly, C. Leamon
20140 citations
Semantic Scholar
Abstract 5492: Study the variation of the glutamate moiety of AG94, a targeted, potent GARFTase inhibitor, as antitumor agents with the 2-amino-6-substituted pyrrolo[2,3-d]pyrimidine scaffold.
A. Gangjee, Sai Zhao, L. Kumar, C. Cherian +4 more
20130 citations
Semantic Scholar
Abstract 5494: Novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate regioisomers target folate receptor alpha positive ovarian cancer cells via inhibition of de novo purine nucleotide biosynthesis.
S. Mitchell-Ryan, Lei Wang, Steven M. Orr, Sita Kugel +3 more
20130 citations
Semantic Scholar
Abstract 3825: The impact of the reduced folate carrier on the collateral sensitivity of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with selective uptake by the proton-coupled folate transporter
S. Desmoulin, Lei Wang, L. Polin, Kathryn White +6 more
20120 citations
Semantic Scholar
Abstract 3826: Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter
C. Cherian, S. Desmoulin, Lei Wang, L. Polin +6 more
20120 citations
Semantic Scholar
Abstract 3822: A tumor-targeted 5-pyrrolo[2,3-d]pyrimidine antifolate is a selective substrate for folate receptor ≤ and potent inhibitor of 5-amino-4-carboxamide formyltransferase inde novopurine nucleotide biosynthesis
S. Mitchell-Ryan, Yiqiang Wang, C. Cherian, Erika Etnyre +3 more
20120 citations
Semantic Scholar
Abstract 1364: Design, synthesis and evaluation of potent antiproliferative and cytotoxic antifolates with selective FRs and PCFT transport over RFC and potent GARFTase inhibition
Lei Wang, C. Cherian, S. Desmoulin, Z. Hou +2 more
20110 citations
Semantic Scholar
Abstract 3250: Design, synthesis and biological evaluation of side chain pemetrexed (PMX) analogues as potent inhibitors of tumors expressing folate receptors via GARFTase inhibition
Yiqiang Wang, Shermaine Mitchell, C. Cherian, S. Desmoulin +4 more
20110 citations
Semantic Scholar
Abstract 2528: Therapeutic targeting of a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by PCFT
S. Desmoulin, Lei Wang, L. Tait, L. Polin +4 more
20110 citations
Semantic Scholar
Abstract 1524: Identification of a critical oligomerization domain of the human reduced folate carrier
Z. Hou, C. Cherian, B. Hsiung, L. Matherly
20100 citations
Semantic Scholar
Abstract 4542: The design, synthesis andin vitroevaluation of selective FR α and β and PCFT substrates with potent GARFTase inhibitory activity as antitumor agents
A. Gangjee, Lei Wang, C. Cherian, S. Desmoulin +3 more
20100 citations
Semantic Scholar
Abstract 4541: The design, synthesis and evaluation of selective FR α and β substrates with potent GARFTase inhibitory activity as antitumor agents
Xilin Zhou, Xin Zhang, Aleem Gang, C. Cherian +3 more
20100 citations
Semantic Scholar
Abstract #1918: The design, synthesis and preclinical evaluation of selective FR and PCFT substrates with potent GARFTase inhibitory activity as antitumor agents
Lei Wang, S. Desmoulin, L. Polin, C. Cherian +3 more
20090 citations
Semantic Scholar
Abstract #1684: Discovery of a glycinamide ribonucleotide formyltransferase inhibitor with solid tumor selectivity via its transport by the proton-coupled folate transporter
S. Desmoulin, Yiqiang Wang, Jian-Mei Wu, Z. Hou +3 more
20090 citations
Semantic Scholar
Discovery of α-folate receptor specific GARFTase inhibitors as selective antitumor agents
A. Gangjee, Yiqiang Wang, Yi-Jun Deng, C. Cherian +2 more
20080 citations
Semantic Scholar
A series of novel 6-substituted 2-amino-4-oxopyrrolo[2,3-d]pyrimidine antifolates specifically transported by folate receptors and targeting the de novo purine biosynthesis pathway
Yi-Jun Deng, Yiqiang Wang, C. Cherian, Z. Hou +2 more
20080 citations
Semantic Scholar
Identification of human reduced folate carrier (hRFC) substrate binding sites by site-directed mutagenesis and affinity labeling strategies
Yi-Jun Deng, Z. Hou, C. Cherian, Jian-Mei Wu +3 more
20070 citations
Semantic Scholar
International Chickpea and Pigeonpea Newsletter
C. Cherian, N. Mallikarjuna
20060 citations
Semantic Scholar
Decay and thermoluminescence studies of CaS:Di, Sm phosphors
C. Cherian
19670 citations
Semantic Scholar

Frequent co-authors

Invite them to SciRah by sharing their profile.

L. Matherly×41
Invite
L. Matherly — researcher profile on SciRah
Z. Hou×34
Invite
Z. Hou — researcher profile on SciRah
A. Gangjee×33
Invite
A. Gangjee — researcher profile on SciRah
Lei Wang×18
Invite
Lei Wang — researcher profile on SciRah

×17

Invite

S. Desmoulin — researcher profile on SciRah

Yiqiang Wang×10

Invite

Yiqiang Wang — researcher profile on SciRah

Invite

L. Polin — researcher profile on SciRah

Invite

Yi-Jun Deng — researcher profile on SciRah

Invite

Jian-Mei Wu — researcher profile on SciRah

Steven M. Orr×9

Invite

Steven M. Orr — researcher profile on SciRah

Kathryn White×8

Invite

Kathryn White — researcher profile on SciRah

Juiwanna Kushner×8

Invite

Juiwanna Kushner — researcher profile on SciRah