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S. Mahboobi · SciRah

Researcher profile · Semantic Scholar

S. Mahboobi

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S. Mahboobi — researcher profile on SciRah

h-index: 27
Works: 100
Citations: 1,881

Most-cited papers

Drugging the HDAC6-HSP90 interplay in malignant cells.
O. Krämer, S. Mahboobi, A. Sellmer
2014TIPS - Trends in Pharmacological Sciences128 citations Open access
Semantic Scholar
Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents.
S. Mahboobi, Herwig Pongratz, Harald Hufsky, J. Hockemeyer +9 more
2001Journal of Medicinal Chemistry87 citations Open access
Semantic Scholar
Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity.
S. Mahboobi, A. Sellmer, M. Winkler, E. Eichhorn +5 more
2010Journal of Medicinal Chemistry84 citations Open access
Semantic Scholar
Natural, semisynthetic and synthetic microtubule inhibitors for cancer therapy
T. Beckers, S. Mahboobi
200384 citations
Semantic Scholar
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
S. Mahboobi, S. Dove, A. Sellmer, M. Winkler +6 more
2009Journal of Medicinal Chemistry79 citations Open access
Semantic Scholar
Concepts to Target MYC in Pancreatic Cancer
M. Wirth, S. Mahboobi, O. Krämer, G. Schneider
2016Molecular Cancer Therapeutics71 citations
Semantic Scholar
Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.
S. Mahboobi, S. Teller, Herwig Pongratz, Harald Hufsky +10 more
2002Journal of Medicinal Chemistry70 citations Open access
Semantic Scholar
Marbostat-100 Defines a New Class of Potent and Selective Antiinflammatory and Antirheumatic Histone Deacetylase 6 Inhibitors.
A. Sellmer, H. Stangl, M. Beyer, Elisabeth Grünstein +10 more
2018Journal of Medicinal Chemistry60 citations Open access
Semantic Scholar
2-Arylamino-4-Amino-5-Aroylthiazoles. “One-Pot” Synthesis and Biological Evaluation of a New Class of Inhibitors of Tubulin Polymerization
R. Romagnoli, P. Baraldi, M. Carrión, O. Cruz-López +9 more
2009Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.
S. Mahboobi, A. Sellmer, H. Hocher, C. Garhammer +4 more
2007Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase.
S. Mahboobi, Andrea Uecker, A. Sellmer, C. Cenac +12 more
2006Journal of Medicinal Chemistry52 citations Open access
Semantic Scholar
A Single Amino Acid Exchange Inverts Susceptibility of Related Receptor Tyrosine Kinases for the ATP Site Inhibitor STI-571* 210
F. Böhmer, L. Karagyozov, Andrea Uecker, H. Serve +3 more
2003Journal of Biological Chemistry52 citations Open access
Semantic Scholar
2-aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors.
T. Beckers, T. Reissmann, Mathias Schmidt, A. Burger +7 more
2002Cancer Research49 citations
Semantic Scholar
Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance
J. Ridinger, E. Koeneke, Fiona R. Kolbinger, Katharina Koerholz +9 more
2018Scientific Reports47 citations Open access
Semantic Scholar
HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3.
Nisintha Mahendrarajah, M. E. Borisova, Sigrid Reichardt, Maren Godmann +8 more
2017Cellular Signalling44 citations Open access
Semantic Scholar
Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells.
Claudia Schäfer, Anja Göder, M. Beyer, N. Kiweler +15 more
2017Cellular Signalling43 citations
Semantic Scholar
3-Bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives as new lead compounds for antibacterially active substances.
S. Mahboobi, E. Eichhorn, A. Popp, A. Sellmer +2 more
2006European journal of medicinal chemistry43 citations
Semantic Scholar
Synthesis of Pyrrolidin-2-ones and of Staurosporine Aglycon (K-252c) by Intermolecular Michael Reaction.
S. Mahboobi, E. Eibler, M. Koller, Sunil Kumar Kc +2 more
1999Journal of Organic Chemistry36 citations
Semantic Scholar
Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases
T. Beckers, S. Mahboobi, A. Sellmer, M. Winkler +8 more
201235 citations
Semantic Scholar
Design and biological evaluation of tetrahydro-β-carboline derivatives as highly potent histone deacetylase 6 (HDAC6) inhibitors.
M. Leonhardt, A. Sellmer, O. Krämer, S. Dove +4 more
2018European journal of medicinal chemistry34 citations Open access
Semantic Scholar
Synthesis of Esters of 3‐(2‐Aminoethyl)‐1H‐indole‐2‐acetic Acid and 3‐(2‐aminoethyl)‐1H‐indole‐2‐malonic acid (= 2‐[3‐(2‐aminoethyl)‐1H‐indol‐2‐yl]propanedioic acid) 4th communication on indoles, indolenines, and indolines
S. Mahboobi, K. Bernauer
198834 citations
Semantic Scholar
Enantioselective Hydrosilylation of Prochiral 3,4‐Dihydro‐2H‐pyrrole Derivatives
R. Becker, H. Brunner, S. Mahboobi, W. Wiegrebe
198533 citations
Semantic Scholar
A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer.
Svenja Lier, A. Sellmer, F. Orben, S. Heinzlmeir +20 more
2021Bioorganic chemistry (Print)32 citations Open access
Semantic Scholar
Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones.
T. Beckers, A. Sellmer, E. Eichhorn, Herwig Pongratz +7 more
2012Bioorganic & Medicinal Chemistry30 citations Open access
Semantic Scholar
[4-(imidazol-1-yl)thiazol-2-yl]phenylamines. A novel class of highly potent colchicine site binding tubulin inhibitors: synthesis and cytotoxic activity on selected human cancer cell lines.
S. Mahboobi, A. Sellmer, H. Hocher, E. Eichhorn +5 more
2006Journal of Medicinal Chemistry28 citations Open access
Semantic Scholar
Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation
Dimitrios Tsitsipatis, A. K. Jayavelu, J. Müller, Reinhard Bauer +5 more
2017OncoTarget27 citations Open access
Semantic Scholar
Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones.
S. Mahboobi, Andrea Uecker, C. Cenac, A. Sellmer +4 more
2007Bioorganic & Medicinal Chemistry27 citations Open access
Semantic Scholar
The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity.
M. Welsh, Charlotte Welsh, M. Ekman, Johan Dixelius +6 more
2004Biochemical Journal25 citations Open access
Semantic Scholar
Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells.
M. Beyer, Sven J. Henninger, Patricia S. Haehnel, Al-Hassan M. Mustafa +9 more
2021Cell Chemical Biology24 citations Open access
Semantic Scholar
How to Distinguish Between the Activity of HDAC1-3 and HDAC6 with Western Blot.
M. Beyer, N. Kiweler, S. Mahboobi, O. Krämer
2017Methods in molecular biology24 citations
Semantic Scholar
Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells
Katrin Noack, Nisintha Mahendrarajah, Dorle Hennig, L. Schmidt +9 more
2016Archives of Toxicology24 citations Open access
Semantic Scholar
Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3
Vanessa Wachholz, Al-Hassan M. Mustafa, Yanira Zeyn, Sven J. Henninger +11 more
2021Archives of Toxicology22 citations Open access
Semantic Scholar
Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition
R. Winkler, Ann-Sophie Mägdefrau, Eva-Maria Piskor, Markus Kleemann +12 more
2021bioRxiv22 citations Open access
Semantic Scholar
Homoarcyriaflavin: Synthesis of Ring-Expanded Arcyriaflavin Analogues.
S. Mahboobi, T. Burgemeister, S. Dove, S. Kuhr +1 more
1999Journal of Organic Chemistry21 citations
Semantic Scholar
Human platelet lysate as validated replacement for animal serum to assess chemosensitivity.
Miriam Pons, G. Nagel, Yanira Zeyn, M. Beyer +7 more
2018ALTEX19 citations Open access
Semantic Scholar
Stent-based release of a selective PDGF-receptor blocker from the bis-indolylmethanon class inhibits restenosis in the rabbit animal model.
E. Jandt, O. Mutschke, S. Mahboobi, Andrea Uecker +5 more
2010Vascular pharmacology19 citations
Semantic Scholar
Bis(1H‐indol‐2‐yl)methanones are effective inhibitors of FLT3‐ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro
F. Heidel, D. Lipka, Fian K. Mirea, S. Mahboobi +7 more
2009British Journal of Haematology16 citations
Semantic Scholar
Synthesis and cytotoxic activity of 2-acyl-1H-indole-4,7-diones on human cancer cell lines.
S. Mahboobi, A. Sellmer, E. Eichhorn, T. Beckers +2 more
2005European journal of medicinal chemistry16 citations
Semantic Scholar
Diastereoselective Spirocyclization of C‐(Alkyloxycarbonyl)formimines of 2‐Substituted 1HIndole‐3‐ethanamines (= Tryptamines): Basic Studies. 5th Communication on Indoles, Indolenines, and Indolines
R. Freund, S. Mahboobi, K. Noack, Peter Schönholzer +1 more
199014 citations
Semantic Scholar
Enantioselective Hydrosilylation and Hydrogenation of Alkaloid Precursors
H. Brunner, Alfred Kürzinger, S. Mahboobi, W. Wiegrebe
198814 citations Open access
Semantic Scholar
A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia.
A. Sellmer, Bernadette Pilsl, M. Beyer, Herwig Pongratz +12 more
2020European journal of medicinal chemistry13 citations Open access
Semantic Scholar
Antibacterial activity of a novel series of 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives--an extended structure-activity relationship study.
S. Mahboobi, E. Eichhorn, M. Winkler, A. Sellmer +1 more
2008European journal of medicinal chemistry13 citations
Semantic Scholar
Synthesis of Naturally Occurring Pyrazine and Imidazole Alkaloids from Botryllus LeachiRID=”a”ID=”a” Dedicated to Prof. G. Märkl on the occasion of his 75th birthday
S. Mahboobi, A. Sellmer, T. Burgemeister, A. Lyssenko +1 more
200412 citations
Semantic Scholar
Enantioselective Synthesis of Some Nicotiana Alkaloids
S. Mahboobi, W. Wiegrebe
198812 citations Open access
Semantic Scholar
Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides: a SAR study on the bioisosterism of pyrimidine and imidazole.
S. Mahboobi, A. Sellmer, Asma Eswayah, S. Elz +2 more
2008European journal of medicinal chemistry11 citations Open access
Semantic Scholar
Pyrrolo[3,4-c]-beta-carboline-diones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.
S. Teller, S. Eluwa, M. Koller, Andrea Uecker +4 more
2000European journal of medicinal chemistry11 citations
Semantic Scholar
Inhibitors of the tyrosine kinases FMS-like tyrosine kinase-3 and WEE1 induce apoptosis and DNA damage synergistically in acute myeloid leukemia cells.
Christoph Hieber, Al-Hassan M. Mustafa, Sarah Neuroth, Sven J. Henninger +9 more
2024Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie10 citations Open access
Semantic Scholar
Histone deacetylase inhibitors modulate hormesis in leukemic cells with mutant FMS-like tyrosine kinase-3
Yanira Zeyn, K. Hausmann, Melisa Halilovic, M. Beyer +6 more
2023Leukemia9 citations Open access
Semantic Scholar
Development of Tubulin Inhibitors as Antimitotic Agents for Cancer Therapy
S. Mahboobi, A. Sellmer, T. Beckers
20069 citations
Semantic Scholar
Chimeric tyrosine kinase-HDAC inhibitors as antiproliferative agents
Andrea Uecker, Marit Sicker, T. Beckers, S. Mahboobi +3 more
2010Anti-Cancer Drugs8 citations
Semantic Scholar

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