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A. Słupianek · SciRah

Researcher profile · Semantic Scholar

A. Słupianek

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A. Słupianek — researcher profile on SciRah

h-index: 28
Works: 61
Citations: 3,385

Most-cited papers

BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.
A. Słupianek, C. Schmutte, Gregory Tombline, Malgorzata Nieborowska‐Skorska +5 more
2001Molecules and Cells331 citations Open access
Semantic Scholar
Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis
Malgorzata Nieborowska‐Skorska, M. Wasik, A. Słupianek, P. Salomoni +3 more
1999Journal of Experimental Medicine302 citations Open access
Semantic Scholar
Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis.
A. Słupianek, M. Nieborowska-Skorska, G. Hoser, A. Morrione +5 more
2001Cancer Research272 citations
Semantic Scholar
BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks.
M. Nowicki, Rafal Falinski, Mateusz Koptyra, A. Słupianek +5 more
2004Blood268 citations
Semantic Scholar
The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells
A. Klejman, Steven J. Schreiner, Malgorzata Nieborowska‐Skorska, A. Słupianek +3 more
2002EMBO Journal224 citations Open access
Semantic Scholar
Fusion Tyrosine Kinases Induce Drug Resistance by Stimulation of Homology-Dependent Recombination Repair, Prolongation of G2/M Phase, and Protection from Apoptosis
A. Słupianek, G. Hoser, I. Majsterek, A. Bronisz +4 more
2002Molecular and Cellular Biology223 citations Open access
Semantic Scholar
Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571
A. Klejman, Lori Rushen, A. Morrione, A. Słupianek +1 more
2002Oncogene166 citations
Semantic Scholar
Personalized synthetic lethality induced by targeting RAD52 in leukemias identified by gene mutation and expression profile.
Kimberly L. Cramer-Morales, M. Nieborowska-Skorska, Kara A. Scheibner, M. Padget +14 more
2013Blood148 citations Open access
Semantic Scholar
Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt.
Miroslaw Majewski, Malgorzata Nieborowska‐Skorska, Paolo Salomoni, A. Słupianek +4 more
1999Cancer Research136 citations
Semantic Scholar
Role of signal transducer and activator of transcription 5 in nucleophosmin/ anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells.
Malgorzata Nieborowska‐Skorska, A. Słupianek, L. Xue, Qian Zhang +5 more
2001Cancer Research126 citations
Semantic Scholar
BCR/ABL and other kinases from chronic myeloproliferative disorders stimulate single-strand annealing, an unfaithful DNA double-strand break repair
Kimberly Cramer, M. Nieborowska-Skorska, Mateusz Koptyra, A. Słupianek +4 more
2008Cancer Research102 citations Open access
Semantic Scholar
BCR/ABL inhibits mismatch repair to protect from apoptosis and induce point mutations.
T. Stokłosa, T. Popławski, Mateusz Koptyra, M. Nieborowska-Skorska +7 more
2008Cancer Research100 citations Open access
Semantic Scholar
BCR/ABL promotes accumulation of chromosomal aberrations induced by oxidative and genotoxic stress
Mateusz Koptyra, Kimberly Cramer, A. Słupianek, C. Richardson +1 more
2008Leukemia90 citations Open access
Semantic Scholar
Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum.
P. Włodarski, M. Kasprzycka, Xiaobin Liu, M. Marzec +3 more
2005Cancer Research81 citations Open access
Semantic Scholar
BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells.
A. Słupianek, M. Nowicki, Mateusz Koptyra, T. Skorski
2006DNA Repair75 citations Open access
Semantic Scholar
Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells
M. Nieborowska-Skorska, K. Sullivan, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka +28 more
2017Journal of Clinical Investigation71 citations Open access
Semantic Scholar
Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1
Qiang Wang, Hong-Tao Zhang, S. Guerrette, Jin-Qiu Chen +6 more
2001Oncogene67 citations
Semantic Scholar
PI3K/Akt/mTOR Signaling Pathway in Blood Malignancies—New Therapeutic Possibilities
Wojciech Wiese, Julia Barczuk, Olga Racinska, Natalia Siwecka +4 more
2023Cancers66 citations Open access
Semantic Scholar
BCR/ABL stimulates WRN to promote survival and genomic instability
A. Słupianek, T. Popławski, S. K. Jozwiakowski, Kimberly Cramer +5 more
2010Cancer Research64 citations Open access
Semantic Scholar
ATR-Chk1 Axis Protects BCR/ABL Leukemia Cells from the Lethal Effect of DNA Double-Strand Breaks
M. Nieborowska-Skorska, T. Stokłosa, M. Datta, A. Czechowska +7 more
2006Cell Cycle60 citations Open access
Semantic Scholar
Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia.
A. Słupianek, Yashodhara Dasgupta, Shu-yue Ren, Ewa Gurdek +4 more
2011Blood51 citations Open access
Semantic Scholar
The chromatin remodeling factor SRCAP modulates expression of prostate specific antigen and cellular proliferation in prostate cancer cells
A. Słupianek, Smitha Yerrum, F. Safadi, M. Monroy
2010Journal of Cellular Physiology48 citations
Semantic Scholar
BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability
A. Słupianek, Rafal Falinski, Pawel Znojek, T. Stokłosa +7 more
2012Leukemia41 citations Open access
Semantic Scholar
Fusion oncogenic tyrosine kinases alter DNA damage and repair after genotoxic treatment: role in drug resistance?
G. Hoser, I. Majsterek, Duane L Romana, A. Słupianek +2 more
2003Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis33 citations
Semantic Scholar
BCR/ABL Recruits p53 Tumor Suppressor Protein to Induce Drug Resistance
T. Stokłosa, A. Słupianek, M. Datta, M. Nieborowska-Skorska +3 more
2004Cell Cycle32 citations Open access
Semantic Scholar
BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin
A. Słupianek, Ewa Gurdek, Mateusz Koptyra, M. Nowicki +3 more
2005Oncogene31 citations Open access
Semantic Scholar
Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells.
L. Rink, A. Słupianek, T. Stokłosa, M. Nieborowska-Skorska +4 more
2007Blood29 citations Open access
Semantic Scholar
NPM/ALK downregulates p27Kip1 in a PI-3K-dependent manner.
A. Słupianek, T. Skorski
2004Experimental Hematology28 citations Open access
Semantic Scholar
ABL-fusion oncoproteins activate multi-pathway of DNA repair: role in drug resistance?
I. Majsterek, A. Słupianek, G. Hoser, T. Skorski +1 more
2004Biochimie26 citations
Semantic Scholar
Brain tumor formation in tuberous sclerosis depends on erk activation
J. Jóźwiak, W. Grajkowska, K. Kotulska, S. Jóźwiak +5 more
2007Neuromolecular medicine24 citations
Semantic Scholar
Imatinib mesylate (STI571) abrogates the resistance to doxorubicin in human K562 chronic myeloid leukemia cells by inhibition of BCR/ABL kinase-mediated DNA repair.
I. Majsterek, T. Śliwiński, T. Popławski, Dariusz Pytel +4 more
2006Mutation research19 citations
Semantic Scholar
[Uracil-DNA glycosylases].
Dariusz Pytel, A. Słupianek, D. Ksiazek, T. Skorski +1 more
2008Postepy biochemii8 citations
Semantic Scholar
TEL-fusion oncogenic tyrosine kinases determine leukemic cells response to idarubicin
I. Majsterek, A. Słupianek, J. Błasiak
2003Anti-Cancer Drugs8 citations
Semantic Scholar
Targeting RAD 51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL 1 leukemia
A. Słupianek, Yashodhara Dasgupta, Shu-yue Ren, Ewa Gurdek +4 more
20116 citations
Semantic Scholar
Induction of transcriptional inhibitor HES1 and the related repression of tumor-suppressor TXNIP are important components of cell-transformation program imposed by oncogenic kinase NPM-ALK.
Qian Zhang, Hong Y. Wang, A. Nayak, S. Nunez-Cruz +10 more
2022American Journal of Pathology5 citations Open access
Semantic Scholar
Endoplasmic Reticulum Stress in Acute Myeloid Leukemia: Pathogenesis, Prognostic Implications, and Therapeutic Strategies
Wojciech Wiese, Grzegorz Galita, Natalia Siwecka, Wioletta Rozpędek-Kamińska +2 more
2025International Journal of Molecular Sciences4 citations Open access
Semantic Scholar
Inflammatory cytokines controlling branching of N-heteroglycans of acute phase protein.
Katarzyna Gryska, A. Słupianek, M. Laciak, A. Górny +3 more
1995Advances in Experimental Medicine and Biology4 citations
Semantic Scholar
Interleukin‐6‐Type Cytokines Affect Glycosylation of Acute Phase Proteins in Vitro a
K. Gryska, A. Słupianek, M. Laciak, H. Baumann +1 more
1995Annals of the New York Academy of Sciences3 citations
Semantic Scholar
Gene Expression and Mutation Analysis (GEMA) –Guided Precision Medicine Targeting PARP1 to Induce Synthetic Lethality in DNA-PK –Deficient Quiescent and BRCA-Deficient Proliferating Leukemia Stem and Progenitor Cells
M. Nieborowska-Skorska, K. Sullivan, Paulina Podszywalow-Bartnicka, G. Hoser +13 more
20142 citations
Semantic Scholar
Oncogene-Induced DNA Repair Defects Promote PARP1-Mediated “Dual Synthetic Lethality” To Eradicate Quiescent and Proliferating Leukemia Stem and Progenitor Cells
A. Słupianek, G. Hoser, Elisabeth Bolton-Gillespie, A. Tulin +5 more
20132 citations
Semantic Scholar
Targeting Rac2 - Mitochondrial Respiratory Chain Complex III Signaling to Prevent Genomic Instability in Leukemia Stem and Progenitor Cells
M. Nieborowska-Skorska, P. Kopinski, R. Ray, G. Hoser +26 more
20112 citations
Semantic Scholar
BCR/ABL Regulates the Expression and Interacts with Werner Syndrome Helicase/Exonuclease To Modulate Its Biochemical Properties.
A. Słupianek, S. K. Jozwiakowski, Ewa Gurdek, M. Nowicki +1 more
20052 citations
Semantic Scholar
BCR/ABL Kinase Disrupts Formation of Mismatch Repair Complex To Induce Genomic Instability.
T. Stokłosa, A. Słupianek, G. Basak, T. Skorski
20052 citations
Semantic Scholar
BCR-ABL1 Kinase Inhibits DNA Glycosylases to Enhance Oxidative DNA Damage and Stimulate Genomic Instability
A. Słupianek, Rafal Falinski, P. Znojek, T. Stokłosa +6 more
20121 citations
Semantic Scholar
ROS-Induced DNA Damage Causing Genomic Instability in CML Stem and/or Progenitor Cells and in Quiescent and/or Proliferating Cells: Role of Mitochondrial Respiratory Chain Complex III.
M. Nieborowska-Skorska, Mateusz Koptyra, E. Bolton, R. Ray +6 more
20091 citations
Semantic Scholar
Selective Anti-Leukemia Targeting of the Interaction Between BCR/ABL and Mammalian RecA Homologs
A. Słupianek, Shu-yue Ren, T. Skorski
20081 citations
Semantic Scholar
BCR/ABL Kinase Inhibits Mismatch Repair To Reduce Apoptosis and Induce Point Mutations.
T. Stokłosa, T. Popławski, G. Basak, A. Słupianek +3 more
20071 citations
Semantic Scholar
[The role of oncogenic tyrosine kinases in the cellular response to anticancer therapy].
A. Słupianek, Dariusz Pytel, I. Majsterek
2007Postępy Higieny i Medycyny Doświadczalnej1 citations
Semantic Scholar
Enhanced Phosphorylation of Nbs1, a Member of DNA Repair/Checkpoint Complex RAD50-Mre11-Nbs1, Can Be Targeted Simultaneously with BCR/ABL Kinase To Eliminate Leukemia Cells.
L. Rink, T. Stokłosa, M. Nieborowska-Skorska, A. Słupianek +2 more
20061 citations
Semantic Scholar
Imatinib Mesylate (STI571) Abrogates the Resistance to Doxorubicin in K562 Chronic Myeloid Leukemia Cells by Inhibition of BCR/ABL Kinase-Mediated DNA Repair.
I. Majsterek, J. Błasiak, A. Słupianek, T. Skorski
20051 citations
Semantic Scholar

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