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Dariusz Pytel · SciRah

Researcher profile · Semantic Scholar

Dariusz Pytel

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Dariusz Pytel — researcher profile on SciRah

h-index: 23
Works: 55
Citations: 2,672

Most-cited papers

The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress
W. Rozpędek, Dariusz Pytel, B. Mucha, H. Leszczyńska +2 more
2016Current molecular medicine774 citations Open access
Semantic Scholar
miR-211 is a pro-survival micro-RNA that regulates chop expression in a PERK-dependent manner
N. Chitnis, Dariusz Pytel, Ekaterina V. Bobrovnikova-Marjon, D. Pant +8 more
2012Molecules and Cells206 citations Open access
Semantic Scholar
The Structure, Activation and Signaling of IRE1 and Its Role in Determining Cell Fate
Natalia Siwecka, Wioletta Rozpędek-Kamińska, Adam Wawrzynkiewicz, Dariusz Pytel +2 more
2021Biomedicines158 citations Open access
Semantic Scholar
Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis
Natalia Siwecka, W. Rozpędek, Dariusz Pytel, Adam Wawrzynkiewicz +4 more
2019International Journal of Molecular Sciences151 citations Open access
Semantic Scholar
PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation
Ekaterina V. Bobrovnikova-Marjon, Dariusz Pytel, M. Riese, L. P. Vaites +4 more
2012Molecular and Cellular Biology120 citations Open access
Semantic Scholar
Tyrosine kinase blockers: new hope for successful cancer therapy.
Dariusz Pytel, T. Śliwiński, T. Popławski, D. Ferriola +1 more
2009Anti-Cancer Agents in Medicinal Chemistry120 citations
Semantic Scholar
Antibacterial, Anti-Inflammatory, Antioxidant, and Antiproliferative Properties of Essential Oils from Hairy and Normal Roots of Leonurus sibiricus L. and Their Chemical Composition
P. Sitarek, P. Ríjo, C. Garcia, Ewa Skała +7 more
2017Oxidative Medicine and Cellular Longevity99 citations Open access
Semantic Scholar
The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases
Wioletta Rozpędek-Kamińska, Natalia Siwecka, Adam Wawrzynkiewicz, Radosław Wojtczak +3 more
2020International Journal of Molecular Sciences76 citations Open access
Semantic Scholar
Unfolded Protein Response and PERK Kinase as a New Therapeutic Target in the Pathogenesis of Alzheimer’s Disease
W. Rozpędek, Łukasz Markiewicz, J. Diehl, Dariusz Pytel +1 more
2015Current Medicinal Chemistry68 citations Open access
Semantic Scholar
The ζ Isoform of Diacylglycerol Kinase Plays a Predominant Role in Regulatory T Cell Development and TCR-Mediated Ras Signaling
Rohan P. Joshi, A. Schmidt, Jayajit Das, Dariusz Pytel +6 more
2013Science Signaling66 citations Open access
Semantic Scholar
BCR/ABL stimulates WRN to promote survival and genomic instability
A. Słupianek, T. Popławski, S. K. Jozwiakowski, Kimberly Cramer +5 more
2010Cancer Research64 citations Open access
Semantic Scholar
Tumor progression and the Different Faces of the PERK kinase
Dariusz Pytel, I. Majsterek, J. Diehl
2015Oncogene62 citations Open access
Semantic Scholar
Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells
T. Kowalczyk, P. Sitarek, Ewa Skała, Monika Toma +5 more
2019Cytotechnology (Dordrecht)61 citations Open access
Semantic Scholar
Altered Expression Levels of MMP1, MMP9, MMP12, TIMP1, and IL-1β as a Risk Factor for the Elevated IOP and Optic Nerve Head Damage in the Primary Open-Angle Glaucoma Patients
L. Markiewicz, Dariusz Pytel, B. Mucha, K. Szymanek +3 more
2015BioMed Research International58 citations Open access
Semantic Scholar
PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma
Dariusz Pytel, Yan Gao, K. Maćkiewicz, Yuliya V. Katlinskaya +11 more
2016PLoS Genetics48 citations Open access
Semantic Scholar
Carbon monoxide activates PERK-regulated autophagy to induce immunometabolic reprogramming and boost anti-tumor T cell function
Paramita Chakraborty, Rasesh Y. Parikh, Seungho Choi, Danh T Tran +19 more
2022Cancer Research47 citations Open access
Semantic Scholar
UPR-inducible micro-RNAs contribute to stressful situations
N. Chitnis, Dariusz Pytel, J. A. Diehl
2013TIBS -Trends in Biochemical Sciences. Regular ed46 citations Open access
Semantic Scholar
BCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability
A. Słupianek, Rafal Falinski, Pawel Znojek, T. Stokłosa +7 more
2012Leukemia41 citations Open access
Semantic Scholar
PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage
Ekaterina V. Bobrovnikova-Marjon, C. Grigoriadou, Dariusz Pytel, Fang Zhang +4 more
2010Oncogene41 citations Open access
Semantic Scholar
The FBXO4 Tumor Suppressor Functions as a Barrier to BrafV600E-Dependent Metastatic Melanoma
E. Lee, Zhao Lian, K. D'Andrea, Richard Letrero +11 more
2013Molecular and Cellular Biology36 citations Open access
Semantic Scholar
The Essential Oils of Rhaponticum carthamoides Hairy Roots and Roots of Soil-Grown Plants: Chemical Composition and Antimicrobial, Anti-Inflammatory, and Antioxidant Activities
Ewa Skała, P. Ríjo, C. Garcia, P. Sitarek +6 more
2016Oxidative Medicine and Cellular Longevity29 citations Open access
Semantic Scholar
Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors
Dariusz Pytel, K. Seyb, Min Liu, S. Ray +5 more
2014Journal of biomolecular screening27 citations Open access
Semantic Scholar
Analysis of the Expression and Polymorphism of APOE, HSP, BDNF, and GRIN2B Genes Associated with the Neurodegeneration Process in the Pathogenesis of Primary Open Angle Glaucoma
A. Nowak, I. Majsterek, K. Przybyłowska-Sygut, Dariusz Pytel +3 more
2015BioMed Research International26 citations Open access
Semantic Scholar
Molecular Basis of Human Diseases and Targeted Therapy Based on Small-Molecule Inhibitors of ER Stress-Induced Signaling Pathways.
Wioletta Rozpędek, A. Nowak, Dariusz Pytel, J. Diehl +1 more
2017Current molecular medicine23 citations
Semantic Scholar
Interplay between Redox Signaling, Oxidative Stress, and Unfolded Protein Response (UPR) in Pathogenesis of Human Diseases
T. Popławski, Dariusz Pytel, J. Dziadek, I. Majsterek
2019Oxidative Medicine and Cellular Longevity22 citations Open access
Semantic Scholar
Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation
B. Mucha, Shuo Qie, Sagar Bajpai, V. Tarallo +20 more
2022Nature Communications21 citations Open access
Semantic Scholar
Inhibition of the PERK-Dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease.
W. Rozpędek, Dariusz Pytel, T. Popławski, A. Walczak +6 more
2019Current Alzheimer Research20 citations
Semantic Scholar
Imatinib mesylate (STI571) abrogates the resistance to doxorubicin in human K562 chronic myeloid leukemia cells by inhibition of BCR/ABL kinase-mediated DNA repair.
I. Majsterek, T. Śliwiński, T. Popławski, Dariusz Pytel +4 more
2006Mutation research19 citations
Semantic Scholar
Induction of apoptosis in human glioma cell lines of various grades through the ROS-mediated mitochondrial pathway and caspase activation by Rhaponticum carthamoides transformed root extract
Ewa Skała, T. Kowalczyk, Monika Toma, J. Szemraj +6 more
2017Molecular and Cellular Biochemistry17 citations
Semantic Scholar
The role of base excision repair in the development of primary open angle glaucoma in the Polish population.
M. Cuchra, L. Markiewicz, B. Mucha, Dariusz Pytel +5 more
2015Mutation research16 citations
Semantic Scholar
The role of base excision repair in pathogenesis of breast cancer in the Polish population
M. Cuchra, B. Mucha, L. Markiewicz, K. Przybyłowska-Sygut +4 more
2016Molecular Carcinogenesis14 citations
Semantic Scholar
The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment
Wioletta Rozpędek-Kamińska, Grzegorz Galita, Natalia Siwecka, S. Carroll +4 more
2021International Journal of Molecular Sciences13 citations Open access
Semantic Scholar
Breaking the DNA Damage Response via Serine/Threonine Kinase Inhibitors to Improve Cancer Treatment.
W. Rozpędek, Dariusz Pytel, Alicja Nowak-Zduńczyk, D. Lewko +3 more
2019Current Medicinal Chemistry13 citations
Semantic Scholar
Comparative study of DNA damage, cell cycle and apoptosis in human K562 and CCRF-CEM leukemia cells: role of BCR/ABL in therapeutic resistance.
Dariusz Pytel, T. Wysocki, I. Majsterek
2006Comparative biochemistry and physiology. Toxicology & pharmacology : CBP13 citations
Semantic Scholar
Use of small-molecule inhibitory compound of PERK-dependent signaling pathway as a promising target-based therapy for colorectal cancer.
W. Rozpędek, Dariusz Pytel, Adam Wawrzynkiewicz, Natalia Siwecka +4 more
2020Current Cancer Drug Targets12 citations
Semantic Scholar
Inhibition of PERK-dependent pro-adaptive signaling pathway as a promising approach for cancer treatment.
W. Rozpędek, Dariusz Pytel, Ł. Dziki, A. Nowak +3 more
2017Polski przeglad chirurgiczny12 citations
Semantic Scholar
Nucleotide Excision Repair Capacity and XPC and XPD Gene Polymorphism Modulate Colorectal Cancer Risk
B. Mucha, Dariusz Pytel, L. Markiewicz, M. Cuchra +5 more
2017Clinical colorectal cancer12 citations
Semantic Scholar
DNA Damage and Repair of Head and Neck Cancer Cells after Radio- and Chemotherapy
P. Rusin, A. Walczak, Anita Zwierzchlejska, J. Olszewski +7 more
2009Zeitschrift für Naturforschung C - A Journal of Biosciences11 citations Open access
Semantic Scholar
[Uracil-DNA glycosylases].
Dariusz Pytel, A. Słupianek, D. Ksiazek, T. Skorski +1 more
2008Postepy biochemii8 citations
Semantic Scholar
Imatinib (STI571) Inhibits DNA Repair in Human Leukemia Oncogenic Tyrosine Kinase-Expressing Cells
I. Majsterek, M. Arabski, A. Czechowska, Dariusz Pytel +3 more
2006Zeitschrift für Naturforschung C - A Journal of Biosciences7 citations Open access
Semantic Scholar
The diversification of SARS-CoV-2 Omicron variants and evaluation of their detection with molecular and rapid antigen assays.
Mark Anderson, V. Holzmayer, B. Harris, Austin Hodges +8 more
2023Journal of Clinical Virology3 citations Open access
Semantic Scholar
Small-molecule inhibitors of the PERK-mediated Unfolded Protein Response signaling pathway in targeted therapy for colorectal cancer.
Wioletta Rozpędek-Kamińska, Danuta Piotrzkowska, Grzegorz Galita, Dariusz Pytel +4 more
2022Polski przeglad chirurgiczny3 citations
Semantic Scholar
Potential therapeutic application of PERK inhibitors
Justyna Basak, W. Rozpędek, Dariusz Pytel, I. Majsterek
2019Postepy biochemii3 citations Open access
Semantic Scholar
[Small molecule inhibitors of PERK-dependent signaling pathway as a novel, therapeutic molecular strategy in Alzheimer's disease treatment].
W. Rozpędek, Dariusz Pytel, J. Diehl, I. Majsterek
2016Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego3 citations
Semantic Scholar
[Tyrosine kinases. New target of anticancer therapy].
I. Majsterek, Dariusz Pytel, J. Błasiak
2005Postepy biochemii3 citations
Semantic Scholar
Evaluation of the LDN-0060609 PERK Inhibitor as a Selective Treatment for Primary Open-Angle Glaucoma: An In Vitro Study on Human Retinal Astrocytes
Wioletta Rozpędek-Kamińska, Grzegorz Galita, Kamil Saramowicz, Zuzanna Granek +4 more
2024International Journal of Molecular Sciences2 citations Open access
Semantic Scholar
Inhibitor of pro-apoptotic PERK-dependent signalling pathway as a novel treatment strategy in Alzheimer’s disease treatment
W. Rozpędek, Justyna Basak, Igor Sokolowski, Radosław Wojtczak +3 more
2019Pharmacotherapy in Psychiatry and Neurology2 citations Open access
Semantic Scholar
The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease
W. Rozpędek, A. Nowak, Dariusz Pytel, D. Lewko +2 more
20162 citations Open access
Semantic Scholar
[The role of the adaptive stress response in the pathogenesis of neurodegenerative diseases, cancer and diabetes mellitus type 2].
W. Rozpędek, Łukasz Markiewicz, J. Diehl, Dariusz Pytel +1 more
2015Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego2 citations
Semantic Scholar
Autophagy Induced due to Moderate Endoplasmic Reticulum Stress in T Cells Enhances Immunotherapeutic Tumor Control
Paramita Chakraborty, S. Chatterjee, Danh T Tran, Dariusz Pytel +8 more
2020Journal of Immunology1 citations
Semantic Scholar

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W. Rozpędek×12
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