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Kit I. Tong · SciRah

Researcher profile · Semantic Scholar

Kit I. Tong

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Kit I. Tong — researcher profile on SciRah

h-index: 29
Works: 40
Citations: 11K

Most-cited papers

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
M. Komatsu, H. Kurokawa, S. Waguri, K. Taguchi +15 more
2010Nature Cell Biology2,397 citations
Semantic Scholar
Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1
Akira Kobayashi, Moon-Il Kang, Y. Watai, Kit I. Tong +3 more
2006Molecular and Cellular Biology922 citations Open access
Semantic Scholar
Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles.
K. Itoh, Kit I. Tong, M. Yamamoto
2004Free Radical Biology & Medicine881 citations
Semantic Scholar
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
T. Shibata, T. Ohta, Kit I. Tong, Akiko Kokubu +5 more
2008Proceedings of the National Academy of Sciences of the United States of America768 citations Open access
Semantic Scholar
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.
B. Padmanabhan, Kit I. Tong, T. Ohta, Yoshihiro Nakamura +6 more
2006Molecules and Cells751 citations Open access
Semantic Scholar
Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model
Kit I. Tong, Y. Katoh, H. Kusunoki, K. Itoh +2 more
2006Molecular and Cellular Biology746 citations Open access
Semantic Scholar
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism
Kit I. Tong, Akira Kobayashi, F. Katsuoka, M. Yamamoto
2006Biological chemistry488 citations
Semantic Scholar
Solution structure of the epithelial cadherin domain responsible for selective cell adhesion
M. Overduin, T. Harvey, S. Bagby, Kit I. Tong +3 more
1995Science437 citations
Semantic Scholar
Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response
Kit I. Tong, B. Padmanabhan, Akira Kobayashi, Cheng-Wei Shang +3 more
2007Molecular and Cellular Biology426 citations Open access
Semantic Scholar
Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand
I. Bosanac, J. Alattia, T. Mal, Jenny Chan +9 more
2002Nature318 citations
Semantic Scholar
DREAM is a critical transcriptional repressor for pain modulation.
H. M. Cheng, G. M. Pitcher, S. Laviolette, I. Whishaw +13 more
2002Cell273 citations Open access
Semantic Scholar
Photo-induced peptide cleavage in the green-to-red conversion of a fluorescent protein.
H. Mizuno, T. Mal, Kit I. Tong, R. Ando +3 more
2003Molecules and Cells272 citations Open access
Semantic Scholar
NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ
Toshiyuki Tanaka, S. Saha, C. Tomomori, R. Ishima +11 more
1998Nature260 citations
Semantic Scholar
Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ
C. Tomomori, Toshiyuki Tanaka, R. Dutta, Heiyoung Park +9 more
1999Nature Structural Biology247 citations
Semantic Scholar
Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
T. Ogura, Kit I. Tong, K. Mio, Y. Maruyama +3 more
2010Proceedings of the National Academy of Sciences of the United States of America242 citations Open access
Semantic Scholar
Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.
Y. Katoh, K. Iida, Moon-Il Kang, Akira Kobayashi +6 more
2005Archives of Biochemistry and Biophysics224 citations
Semantic Scholar
FRET-based in vivo Ca2+ imaging by a new calmodulin-GFP fusion molecule
Kevin Truong, A. Sawano, H. Mizuno, H. Hama +4 more
2001Nature Structural Biology217 citations
Semantic Scholar
Solution structure of a TBP-TAF(II)230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP.
Ding-Jiang Liu, R. Ishima, Kit I. Tong, S. Bagby +5 more
1998Cell207 citations Open access
Semantic Scholar
Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism*
Emilia Kansanen, G. Bonacci, F. Schopfer, Suvi M. Kuosmanen +8 more
2011Journal of Biological Chemistry203 citations Open access
Semantic Scholar
The Critical Role of Nitric Oxide Signaling, via Protein S-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response*
Shigemoto Fujii, T. Sawa, H. Ihara, Kit I. Tong +7 more
2010Journal of Biological Chemistry135 citations Open access
Semantic Scholar
Cytoprotective role of Nrf2/Keap1 system in methylmercury toxicity.
T. Toyama, D. Sumi, Y. Shinkai, A. Yasutake +4 more
2007Biochemical and Biophysical Research Communications - BBRC132 citations
Semantic Scholar
Calcium-regulated DNA Binding and Oligomerization of the Neuronal Calcium-sensing Protein, Calsenilin/DREAM/KChIP3*
M. Osawa, Kit I. Tong, C. Lilliehook, W. Wasco +5 more
2001Journal of Biological Chemistry122 citations Open access
Semantic Scholar
Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein.
S. Bagby, Sungjoon Kim, E. Maldonado, Kit I. Tong +2 more
1995Cell118 citations Open access
Semantic Scholar
Mg2+ and Ca2+ Differentially Regulate DNA Binding and Dimerization of DREAM*
M. Osawa, A. Dace, Kit I. Tong, A. Valiveti +2 more
2005Journal of Biological Chemistry107 citations Open access
Semantic Scholar
Crystallographic evidence for water-assisted photo-induced peptide cleavage in the stony coral fluorescent protein Kaede.
I. Hayashi, H. Mizuno, Kit I. Tong, T. Furuta +4 more
2007Journal of Molecular Biology82 citations
Semantic Scholar
Lateral self‐assembly of E‐cadherin directed by cooperative calcium binding
J. Alattia, J. Ames, T. Porumb, Kit I. Tong +4 more
1997FEBS Letters76 citations
Semantic Scholar
A simple method for amino acid selective isotope labeling of recombinant proteins in E. coli
Kit I. Tong, Masayuki Yamamoto, Toshiyuki Tanaka
2008Journal of Biomolecular NMR65 citations
Semantic Scholar
The button test: A small scale method using microdialysis cells for assessing protein solubility at concentrations suitable for NMR
S. Bagby, Kit I. Tong, Ding-Jiang Liu, J. Alattia +1 more
1997Journal of Biomolecular NMR41 citations
Semantic Scholar
Diffraction Structural Biology Synchrotron Radiation Structural Insights into the Similar Modes of Nrf2 Transcription Factor Recognition by the Cytoplasmic Repressor Keap1
B. Padmanabhan, Kit I. Tong, Akira Kobayashi, M. Yamamoto +1 more
29 citations
Semantic Scholar
1H, 15N and 13C resonance assignments and monomeric structure of the amino-terminal extracellular domain of epithelial cadherin
M. Overduin, Kit I. Tong, C. Kay, M. Ikura
1996Journal of Biomolecular NMR25 citations
Semantic Scholar
Purification and spectroscopic characterization of a recombinant amino‐terminal polypeptide fragment of mouse epithelial cadherin
Kit I. Tong, P. Yau, M. Overduin, S. Bagby +3 more
1994FEBS Letters25 citations
Semantic Scholar
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy ( Proceedings of the National Academy of Sciences of the United States of America (2008) 105, 36, (13568-13573) DOI: 10.1073/pnas.0806268105)
T. Shibata, T. Ohta, Kit I. Tong, Akiko Kokubu +5 more
200916 citations Open access
Semantic Scholar
Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1.
B. Padmanabhan, Maria Scharlock, Kit I. Tong, Yoshihiro Nakamura +6 more
2005Acta Crystallographica. Section F : Structural Biology and Crystallization Communications16 citations Open access
Semantic Scholar
Selective isotope labeling of recombinant proteins in Escherichia coli.
Kit I. Tong, Masayuki Yamamoto, Toshiyuki Tanaka
2012Methods in molecular biology8 citations
Semantic Scholar
[Oxidative/electrophilic stress sensor Keap1 regulates the rapid turnover of transcripition factor Nrf2].
Akira Kobayashi, Kit I. Tong
2006Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme8 citations
Semantic Scholar
Structural basis for the defects of human lung cancer somatic mutations in the repression activity of Keap1 on Nrf2
B. Padmanabhan, Kit I. Tong, Yoshihiro Nakamura, T. Ohta +7 more
20062 citations
Semantic Scholar
SOLUTION STRUCTURE OF A TBP-TAFII230 COMPLEX: PROTEIN MIMICRY OF THE MINOR GROOVE SURFACE OF THE TATA BOX UNWOUND BY TBP, NMR, 25 STRUCTURES
Ding-Jiang Liu, R. Ishima, Kit I. Tong, S. Bagby +5 more
19992 citations
Semantic Scholar
Crystal structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with IP3
I. Bosanac, J. Alattia, T. Mal, Jenny Chan +9 more
20020 citations
Semantic Scholar
Letter to the Editor: Sequence-specific resonance assignments and partial unfolding of extracellular domains II and III of E-cadherin
J. Alattia, Frances K. Tong, Kit I. Tong, Mitsuhiko Ikura
20000 citations
Semantic Scholar
NMRstructureof thehistidine kinasedomainof the E . coli osmosensorEnvZ
Toshiyuki Tanaka, S. Saha, C. Tomomori, R. Ishima +11 more
0 citations
Semantic Scholar

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