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R. Ishima · SciRah

Researcher profile · Semantic Scholar

R. Ishima

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R. Ishima — researcher profile on SciRah

h-index: 38
Works: 127
Citations: 5,248

Most-cited papers

Rapid structural fluctuations of the free HIV protease flaps in solution: Relationship to crystal structures and comparison with predictions of dynamics calculations
D. Freedberg, R. Ishima, J. Jacob, Yun-Xing Wang +3 more
2002Protein Science204 citations Open access
Semantic Scholar
Extending the range of amide proton relaxation dispersion experiments in proteins using a constant-time relaxation-compensated CPMG approach
R. Ishima, D. Torchia
2003Journal of Biomolecular NMR155 citations
Semantic Scholar
HIV-1 protease: structure, dynamics, and inhibition.
J. Louis, R. Ishima, D. Torchia, I. Weber
2007Advances in Pharmacology118 citations
Semantic Scholar
Engineered Human Antibody Constant Domains with Increased Stability*
R. Gong, B. Vu, Yang Feng, Darue A. Prieto +7 more
2009Journal of Biological Chemistry92 citations Open access
Semantic Scholar
Folded Monomer of HIV-1 Protease*
R. Ishima, R. Ghirlando, J. Tőzsér, A. Gronenborn +2 more
2001Journal of Biological Chemistry90 citations Open access
Semantic Scholar
Structural features and ligand binding properties of tandem WW domains from YAP and TAZ, nuclear effectors of the Hippo pathway.
Claire Webb, A. Upadhyay, F. Giuntini, I. Eggleston +3 more
2011Biochemistry88 citations
Semantic Scholar
A solution NMR study of the binding kinetics and the internal dynamics of an HIV‐1 protease‐substrate complex
E. Katoh, John M. Louis, T. Yamazaki, A. Gronenborn +2 more
2003Protein Science87 citations Open access
Semantic Scholar
Effect of the Active Site D25N Mutation on the Structure, Stability, and Ligand Binding of the Mature HIV-1 Protease*
J. Sayer, Fengling Liu, R. Ishima, I. Weber +1 more
2008Journal of Biological Chemistry84 citations Open access
Semantic Scholar
Comparison of methyl rotation axis order parameters derived from model-free analyses of (2)H and (13)C longitudinal and transverse relaxation rates measured in the same protein sample.
R. Ishima, A. Petkova, John M. Louis, D. Torchia
2001Journal of the American Chemical Society84 citations
Semantic Scholar
Solution Structure of the Mature HIV-1 Protease Monomer
R. Ishima, D. Torchia, Shannon M Lynch, A. Gronenborn +1 more
2003Journal of Biological Chemistry80 citations Open access
Semantic Scholar
Carbonyl carbon transverse relaxation dispersion measurements and ms-μs timescale motion in a protein hydrogen bond network
R. Ishima, J. Baber, J. Louis, D. Torchia
200476 citations
Semantic Scholar
Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability W.Wang, W.W.Prosise, J.Chen, S.Shane Taremi, H.V.Le, V.Madison, X.Cui, A.Thomas, K.-C.Cheng and C.A.Lesburg 425 Directed evolution of a biterminal bacterial display scaffold enhances the display o
J. Rice, P. Daugherty, Gabriella Miklóssy, J. Tőzsér +4 more
200874 citations
Semantic Scholar
Differential Flap Dynamics in Wild-type and a Drug Resistant Variant of HIV-1 Protease Revealed by Molecular Dynamics and NMR Relaxation
Yufeng Cai, N. K. Yilmaz, W. Myint, R. Ishima +1 more
2012Journal of Chemical Theory and Computation66 citations Open access
Semantic Scholar
Mutational and Structural Studies Aimed at Characterizing the Monomer of HIV-1 Protease and Its Precursor*
R. Ishima, D. Torchia, J. Louis
2007Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Inhibitors of HIV-1 Reverse Transcriptase—Associated Ribonuclease H Activity
T. Ilina, Krystal LaBarge, S. Sarafianos, R. Ishima +1 more
2012Biology55 citations Open access
Semantic Scholar
Interaction between the enamel matrix proteins amelogenin and ameloblastin.
Hanumanth H Ravindranath, Li-Sha Chen, M. Zeichner-David, R. Ishima +1 more
2004Biochemical and Biophysical Research Communications - BBRC54 citations
Semantic Scholar
NMR studies on domain diffusion and alignment in modular GB1 repeats.
J. D. Walsh, Katlyn K. Meier, R. Ishima, A. Gronenborn
2010Biophysical Journal48 citations Open access
Semantic Scholar
A large library based on a novel (CH2) scaffold: identification of HIV-1 inhibitors
Xiao-Dong Xiao, Yang Feng, B. Vu, R. Ishima +1 more
2009Biochemical and Biophysical Research Communications - BBRC47 citations Open access
Semantic Scholar
19F NMR relaxation studies of fluorosubstituted tryptophans
Man-Man Lu, R. Ishima, T. Polenova, A. Gronenborn
2019Journal of Biomolecular NMR43 citations Open access
Semantic Scholar
A diverse view of protein dynamics from NMR studies of HIV‐1 protease flaps
R. Ishima, John M. Louis
2007Proteins: Structure, Function, and Bioinformatics43 citations
Semantic Scholar
Revisiting Monomeric HIV-1 Protease
J. Louis, R. Ishima, Issa Nesheiwat, L. Pannell +3 more
2003Journal of Biological Chemistry43 citations Open access
Semantic Scholar
Error estimation and global fitting in transverse-relaxation dispersion experiments to determine chemical-exchange parameters
R. Ishima, D. Torchia
2005Journal of Biomolecular NMR42 citations
Semantic Scholar
Interaction of HIV-1 Reverse Transcriptase Ribonuclease H with an Acylhydrazone Inhibitor
Q. Gong, L. Menon, T. Ilina, L. Miller +3 more
2010Chemical Biology and Drug Design41 citations Open access
Semantic Scholar
Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease
Yufeng Cai, W. Myint, J. Paulsen, C. Schiffer +2 more
2014Journal of Chemical Theory and Computation39 citations Open access
Semantic Scholar
Structural Basis of the Allosteric Inhibitor Interaction on the HIV-1 Reverse Transcriptase RNase H domain
Martin T. Christen, L. Menon, Nataliya A. Myshakina, J. Ahn +2 more
2012Chemical Biology and Drug Design38 citations Open access
Semantic Scholar
Accuracy of Optimized Chemical-exchange Parameters Derived by Fitting CPMG R2 Dispersion Profiles when R20a ≠ R20b
R. Ishima, D. Torchia
2006Journal of Biomolecular NMR35 citations
Semantic Scholar
A highly-specific fully-human antibody and CAR-T cells targeting CD66e/CEACAM5 are cytotoxic for CD66e-expressing cancer cells in vitro and in vivo.
Du-San Baek, Ye-Jin Kim, Sandra Vergara, Alex Conard +5 more
2021Cancer Letters33 citations
Semantic Scholar
Structures of TGF-β with betaglycan and signaling receptors reveal mechanisms of complex assembly and signaling
L. Wieteska, Alexander B. Taylor, Emma Punch, Jonathan A. Coleman +11 more
2025Nature Communications30 citations Open access
Semantic Scholar
Conformational plasticity of the NNRTI-binding pocket in HIV-1 reverse transcriptase - A fluorine NMR study
N. G. Sharaf, R. Ishima, A. Gronenborn
2016Biochemistry30 citations Open access
Semantic Scholar
Revealing the dimer dissociation and existence of a folded monomer of the mature HIV‐2 protease
John M. Louis, R. Ishima, Annie Aniana, J. Sayer
2009Protein Science28 citations Open access
Semantic Scholar
The p66 Immature Precursor of HIV-1 Reverse Transcriptase
N. G. Sharaf, Eric Poliner, R. Slack, Martin T. Christen +4 more
2014Proteins: Structure, Function, and Bioinformatics26 citations Open access
Semantic Scholar
NMR‐Based Screening of Membrane Protein Ligands
N. Yanamala, Arpan Dutta, B. Beck, Bart Van Fleet +5 more
2010Chemical Biology and Drug Design25 citations Open access
Semantic Scholar
Optimized labeling of 13CHD2 methyl isotopomers in perdeuterated proteins: Potential advantages for 13C relaxation studies of methyl dynamics of larger proteins
R. Ishima, J. Louis, D. Torchia
2001Journal of Biomolecular NMR25 citations
Semantic Scholar
Target binding to S100B reduces dynamic properties and increases Ca2+-binding affinity for wild type and EF-hand mutant proteins
M. Liriano, Kristen M. Varney, N. Wright, Cassandra Hoffman +3 more
2012Journal of Molecular Biology24 citations Open access
Semantic Scholar
15N–{1H} NOE experiment at high magnetic field strengths
Q. Gong, R. Ishima
2007Journal of Biomolecular NMR24 citations
Semantic Scholar
Recent developments in (15)N NMR relaxation studies that probe protein backbone dynamics.
R. Ishima
2012Topics in current chemistry23 citations
Semantic Scholar
Highly conserved glycine 86 and arginine 87 residues contribute differently to the structure and activity of the mature HIV-1 protease
R. Ishima, Q. Gong, Y. Tie, I. T. Weber +1 more
2010Proteins: Structure, Function, and Bioinformatics21 citations Open access
Semantic Scholar
Chemical exchange effects during refocusing pulses in constant-time CPMG relaxation dispersion experiments
W. Myint, R. Ishima
2009Journal of Biomolecular NMR20 citations
Semantic Scholar
Conformational Dynamics of Recoverin’s Ca2+-myristoyl Switch Probed by 15N NMR Relaxation Dispersion and Chemical Shift Analysis
Xianzhong Xu, R. Ishima, James B. Ames
2011Proteins: Structure, Function, and Bioinformatics19 citations Open access
Semantic Scholar
Characterization of specific protein association by 15N CPMG relaxation dispersion NMR: the GB1(A34F) monomer-dimer equilibrium.
J. Jee, R. Ishima, A. Gronenborn
2008Journal of Physical Chemistry B19 citations
Semantic Scholar
Revisiting Monomeric HIV-1 Protease CHARACTERIZATION AND REDESIGN FOR IMPROVED PROPERTIES*
J. Louis, R. Ishima, Issa Nesheiwat, L. Pannell +3 more
200319 citations
Semantic Scholar
CPMG relaxation dispersion.
R. Ishima
2014Methods in molecular biology17 citations
Semantic Scholar
Inhibitors of HIV-1 Nef-mediated activation of the myeloid Src-family kinase Hck block HIV-1 replication in macrophages and disrupt MHC-I downregulation
Lori A. Emert-Sedlak, O. Moukha-Chafiq, Haibin Shi, Shou-Cheng Du +15 more
2022ACS Infectious Diseases15 citations Open access
Semantic Scholar
Preclinical assessment of a novel human antibody VH domain targeting mesothelin as an antibody-drug conjugate
Ze-Hua Sun, Xiao-Jie Chu, Cynthia Adams, T. Ilina +9 more
2023Molecular Therapy: Oncolytics13 citations Open access
Semantic Scholar
Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by NMR
S. N. Khan, J. Persons, J. Paulsen, Michel Guerrero +3 more
2018Biochemistry13 citations Open access
Semantic Scholar
Practical aspects of 15N CPMG transverse relaxation experiments for proteins in solution
W. Myint, Q. Gong, R. Ishima
200913 citations
Semantic Scholar
ProstaNet: A Novel Geometric Vector Perceptrons–Graph Neural Network Algorithm for Protein Stability Prediction in Single- and Multiple-Point Mutations with Experimental Validation
Tianjian Liang, Zehua Sun, R. Ishima, Xiang-Qun Xie +3 more
2025Research12 citations Open access
Semantic Scholar
A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase
K. Kirby, Nataliya A. Myshakina, Martin T. Christen, Yue-Lei Chen +12 more
2017Antimicrobial Agents and Chemotherapy12 citations Open access
Semantic Scholar
Novel macromolecular inhibitors of human immunodeficiency virus-1 protease.
Gabriella Miklóssy, J. Tőzsér, J. Kádas, R. Ishima +2 more
2008Protein engineering, design & selection : PEDS12 citations Open access
Semantic Scholar
Carbonyl carbon transverse relaxation dispersion measurements and ms-micros timescale motion in a protein hydrogen bond network.
R. Ishima, J. Baber, John M. Louis, D. Torchia
2004Journal of Biomolecular NMR12 citations
Semantic Scholar

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C. Schiffer — researcher profile on SciRah