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L. Kaminskas · SciRah

Researcher profile · Semantic Scholar

L. Kaminskas

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L. Kaminskas — researcher profile on SciRah

h-index: 38
Works: 106
Citations: 5,077

Most-cited papers

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity
Natalie L. Trevaskis, L. Kaminskas, C. Porter
2015Nature reviews. Drug discovery603 citations Open access
Semantic Scholar
Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties.
L. Kaminskas, B. Boyd, C. Porter
2011Nanomedicine191 citations
Semantic Scholar
Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy.
L. Kaminskas, Victoria M Mcleod, Gemma M. Ryan, B. Kelly +5 more
2014Journal of Controlled Release169 citations
Semantic Scholar
The impact of molecular weight and PEG chain length on the systemic pharmacokinetics of PEGylated poly l-lysine dendrimers.
L. Kaminskas, B. Boyd, Peter Karellas, G. Krippner +3 more
2008Molecular Pharmaceutics164 citations
Semantic Scholar
A comparison of changes to doxorubicin pharmacokinetics, antitumor activity, and toxicity mediated by PEGylated dendrimer and PEGylated liposome drug delivery systems.
L. Kaminskas, Victoria M Mcleod, B. Kelly, Gian Sberna +4 more
2012Nanomedicine: Nanotechnology, Biology and Medicine163 citations
Semantic Scholar
The effect of amino acid excipients on morphology and solid-state properties of multi-component spray-dried formulations for pulmonary delivery of biomacromolecules.
Tomás Sou, L. Kaminskas, Tri-Hung Nguyen, Renée Carlberg +2 more
2013European journal of pharmaceutics and biopharmaceutics147 citations Open access
Semantic Scholar
PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats.
L. Kaminskas, J. Kota, Victoria M Mcleod, B. Kelly +2 more
2009Journal of Controlled Release146 citations
Semantic Scholar
Cationic poly-L-lysine dendrimers: pharmacokinetics, biodistribution, and evidence for metabolism and bioresorption after intravenous administration to rats.
B. Boyd, L. Kaminskas, Peter Karellas, G. Krippner +2 more
2006Molecular Pharmaceutics145 citations
Semantic Scholar
Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-l-lysine dendrimers.
L. Kaminskas, B. Kelly, Victoria M Mcleod, B. Boyd +3 more
2009Molecular Pharmaceutics132 citations Open access
Semantic Scholar
Targeting the lymphatics using dendritic polymers (dendrimers).
L. Kaminskas, C. Porter
2011Advanced Drug Delivery Reviews131 citations
Semantic Scholar
New developments in dry powder pulmonary vaccine delivery.
Tomás Sou, E. Meeusen, M. de Veer, David A. V. Morton +2 more
2011Trends in Biotechnology129 citations Open access
Semantic Scholar
Association of chemotherapeutic drugs with dendrimer nanocarriers: an assessment of the merits of covalent conjugation compared to noncovalent encapsulation.
L. Kaminskas, Victoria M Mcleod, C. Porter, B. Boyd
2012Molecular Pharmaceutics128 citations
Semantic Scholar
Nano-chemotherapeutics: maximising lymphatic drug exposure to improve the treatment of lymph-metastatic cancers.
Gemma M. Ryan, L. Kaminskas, C. Porter
2014Journal of Controlled Release127 citations Open access
Semantic Scholar
Prediction and Optimization of Pharmacokinetic and Toxicity Properties of the Ligand.
Douglas E. V. Pires, L. Kaminskas, D. Ascher
2018Methods in molecular biology123 citations
Semantic Scholar
Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker.
L. Kaminskas, B. Kelly, Victoria M Mcleod, Gian Sberna +3 more
2011Journal of Controlled Release123 citations
Semantic Scholar
Pulmonary administration of PEGylated polylysine dendrimers: absorption from the lung versus retention within the lung is highly size-dependent.
Gemma M. Ryan, L. Kaminskas, B. Kelly, D. Owen +2 more
2013Molecular Pharmaceutics109 citations
Semantic Scholar
Influence of Size and Shape on the Biodistribution of Nanoparticles Prepared by Polymerization-Induced Self-Assembly.
S. Kaga, N. Truong, L. Esser, D. Senyschyn +6 more
2017Biomacromolecules98 citations
Semantic Scholar
Disposition and safety of inhaled biodegradable nanomedicines: Opportunities and challenges.
Shadabul Haque, Michael R. Whittaker, M. McIntosh, C. Pouton +1 more
2016Nanomedicine: Nanotechnology, Biology and Medicine85 citations
Semantic Scholar
Polymer-drug conjugates as inhalable drug delivery systems: A review
Nirmal Marasini, Shadabul Haque, L. Kaminskas
201782 citations Open access
Semantic Scholar
PEGylated polylysine dendrimers increase lymphatic exposure to doxorubicin when compared to PEGylated liposomal and solution formulations of doxorubicin.
Gemma M. Ryan, L. Kaminskas, J. Bulitta, M. McIntosh +2 more
2013Journal of Controlled Release79 citations
Semantic Scholar
Differences in colloidal structure of PEGylated nanomaterials dictate the likelihood of accelerated blood clearance.
L. Kaminskas, Victoria M Mcleod, C. Porter, B. Boyd
2011Journal of Pharmacy and Science72 citations
Semantic Scholar
Doxorubicin-conjugated PEGylated dendrimers show similar tumoricidal activity but lower systemic toxicity when compared to PEGylated liposome and solution formulations in mouse and rat tumor models.
L. Kaminskas, Victoria M Mcleod, B. Kelly, C. Cullinane +5 more
2012Molecular Pharmaceutics71 citations
Semantic Scholar
Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae
T. Velkov, Z. Deris, Johnny X. Huang, M. Azad +9 more
2013Innate Immunity70 citations Open access
Semantic Scholar
PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases
L. Kaminskas, D. Ascher, Victoria M Mcleod, M. Herold +3 more
2013Journal of Controlled Release67 citations Open access
Semantic Scholar
Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated PEGylated polylysine dendrimers.
L. Kaminskas, B. Kelly, Victoria M Mcleod, Gian Sberna +3 more
2011Molecular Pharmaceutics61 citations Open access
Semantic Scholar
Investigating the interactions of amino acid components on a mannitol-based spray-dried powder formulation for pulmonary delivery: A design of experiment approach.
Tomás Sou, L. Orlando, M. McIntosh, L. Kaminskas +1 more
2011International journal of pharmaceutics60 citations Open access
Semantic Scholar
A comparison of the lung clearance kinetics of solid lipid nanoparticles and liposomes by following the 3H‐labelled structural lipids after pulmonary delivery in rats
Shadabul Haque, Michael R. Whittaker, M. McIntosh, C. Pouton +2 more
2018European journal of pharmaceutics and biopharmaceutics52 citations
Semantic Scholar
The lymphatic system plays a major role in the intravenous and subcutaneous pharmacokinetics of trastuzumab in rats.
Annette M Dahlberg, L. Kaminskas, Alanna Smith, J. Nicolazzo +3 more
2014Molecular Pharmaceutics52 citations
Semantic Scholar
Microfluidic preparation of drug-loaded PEGylated liposomes, and the impact of liposome size on tumour retention and penetration
Yao-Da Dong, Estefania Tchung, C. Nowell, S. Kaga +4 more
2019Journal of liposome research50 citations Open access
Semantic Scholar
Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats.
L. Kaminskas, Victoria M Mcleod, D. Ascher, Gemma M. Ryan +12 more
2015Molecular Pharmaceutics50 citations
Semantic Scholar
Reducing Dendrimer Generation and PEG Chain Length Increases Drug Release and Promotes Anticancer Activity of PEGylated Polylysine Dendrimers Conjugated with Doxorubicin via a Cathepsin-Cleavable Peptide Linker.
Dharmini C. Mehta, Nathania J. Leong, Victoria M Mcleod, B. Kelly +4 more
2018Molecular Pharmaceutics48 citations Open access
Semantic Scholar
Spray-Dried Influenza Antigen with Trehalose and Leucine Produces an Aerosolizable Powder Vaccine Formulation that Induces Strong Systemic and Mucosal Immunity after Pulmonary Administration
Tomás Sou, David A. V. Morton, Mark Williamson, E. Meeusen +2 more
2015Journal of Aerosol Medicine46 citations Open access
Semantic Scholar
Impact of surface derivatization of poly-L-lysine dendrimers with anionic arylsulfonate or succinate groups on intravenous pharmacokinetics and disposition.
L. Kaminskas, B. Boyd, Peter Karellas, S. Henderson +3 more
2007Molecular Pharmaceutics46 citations
Semantic Scholar
Subunit-based mucosal vaccine delivery systems for pulmonary delivery - Are they feasible?
Nirmal Marasini, L. Kaminskas
2019Drug Development and Industrial Pharmacy43 citations
Semantic Scholar
dendPoint: a web resource for dendrimer pharmacokinetics investigation and prediction
L. Kaminskas, Douglas E. V. Pires, D. Ascher
2019Scientific Reports37 citations Open access
Semantic Scholar
Local inflammation alters the lung disposition of a drug loaded pegylated liposome after pulmonary dosing to rats.
Shadabul Haque, O. Feeney, E. Meeusen, B. Boyd +4 more
2019Journal of Controlled Release36 citations Open access
Semantic Scholar
The impact of size and charge on the pulmonary pharmacokinetics and immunological response of the lungs to PLGA nanoparticles after INTRATRACHEAL administration to rats.
Shadabul Haque, C. Pouton, M. McIntosh, D. Ascher +3 more
2020Nanomedicine: Nanotechnology, Biology and Medicine35 citations
Semantic Scholar
Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury.
P. Burcham, L. Kaminskas, Dino Tan, Simon M. Pyke
2008Mini-Reviews in Medical Chemistry35 citations
Semantic Scholar
Hyaluronic Acid Molecular Weight Determines Lung Clearance and Biodistribution after Instillation
Christopher Kuehl, Ti Zhang, L. Kaminskas, C. Porter +3 more
2016Molecular Pharmaceutics34 citations Open access
Semantic Scholar
Partly-PEGylated Poly-L-lysine dendrimers have reduced plasma stability and circulation times compared with fully PEGylated dendrimers.
L. Kaminskas, Zeming Wu, Nicholas Barlow, G. Y. Krippner +2 more
2009Journal of Pharmacy and Science34 citations
Semantic Scholar
Aerosol Pirfenidone Pharmacokinetics after Inhaled Delivery in Sheep: a Viable Approach to Treating Idiopathic Pulmonary Fibrosis
L. Kaminskas, Cornelia B. Landersdorfer, R. Bischof, Nathania J. Leong +6 more
2019Pharmaceutical Research33 citations Open access
Semantic Scholar
Suggested Procedures for the Reproducible Synthesis of Poly(d,l-lactide-co-glycolide) Nanoparticles Using the Emulsification Solvent Diffusion Platform
Shadabul Haque, B. Boyd, M. McIntosh, C. Pouton +2 more
2018Current Nanoscience33 citations Open access
Semantic Scholar
Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers
Shadabul Haque, Victoria M Mcleod, Seth A. Jones, Sandy Fung +6 more
2017European journal of pharmaceutics and biopharmaceutics32 citations Open access
Semantic Scholar
PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administration.
L. Chan, J. Bulitta, D. Ascher, J. Haynes +4 more
2015Molecular Pharmaceutics32 citations
Semantic Scholar
Optimal PEGylation can improve the exposure of interferon in the lungs following pulmonary administration.
Victoria M Mcleod, L. Chan, Gemma M. Ryan, C. Porter +1 more
2015Journal of Pharmacy and Science29 citations
Semantic Scholar
A Comparison of the Pharmacokinetics and Pulmonary Lymphatic Exposure of a Generation 4 PEGylated Dendrimer Following Intravenous and Aerosol Administration to Rats and Sheep
Gemma M. Ryan, R. Bischof, P. Enkhbaatar, Victoria M Mcleod +5 more
2015Pharmaceutical Research29 citations Open access
Semantic Scholar
Differences in lysine adduction by acrolein and methyl vinyl ketone: implications for cytotoxicity in cultured hepatocytes.
L. Kaminskas, Simon M. Pyke, P. Burcham
2005Chemical Research in Toxicology28 citations
Semantic Scholar
Lymph-directed immunotherapy - Harnessing endogenous lymphatic distribution pathways for enhanced therapeutic outcomes in cancer.
O. Feeney, Gracia Gracia, D. H. Brundel, Natalie L. Trevaskis +3 more
2020Advanced Drug Delivery Reviews26 citations Open access
Semantic Scholar
Recent advances in nano/microparticle-based oral vaccines
Mengdie Li, L. Kaminskas, Nirmal Marasini
2021Journal of Pharmaceutical Investigation25 citations Open access
Semantic Scholar
Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site.
Gemma M. Ryan, Victoria M Mcleod, Dharmini C. Mehta, B. Kelly +4 more
2017Nanomedicine: Nanotechnology, Biology and Medicine25 citations Open access
Semantic Scholar

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