P. Burcham

Most-cited papers

1. Hydralazine Inhibits Rapid Acrolein-Induced Protein Oligomerization: Role of Aldehyde Scavenging and Adduct Trapping in Cross-Link Blocking and Cytoprotection

   P. Burcham, Simon M. Pyke

   2006Molecular Pharmacology92 citations

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2. Genome-wide transcriptional responses to acrolein.

   Colin A. Thompson, P. Burcham

   2008Chemical Research in Toxicology68 citations

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3. Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation.

   J. Walshe, Magdalena M. Serewko-Auret, N. Teakle, S. Cameron +10 more

   2007Cancer Research67 citations Open access

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4. Modified protein carbonyl assay detects oxidised membrane proteins: a new tool for assessing drug- and chemically-induced oxidative cell injury.

   P. Burcham

   2007Journal of pharmacological and toxicological methods49 citations

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5. Acrolein and Human Disease: Untangling the Knotty Exposure Scenarios Accompanying Several Diverse Disorders.

   P. Burcham

   2017Chemical Research in Toxicology46 citations Open access

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6. The ability of thiourea to scavenge hydrogen peroxide and hydroxyl radicals during the intra-coronal bleaching of bloodstained root-filled teeth.

   D. Farmer, P. Burcham, P. Marin

   2006Australian dental journal36 citations Open access

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7. Carbonyl-scavenging drugs & protection against carbonyl stress-associated cell injury.

   P. Burcham, L. Kaminskas, Dino Tan, Simon M. Pyke

   2008Mini-Reviews in Medical Chemistry34 citations

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8. Bioactivation of carboxylic acid compounds by UDP-Glucuronosyltransferases to DNA-damaging intermediates: role of glycoxidation and oxidative stress in genotoxicity.

   B. Sallustio, Y. Degraaf, J. Weekley, P. Burcham

   2006Chemical Research in Toxicology32 citations

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9. Toxicity of smoke extracts towards A549 lung cells: role of acrolein and suppression by carbonyl scavengers.

   P. Burcham, Albert Raso, Colin A. Thompson

   2010Chemico-Biological Interactions31 citations

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10. Intermolecular protein cross-linking during acrolein toxicity: efficacy of carbonyl scavengers as inhibitors of heat shock protein-90 cross-linking in A549 cells.

    P. Burcham, Albert Raso, Colin A. Thompson, D. Tan

    2007Chemical Research in Toxicology28 citations

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11. Differences in lysine adduction by acrolein and methyl vinyl ketone: implications for cytotoxicity in cultured hepatocytes.

    L. Kaminskas, Simon M. Pyke, P. Burcham

    2005Chemical Research in Toxicology28 citations

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12. Intermediate Filament Carbonylation During Acute Acrolein Toxicity in A549 Lung Cells: Functional Consequences, Chaperone Redistribution, and Protection by Bisulfite

    P. Burcham, Albert Raso, Colin A. Thompson

    2010Antioxidants and Redox Signaling27 citations

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13. Protein alkylation, transcriptional responses and cytochrome c release during acrolein toxicity in A549 cells: influence of nucleophilic culture media constituents.

    Colin A. Thompson, P. Burcham

    2008Toxicology in Vitro23 citations Open access

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14. Chaperone Heat Shock Protein 90 Mobilization and Hydralazine Cytoprotection against Acrolein-Induced Carbonyl Stress

    P. Burcham, Albert Raso, L. Kaminskas

    2012Molecular Pharmacology21 citations

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15. Acrolein relaxes mouse isolated tracheal smooth muscle via a TRPA1-dependent mechanism.

    Esther Y Cheah, P. Burcham, Tracy S. Mann, P. Henry

    2014Biochemical Pharmacology20 citations Open access

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16. Prior exposure to acrolein accelerates pulmonary inflammation in influenza A-infected mice.

    Ferrer Ong, P. Henry, P. Burcham

    2012Toxicology Letters20 citations

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17. Carboxylic acid drug-induced DNA nicking in HEK293 cells expressing human UDP-glucuronosyltransferases: role of acyl glucuronide metabolites and glycation pathways.

    Hamish T Southwood, Y. Degraaf, P. Mackenzie, J. Miners +2 more

    2007Chemical Research in Toxicology20 citations

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18. Potentialities and pitfalls accompanying chemico-pharmacological strategies against endogenous electrophiles and carbonyl stress.

    P. Burcham

    2008Chemical Research in Toxicology19 citations

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19. Carbonyl scavengers as pharmacotherapies in degenerative disease: Hydralazine repurposing and challenges in clinical translation.

    P. Burcham

    2018Biochemical Pharmacology16 citations Open access

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20. Acrolein and the Lung: Chemical, Molecular, and Pathological Aspects

    P. Burcham, Colin A. Thompson, P. Henry

    201015 citations

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21. Effect of N‐acetylcysteine supplementation on oxidative stress status and alveolar inflammation in people exposed to asbestos: A double‐blind, randomized clinical trial

    H. Alfonso, P. Franklin, S. Ching, K. Croft +6 more

    2015Respirology (Carlton South. Print)14 citations

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22. An Introduction to Toxicology

    P. Burcham

    2013Springer London13 citations

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23. Michael addition of acrolein to lysinyl and N-terminal residues of a model peptide: targets for cytoprotective hydrazino drugs.

    L. Kaminskas, Simon M. Pyke, P. Burcham

    2007Rapid Communications in Mass Spectrometry13 citations

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24. Airborne acrolein induces keratin-8 (Ser-73) hyperphosphorylation and intermediate filament ubiquitination in bronchiolar lung cell monolayers.

    P. Burcham, Albert Raso, P. Henry

    2014Toxicology12 citations

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25. Role of reactive carbonyls and superoxide radicals in protein damage by cigarette smoke extracts: Comparison of Heat-Not-Burn e-cigarettes to conventional cigarettes.

    N. Merritt, Cameron Urquhart, P. Burcham

    2024Chemico-Biological Interactions7 citations Open access

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26. Target-Organ Toxicity: Liver and Kidney

    P. Burcham

    20147 citations

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27. Influenza A infection attenuates relaxation responses of mouse tracheal smooth muscle evoked by acrolein.

    Esther Y Cheah, Tracy S. Mann, P. Burcham, P. Henry

    2015Biochemical Pharmacology5 citations

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28. Nanotoxicology: A Primer for Chemists

    P. Burcham

    20105 citations

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29. Molecular Basis for Adaptive Responses during Chemically Induced Hepatotoxicity

    P. Burcham

    20065 citations Open access

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30. Functional characterisation and application of an ex vivo perfusion-superfusion system in murine airways.

    Esther Y Cheah, Tracy S. Mann, P. Burcham, P. Henry

    2017Journal of pharmacological and toxicological methods4 citations

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31. Toxicology down under: past achievements, present realities, and future prospects.

    P. Burcham

    2008Chemical Research in Toxicology4 citations

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32. New insights into the chemical and molecular basis for acrolein toxicity

    P. Burcham

    20074 citations

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33. Faculty Opinions recommendation of Reproducing human and cross-species drug toxicities using a Liver-Chip.

    P. Burcham

    2019Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature3 citations

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34. Toxicokinetics: The Behaviour of Chemicals in the Body

    P. Burcham

    20143 citations

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35. The Emergence of Modern Toxicology

    P. Burcham

    20143 citations

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36. Core Concepts in Toxicology

    P. Burcham

    20142 citations

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37. Faculty Opinions recommendation of Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.

    P. Burcham

    20092 citations

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38. Faculty Opinions recommendation of Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.

    P. Burcham

    20082 citations

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39. Drug reactions with aldehyde adducts as a novel route to protein haptenisation: Recent tentative clinical evidence for a role in hydralazine vasotoxicity.

    P. Burcham

    2025Biochemical Pharmacology1 citations Open access

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40. An immunoblot assay for cysteine oxidation by reactive oxygen species allows detection of novel thioprotective efficacy of black tea extracts.

    P. Burcham, Julie Le, Louis Ma

    2021Journal of pharmacological and toxicological methods1 citations Open access

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41. Faculty Opinions recommendation of 3,4-Methylenedioxymethamphetamine Hepatotoxicity under the Heat Stress Condition: Novel Insights from in Vitro Metabolomic Studies.

    P. Burcham

    20201 citations

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42. Faculty Opinions recommendation of Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization.

    P. Burcham

    20161 citations

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43. Everyday Toxicology II: Tobacco

    P. Burcham

    20141 citations

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44. Toxicodynamics: How Chemicals Harm Cells

    P. Burcham

    20141 citations

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45. Chemicals and Cancer

    P. Burcham

    20141 citations

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46. Science in Two Minds: Reflections on the Missional Disunity Within Contemporary Medicine

    P. Burcham

    20141 citations

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47. Faculty Opinions recommendation of Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment.

    P. Burcham

    20131 citations

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48. Faculty Opinions recommendation of Thirdhand tobacco smoke: a tobacco-specific lung carcinogen on surfaces in smokers' homes.

    P. Burcham

    20131 citations

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49. Faculty Opinions recommendation of SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress.

    P. Burcham

    20101 citations

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50. Faculty Opinions recommendation of Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke.

    P. Burcham

    20091 citations

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