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W. Cromlish · SciRah

Researcher profile · Semantic Scholar

W. Cromlish

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W. Cromlish — researcher profile on SciRah

h-index: 29
Works: 48
Citations: 6,137

Most-cited papers

Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.
M. Elchebly, P. Payette, Eva Michaliszyn, W. Cromlish +10 more
1999Science2,237 citations
Semantic Scholar
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.
J. Gauthier, N. Chauret, W. Cromlish, S. Desmarais +25 more
2008Bioorganic & Medicinal Chemistry Letters443 citations Open access
Semantic Scholar
Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
Chi-Chung Chan, S. Boyce, C. Brideau, S. Charleson +21 more
1999Journal of Pharmacology and Experimental Therapeutics428 citations Open access
Semantic Scholar
A Natural Disruption of the Secretory Group II Phospholipase A2 Gene in Inbred Mouse Strains (*)
B. Kennedy, P. Payette, J. Mudgett, P. Vadas +5 more
1995Journal of Biological Chemistry366 citations Open access
Semantic Scholar
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
P. Prasit, Zhen Wang, C. Brideau, Chi-Chung Chan +32 more
1999Bioorganic & Medicinal Chemistry Letters360 citations Open access
Semantic Scholar
Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor
D. Riendeau, M. Percival, S. Boyce, C. Brideau +25 more
1997British Journal of Pharmacology315 citations Open access
Semantic Scholar
Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays.
D. Riendeau, S. Charleson, W. Cromlish, J. Mancini +2 more
1997Canadian Journal of Physiology and Pharmacology196 citations
Semantic Scholar
Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid.
G. O'Neill, J. Mancini, S. Kargman, J. Yergey +6 more
1994Molecular Pharmacology182 citations
Semantic Scholar
Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.
J. Falgueyret, S. Desmarais, R. Oballa, W. Black +7 more
2005Journal of Medicinal Chemistry153 citations Open access
Semantic Scholar
Transcriptional regulation by the immediate early protein of pseudorabies virus during in vitro nucleosome assembly.
J. Workman, S. M. Abmayr, W. Cromlish, R. Roeder
1988Cell136 citations
Semantic Scholar
Cloning and expression of rat prostaglandin endoperoxide synthase (cyclooxygenase)-2 cDNA.
Brian P. Kennedy, Chi-Chung Chan, S. A. Culp, W. Cromlish
1993Biochemical and Biophysical Research Communications - BBRC107 citations
Semantic Scholar
Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells.
S. Kargman, E. Wong, G. Greig, J. Falgueyret +9 more
1996Biochemical Pharmacology102 citations
Semantic Scholar
Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.
Bernard Côté, J. Burch, E. Asante-Appiah, C. Bayly +33 more
2014Bioorganic & Medicinal Chemistry Letters97 citations
Semantic Scholar
The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.
G. Scapin, Sangita Patel, J. W. Becker, Qingping Wang +12 more
2003Biochemistry97 citations Open access
Semantic Scholar
Functional identification of the active-site nucleophile of the human 85-kDa cytosolic phospholipase A2.
Zheng Huang, Paul Payette, Khalid Abdullah, W. Cromlish +1 more
1996Biochemistry86 citations
Semantic Scholar
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.
Cheuk K. Lau, C. Bayly, J. Gauthier, Chun-Sing Li +13 more
2004Bioorganic & Medicinal Chemistry Letters72 citations Open access
Semantic Scholar
The development of potent non-peptidic PTP-1B inhibitors.
C. Dufresne, P. Roy, Zhaoyin Wang, E. Asante-Appiah +13 more
2004Bioorganic & Medicinal Chemistry Letters60 citations Open access
Semantic Scholar
The identification of potent, selective, and bioavailable cathepsin S inhibitors.
J. Gauthier, W. Black, I. Courchesne, W. Cromlish +12 more
2007Bioorganic & Medicinal Chemistry Letters52 citations Open access
Semantic Scholar
An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells.
J. Falgueyret, W. Black, W. Cromlish, S. Desmarais +9 more
2004Analytical Biochemistry51 citations
Semantic Scholar
A new series of selective COX-2 inhibitors : 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles
P. Roy, Y. Leblanc, R. Ball, C. Brideau +17 more
199750 citations
Semantic Scholar
Genetic and pharmacological evaluation of cathepsin s in a mouse model of asthma.
Kathleen Deschamps, W. Cromlish, S. Weicker, S. Lamontagne +9 more
2011American Journal of Respiratory Cell and Molecular Biology49 citations
Semantic Scholar
Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells
E. Wong, C. Deluca, C. Boily, S. Charleson +9 more
1997Inflammation Research48 citations Open access
Semantic Scholar
Selective inhibition of cyclooxygenase-1 and -2 using intact insect cell assays.
W. Cromlish, Brian P. Kennedy
1996Biochemical Pharmacology48 citations
Semantic Scholar
Synthesis and biological evaluation of 2,3-diarylthiophenes as selective cox-2 inhibitors. part II: Replacing the heterocycle
J. Gauthier, Y. Leblanc, W. Black, Chi-Chung Chan +15 more
199645 citations
Semantic Scholar
High-level expression of active human cyclooxygenase-2 in insect cells.
W. Cromlish, Paul Payette, S. A. Culp, Marc Ouellet +2 more
1994Archives of Biochemistry and Biophysics40 citations
Semantic Scholar
NOVEL 1,2-DIARYLCYCLOBUTENES : SELECTIVE AND ORALLY ACTIVE COX-2 INHIBITORS
R. Friesen, D. Dubé, R. Fortin, R. Frenette +9 more
199635 citations
Semantic Scholar
3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
W. Black, C. Brideau, Chi-Chung Chan, S. Charleson +11 more
2003Bioorganic & Medicinal Chemistry Letters33 citations Open access
Semantic Scholar
Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors
M. Thérien, C. Brideau, C. Chan, W. Cromlish +13 more
199732 citations
Semantic Scholar
The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor.
Elise Isabel, Kevin P. Bateman, N. Chauret, W. Cromlish +27 more
2010Bioorganic & Medicinal Chemistry Letters29 citations Open access
Semantic Scholar
Selective inhibitors of COX-2.
G. O'Neill, B. P. Kennedy, J. Mancini, S. Kargman +6 more
1995Agents and actions. Supplements28 citations
Semantic Scholar
Transcriptionally active immediate-early protein of pseudorabies virus binds to specific sites on class II gene promoters
W. Cromlish, S. M. Abmayr, J. Workman, Masami Horikoshi +1 more
1989Journal of Virology28 citations Open access
Semantic Scholar
Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.
Cheuk K. Lau, C. Brideau, Chi-Chung Chan, S. Charleson +12 more
1999Bioorganic & Medicinal Chemistry Letters27 citations Open access
Semantic Scholar
A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.
Chun-Sing Li, W. Black, C. Brideau, Chi-Chung Chan +15 more
1999Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Human cytosolic phospholipase A2 expressed in insect cells is extensively phosphorylated on Ser-505.
Khalid Abdullah, W. Cromlish, Paul Payette, F. Laliberté +3 more
1995Biochimica et Biophysica Acta24 citations
Semantic Scholar
Basal Activation of p70S6K Results in Adipose-specific Insulin Resistance in Protein-tyrosine Phosphatase 1B–/– Mice*
S. C. Ruffolo, P. Forsell, Xi-Ling Yuan, S. Desmarais +4 more
2007Journal of Biological Chemistry15 citations Open access
Semantic Scholar
PTP1B-dependent insulin receptor phosphorylation/residency in the endocytic recycling compartment of CHO-IR cells.
W. Cromlish, Man Tang, Robert Kyskan, Linda B. Tran +1 more
2006Biochemical Pharmacology15 citations
Semantic Scholar
Development and validation of an intact cell assay for protein tyrosine phosphatases using recombinant baculoviruses.
W. Cromlish, Paul Payette, B. Kennedy
1999Biochemical Pharmacology15 citations
Semantic Scholar
Characterization of a stable, hypertensive rat model suitable for the consecutive evaluation of human renin inhibitors
René St-Jacques, S. Toulmond, Anick Auger, C. Binkert +9 more
2011Journal of the Renin-Angiotensin-Aldosterone System5 citations Open access
Semantic Scholar
Pharmacological and genetic evidence that cathepsin B is not the physiological activator of rodent prorenin
M. Percival, S. Toulmond, N. Coulombe, W. Cromlish +5 more
2010Biological chemistry3 citations
Semantic Scholar
A New Series of Selective COX-2 Inhibitors: 5,6-Diarylthiazolo(3,2-b)( 1,2,4)triazoles.
P. Roy, Y. Leblanc, R. Ball, C. Brideau +17 more
19973 citations
Semantic Scholar
Synthesis and Biological Evaluation of 2,3-Diarylthiophenes as Selective COX-2 Inhibitors. Part 2. Replacing the Heterocycle
J. Gauthier, Y. Leblanc, W. Black, Chi-Chung Chan +15 more
19961 citations
Semantic Scholar
Purification of baculovirus-overexpressed cytosolic phospholipase A2 using a single-step affinity column chromatography.
Khalid Abdullah, S. Léger, H. Perrier, W. Cromlish +2 more
1995Protein Expression and Purification1 citations
Semantic Scholar
heart failure and cachexia Cardiac gene expression profile in rats with terminal
A. Fiebeler, H. Haller, F. Luft, D. Müller +26 more
20150 citations
Semantic Scholar
Cathepsin S in a Murine Model of Allergic Asthma (B108)
S. Weicker, W. Cromlish, S. Lamontagne, J. Gauthier +10 more
2007Journal of Immunology0 citations
Semantic Scholar
Erratum to “An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells” [Anal. Biochem. 335 (2004) 218–227]
J. Falgueyret, W. Black, W. Cromlish, S. Desmarais +9 more
20050 citations
Semantic Scholar
THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 2
G. Scapin, Sangita Patel, J. W. Becker, Qingping Wang +12 more
20030 citations
Semantic Scholar
Synthesis and Biological Evaluation of 5,6-Diarylimidazo(2.1-b) thiazole as Selective COX-2 Inhibitors.
M. Thérien, C. Brideau, C. Chan, W. Cromlish +13 more
19970 citations
Semantic Scholar
Novel 1,2‐Diarylcyclobutenes: Selective and Orally Active COX‐2 Inhibitors.
R. Friesen, D. Dubé, R. Fortin, R. Frenette +9 more
19970 citations
Semantic Scholar

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