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D. Riendeau · SciRah

Researcher profile · Semantic Scholar

D. Riendeau

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D. Riendeau — researcher profile on SciRah

h-index: 48
Works: 148
Citations: 9,116

Most-cited papers

Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts.
S. Kargman, S. Charleson, M. Cartwright, J. Frank +4 more
1996Gastroenterology488 citations Open access
Semantic Scholar
Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.
D. Riendeau, M. Percival, C. Brideau, S. Charleson +21 more
2001Journal of Pharmacology and Experimental Therapeutics485 citations Open access
Semantic Scholar
The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.
J. Gauthier, N. Chauret, W. Cromlish, S. Desmarais +25 more
2008Bioorganic & Medicinal Chemistry Letters443 citations Open access
Semantic Scholar
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
P. Prasit, Zhen Wang, C. Brideau, Chi-Chung Chan +32 more
1999Bioorganic & Medicinal Chemistry Letters360 citations Open access
Semantic Scholar
Characterization of rofecoxib as a cyclooxygenase‐2 isoform inhibitor and demonstration of analgesia in the dental pain model
Elliot W. Ehrich, A. Dallob, I. de Lepeleire, A. van Hecken +8 more
1999Clinical pharmacology and therapy334 citations
Semantic Scholar
Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor
D. Riendeau, M. Percival, S. Boyce, C. Brideau +25 more
1997British Journal of Pharmacology315 citations Open access
Semantic Scholar
Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor–Deficient Mice
M. Burleigh, V. Babaev, J. Oates, Raymond C. Harris +6 more
2002Circulation303 citations Open access
Semantic Scholar
Carrageenan-induced Paw Edema in Rat Elicits a Predominant Prostaglandin E2 (PGE2) Response in the Central Nervous System Associated with the Induction of Microsomal PGE2 Synthase-1*
J. Guay, K. Bateman, R. Gordon, J. Mancini +1 more
2004Journal of Biological Chemistry272 citations Open access
Semantic Scholar
Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis*
J. Mancini, Katherine Blood, J. Guay, R. Gordon +3 more
2001Journal of Biological Chemistry243 citations Open access
Semantic Scholar
Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets.
D. Riendeau, J. Guay, Philip K. Weech, F. Laliberté +6 more
1994Journal of Biological Chemistry242 citations Open access
Semantic Scholar
Quinolines as potent 5-lipoxygenase inhibitors: synthesis and biological profile of L-746,530.
D. Dubé, M. Blouin, C. Brideau, Chi-Chung Chan +10 more
1998Bioorganic & Medicinal Chemistry Letters238 citations Open access
Semantic Scholar
Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays.
D. Riendeau, S. Charleson, W. Cromlish, J. Mancini +2 more
1997Canadian Journal of Physiology and Pharmacology196 citations
Semantic Scholar
Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model
D. Claveau, M. Sirinyan, J. Guay, R. Gordon +4 more
2003Journal of Immunology192 citations Open access
Semantic Scholar
Identification and Characterization of a Novel Microsomal Enzyme with Glutathione-dependent Transferase and Peroxidase Activities*
Per-Johan Jakobsson, J. Mancini, D. Riendeau, A. Ford-hutchinson
1997Journal of Biological Chemistry174 citations Open access
Semantic Scholar
MF63 [2-(6-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation
Dai-Gen Xu, Steve Rowland, P. Clark, A. Giroux +9 more
2008Journal of Pharmacology and Experimental Therapeutics153 citations
Semantic Scholar
Lysosomotropism of basic cathepsin K inhibitors contributes to increased cellular potencies against off-target cathepsins and reduced functional selectivity.
J. Falgueyret, S. Desmarais, R. Oballa, W. Black +7 more
2005Journal of Medicinal Chemistry153 citations Open access
Semantic Scholar
A high level of cyclooxygenase-2 inhibitor selectivity is associated with a reduced interference of platelet cyclooxygenase-1 inactivation by aspirin
M. Ouellet, D. Riendeau, M. Percival
2001Proceedings of the National Academy of Sciences of the United States of America145 citations Open access
Semantic Scholar
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.
D. Riendeau, Renée Aspiotis, D. Ethier, Y. Gareau +8 more
2005Bioorganic & Medicinal Chemistry Letters143 citations Open access
Semantic Scholar
Arginine 120 of Prostaglandin G/H Synthase-1 Is Required for the Inhibition by Nonsteroidal Anti-inflammatory Drugs Containing a Carboxylic Acid Moiety *
J. Mancini, D. Riendeau, J. Falgueyret, P. Vickers +1 more
1995Journal of Biological Chemistry138 citations Open access
Semantic Scholar
Deletion of Microsomal Prostaglandin E2 (PGE2) Synthase-1 Reduces Inducible and Basal PGE2 Production and Alters the Gastric Prostanoid Profile*
L. Boulet, M. Ouellet, K. Bateman, D. Ethier +4 more
2004Journal of Biological Chemistry135 citations Open access
Semantic Scholar
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Bernard Côté, L. Boulet, C. Brideau, D. Claveau +16 more
2007Bioorganic & Medicinal Chemistry Letters130 citations Open access
Semantic Scholar
Prostacyclin Antagonism Reduces Pain and Inflammation in Rodent Models of Hyperalgesia and Chronic Arthritis
Anne-Marie Pulichino, Steve Rowland, T. Wu, P. Clark +4 more
2006Journal of Pharmacology and Experimental Therapeutics127 citations
Semantic Scholar
Conversion of Prostaglandin G/H Synthase-1 into an Enzyme Sensitive to PGHS-2-selective Inhibitors by a Double His513 → Arg and Ile523 → Val Mutation*
E. Wong, C. Bayly, H. Waterman, D. Riendeau +1 more
1997Journal of Biological Chemistry123 citations Open access
Semantic Scholar
Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.
J. Falgueyret, Renata M. Oballa, O. Okamoto, G. Wesolowski +6 more
2001Journal of Medicinal Chemistry107 citations Open access
Semantic Scholar
2-Pyridinyl-3-(4-methylsulfonyl)phenylpyridines: selective and orally active cyclooxygenase-2 inhibitors.
Richard W. Friesen, C. Brideau, Chi-Chung Chan, S. Charleson +15 more
1998Bioorganic & Medicinal Chemistry Letters106 citations Open access
Semantic Scholar
Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells.
S. Kargman, E. Wong, G. Greig, J. Falgueyret +9 more
1996Biochemical Pharmacology102 citations
Semantic Scholar
Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.
James T. Palmer, C. Bryant, Dan Wang, D. Davis +29 more
2005Journal of Medicinal Chemistry90 citations Open access
Semantic Scholar
Chapter 21. Selective Cyclooxygenase-2 Inhibitors
P. Prasit, D. Riendeau
199788 citations
Semantic Scholar
Inhibition of the Activation of Multiple Serine Proteases with a Cathepsin C Inhibitor Requires Sustained Exposure to Prevent Pro-enzyme Processing*
N. Méthot, Joel Rubin, D. Guay, Christian Beaulieu +4 more
2007Journal of Biological Chemistry80 citations Open access
Semantic Scholar
Urogenital distribution of a mouse membrane-associated prostaglandin E(2) synthase.
Y. Guan, Yahua Zhang, A. Schneider, D. Riendeau +5 more
2001AJP - Renal Physiology77 citations
Semantic Scholar
Effect of Cathepsin K Inhibitor Basicity on in Vivo Off-Target Activities
S. Desmarais, W. Black, R. Oballa, S. Lamontagne +5 more
2008Molecular Pharmacology74 citations
Semantic Scholar
Identification of a potent and selective non-basic cathepsin K inhibitor.
Chun-Sing Li, D. Deschênes, S. Desmarais, J. Falgueyret +14 more
2006Bioorganic & Medicinal Chemistry Letters72 citations Open access
Semantic Scholar
Pyridazinones as selective cyclooxygenase-2 inhibitors.
Chun-Sing Li, C. Brideau, Chi-Chung Chan, C. Savoie +10 more
2003Bioorganic & Medicinal Chemistry Letters66 citations Open access
Semantic Scholar
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.
A. Giroux, L. Boulet, C. Brideau, Anh M. Chau +17 more
2009Bioorganic & Medicinal Chemistry Letters65 citations Open access
Semantic Scholar
Inhibition of inducible prostaglandin E2 synthase by 15-deoxy-Δ12,14-prostaglandin J2 and polyunsaturated fatty acids
O. Quraishi, J. Mancini, D. Riendeau
200261 citations
Semantic Scholar
Purification and characterization of recombinant microsomal prostaglandin E synthase-1.
M. Ouellet, J. Falgueyret, P. Ear, A. Pen +3 more
2002Protein Expression and Purification58 citations
Semantic Scholar
In Vivo Inhibition of Serine Protease Processing Requires a High Fractional Inhibition of Cathepsin C
N. Méthot, D. Guay, Joel Rubin, D. Ethier +7 more
2008Molecular Pharmacology55 citations
Semantic Scholar
Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.
D. Delorme, Y. Ducharme, C. Brideau, Chi-Chung Chan +16 more
1996Journal of Medicinal Chemistry53 citations Open access
Semantic Scholar
An activity-based probe for the determination of cysteine cathepsin protease activities in whole cells.
J. Falgueyret, W. Black, W. Cromlish, S. Desmarais +9 more
2004Analytical Biochemistry51 citations
Semantic Scholar
Synthesis and biological evaluation of 2,3-diarylthiophenes as selective Cox-2 and Cox-1 inhibitors
Y. Leblanc, J. Gauthier, D. Ethier, J. Guay +6 more
199551 citations
Semantic Scholar
2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors.
W. Black, C. Brideau, Chi-Chung Chan, S. Charleson +16 more
1999Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Cyclo-oxygenase-2 contributes to constitutive prostanoid production in rat kidney and brain.
P. Hétu, D. Riendeau
2005Biochemical Journal48 citations Open access
Semantic Scholar
Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells
E. Wong, C. Deluca, C. Boily, S. Charleson +9 more
1997Inflammation Research48 citations Open access
Semantic Scholar
Substituted coumarins as potent 5-lipoxygenase inhibitors.
E. Grimm, C. Brideau, N. Chauret, Chi-Chung Chan +11 more
2006Bioorganic & Medicinal Chemistry Letters47 citations Open access
Semantic Scholar
In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663).
N. Chauret, J. Yergey, C. Brideau, Richard W. Friesen +6 more
2001Bioorganic & Medicinal Chemistry Letters47 citations Open access
Semantic Scholar
Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX isoforms in normal aortic endothelium.
D. Kawka, M. Ouellet, P. Hétu, I. Singer +1 more
2007Biochimica et Biophysica Acta46 citations
Semantic Scholar
Synthesis and biological evaluation of 2,3-diarylthiophenes as selective cox-2 inhibitors. part II: Replacing the heterocycle
J. Gauthier, Y. Leblanc, W. Black, Chi-Chung Chan +15 more
199645 citations
Semantic Scholar
Effects of COX-2 inhibitors on aortic prostacyclin production in cholesterol-fed rabbits.
Elizabeth Wong, Jingqi Huang, P. Tagari, D. Riendeau
2001Atherosclerosis41 citations
Semantic Scholar
Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).
D. Nicoll-Griffith, James A. Yergey, Laird A. Trimble, José M. Silva +15 more
2000Bioorganic & Medicinal Chemistry Letters41 citations Open access
Semantic Scholar
SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor.
Y. Leblanc, P. Roy, S. Boyce, C. Brideau +13 more
1999Bioorganic & Medicinal Chemistry Letters41 citations Open access
Semantic Scholar

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J. Mancini×21
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J. Mancini — researcher profile on SciRah
J. Guay×18
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J. Guay — researcher profile on SciRah
D. Ethier×16
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D. Ethier — researcher profile on SciRah
M. Percival×15
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M. Percival — researcher profile on SciRah

×14

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C. Brideau — researcher profile on SciRah

J. Falgueyret×14

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J. Falgueyret — researcher profile on SciRah

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R. Gordon — researcher profile on SciRah

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E. Wong — researcher profile on SciRah

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S. Charleson — researcher profile on SciRah

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W. Cromlish — researcher profile on SciRah

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M. Ouellet — researcher profile on SciRah

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P. Prasit — researcher profile on SciRah