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C. Fabre · SciRah

Researcher profile · Semantic Scholar

C. Fabre

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C. Fabre — researcher profile on SciRah

h-index: 24
Works: 67
Citations: 2,382

Most-cited papers

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.
N. Mimura, M. Fulciniti, G. Gorgun, Yu-Tzu Tai +21 more
2011Blood411 citations Open access
Semantic Scholar
Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma.
G. Görgün, E. Calabrese, E. Soydan, T. Hideshima +13 more
2009Blood225 citations Open access
Semantic Scholar
TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts
Angelo L Grauel, Beverly Nguyen, David A. Ruddy, Tyler Laszewski +34 more
2020Nature Communications173 citations Open access
Semantic Scholar
Targeting NF-κB in hematologic malignancies
T. Braun, G. Carvalho, C. Fabre, J. Grosjean +2 more
2006Cell Death and Differentiation148 citations
Semantic Scholar
Rituximab antiproliferative effect in B-lymphoma cells is associated with acid-sphingomyelinase activation in raft microdomains.
C. Bezombes, Solène Grazide, C. Garret, C. Fabre +4 more
2004Blood139 citations Open access
Semantic Scholar
Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical study.
S. Boehrer, L. Adès, T. Braun, L. Galluzzi +8 more
2008Blood123 citations
Semantic Scholar
PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor
R. González-Polo, G. Carvalho, T. Braun, D. Decaudin +9 more
2005Oncogene92 citations
Semantic Scholar
Targeting NF-kappaB in hematologic malignancies.
T. Braun, G. Carvalho, C. Fabre, J. Grosjean +2 more
2006Cell Death and Differentiation82 citations
Semantic Scholar
New Proteasome Inhibitors in Myeloma
P. Lawasut, D. Chauhan, J. Laubach, C. Hayes +6 more
2012Current Hematologic Malignancy Reports81 citations
Semantic Scholar
Dual inhibition of canonical and non-canonical NF-κB pathways demonstrates significant anti-tumor activities in multiple myeloma
C. Fabre, N. Mimura, Kathryn L. Bobb, Sun-Young Kong +12 more
2012Clinical Cancer Research78 citations Open access
Semantic Scholar
ATM mediates constitutive NF-κB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia
J. Grosjean-Raillard, M. Tailler, L. Adès, J.-L. Perfettini +5 more
2009Oncogene78 citations
Semantic Scholar
Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type TP53 Solid Tumors and Acute Leukemia
E. Stein, D. DeAngelo, J. Chromik, M. Chatterjee +21 more
2021Clinical Cancer Research68 citations Open access
Semantic Scholar
NF-κB inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia
C. Fabre, G. Carvalho, E. Tasdemir, T. Braun +8 more
2007Oncogene64 citations Open access
Semantic Scholar
Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma: Results From a Proof-of-Concept, Phase Ib Study.
A. A. Abdul Razak, S. Bauer, C. Suárez, Chia-Chi Lin +13 more
2021Clinical Cancer Research61 citations
Semantic Scholar
A novel effect of DNA methyltransferase and histone deacetylase inhibitors : NFκB inhibition in malignant myeloblasts
C. Fabre, J. Grosjean, M. Tailler, S. Boehrer +5 more
2008Cell Cycle51 citations Open access
Semantic Scholar
Inhibition of NEMO, the regulatory subunit of the IKK complex, induces apoptosis in high-risk myelodysplastic syndrome and acute myeloid leukemia
G. Carvalho, C. Fabre, T. Braun, J. Grosjean +8 more
2007Oncogene50 citations
Semantic Scholar
Inhibition of MDM2 Promotes Antitumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment
H. Wang, Iain J. Mulford, F. Sharp, Jinsheng Liang +16 more
2021Cancer Research47 citations
Semantic Scholar
Clinical study of the novel cyclin-dependent kinase inhibitor dinaciclib in combination with rituximab in relapsed/refractory chronic lymphocytic leukemia patients
C. Fabre, M. Gobbi, C. Ezzili, Mustapha Zoubir +7 more
2014Cancer Chemotherapy and Pharmacology45 citations
Semantic Scholar
Histone deacetylase inhibitors in multiple myeloma: rationale and evidence for their use in combination therapy.
J. Kaufman, C. Fabre, S. Lonial, P. Richardson
2013Clinical Lymphoma, Myeloma & Leukemia43 citations
Semantic Scholar
NF-kappaB inhibition sensitizes to starvation-induced cell death in high-risk myelodysplastic syndrome and acute myeloid leukemia.
C. Fabre, G. Carvalho, E. Tasdemir, T. Braun +8 more
2007Oncogene39 citations
Semantic Scholar
Frequent Engagement of RelB Activation Is Critical for Cell Survival in Multiple Myeloma
F. Cormier, H. Monjanel, C. Fabre, K. Billot +6 more
2013PLoS ONE35 citations Open access
Semantic Scholar
Flt3 receptor inhibition reduces constitutive NFκB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia
J. Grosjean-Raillard, L. Adès, S. Boehrer, M. Tailler +6 more
2008Apoptosis32 citations
Semantic Scholar
Pharmacokinetic–pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies
S. Bauer, G. Demetri, E. Halilovic, R. Dummer +11 more
2021British Journal of Cancer31 citations Open access
Semantic Scholar
Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma.
D. Decaudin, Estelle Frisch Dit Leitz, F. Némati, M. Tarin +9 more
2020European Journal of Cancer26 citations Open access
Semantic Scholar
Translational Modeling of Anticancer Efficacy to Predict Clinical Outcomes in a First-in-Human Phase 1 Study of MDM2 Inhibitor HDM201
N. Guerreiro, A. Jullion, S. Ferretti, C. Fabre +1 more
2021AAPS Journal17 citations Open access
Semantic Scholar
Differentiating megakaryocytes in myelodysplastic syndromes succumb to mitochondrial derangement without caspase activation
T. Braun, G. Carvalho, J. Grosjean, L. Adès +5 more
2007Apoptosis17 citations
Semantic Scholar
Abstract CT009: Results of a dose- and regimen-finding Phase Ib study of HDM201 in combination with ribociclib in patients with locally advanced or metastatic liposarcoma
A. Razak, S. Bauer, J. Blay, R. Quek +13 more
2018Clinical Trials15 citations
Semantic Scholar
Erratum to: Flt3 receptor inhibition reduces constitutive NFκB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia
J. Grosjean-Raillard, L. Adès, S. Boehrer, M. Tailler +6 more
2008Apoptosis15 citations Open access
Semantic Scholar
Phase Ib study of the anti-TGF-β monoclonal antibody (mAb) NIS793 combined with spartalizumab (PDR001), a PD-1 inhibitor, in patients (pts) with advanced solid tumors.
T. Bauer, Chia-Chi Lin, R. Greil, M. Goebeler +15 more
202113 citations
Semantic Scholar
Characterization and phase I study of CLR457, an orally bioavailable pan-class I PI3-kinase inhibitor
J. Harding, T. Bauer, D. Tan, P. Bedard +8 more
2018Investigational new drugs12 citations Open access
Semantic Scholar
Younger donor’s age and upfront tandem are two independent prognostic factors for survival in multiple myeloma patients treated by tandem autologous-allogeneic stem cell transplantation: a retrospective study from the Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC)
C. Fabre, S. Koscielny, M. Mohty, N. Fégueux +12 more
2012Haematologica10 citations Open access
Semantic Scholar
Phase II study of the anti-TGF-β monoclonal antibody (mAb) NIS793 with and without the PD-1 inhibitor spartalizumab in combination with nab-paclitaxel/gemcitabine (NG) versus NG alone in patients (pts) with first-line metastatic pancreatic ductal adenocarcinoma (mPDAC).
Li-Yuan Bai, T. Macarulla, P. Grell, C. Chee +16 more
2021Journal of Clinical Oncology8 citations
Semantic Scholar
A First-in-Human, Phase 1, Multicenter, Open-label, Dose-Escalation Study of PCA062, an Antibody-Drug Conjugate Targeting P-Cadherin, in Patients with Solid Tumors.
M. Duca, D. Lim, V. Subbiah, S. Takahashi +11 more
2022Molecular Cancer Therapeutics7 citations
Semantic Scholar
Siremadlin (HDM201) Is Well Tolerated and Demonstrates Clinical Activity in Patients with Acute Myeloid Leukemia Who Have Relapsed after Allogeneic Stem Cell Transplantation: A Subset Analysis of Safety and Preliminary Efficacy
E. Stein, J. Chromik, C. Carpio, R. Mous +11 more
2021Blood7 citations Open access
Semantic Scholar
Response to Azacytidine (AZA) in MDS or AML with Del 5q : Current Results of the French ATU Program
R. Itzykson, S. Thepot, C. Fabre, F. Dreyfus +19 more
20087 citations
Semantic Scholar
Preliminary Results from a Phase Ib Study Exploring MDM2 Inhibitor Siremadlin (HDM201) in Combination with B-Cell Lymphoma-2 (BCL-2) Inhibitor Venetoclax in Patients with Acute Myeloid Leukemia (AML) or High-Risk Myelodysplastic Syndrome (HR-MDS)
A. Wei, M. Breccia, M. Ooi, M. T. Cedena Romero +8 more
2021Blood6 citations
Semantic Scholar
Targeting NF-jB in hematologic malignancies
T. Braun, G. Carvalho, C. Fabre, J. Grosjean +2 more
20066 citations
Semantic Scholar
Treatment of High Risk MDS and AML Post-MDS with Azacytidine (AZA): Preliminary Results of the French ATU Program.
C. Fabre, F. Chermat, L. Legros, Sophie Park +11 more
20065 citations
Semantic Scholar
Correction: Dual Inhibition of Canonical and Noncanonical NF-κB Pathways Demonstrates Significant Antitumor Activities in Multiple Myeloma
C. Fabre, N. Mimura, Kathryn L. Bobb, Sun-Young Kong +12 more
2019Clinical Cancer Research3 citations
Semantic Scholar
DEPTOR Is a Regulator of Response to mTOR Kinase Inhibitors in Multiple Myeloma
Diana Cirstea, T. Hideshima, L. Santo, Homare Eda +12 more
20112 citations
Semantic Scholar
Targeting IRE1α-XBP1 Pathway Is a Novel Therapeutic Strategy In Multiple Myeloma
N. Mimura, T. Hideshima, G. Gorgun, Diana Cirstea +11 more
20102 citations
Semantic Scholar
AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor with Potent Activity Against Aurora Kinase and STAT3 In Combination with Lenalidomide Results In Synergistic Anti-Myeloma Activity
L. Santo, T. Hideshima, Diana Cirstea, Madhavi Bandi +14 more
20102 citations
Semantic Scholar
Treatment of AML with Azacytidine (AZA): Current Results of the French ATU Program.
C. Fabre, C. Gardin, R. M’bida, B. Quesnel +19 more
20072 citations
Semantic Scholar
Phase Ib study testing neoadjuvant transforming growth factor (TGF)-β antibody, NIS793, plus 5-fluorouracil, irinotecan, and oxaliplatin chemotherapy (FOLFIRINOX) in patients (pts) with borderline resectable (BR)/locally advanced (LA) pancreatic ductal adenocarcinoma (PDAC).
C. Weekes, D. Ting, A. Parikh, Stacie Ittershagen +10 more
2023Journal of Clinical Oncology1 citations Open access
Semantic Scholar
Disruption of Bcl-2 Heterodimerization by the BH3 Mimetic ABT-737 Restores Spontaneous Apoptosis and Induces Differentiation in High Risk MDS and AML.
L. Adès, S. Boehrer, T. Braun, J. Grosjean +3 more
20071 citations
Semantic Scholar
P149 Treatment of high risk MDS and AML post-MDS with azacytidine (AZA): current results of the French ATU program
C. Fabre, M. Sébert, E. Hernández, F. Chermat +14 more
20071 citations
Semantic Scholar
Non-Myeloablative Allogeneic Hematopoietic Transplantation in Relapsed/Primary Refractory Follicular Lymphoma.
C. Fabre, C. Récher, A. Huynh, F. Rigal-huguet +5 more
20041 citations
Semantic Scholar
[Study of the preventive action of a polybacterian lysate against some respiratory diseases in a geriatric population (author's transl)].
Y. Mémin, C. Fabre, J. Larribaud, J. Dry
1979The´rapie (Paris)1 citations
Semantic Scholar
Corrigendum to "Preclinical evaluation of drug combinations identifies co-inhibition of Bcl-2/XL/W and MDM2 as a potential therapy in uveal melanoma" [Eur J Cancer 126 (2020) 93-103].
D. Decaudin, Estelle Frisch Dit Leitz, F. Némati, M. Tarin +9 more
2023European Journal of Cancer0 citations Open access
Semantic Scholar
P-5 Phase II study (daNIS-1) of the anti-TGF-β monoclonal antibody (mAb) NIS793 +/- spartalizumab in combination with nab-paclitaxel/gemcitabine (NG) versus NG alone in patients with first-line metastatic pancreatic ductal adenocarcinoma (mPDAC)
S. Sivakumar, T. Macarulla, P. Grell, C. Chee +16 more
2022Annals of Oncology0 citations Open access
Semantic Scholar

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