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A. Kienhuis · SciRah

Researcher profile · Semantic Scholar

A. Kienhuis

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A. Kienhuis — researcher profile on SciRah

h-index: 23
Works: 58
Citations: 1,316

Most-cited papers

Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology
W. Heijne, A. Kienhuis, B. van Ommen, R. Stierum +1 more
2005Espert Review of Proteomics172 citations Open access
Semantic Scholar
Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling
Marja Driessen, A. Kienhuis, J. Pennings, T. Pronk +5 more
2013Archives of Toxicology88 citations Open access
Semantic Scholar
Development of a Roadmap for Action on New Approach Methodologies in Risk Assessment
Sylvia E. Escher, F. Partosch, S. Konzok, P. Jennings +6 more
2022EFSA Supporting Publications82 citations Open access
Semantic Scholar
Assessing the Metabolic Competence of Sandwich-Cultured Mouse Primary Hepatocytes
K. Mathijs, A. Kienhuis, Karen J. J. Brauers, D. Jennen +3 more
2009Drug Metabolism And Disposition67 citations
Semantic Scholar
A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen.
Marja Driessen, A. Vitins, J. Pennings, A. Kienhuis +2 more
2015Toxicology Letters62 citations
Semantic Scholar
Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.
A. Kienhuis, M. V. D. van de Poll, H. Wortelboer, M. van Herwijnen +7 more
2009Toxicological Sciences53 citations
Semantic Scholar
Mechanisms of amiodarone and valproic acid induced liver steatosis in mouse in vivo act as a template for other hepatotoxicity models
A. Vitins, A. Kienhuis, E. Speksnijder, Marianne Roodbergen +2 more
2014Archives of Toxicology48 citations Open access
Semantic Scholar
Potential harmful health effects of inhaling nicotine-free shisha-pen vapor: a chemical risk assessment of the main components propylene glycol and glycerol
A. Kienhuis, Lya G. Soeteman-Hernández, Peter M. J. Bos, H. Cremers +2 more
2015Tobacco Induced Diseases46 citations Open access
Semantic Scholar
Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study.
A. Kienhuis, J. Bessems, J. Pennings, Marja Driessen +4 more
2011Toxicology and Applied Pharmacology44 citations Open access
Semantic Scholar
Workshop on acceleration of the validation and regulatory acceptance of alternative methods and implementation of testing strategies.
A. Piersma, T. Burgdorf, K. Louekari, B. Desprez +12 more
2018Toxicology in Vitro43 citations Open access
Semantic Scholar
Fish embryo toxicity test, threshold approach, and moribund as approaches to implement 3R principles to the acute fish toxicity test.
Z. Dang, L. V. D. van der Ven, A. Kienhuis
2017Chemosphere43 citations
Semantic Scholar
A sandwich-cultured rat hepatocyte system with increased metabolic competence evaluated by gene expression profiling.
A. Kienhuis, H. Wortelboer, W. J. Maas, M. van Herwijnen +3 more
2007Toxicology in Vitro43 citations
Semantic Scholar
Toxicogenomics concepts and applications to study hepatic effects of food additives and chemicals.
R. Stierum, W. Heijne, A. Kienhuis, B. van Ommen +1 more
2005Toxicology and Applied Pharmacology41 citations
Semantic Scholar
Workshop on the validation and regulatory acceptance of innovative 3R approaches in regulatory toxicology - Evolution versus revolution.
T. Burgdorf, A. Piersma, R. Landsiedel, R. Clewell +14 more
2019Toxicology in Vitro40 citations Open access
Semantic Scholar
A Dose-Response Modeling Approach Shows That Effects From Mixture Exposure to the Skin Sensitizers Isoeugenol and Cinnamal Are in Line With Dose Addition and Not With Synergism.
A. Kienhuis, W. Slob, E. Gremmer, J. Vermeulen +1 more
2015Toxicological Sciences38 citations Open access
Semantic Scholar
Comparison of Coumarin-Induced Toxicity between Sandwich-Cultured Primary Rat Hepatocytes and Rats in Vivo: A Toxicogenomics Approach
A. Kienhuis, H. Wortelboer, J. Hoflack, E. Moonen +4 more
2006Drug Metabolism And Disposition38 citations
Semantic Scholar
Applicability of organ-on-chip systems in toxicology and pharmacology
M. Schneider, M. Oelgeschlaeger, T. Burgdorf, P. V. van Meer +4 more
2021Critical Reviews in Toxicology36 citations Open access
Semantic Scholar
The Rise of Three Rs Centres and Platforms in Europe*
W. Neuhaus, B. Reininger-Gutmann, B. Rinner, R. Plasenzotti +61 more
2022Alternatives to laboratory animals : ATLA35 citations Open access
Semantic Scholar
A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo.
A. Kienhuis, M. V. D. van de Poll, C. Dejong, Ralph W. H. Gottschalk +5 more
2009Toxicology in Vitro31 citations
Semantic Scholar
An inventory of methods suitable to assess additive-induced characterising flavours of tobacco products.
R. Talhout, S. vandeNobelen, A. Kienhuis
2016Drug and Alcohol Dependence27 citations
Semantic Scholar
Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans.
Marja Driessen, A. Kienhuis, A. Vitins, J. Pennings +5 more
2014Toxicology Letters24 citations
Semantic Scholar
Vegetables affect the expression of genes involved in anticarcinogenic processes in the colonic mucosa of C57BL/6 female mice.
S. V. van Breda, E. van Agen, S. Van Sanden, T. Burzykowski +3 more
2005Journal of NutriLife24 citations Open access
Semantic Scholar
The role of trust in the use of artificial intelligence for chemical risk assessment.
P. Wassenaar, J. Minnema, J. Vriend, W. Peijnenburg +2 more
2024Regulatory toxicology and pharmacology : RTP23 citations Open access
Semantic Scholar
The value of organs-on-chip for regulatory safety assessment.
M. Heringa, Margriet V. D. Z. Park, A. Kienhuis, R. Vandebriel
2019ALTEX20 citations Open access
Semantic Scholar
An Inventory of Methods for the Assessment of Additive Increased Addictiveness of Tobacco Products
Suzanne van de Nobelen, A. Kienhuis, R. Talhout
2016Nicotine & Tobacco Research18 citations Open access
Semantic Scholar
Cyclosporine A treated in vitro models induce cholestasis response through comparison of phenotype-directed gene expression analysis of in vivo Cyclosporine A-induced cholestasis.
A. Kienhuis, A. Vitins, J. Pennings, T. Pronk +5 more
2013Toxicology Letters18 citations Open access
Semantic Scholar
Options for waterpipe product regulation: A systematic review on product characteristics that affect attractiveness, addictiveness and toxicity of waterpipe use
A. Kienhuis, R. Talhout
2020Tobacco Induced Diseases17 citations Open access
Semantic Scholar
Animal-free safety assessment of chemicals: an innovation system perspective
Marjolein J. Hoogstraaten, J. Vriend, Victoria C. de Leeuw, Simona O. Negro +3 more
2024Archives of Toxicology14 citations Open access
Semantic Scholar
Validation redefined.
A. Piersma, J. van Benthem, J. Ezendam, A. Kienhuis
2018Toxicology in Vitro13 citations Open access
Semantic Scholar
The virtual human in chemical safety assessment
A. Piersma, J. van Benthem, J. Ezendam, Y. Staal +1 more
2019Current Opinion in Toxicology12 citations
Semantic Scholar
Building trust in the integration of artificial intelligence into chemical risk assessment: findings from the 2024 ECETOC workshop
T. Gant, A. Boxall, D. Burgwinkel, Maryam Zare Jeddi +19 more
2026Archives of Toxicology11 citations Open access
Semantic Scholar
Identification of proteome markers for drug-induced liver injury in zebrafish embryos.
Marja Driessen, Suzanne van der Plas - Duivesteijn, A. Kienhuis, E. van den Brandhof +6 more
2022Toxicology8 citations Open access
Semantic Scholar
The importance of variations in in vitro dosimetry to support risk assessment of inhaled toxicants.
Y. Staal, L. Geraets, B. Rothen-Rutishauser, M. Clift +3 more
2023ALTEX6 citations Open access
Semantic Scholar
In Vitro, In Vivo Comparison of Cyclosporin A Induced Hepatic Protein Expression Profiles
Freek G. Bouwman, A. Van Summeren, A. Kienhuis, L. V. D. van der Ven +5 more
20165 citations Open access
Semantic Scholar
[Pharmacogenetics in primary health care: implementation and future expectations].
E. Houwink, T. Rigter, J. Swen, M. Cornel +3 more
2015Nederlandsch tijdschrift voor geneeskunde5 citations
Semantic Scholar
How to organise a successful toxicology workshop? A participant perspective on the Collaboration to Harmonise the Assessment of Next Generation Evidence (CHANGE) workshop in Oslo, 18–20 June 2024
M. Diemar, Arianna Giusti, C. Michel-Caillet, D. M. Leme +9 more
2025Archives of Toxicology3 citations Open access
Semantic Scholar
Website Use and Effects of Online Information About Tobacco Additives Among the Dutch General Population: A Randomized Controlled Trial
D. Reinwand, R. Crutzen, A. Kienhuis, R. Talhout +1 more
2017Journal of Medical Internet Research3 citations Open access
Semantic Scholar
A test strategy for the assessment of additive attributed toxicity of tobacco products.
A. Kienhuis, Y. Staal, Lya G. Soeteman-Hernández, Suzanne van de Nobelen +1 more
2016Food and Chemical Toxicology3 citations
Semantic Scholar
Supplements for the elderly : An inventory of vitamins and minerals available for elderly in the Netherlands
Jansen Ehjm, A. Kienhuis, Prs
20143 citations
Semantic Scholar
A roadmap towards a human-centric safety assessment of advanced therapy medicinal products.
Hsiao-Tzu Chien, Victoria C. de Leeuw, J. V. van Esterik, F. Russel +3 more
2024Regulatory toxicology and pharmacology : RTP2 citations Open access
Semantic Scholar
New Approach Methodologies (NAMs) for ad hoc human health risk assessment of food and non-food products - Proceedings of a workshop.
L. de Wit, H. Hendriks, J. van Engelen, H. Heusinkveld +5 more
2024Regulatory toxicology and pharmacology : RTP2 citations Open access
Semantic Scholar
Analysis of Manufacturer's Information on Tobacco Product Additive Use
L. V. van Nierop, J. Pennings, E. Schenk, A. Kienhuis +1 more
2019Tobacco Regulatory Science2 citations Open access
Semantic Scholar
Report of Collaboration to Harmonise the Assessment of Next Generation Evidence (CHANGE) 2nd workshop in Oslo, June 24 - 26, 2025 – participants perspectives on the CHANGE working methodology.
M. Diemar, Arianna Giusti, C. Rousselle, H. Hollnagel +8 more
2026NAM Journal1 citations Open access
Semantic Scholar
Innovating human chemical hazard and risk assessment through an holistic approach
A. Piersma, H. Heusinkveld, E. Hessel, A. Kienhuis
2023Current Opinion in Toxicology1 citations Open access
Semantic Scholar
Applicability of generic PBK modelling in chemical hazard assessment: A case study with IndusChemFate.
S. Fragki, A. Piersma, J. Westerhout, A. Kienhuis +2 more
2022Regulatory toxicology and pharmacology : RTP1 citations Open access
Semantic Scholar
Chapter 7:Dissecting Modes of Action of Non-genotoxic Carcinogens
M. Schaap, J. van Benthem, M. Jacobs, A. Colacci +3 more
20161 citations
Semantic Scholar
Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
A. Kienhuis
20141 citations
Semantic Scholar
Extrapolation steps in quantitative in vitro to in vivo extrapolation to advance in vitro-based chemical risk assessment for human health
M. J. M. Benschop, J. Minnema, E. Kasteel, A. Kienhuis +5 more
2026Current Research in Toxicology0 citations Open access
Semantic Scholar
Pursuing societal impact in research projects on NAM development: An analysis of routes to impact
Tessel B. Wijne, W. Boon, A. Kienhuis, E. Moors +1 more
2025NAM journal0 citations Open access
Semantic Scholar
Including genetic susceptibility towards Parkinson’s disease in NAM-based hazard and risk assessment of pesticides: a semi-systematic review
J. J. Meerman, V. D. de Bruijn, T. Luechtefeld, J. van Engelen +2 more
2025NAM journal0 citations Open access
Semantic Scholar

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