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H. Wortelboer · SciRah

Researcher profile · Semantic Scholar

H. Wortelboer

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H. Wortelboer — researcher profile on SciRah

h-index: 36
Works: 82
Citations: 3,723

Most-cited papers

The interplay of glutathione-related processes in antioxidant defense.
N. Cnubben, I. Rietjens, H. Wortelboer, J. V. van Zanden +1 more
2001Environmental Toxicology and Pharmacology356 citations Open access
Semantic Scholar
Structure elucidation of acid reaction products of indole-3-carbinol: detection in vivo and enzyme induction in vitro.
C. A. De Kruif, J. Marsman, J. Venekamp, H. Falke +3 more
1991Chemico-Biological Interactions186 citations
Semantic Scholar
Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.
J. V. van Zanden, H. Wortelboer, S. Bijlsma, A. Punt +4 more
2005Biochemical Pharmacology178 citations Open access
Semantic Scholar
The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and in intact monolayers.
H. Wortelboer, C. A. De Kruif, A. A. V. van Iersel, H. Falke +2 more
1990Biochemical Pharmacology169 citations
Semantic Scholar
Variability in P-Glycoprotein Inhibitory Potency (IC50) Using Various in Vitro Experimental Systems: Implications for Universal Digoxin Drug-Drug Interaction Risk Assessment Decision Criteria
J. Bentz, Michael P. O'Connor, D. Bednarczyk, J. Coleman +35 more
2013Drug Metabolism And Disposition157 citations Open access
Semantic Scholar
Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties.
M. Balvers, K. Verhoeckx, P. Plastina, H. Wortelboer +2 more
2010Biochimica et Biophysica Acta143 citations Open access
Semantic Scholar
Comparison of cytochrome P450 isoenzyme profiles in rat liver and hepatocyte cultures. The effects of model inducers on apoproteins and biotransformation activities.
H. Wortelboer, C. A. De Kruif, A. A. V. van Iersel, H. Falke +2 more
1991Biochemical Pharmacology126 citations
Semantic Scholar
Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells.
J. V. van Zanden, L. Geraets, H. Wortelboer, P. van Bladeren +2 more
2004Biochemical Pharmacology112 citations Open access
Semantic Scholar
Fish oil and inflammatory status alter the n-3 to n-6 balance of the endocannabinoid and oxylipin metabolomes in mouse plasma and tissues
M. Balvers, K. Verhoeckx, S. Bijlsma, C. Rubingh +3 more
2012Metabolomics111 citations Open access
Semantic Scholar
Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin.
H. Wortelboer, M. Usta, A. van der Velde, M. Boersma +5 more
2003Chemical Research in Toxicology111 citations Open access
Semantic Scholar
Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes.
C. Wegler, F. Gaugaz, T. B. Andersson, J. Wiśniewski +13 more
2017Molecular Pharmaceutics110 citations Open access
Semantic Scholar
A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices.
J. Westerhout, E. van de Steeg, Dimitri Grossouw, E. Zeijdner +3 more
2014European Journal of Pharmaceutical Sciences110 citations
Semantic Scholar
The effect of quercetin phase II metabolism on its MRP1 and MRP2 inhibiting potential.
J. V. van Zanden, H. van der Woude, Judith Vaessen, M. Usta +3 more
2007Biochemical Pharmacology82 citations Open access
Semantic Scholar
Regional Expression Levels of Drug Transporters and Metabolizing Enzymes along the Pig and Human Intestinal Tract and Comparison with Caco-2 Cells
S. Vaessen, M. V. van Lipzig, R. Pieters, C. Krul +2 more
2017Drug Metabolism And Disposition76 citations Open access
Semantic Scholar
Acid reaction products of indole-3-carbinol and their effects on cytochrome P450 and phase II enzymes in rat and monkey hepatocytes.
H. Wortelboer, C. A. De Kruif, A. A. V. van Iersel, H. Falke +2 more
1992Biochemical Pharmacology75 citations
Semantic Scholar
Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4.
Azza A. K. El-Sheikh, R. Greupink, H. Wortelboer, J. J. van den Heuvel +4 more
2013Translational Research: The Journal of Laboratory and Clinical Medicine74 citations
Semantic Scholar
Effects of indole-3-carbinol on biotransformation enzymes in the rat: in vivo changes in liver and small intestinal mucosa in comparison with primary hepatocyte cultures.
H. Wortelboer, E. V. D. van der Linden, C. A. De Kruif, Jan Noordhoek +3 more
1992Food and Chemical Toxicology72 citations
Semantic Scholar
Presence, formation and putative biological activities of N-acyl serotonins, a novel class of fatty-acid derived mediators, in the intestinal tract.
K. Verhoeckx, T. Voortman, M. Balvers, H. Hendriks +2 more
2011Biochimica et Biophysica Acta71 citations Open access
Semantic Scholar
Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.
S. Bosgra, E. van de Steeg, M. Vlaming, K. Verhoeckx +3 more
2014European Journal of Pharmaceutical Sciences67 citations
Semantic Scholar
Drug-Drug Interactions between Rosuvastatin and Oral Antidiabetic Drugs Occurring at the Level of OATP1B1
E. van de Steeg, R. Greupink, M. Schreurs, I. H. G. Nooijen +10 more
2013Drug Metabolism And Disposition60 citations Open access
Semantic Scholar
Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in Caco-2 cells.
M. Usta, H. Wortelboer, J. Vervoort, M. Boersma +3 more
2007Chemical Research in Toxicology60 citations Open access
Semantic Scholar
Reversal of in vitro cellular MRP1 and MRP2 mediated vincristine resistance by the flavonoid myricetin.
J. V. van Zanden, A. de Mul, H. Wortelboer, M. Usta +3 more
2005Biochemical Pharmacology58 citations Open access
Semantic Scholar
Time-dependent effect of in vivo inflammation on eicosanoid and endocannabinoid levels in plasma, liver, ileum and adipose tissue in C57BL/6 mice fed a fish-oil diet.
M. Balvers, K. Verhoeckx, J. Meijerink, S. Bijlsma +3 more
2012International Immunopharmacology56 citations Open access
Semantic Scholar
Effects of cooked brussels sprouts on cytochrome P-450 profile and phase II enzymes in liver and small intestinal mucosa of the rat.
H. Wortelboer, C. A. De Kruif, A. A. V. van Iersel, Jan Noordhoek +3 more
1992Food and Chemical Toxicology56 citations Open access
Semantic Scholar
Parallelogram approach using rat-human in vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans.
A. Kienhuis, M. V. D. van de Poll, H. Wortelboer, M. van Herwijnen +7 more
2009Toxicological Sciences53 citations
Semantic Scholar
Application of Receiver Operating Characteristic Analysis to Refine the Prediction of Potential Digoxin Drug Interactions
H. Ellens, Shi-Bing Deng, J. Coleman, J. Bentz +29 more
2013Drug Metabolism And Disposition51 citations Open access
Semantic Scholar
Inhibition of multidrug resistance proteins MRP1 and MRP2 by a series of alpha,beta-unsaturated carbonyl compounds.
H. Wortelboer, M. Usta, J. V. van Zanden, P. van Bladeren +2 more
2005Biochemical Pharmacology48 citations Open access
Semantic Scholar
Nutrient-induced glucagon like peptide-1 release is modulated by serotonin.
D. Ripken, N. van der Wielen, H. Wortelboer, J. Meijerink +2 more
2016Journal of Nutritional Biochemistry45 citations Open access
Semantic Scholar
Liquid chromatography-tandem mass spectrometry analysis of free and esterified fatty acid N-acyl ethanolamines in plasma and blood cells.
M. Balvers, H. Wortelboer, R. Witkamp, K. Verhoeckx
2013Analytical Biochemistry45 citations Open access
Semantic Scholar
Measurement of palmitoylethanolamide and other N-acylethanolamines during physiological and pathological conditions.
M. Balvers, K. Verhoeckx, J. Meijerink, H. Wortelboer +1 more
2013CNS and Neurological Disorders - Drug Targets45 citations Open access
Semantic Scholar
A sandwich-cultured rat hepatocyte system with increased metabolic competence evaluated by gene expression profiling.
A. Kienhuis, H. Wortelboer, W. J. Maas, M. van Herwijnen +3 more
2007Toxicology in Vitro43 citations
Semantic Scholar
Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants
Bianca D. van Groen, E. van de Steeg, M. Mooij, M. V. van Lipzig +11 more
2018European Journal of Pharmaceutical Sciences41 citations Open access
Semantic Scholar
Ex vivo systems to study host-microbiota interactions in the gastrointestinal tract.
Guus Roeselers, M. Ponomarenko, S. Lukovac, H. Wortelboer
2013Best practice & research. Clinical gastroenterology41 citations
Semantic Scholar
Increasing oxime efficacy by blood-brain barrier modulation.
M. Joosen, M. van der Schans, C. V. van Dijk, Willem C. Kuijpers +2 more
2011Toxicology Letters38 citations
Semantic Scholar
Comparison of Coumarin-Induced Toxicity between Sandwich-Cultured Primary Rat Hepatocytes and Rats in Vivo: A Toxicogenomics Approach
A. Kienhuis, H. Wortelboer, J. Hoflack, E. Moonen +4 more
2006Drug Metabolism And Disposition38 citations
Semantic Scholar
Interlaboratory comparison of microsomal ethoxyresorufin and pentoxyresorufin O-dealkylation determinations: standardization of assay conditions
A. Rutten, H. Falke, J. F. Catsburg, H. Wortelboer +5 more
2006Archives of Toxicology37 citations Open access
Semantic Scholar
Steviol glycoside rebaudioside A induces glucagon-like peptide-1 and peptide YY release in a porcine ex vivo intestinal model.
D. Ripken, N. van der Wielen, H. Wortelboer, J. Meijerink +2 more
2014Journal of Agricultural and Food Chemistry35 citations Open access
Semantic Scholar
Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3.
E. Gozalpour, R. Greupink, H. Wortelboer, A. Bilos +3 more
2014Molecular Pharmaceutics33 citations
Semantic Scholar
Protein transport across the small intestine in food allergy.
M. Reitsma, J. Westerhout, H. Wichers, H. Wortelboer +1 more
2014Molecular Nutrition & Food Research33 citations Open access
Semantic Scholar
Effects of long- and short-chain fatty acids on the release of gastrointestinal hormones using an ex vivo porcine intestinal tissue model.
T. Voortman, H. Hendriks, R. Witkamp, H. Wortelboer
2012Journal of Agricultural and Food Chemistry32 citations Open access
Semantic Scholar
A higher throughput and physiologically relevant two-compartmental human ex vivo intestinal tissue system for studying gastrointestinal processes.
Lianne J. Stevens, M. V. van Lipzig, S. Erpelinck, A. Pronk +3 more
2019European Journal of Pharmaceutical Sciences31 citations
Semantic Scholar
Combined Analysis of Pharmacokinetic and Efficacy Data of Preclinical Studies with Statins Markedly Improves Translation of Drug Efficacy to Human Trials
E. van de Steeg, R. Kleemann, Harm T. Jansen, W. van Duyvenvoorde +3 more
2013Journal of Pharmacology and Experimental Therapeutics29 citations
Semantic Scholar
Grip on health: A complex systems approach to transform health care
H. V. van Wietmarschen, H. Wortelboer, J. van der Greef
2018Journal of Evaluation In Clinical Practice27 citations
Semantic Scholar
Special Section on Pediatric Drug Disposition and Pharmacokinetics Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life
M. Mooij, E. van de Steeg, J. van Rosmalen, J. Windster +6 more
201626 citations
Semantic Scholar
Antioxidant status of Fanconi anemia fibroblasts
J. Gille, H. Wortelboer, H. Joenje
1987Human Genetics25 citations
Semantic Scholar
The Use of Liver Cell Cultures Derived from Different Mammalian Species in In Vitro Toxicological Studies: Implementation in Extrapolation Models?
B. Blaauboer, H. Wortelboer, W. Mennes
199023 citations
Semantic Scholar
Glutathione-dependent interaction of heavy metal compounds with multidrug resistance proteins MRP1 and MRP2.
H. Wortelboer, M. Balvers, M. Usta, P. van Bladeren +1 more
2008Environmental Toxicology and Pharmacology22 citations Open access
Semantic Scholar
Generation of Bayesian prediction models for OATP-mediated drug-drug interactions based on inhibition screen of OATP1B1, OATP1B1∗15 and OATP1B3.
E. van de Steeg, J. Venhorst, Harm T. Jansen, I. H. G. Nooijen +3 more
2015European Journal of Pharmaceutical Sciences21 citations
Semantic Scholar
The effect of chitosan on the bioaccessibility and intestinal permeability of acyclovir
Marlies Kubbinga, P. Augustijns, Mauricio A. García, Christian Heinen +3 more
2019European journal of pharmaceutics and biopharmaceutics20 citations Open access
Semantic Scholar
Effect of normobaric hyperoxia on antioxidant defenses of HeLa and CHO cells.
J. Gille, H. Wortelboer, H. Joenje
1988Free Radical Biology & Medicine20 citations
Semantic Scholar

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