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J. Shern · SciRah

Researcher profile · Semantic Scholar

J. Shern

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J. Shern — researcher profile on SciRah

h-index: 41
Works: 198
Citations: 8,906

Most-cited papers

Molecular testing of rhabdomyosarcoma in clinical trials to improve risk stratification and outcome: A consensus view from European paediatric Soft tissue sarcoma Study Group, Children's Oncology Group and Cooperative Weichteilsarkom-Studiengruppe.
S. Hettmer, C. Linardic, A. Kelsey, E. Rudzinski +18 more
2022European Journal of Cancer70 citations Open access
Semantic Scholar
Urine cell-free DNA multi-omics to detect MRD and predict survival in bladder cancer patients
P. Chauhan, Alexander L. Shiang, I. Alahi, R. Sundby +17 more
2023npj Precision Oncology63 citations Open access
Semantic Scholar
Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study
J. Szymanski, R. Sundby, P. Jones, Divya Srihari +17 more
2021medRxiv63 citations Open access
Semantic Scholar
Selumetinib in adults with NF1 and inoperable plexiform neurofibroma: a phase 2 trial
A. Gross, Geraldine O'Sullivan Coyne, E. Dombi, Cecilia Tibery +31 more
2025Nature Medicine46 citations Open access
Semantic Scholar
Multiple Nf1 Schwann cell populations reprogram the plexiform neurofibroma tumor microenvironment
Leah J. Kershner, Kwangmin Choi, Jian-Qiang Wu, Xi-Yuan Zhang +4 more
2022JCI Insight46 citations Open access
Semantic Scholar
The Childhood Cancer Data Initiative: Using the Power of Data to Learn From and Improve Outcomes for Every Child and Young Adult With Pediatric Cancer
Joseph A. Flores-Toro, Subhashini Jagu, G. Armstrong, David F Arons +25 more
2023Journal of Clinical Oncology42 citations Open access
Semantic Scholar
Cooperative armoring of CAR and TCR T-cells by T cell-restricted IL-15 and IL-21 universally enhances solid tumor efficacy
Rosa Nguyen, Ekaterina Doubrovina, C. M. Mousset, Benjamin Y Jin +14 more
2023Clinical Cancer Research40 citations Open access
Semantic Scholar
Circulating Tumor DNA Is Prognostic in Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group
S. Abbou, Kelly S. Klega, J. Tsuji, Mohammad Tanhaemami +13 more
2023Journal of Clinical Oncology30 citations Open access
Semantic Scholar
Anti-GD2 antibodies conjugated to IL15 and IL21 mediate potent anti-tumor cytotoxicity against neuroblastoma
Rosa Nguyen, Xi-Yuan Zhang, Ming Sun, Shahroze Abbas +4 more
2022Clinical Cancer Research29 citations Open access
Semantic Scholar
KDM3B inhibitors disrupt the oncogenic activity of PAX3-FOXO1 in fusion-positive rhabdomyosarcoma
Y. Kim, B. Gryder, Ranu Sinniah, Megan L. Peach +28 more
2024Nature Communications25 citations Open access
Semantic Scholar
Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics
R. Sundby, J. Szymanski, A. Pan, P. Jones +25 more
2024medRxiv23 citations Open access
Semantic Scholar
Predicting Molecular Subtype and Survival of Rhabdomyosarcoma Patients using Deep Learning of H&E Images: A Report from the Children’s Oncology Group
D. Milewski, Hyun Jung, G. Brown, Yan-Ling Liu +21 more
2022Clinical Cancer Research23 citations Open access
Semantic Scholar
HAND2 assists MYCN enhancer invasion to regulate a noradrenergic neuroblastoma phenotype
Man Xu, Ming Sun, Xi-Yuan Zhang, Rosa Nguyen +4 more
2023Cancer Research22 citations Open access
Semantic Scholar
Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-14 amplification.
T. Nguyen, Prasantha L. Vemu, Gregory Hoy, Salah Boudjadi +5 more
2021Journal of Clinical Investigation21 citations Open access
Semantic Scholar
Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor
Xi-Yuan Zhang, Hannah E. Lou, Vishaka Gopalan, Zhi-Hui Liu +11 more
2022Cell Reports20 citations Open access
Semantic Scholar
Phase I trial of ganitumab plus dasatinib to cotarget the insulin-like growth factor 1 receptor and Src family kinase YES in rhabdomyosarcoma
S. Akshintala, R. Sundby, Donna Bernstein, J. Glod +18 more
2023Clinical Cancer Research17 citations Open access
Semantic Scholar
The combination of trametinib and ganitumab is effective in RAS-mutated PAX-fusion negative rhabdomyosarcoma models
K. Hebron, X. Wan, Jacob S. Roth, D. Liewehr +30 more
2022Clinical Cancer Research15 citations Open access
Semantic Scholar
Liquid Biopsies in Pediatric Oncology: Opportunities and Obstacles
R. Sundby, Alex C. Pan, J. Shern
2021Current opinion in pediatrics15 citations Open access
Semantic Scholar
Germline Genetic Testing and Survival Outcomes Among Children With Rhabdomyosarcoma
Bailey A. Martin-Giacalone, He Li, M. Scheurer, D. Casey +20 more
2024JAMA Network Open14 citations Open access
Semantic Scholar
MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription
Zhi-Hui Liu, Xi-Yuan Zhang, Man Xu, Jason J Hong +4 more
2024PLoS Biology13 citations Open access
Semantic Scholar
A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-associated Renal Cell Carcinoma
John A. Ligon, R. Sundby, Mary F. Wedekind Malone, Fernanda I. Arnaldez +28 more
2022Clinical Cancer Research13 citations Open access
Semantic Scholar
GPC2-targeted CAR T cells engineered with NFAT-inducible membrane-tethered IL-15/IL-21 exhibit enhanced activity against neuroblastoma
Reona Okada, Jeyshka M. Reyes-González, Constanza Rodriguez, Taisuke Kondo +11 more
2025Cancer immunology research12 citations
Semantic Scholar
Targeting SWI/SNF ATPases reduces neuroblastoma cell plasticity
Man Xu, Jason J Hong, Xi-Yuan Zhang, Ming Sun +12 more
2024EMBO Journal12 citations Open access
Semantic Scholar
Childhood cancer data initiative: Status report
Subhashini Jagu, E. Mardis, M. Wedekind, Brigitte C. Widemann +4 more
2023Pediatric Blood & Cancer11 citations Open access
Semantic Scholar
Estimated Prevalence, Tumor Spectrum, and Neurofibromatosis Type 1-Like Phenotype of CDKN2A-Related Melanoma-Astrocytoma Syndrome.
Michael R. Sargen, Jung Kim, T. Potjer, M. Velthuizen +18 more
2023JAMA dermatology10 citations Open access
Semantic Scholar
Inhibition of NAD+-dependent metabolic processes induces cellular necrosis and tumor regression in rhabdomyosarcoma models
G. McKay-Corkum, V. Collins, C. Yeung, Takeshi Ito +17 more
2023Clinical Cancer Research10 citations Open access
Semantic Scholar
MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma
Zhi-Hui Liu, Jason J Hong, Xi-Yuan Zhang, Carly M. Sayers +10 more
2025Oncogenesis8 citations Open access
Semantic Scholar
Childhood Cancer Data Initiative: Expanded access to tumor molecular profiling for children, adolescents, and young adults
Joseph A. Flores-Toro, Subhashini Jagu, Malcolm A. Smith, J. Shern +27 more
2025Journal of the National Cancer Institute7 citations
Semantic Scholar
Loss of CASZ1 tumor suppressor linked to oncogenic subversion of neuroblastoma core regulatory circuitry
Zhi-Hui Liu, Xi-Yuan Zhang, Man Xu, Hai-Yan Lei +2 more
2022Cell Death and Disease7 citations Open access
Semantic Scholar
SARC031: A Phase II Trial of Selumetinib and Sirolimus for Patients with Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumors (MPNST)
A. Kim, K. Ballman, P. Wolters, Rachel S. Heise +20 more
2026Clinical Cancer Research6 citations Open access
Semantic Scholar
Cutaneous mosaic RASopathies associated with rhabdomyosarcoma
O. Davies, A. Bruckner, T. McCalmont, L. Mascarenhas +5 more
2022Pediatric Blood & Cancer6 citations
Semantic Scholar
Preclinical Therapeutic Efficacy of RAF/MEK/ERK and IGF1R/AKT/mTOR Inhibition in Neuroblastoma
Stacey Stauffer, Jacob S. Roth, Edjay R. Hernandez, Josh Kowalczyk +18 more
2024Cancers5 citations Open access
Semantic Scholar
Protocol for using single-cell sequencing to study the heterogeneity of NF1 nerve sheath tumors from clinical biospecimens
Xi-Yuan Zhang, Vishaka Gopalan, Neeraja Syed, S. Hannenhalli +1 more
2023STAR Protocols5 citations Open access
Semantic Scholar
Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromas
Niousha Ahmari, Kwangmin Choi, Jian-Qiang Wu, Tilat A. Rizvi +8 more
2025Life Science Alliance4 citations Open access
Semantic Scholar
ASAP1 and ARF1 regulate myogenic differentiation in rhabdomyosarcoma by modulating TAZ activity
K. Hebron, Olivia L. Perkins, Angela Kim, X. Jian +6 more
2024Molecular Cancer Research4 citations Open access
Semantic Scholar
Loss of Chromosome 3q Is a Prognostic Marker in Fusion-Negative Rhabdomyosarcoma
Carina A. Dehner, Robert C. Bell, Yang Cao, Kevin He +5 more
2023JCO Precision Oncology4 citations Open access
Semantic Scholar
Prioritization of novel agents for further investigation in pediatric non-rhabdomyosarcoma soft tissue sarcomas: a report from the Children’s Oncology Group
Jacquelyn N. Crane, David P. Douglass, Saphna Oberoi, N. Collins +18 more
2025European Journal of Cancer2 citations
Semantic Scholar
Biological Advances and Current Challenges for Pediatric Rhabdomyosarcoma
K. Hebron, P. Odeniyide, Yun Wei, B. Gryder +36 more
2026Cancers1 citations Open access
Semantic Scholar
Fusion-positive rhabdomyosarcoma oncofusions share a common interactome
S. Zimmerman, C. Delaney, B.-K. Lau, L. B. DeGraw +12 more
2026Nature Communications1 citations Open access
Semantic Scholar
A Sustainable Community-Wide Model to Enhance Cancer Data Usage and Utility
Emily S. Boja, Mousumi Ghosh, Ying Huang, Tung-Shing Mamie Lih +58 more
2026JCO Clinical Cancer Informatics1 citations Open access
Semantic Scholar
SPPL3-glycosylation axis governs CD22 CAR T-cell susceptibility in B-ALL independent of antigen recognition
Jaehyun Suh, U. Jo, Craig J. Thomas, Nirali N. Shah +3 more
2025Blood1 citations
Semantic Scholar
The impact of genetic ancestry on survival outcomes in pediatric rhabdomyosarcoma: A report from the Children’s Oncology Group
Ekene A. Onwuka, Christina L Magyar, Bailey A. Martin-Giacalone, M. Scheurer +18 more
2025HGG advances1 citations Open access
Semantic Scholar
Abstract 6921: NAMPT inhibition impacts energy metabolism, induces DNA damage, and mediates tumor regression in preclinical neuroblastoma models
Amy Yu, Sophia Varriano, Amy M. James, Kristine A Isanogle +19 more
2025Cancer Research1 citations
Semantic Scholar
CCDI-COG molecular characterization initiative: The expanding data on childhood cancer.
E. Rudzinski, K. Parbhoo, N. Ramirez, J. Shern +16 more
2025Journal of Clinical Oncology1 citations Open access
Semantic Scholar
Activity of direct KRAS(G12C) inhibitors in preclinical models of pediatric cancer
Hannah E Price, Stacey Stauffer, Hyun Lee, Kristine A Isanogle +18 more
2025Molecular Cancer Therapeutics1 citations Open access
Semantic Scholar
Integrated molecular characterization of pediatric soft tissue sarcomas: A report from the COG and CCDI molecular characterization initiative.
Sapna Oberoi, J. Meade, E. Rudzinski, Avery T. Funkhouser +15 more
2025Journal of Clinical Oncology1 citations
Semantic Scholar
NAPRT expression and epigenetic regulation in pediatric rhabdomyosarcoma as a potential biomarker for NAMPT inhibition
Angela Kim, Prateek Bhardwaj, Collin D. Heer, Sophia J. Zhao +22 more
2025bioRxiv1 citations
Semantic Scholar
Promise and Perils of Precision Oncology for Patients With Pediatric and Young Adult Sarcomas.
A. Church, Claire E. Wakefield, Kate Hetherington, J. Shern
2024American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting1 citations
Semantic Scholar
MYCN driven oncogenesis involves cooperation with WDR5 to activate canonical MYC targets and G9a to repress differentiation genes
Zhi-Hui Liu, Xi-Yuan Zhang, Man Xu, Jason J Hong +4 more
2023bioRxiv1 citations Open access
Semantic Scholar
A “cooperative collaboration” between HAND2 and MYCN shapes neuroblastoma cell identity
Man Xu, Ming Sun, Xi-Yuan Zhang, Rosa Nguyen +4 more
2022bioRxiv1 citations Open access
Semantic Scholar

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