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E. Dombi · SciRah

Researcher profile · Semantic Scholar

E. Dombi

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E. Dombi — researcher profile on SciRah

h-index: 47
Works: 163
Citations: 6,983

Most-cited papers

Selumetinib in Children with Inoperable Plexiform Neurofibromas.
A. Gross, P. Wolters, E. Dombi, A. Baldwin +27 more
2020New England Journal of Medicine423 citations Open access
Semantic Scholar
Selumetinib in Children with Inoperable Plexiform Neurofibromas
A. Gross, P. Wolters, E. Dombi, A. Baldwin +25 more
2020New England Journal of Medicine182 citations Open access
Semantic Scholar
Management of Neurofibromatosis Type 1-Associated Plexiform Neurofibromas.
Michael Fisher, J. Blakeley, Brian D. Weiss, E. Dombi +22 more
2022Neuro-Oncology152 citations Open access
Semantic Scholar
Immune determinants of CAR-T cell expansion in solid tumor patients receiving GD2 CAR-T cell therapy
Sabina Kaczanowska, Tara Murty, A. Alimadadi, Cristina F. Contreras +40 more
2023Cancer Cell107 citations
Semantic Scholar
The characteristics of 76 atypical neurofibromas as precursors to neurofibromatosis 1 associated malignant peripheral nerve sheath tumors
C. Higham, E. Dombi, A. Rogiers, S. Bhaumik +10 more
2018Neuro-Oncology105 citations Open access
Semantic Scholar
NF106: A Neurofibromatosis Clinical Trials Consortium Phase II Trial of the MEK Inhibitor Mirdametinib (PD-0325901) in Adolescents and Adults With NF1-Related Plexiform Neurofibromas
Brian D. Weiss, P. Wolters, S. Plotkin, B. Widemann +17 more
2021Journal of Clinical Oncology104 citations Open access
Semantic Scholar
Association of plexiform neurofibroma volume changes and development of clinical morbidities in neurofibromatosis 1
A. Gross, Gulpreet Singh, S. Akshintala, A. Baldwin +6 more
2018Neuro-Oncology98 citations Open access
Semantic Scholar
Long-Term Safety and Efficacy of Selumetinib in Children with Neurofibromatosis Type 1 on a Phase 1/2 Trial for Inoperable Plexiform Neurofibromas.
A. Gross, E. Dombi, P. Wolters, A. Baldwin +15 more
2023Neuro-Oncology94 citations Open access
Semantic Scholar
Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define pre-malignant neurofibromatosis type 1-associated atypical neurofibromas.
A. Pemov, N. Hansen, Sivasish Sindiri, R. Patidar +15 more
2019Neuro-Oncology94 citations Open access
Semantic Scholar
Pharmacodynamic Study of Miransertib in Individuals with Proteus Syndrome.
K. Keppler-Noreuil, Julie C. Sapp, M. Lindhurst, T. Darling +13 more
2019American Journal of Human Genetics89 citations Open access
Semantic Scholar
MEK Inhibitors for Neurofibromatosis Type 1 Manifestations: Clinical Evidence and Consensus.
P. de Blank, A. Gross, S. Akshintala, J. Blakeley +28 more
2022Neuro-Oncology88 citations Open access
Semantic Scholar
SARC006: Phase II Trial of Chemotherapy in Sporadic and Neurofibromatosis Type 1 Associated Chemotherapy-Naive Malignant Peripheral Nerve Sheath Tumors
C. Higham, S. Steinberg, E. Dombi, A. Perry +18 more
2017Sarcoma81 citations Open access
Semantic Scholar
Current whole-body MRI applications in the neurofibromatoses
S. Ahlawat, L. Fayad, M. Khan, M. Bredella +12 more
2016Neurology79 citations Open access
Semantic Scholar
Cabozantinib for neurofibromatosis type 1-related plexiform neurofibromas: a phase 2 trial
M. Fisher, C-S. Shih, Steven D. Rhodes, Amy E. Armstrong +26 more
2021Nature Medicine78 citations Open access
Semantic Scholar
Orbital/Peri-Orbital Plexiform Neurofibromas in Children with Neurofibromatosis type 1: Multi-disciplinary Recommendations for Care
R. Avery, J. Katowitz, M. Fisher, G. Heidary +10 more
2016Ophthalmology (Rochester, Minn.)70 citations Open access
Semantic Scholar
Longitudinal evaluation of peripheral nerve sheath tumors in neurofibromatosis type 1: Growth analysis of plexiform neurofibromas and distinct nodular lesions.
S. Akshintala, A. Baldwin, D. Liewehr, A. Goodwin +5 more
2020Neuro-Oncology67 citations Open access
Semantic Scholar
Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1
Sara H. Isakson, A. Rizzardi, Alex Coutts, D. F. Carlson +18 more
2018Communications Biology67 citations Open access
Semantic Scholar
Phase II trial of pegylated interferon alfa-2b in young patients with neurofibromatosis type 1 and unresectable plexiform neurofibromas
R. Jakacki, E. Dombi, S. Steinberg, S. Goldman +8 more
2016Neuro-Oncology64 citations Open access
Semantic Scholar
STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma
Jonathan S. Fletcher, Mitchell G. Springer, Kwangmin Choi, E. Jousma +5 more
2018Oncogene61 citations Open access
Semantic Scholar
Abbreviated Title:
Melissa Amaya, T. Whitcomb, A. Baldwin, J. Derdak +8 more
201757 citations
Semantic Scholar
Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016)
B. Widemann, Yao Lu, D. Reinke, S. Okuno +14 more
2019Sarcoma54 citations Open access
Semantic Scholar
Selumetinib in adults with NF1 and inoperable plexiform neurofibroma: a phase 2 trial
A. Gross, Geraldine O'Sullivan Coyne, E. Dombi, Cecilia Tibery +31 more
2025Nature Medicine46 citations Open access
Semantic Scholar
Current status of MEK inhibitors in the treatment of plexiform neurofibromas
A. Gross, E. Dombi, B. Widemann
2020Child's Nervous System43 citations
Semantic Scholar
Safe marginal resection of atypical neurofibromas in neurofibromatosis type 1
Charlie N Nelson, E. Dombi, J. Rosenblum, M. Miettinen +7 more
2019Journal of Neurosurgery41 citations Open access
Semantic Scholar
Phase 1 open-label trial of intravenous administration of MVA-BN-brachyury-TRICOM vaccine in patients with advanced cancer
P. DeMaria, Katherine Lee-Wisdom, R. Donahue, R. Madan +17 more
2021Journal for ImmunoTherapy of Cancer36 citations Open access
Semantic Scholar
Cxcr3-expressing leukocytes are necessary for neurofibroma formation in mice.
Jonathan S. Fletcher, Jian-Qiang Wu, W. Jessen, Jay Pundavela +7 more
2019JCI Insight36 citations Open access
Semantic Scholar
The MEK inhibitor selumetinib reduces spinal neurofibroma burden in patients with NF1 and plexiform neurofibromas.
Sadhana Jackson, E. Baker, A. Gross, P. Whitcomb +10 more
2020Neuro-Oncology Advances35 citations Open access
Semantic Scholar
Cdkn2a loss in a model of neurofibroma demonstrates stepwise tumor progression to atypical neurofibroma and MPNST
K. Chaney, Melissa R. Perrino, Leah J. Kershner, Ami V. Patel +7 more
2020Cancer Research35 citations Open access
Semantic Scholar
KOMET: a phase 3, multicentre, international, randomised, placebo-controlled study to assess the efficacy and safety of selumetinib in adults with neurofibromatosis type 1 and symptomatic, inoperable plexiform neurofibromas
Alice P Chen, G. Coyne, P. Wolters, Staci Martin +15 more
2025The Lancet30 citations Open access
Semantic Scholar
Outcomes of Children and Adolescents with Advanced Hereditary Medullary Thyroid Carcinoma Treated with Vandetanib
I. L. Kraft, S. Akshintala, Y. Zhu, Hai-Yan Lei +13 more
2017Clinical Cancer Research30 citations Open access
Semantic Scholar
SARC016: Phase II study of everolimus in combination with bevacizumab in sporadic and neurofibromatosis type 1 (NF1) related refractory malignant peripheral nerve sheath tumors (MPNST).
B. Widemann, C. Meyer, G. Cote, R. Chugh +13 more
201630 citations
Semantic Scholar
Volumetric MRI analysis of plexiform neurofibromas in neurofibromatosis type 1: Comparison of 2 methods
Wenli Cai, S. Steinberg, M. Bredella, Gina M. Basinsky +6 more
2017Academic Radiology28 citations Open access
Semantic Scholar
Selumetinib in Children with Neurofibromatosis Type 1 and Asymptomatic Inoperable Plexiform Neurofibroma At Risk for Developing Tumor-Related Morbidity.
A. Gross, Brittany Glassberg, P. Wolters, E. Dombi +19 more
2022Neuro-Oncology25 citations Open access
Semantic Scholar
Pediatric PK/PD Phase I Trial of Pexidartinib in Relapsed and Refractory Leukemias and Solid Tumors Including Neurofibromatosis Type I related Plexiform Neurofibromas
Lauren H. Boal, J. Glod, Melissa Spencer, M. Kasai +10 more
2020Clinical Cancer Research24 citations Open access
Semantic Scholar
NFB-17. MEK INHIBITOR BINIMETINIB SHOWS CLINICAL ACTIVITY IN CHILDREN WITH NEUROFIBROMATOSIS TYPE 1- ASSOCIATED PLEXIFORM NEUROFIBROMAS: A REPORT FROM PNOC AND THE NF CLINICAL TRIALS CONSORTIUM
S. Mueller, A. Reddy, E. Dombi, J. Allen +14 more
2020Neuro-Oncology24 citations Open access
Semantic Scholar
Early Detection of Malignant and Premalignant Peripheral Nerve Tumors Using Cell-Free DNA Fragmentomics
R. Sundby, J. Szymanski, A. Pan, P. Jones +25 more
2024medRxiv23 citations Open access
Semantic Scholar
Contemporary Approach to NF1-Associated Malignant Peripheral Nerve Sheath Tumors
A. Hirbe, Carina A. Dehner, E. Dombi, V. Eulo +4 more
2024American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting23 citations
Semantic Scholar
A molecular basis for neurofibroma-associated skeletal manifestations in NF1
Yun Ma, A. Gross, E. Dombi, A. Pemov +10 more
2020Genetics in Medicine23 citations Open access
Semantic Scholar
MicroRNA-155 contributes to plexiform neurofibroma growth downstream of MEK
Youjin Na, Ashley Hall, Kwangmin Choi, Liang-Liang Hu +9 more
2020Oncogene20 citations Open access
Semantic Scholar
A Phase II Trial of Vandetanib (ZD6474, Caprelsa®) in Children and Adults with Succinate Dehydrogenase Deficient Gastrointestinal Stromal Tumor
J. Glod, Fernanda I. Arnaldez, L. Wiener, Melissa Spencer +11 more
2019Clinical Cancer Research18 citations Open access
Semantic Scholar
Phase I trial of ganitumab plus dasatinib to cotarget the insulin-like growth factor 1 receptor and Src family kinase YES in rhabdomyosarcoma
S. Akshintala, R. Sundby, Donna Bernstein, J. Glod +18 more
2023Clinical Cancer Research17 citations Open access
Semantic Scholar
Doxorubicin pharmacokinetics and toxicity in patients with aggressive lymphoma and hepatic impairment
Catherine Lai, D. Cole, S. Steinberg, N. Lucas +6 more
2022Blood Advances17 citations Open access
Semantic Scholar
NFM-06. NF106: PHASE 2 TRIAL OF THE MEK INHIBITOR PD-0325901 IN ADOLESCENTS AND ADULTS WITH NF1-RELATED PLEXIFORM NEUROFIBROMAS: AN NF CLINICAL TRIALS CONSORTIUM STUDY
Brian D. Weiss, S. Plotkin, B. Widemann, James Tonsgard +12 more
2018Neuro-Oncology17 citations Open access
Semantic Scholar
Phase II trial of the MEK 1/2 inhibitor selumetinib (AZD6244, ARRY-142886 Hydrogen Sulfate) in adults with neurofibromatosis type 1 (NF1) and inoperable plexiform neurofibromas (PN).
Geraldine O'Sullivan Coyne, A. Gross, E. Dombi, C. Tibery +14 more
202016 citations
Semantic Scholar
Cediranib Phase II Study in Children with Metastatic Alveolar Soft Part Sarcoma (ASPS).
Julia W Cohen, B. Widemann, J. Derdak, E. Dombi +8 more
2019Pediatric Blood & Cancer16 citations Open access
Semantic Scholar
Combining SOS1 and MEK Inhibitors in a Murine Model of Plexiform Neurofibroma Results in Tumor Shrinkage
Mark Jackson, Niousha Ahmari, Jian-Qiang Wu, Tilat A. Rizvi +11 more
2023Journal of Pharmacology and Experimental Therapeutics14 citations Open access
Semantic Scholar
A Phase II Trial of Guadecitabine in Children and Adults with SDH-Deficient GIST, Pheochromocytoma, Paraganglioma, and HLRCC-associated Renal Cell Carcinoma
John A. Ligon, R. Sundby, Mary F. Wedekind Malone, Fernanda I. Arnaldez +28 more
2022Clinical Cancer Research13 citations Open access
Semantic Scholar
RUNX represses Pmp22 to drive neurofibromagenesis
Ashley Hall, Kwangmin Choi, Wei Liu, J. Rose +17 more
2019Science Advances12 citations Open access
Semantic Scholar
NFM-07. SPRINT: PHASE II STUDY OF THE MEK 1/2 INHIBITOR SELUMETINIB (AZD6244, ARRY-142886) IN CHILDREN WITH NEUROFIBROMATOSIS TYPE 1 (NF1) AND INOPERABLE PLEXIFORM NEUROFIBROMAS (PN)
A. Gross, P. Wolters, A. Baldwin, E. Dombi +16 more
2018Neuro-Oncology10 citations Open access
Semantic Scholar
The NIH Pediatric/Young Adult Chordoma Clinic and Natural History Study: Making Advances in a Very Rare Tumor
Liny John, Hannah Smith, Maran Ilanchezhian, R. Lockridge +28 more
2023Pediatric Blood & Cancer9 citations Open access
Semantic Scholar

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B. Widemann×35
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B. Widemann — researcher profile on SciRah
A. Gross×18
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A. Gross — researcher profile on SciRah
S. Steinberg×17
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S. Steinberg — researcher profile on SciRah
P. Wolters×13
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P. Wolters — researcher profile on SciRah

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J. Blakeley — researcher profile on SciRah

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A. Baldwin — researcher profile on SciRah

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J. Glod — researcher profile on SciRah

Staci Martin×10

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Staci Martin — researcher profile on SciRah

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J. Derdak — researcher profile on SciRah

Brian D. Weiss×9

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Brian D. Weiss — researcher profile on SciRah

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