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M. Jücker · SciRah

Researcher profile · Semantic Scholar

M. Jücker

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M. Jücker — researcher profile on SciRah

h-index: 28
Works: 81
Citations: 3,069

Most-cited papers

The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism
Ling-Yu Tian, Daniel J. Smit, M. Jücker
2023International Journal of Molecular Sciences319 citations Open access
Semantic Scholar
Distinct functions of AKT isoforms in breast cancer: a comprehensive review
Nico Hinz, M. Jücker
2019Cell Communication and Signaling315 citations Open access
Semantic Scholar
The Role of mTOR Signaling as a Therapeutic Target in Cancer
N. V. Popova, M. Jücker
2021International Journal of Molecular Sciences245 citations Open access
Semantic Scholar
PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer.
Franziska E. Marquard, M. Jücker
2019Biochemical Pharmacology234 citations
Semantic Scholar
The Functional Role of Extracellular Matrix Proteins in Cancer
N. V. Popova, M. Jücker
2022Cancers216 citations Open access
Semantic Scholar
COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer
Bianca T. Hofmann, Laura Schlüter, P. Lange, B. Mercanoglu +14 more
2015Molecular Cancer115 citations Open access
Semantic Scholar
Characterization of circulating breast cancer cells with tumorigenic and metastatic capacity
Claudia Koch, A. Kuske, S. Joosse, Gökhan Yigit +27 more
2020EMBO Molecular Medicine106 citations Open access
Semantic Scholar
Tight Junction Proteins Claudin-1 and Occludin Are Important for Cutaneous Wound Healing.
Thomas Volksdorf, J. Heilmann, S. Eming, Kathrin Schawjinski +7 more
2017American Journal of Pathology94 citations Open access
Semantic Scholar
Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects
J. Wellbrock, E. Latuske, Julian Köhler, Katharina Wagner +16 more
2015Clinical Cancer Research93 citations
Semantic Scholar
Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3β signaling and leads to an increased transit time through the G1 phase of the cell cycle
S. Horn, E. Endl, B. Fehse, M. Weck +2 more
2004Leukemia82 citations Open access
Semantic Scholar
Combined targeting of AKT and mTOR using MK‐2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma
F. Ewald, Nicole Grabinski, A. Grottke, S. Windhorst +9 more
2013International Journal of Cancer80 citations Open access
Semantic Scholar
Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer +14 more
2021Nature Communications70 citations Open access
Semantic Scholar
Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4
A. Grottke, F. Ewald, T. Lange, Dominik Nörz +8 more
2016PLoS ONE68 citations Open access
Semantic Scholar
Dual Inhibition of PI3K-AKT-mTOR- and RAF-MEK-ERK-signaling is synergistic in cholangiocarcinoma and reverses acquired resistance to MEK-inhibitors
F. Ewald, Dominik Nörz, A. Grottke, Bianca T. Hofmann +2 more
2014Investigational new drugs56 citations
Semantic Scholar
Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells
Marina Holler, A. Grottke, Katharina Mueck, Julia Manes +3 more
2016PLoS ONE49 citations Open access
Semantic Scholar
Akt isoform specific effects in ovarian cancer progression
Nicolle M. Linnerth-Petrik, L. Santry, R. Moorehead, M. Jücker +2 more
2016OncoTarget49 citations Open access
Semantic Scholar
ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: identification of novel targets for concerted therapy concepts.
M. Kebenko, Astrid Drenckhan, S. Gros, M. Jücker +8 more
2015Cellular Signalling47 citations
Semantic Scholar
AKT3 regulates ErbB2, ErbB3 and estrogen receptor α expression and contributes to endocrine therapy resistance of ErbB2(+) breast tumor cells from Balb-neuT mice.
Nicole Grabinski, Katharina Möllmann, K. Milde-langosch, V. Müller +4 more
2014Cellular Signalling46 citations
Semantic Scholar
Combined targeting of AKT and mTOR synergistically inhibits proliferation of hepatocellular carcinoma cells
Nicole Grabinski, F. Ewald, Bianca T. Hofmann, K. Staufer +3 more
2012Molecular Cancer44 citations Open access
Semantic Scholar
Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2.
S. Werner, B. Brors, J. Eick, Elsa Marques +20 more
2015Cancer Discovery42 citations Open access
Semantic Scholar
Vertical Targeting of AKT and mTOR as Well as Dual Targeting of AKT and MEK Signaling Is Synergistic in Hepatocellular Carcinoma
F. Ewald, Dominik Nörz, A. Grottke, Johanna Bach +4 more
2015Journal of Cancer41 citations Open access
Semantic Scholar
PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression
I. Hohensee, Han-Ning Chuang, A. Grottke, S. Werner +12 more
2016OncoTarget39 citations Open access
Semantic Scholar
Reduced proliferation of CD34+ cells from patients with acute myeloid leukemia after gene transfer of INPP5D
A. Metzner, C. Precht, B. Fehse, W. Fiedler +4 more
2009Gene Therapy37 citations Open access
Semantic Scholar
Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling.
Helena Brauer, Julia Strauss, Wiebke Wegner, C. Müller-Tidow +2 more
2012Cellular Signalling35 citations
Semantic Scholar
High Sensitivity of Circulating Tumor Cells Derived from a Colorectal Cancer Patient for Dual Inhibition with AKT and mTOR Inhibitors
Daniel J. Smit, L. Cayrefourcq, Marie-Therese Haider, Nico Hinz +3 more
2020Cells33 citations Open access
Semantic Scholar
Circulating tumor cells as a promising target for individualized drug susceptibility tests in cancer therapy.
Daniel J. Smit, K. Pantel, M. Jücker
2021Biochemical Pharmacology31 citations
Semantic Scholar
Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia
E. Latuske, H. Stamm, Marianne Klokow, G. Vohwinkel +6 more
2017OncoTarget31 citations Open access
Semantic Scholar
The tumor suppressor SHIP1 colocalizes in nucleolar cavities with p53 and components of PML nuclear bodies
Patrick A. H. Ehm, Marcus M. Nalaskowski, Torsten Wundenberg, M. Jücker
2015The Nucleus29 citations Open access
Semantic Scholar
The inositol 5-phosphatase SHIP is expressed as 145 and 135 kDa proteins in blood and bone marrow cells in vivo, whereas carboxyl-truncated forms of SHIP are generated by proteolytic cleavage in vitro
S. D. Horn, Johann Meyer, J. Heukeshoven, B. Fehse +6 more
2001Leukemia26 citations
Semantic Scholar
SHIP1, but not an AML-derived SHIP1 mutant, suppresses myeloid leukemia growth in a xenotransplantation mouse model
M. Täger, S. Horn, E. Latuske, Patrick A. H. Ehm +7 more
2017Gene Therapy23 citations
Semantic Scholar
The Role of PI3K/AKT/mTOR Signaling in Tumor Radioresistance and Advances in Inhibitor Research
Jian Zhan, M. Jücker
2025International Journal of Molecular Sciences21 citations Open access
Semantic Scholar
The Functional Roles of the Src Homology 2 Domain-Containing Inositol 5-Phosphatases SHIP1 and SHIP2 in the Pathogenesis of Human Diseases
Spike Murphy Müller, M. Jücker
2024International Journal of Molecular Sciences20 citations Open access
Semantic Scholar
Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo
A. Schulte, F. Ewald, M. Spyra, Daniel J. Smit +4 more
2020International Journal of Molecular Sciences19 citations Open access
Semantic Scholar
Activation of CD44/PAK1/AKT signaling promotes resistance to FGFR1 inhibition in squamous-cell lung cancer
O. Elakad, B. Häupl, V. Labitzky, Sha Yao +9 more
2022npj Precision Oncology18 citations Open access
Semantic Scholar
Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis
Nico Hinz, Anke Baranowsky, Michael Horn, M. Kriegs +6 more
2021Cells18 citations Open access
Semantic Scholar
AKT in Bone Metastasis of Solid Tumors: A Comprehensive Review
Nico Hinz, M. Jücker
2021Cancers17 citations Open access
Semantic Scholar
Modeling Spontaneous Bone Metastasis Formation of Solid Human Tumor Xenografts in Mice
V. Labitzky, Anke Baranowsky, Hanna Maar, Sandra Hanika +14 more
2020Cancers17 citations Open access
Semantic Scholar
Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM+ and CD90+ Human Hepatocellular Carcinoma Cells in an Orthotopic Mouse Model
M. Moustafa, Katarzyna-Krystyna Dähling, A. Günther, Leonie Riebandt +12 more
2022Cancers15 citations Open access
Semantic Scholar
H2S preconditioning of human adipose tissue-derived stem cells increases their efficacy in an in vitro model of cell therapy for simulated ischemia.
E. Dongó, Z. Benkó, A. Csizmazia, G. Marosi +4 more
2014Life Science15 citations
Semantic Scholar
Impact of AKT1 on cell invasion and radiosensitivity in a triple negative breast cancer cell line developing brain metastasis
Joanna Kempska, L. Oliveira-Ferrer, A. Grottke, M. Qi +13 more
2023Frontiers in Oncology14 citations Open access
Semantic Scholar
Gene transfer of SHIP-1 inhibits proliferation of juvenile myelomonocytic leukemia cells carrying KRAS2 or PTPN11 mutations
A. Metzner, M. Horstmann, B. Fehse, G. Ortmeyer +4 more
2007Gene Therapy14 citations Open access
Semantic Scholar
Tumor cell integrin β4 and tumor stroma E-/P-selectin cooperatively regulate tumor growth in vivo
Sandra Genduso, V. Freytag, Daniela Schetler, Lennart Kirchner +24 more
2023Journal of Hematology & Oncology13 citations Open access
Semantic Scholar
Analysis of the FLVR motif of SHIP1 and its importance for the protein stability of SH2 containing signaling proteins.
Patrick A. H. Ehm, Fabiola Lange, C. Hentschel, A. Jepsen +7 more
2019Cellular Signalling13 citations Open access
Semantic Scholar
Truncated O-GalNAc glycans impact on fundamental signaling pathways in pancreatic cancer.
Bianca T. Hofmann, Aeint-Steffen Picksak, M. Kwiatkowski, Katharina Grupp +9 more
2021Glycobiology12 citations
Semantic Scholar
Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity
Spike Murphy Müller, Nina Nelson, M. Jücker
2025Biomolecules10 citations Open access
Semantic Scholar
Differential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancer
Hannah Voß, Marcus Wurlitzer, Daniel J. Smit, F. Ewald +14 more
2020Clinical and Experimental Metastasis10 citations Open access
Semantic Scholar
Nuclear accumulation of SHIP1 mutants derived from AML patients leads to increased proliferation of leukemic cells.
Marcus M. Nalaskowski, Patrick A. H. Ehm, Christoph Rehbach, Nina Nelson +3 more
2018Cellular Signalling10 citations
Semantic Scholar
All Three AKT Isoforms Can Upregulate Oxygen Metabolism and Lactate Production in Human Hepatocellular Carcinoma Cell Lines
Ling-Yu Tian, Daniel J. Smit, Nadezhda V. Popova, Stefan Horn +3 more
2024International Journal of Molecular Sciences9 citations Open access
Semantic Scholar
Combined Targeting of AKT and mTOR Synergistically Inhibits Formation of Primary Colorectal Carcinoma Tumouroids In Vitro: A 3D Tumour Model for Pre-therapeutic Drug Screening
Dominik Nörz, C. Mullins, Daniel J. Smit, M. Linnebacher +8 more
2021Anticancer Research9 citations Open access
Semantic Scholar
K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3
Rebekka Geißert, Angela Lammert, Stefanie Wirth, Rabea Hönig +9 more
2024Cell Communication and Signaling8 citations Open access
Semantic Scholar

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