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J. Wellbrock · SciRah

Researcher profile · Semantic Scholar

J. Wellbrock

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J. Wellbrock — researcher profile on SciRah

h-index: 23
Works: 80
Citations: 1,962

Most-cited papers

The Tim-3-galectin-9 Secretory Pathway is Involved in the Immune Escape of Human Acute Myeloid Leukemia Cells
Isabel Gonçalves Silva, I. Yasinska, S. Sakhnevych, W. Fiedler +11 more
2017EBioMedicine218 citations Open access
Semantic Scholar
Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma.
I. Ben-Batalla, Alexander Schultze, M. Wroblewski, R. Erdmann +20 more
2013Blood207 citations Open access
Semantic Scholar
Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity
I. Yasinska, N. Meyer, S. Schlichtner, R. Hussain +12 more
2020Frontiers in Immunology100 citations Open access
Semantic Scholar
Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia
A. Gottschlich, Moritz Thomas, R. Grünmeier, S. Lesch +42 more
2023Nature Biotechnology95 citations Open access
Semantic Scholar
Immune checkpoints PVR and PVRL2 are prognostic markers in AML and their blockade represents a new therapeutic option
H. Stamm, F. Klingler, Eva-Maria Grossjohann, J. Muschhammer +15 more
2018Oncogene94 citations Open access
Semantic Scholar
Expression of Hedgehog Pathway Mediator GLI Represents a Negative Prognostic Marker in Human Acute Myeloid Leukemia and Its Inhibition Exerts Antileukemic Effects
J. Wellbrock, E. Latuske, Julian Köhler, Katharina Wagner +16 more
2015Clinical Cancer Research93 citations
Semantic Scholar
Comparison Between Minimally Invasive Surgery and Conventional Open Surgery for Patients With Spinal Metastasis: A Prospective Propensity Score-Matched Study
N. Hansen‐Algenstaedt, M. Kwan, P. Algenstaedt, C. Chiu +6 more
2017Spine89 citations
Semantic Scholar
Targeting the TIGIT-PVR immune checkpoint axis as novel therapeutic option in breast cancer
H. Stamm, L. Oliveira-Ferrer, Eva-Maria Grossjohann, J. Muschhammer +7 more
2019Oncoimmunology83 citations Open access
Semantic Scholar
TIGIT blockade repolarizes AML-associated TIGIT+ M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis
F. Brauneck, B. Fischer, Marius Witt, J. Muschhammer +11 more
2022Journal for ImmunoTherapy of Cancer82 citations Open access
Semantic Scholar
Acute Myeloid Leukemia and the Bone Marrow Niche—Take a Closer Look
L. Behrmann, J. Wellbrock, W. Fiedler
2018Frontiers in Oncology77 citations Open access
Semantic Scholar
Transforming growth factor beta type 1 (TGF-β) and hypoxia-inducible factor 1 (HIF-1) transcription complex as master regulators of the immunosuppressive protein galectin-9 expression in human cancer and embryonic cells
A. T. H. Selnø, S. Schlichtner, I. Yasinska, S. Sakhnevych +11 more
2020Aging52 citations Open access
Semantic Scholar
ErbB2 signaling activates the Hedgehog pathway via PI3K-Akt in human esophageal adenocarcinoma: identification of novel targets for concerted therapy concepts.
M. Kebenko, Astrid Drenckhan, S. Gros, M. Jücker +8 more
2015Cellular Signalling47 citations
Semantic Scholar
Combined Blockade of TIGIT and CD39 or A2AR Enhances NK-92 Cell-Mediated Cytotoxicity in AML
F. Brauneck, Elisa Seubert, J. Wellbrock, J. Schulze zur Wiesch +6 more
2021International Journal of Molecular Sciences46 citations Open access
Semantic Scholar
High mobility group box 1 (HMGB1) acts as an “alarmin” to promote acute myeloid leukaemia progression
I. Yasinska, Isabel Gonçalves Silva, S. Sakhnevych, Laura Ruegg +11 more
2018Oncoimmunology42 citations Open access
Semantic Scholar
Tissue-Specific Expression of TIGIT, PD-1, TIM-3, and CD39 by γδ T Cells in Ovarian Cancer
P. Weimer, J. Wellbrock, T. Sturmheit, L. Oliveira-Ferrer +8 more
2022Cells41 citations Open access
Semantic Scholar
Bone Marrow-Resident Vδ1 T Cells Co-express TIGIT With PD-1, TIM-3 or CD39 in AML and Myeloma
F. Brauneck, P. Weimer, J. Schulze zur Wiesch, K. Weisel +6 more
2021Frontiers in Medicine39 citations Open access
Semantic Scholar
Interaction of PVR/PVRL2 with TIGIT/DNAM-1 as a novel immune checkpoint axis and therapeutic target in cancer
H. Stamm, J. Wellbrock, W. Fiedler
2018Mammalian Genome37 citations
Semantic Scholar
Increased frequency of TIGIT+CD73-CD8+ T cells with a TOX+ TCF-1low profile in patients with newly diagnosed and relapsed AML
F. Brauneck, F. Haag, R. Woost, N. Wildner +8 more
2021Oncoimmunology32 citations Open access
Semantic Scholar
Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia
E. Latuske, H. Stamm, Marianne Klokow, G. Vohwinkel +6 more
2017OncoTarget31 citations Open access
Semantic Scholar
High Mobility Group Box 1 (HMGB1) Induces Toll-Like Receptor 4-Mediated Production of the Immunosuppressive Protein Galectin-9 in Human Cancer Cells
Anette Teo Hansen Selnø, S. Schlichtner, I. Yasinska, S. Sakhnevych +7 more
2021Frontiers in Immunology28 citations Open access
Semantic Scholar
Strong fascin expression promotes metastasis independent of its F-actin bundling activity
Lisa S. Heinz, S. Muhs, Johanna Schiewek, Saskia Grüb +9 more
2017OncoTarget27 citations Open access
Semantic Scholar
Expression of CD39 is associated with T cell exhaustion in ovarian cancer and its blockade reverts T cell dysfunction
Marius Witt, L. Oliveira-Ferrer, Friedrich Koch-Nolte, Stephan Menzel +11 more
2024Oncoimmunology25 citations Open access
Semantic Scholar
SHIP1, but not an AML-derived SHIP1 mutant, suppresses myeloid leukemia growth in a xenotransplantation mouse model
M. Täger, S. Horn, E. Latuske, Patrick A. H. Ehm +7 more
2017Gene Therapy23 citations
Semantic Scholar
New Antiangiogenic Strategies beyond Inhibition of Vascular Endothelial Growth Factor with Special Focus on Axon Guidance Molecules
A. Pircher, J. Wellbrock, W. Fiedler, I. Heidegger +2 more
2014Oncology22 citations
Semantic Scholar
Clinical experience with antiangiogenic therapy in leukemia.
J. Wellbrock, W. Fiedler
2011Current Cancer Drug Targets22 citations
Semantic Scholar
Immunosuppressive M2 TAMs represent a promising target population to enhance phagocytosis of ovarian cancer cells in vitro
F. Brauneck, L. Oliveira-Ferrer, J. Muschhammer, T. Sturmheit +10 more
2023Frontiers in Immunology21 citations Open access
Semantic Scholar
Supplementary Information Development and Characterization of a Spontaneously Metastatic Patient-Derived Xenograft Model of Human Prostate Cancer
T. Lange, S. Oh-Hohenhorst, S. Joosse, K. Pantel +14 more
201821 citations
Semantic Scholar
Downregulation of GLI3 Expression Mediates Chemotherapy Resistance in Acute Myeloid Leukemia
F. Freisleben, L. Behrmann, Vanessa Thaden, J. Muschhammer +3 more
2020International Journal of Molecular Sciences19 citations Open access
Semantic Scholar
The bone marrow stromal niche: a therapeutic target of hematological myeloid malignancies
L. Behrmann, J. Wellbrock, W. Fiedler
2020Expert opinion on therapeutic targets19 citations
Semantic Scholar
Combination therapy targeting integrins reduces glioblastoma tumor growth through antiangiogenic and direct antitumor activity and leads to activation of the pro-proliferative prolactin pathway
L. Oliveira-Ferrer, J. Wellbrock, U. Bartsch, E. M. Murga Penas +5 more
2013Molecular Cancer19 citations Open access
Semantic Scholar
Mechanisms of Tumor-Lymphatic Interactions in Invasive Breast and Prostate Carcinoma
L. Oliveira-Ferrer, K. Milde-langosch, K. Eylmann, M. Rossberg +5 more
2020International Journal of Molecular Sciences18 citations Open access
Semantic Scholar
Intrinsic BMP Antagonist Gremlin-1 as a Novel Circulating Marker in Pulmonary Arterial Hypertension
J. Wellbrock, L. Harbaum, H. Stamm, J. K. Hennigs +5 more
2015Lung18 citations
Semantic Scholar
Overexpression of Gremlin-1 in Patients with Loeys-Dietz Syndrome: Implications on Pathophysiology and Early Disease Detection
J. Wellbrock, Sara Sheikhzadeh, L. Oliveira-Ferrer, H. Stamm +14 more
2014PLoS ONE18 citations Open access
Semantic Scholar
Highly specific targeting of human acute myeloid leukaemia cells using pharmacologically active nanoconjugates.
I. Yasinska, G. Ceccone, I. Ojea-Jiménez, J. Ponti +12 more
2018Nanoscale15 citations Open access
Semantic Scholar
Mebendazole Mediates Proteasomal Degradation of GLI Transcription Factors in Acute Myeloid Leukemia
F. Freisleben, F. Modemann, J. Muschhammer, H. Stamm +6 more
2021International Journal of Molecular Sciences14 citations Open access
Semantic Scholar
Deoxycytidine kinase is downregulated under hypoxic conditions and confers resistance against cytarabine in acute myeloid leukaemia
Nicole Degwert, E. Latuske, G. Vohwinkel, H. Stamm +4 more
2016European Journal of Haematology13 citations
Semantic Scholar
The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia
Arne Velthaus, K. Cornils, J. K. Hennigs, Saskia Grüb +7 more
2019Cancers11 citations Open access
Semantic Scholar
Sunitinib treatment reduces tumor growth and limits changes in microvascular properties after minor surgical intervention in an in vivo model of secondary breast cancer growth in bone
M. Schroeder, Lennart Viezens, J. Wellbrock, W. Fiedler +4 more
2016Journal of Surgical Oncology11 citations
Semantic Scholar
Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression
S. Sakhnevych, I. Yasinska, A. Bratt, Ouafa Benlaouer +8 more
2018Cellular & Molecular Immunology10 citations Open access
Semantic Scholar
CD146: a new partner for VEGFR2.
J. Wellbrock, W. Fiedler
2012Blood10 citations
Semantic Scholar
Effect of the actin- and calcium-regulating activities of ITPKB on the metastatic potential of lung cancer cells.
Selina Bader, Elina Glaubke, Saskia Grüb, S. Muhs +4 more
2018Biochemical Journal9 citations
Semantic Scholar
RUNX1 Upregulation by Cytotoxic Drugs Promotes Apoptosis.
D. Speidel, J. Wellbrock, Melissa Abas
2017Cancer Research7 citations Open access
Semantic Scholar
The BET bromodomain inhibitor ZEN-3365 targets the Hedgehog signaling pathway in acute myeloid leukemia
J. Wellbrock, L. Behrmann, J. Muschhammer, F. Modemann +5 more
2021Annals of Hematology6 citations Open access
Semantic Scholar
Mebendazole Mediates Its Anti-Leukemic Effects By Proteasomal Degradation of GLI Transcription Factors Via Inhibition of HSP70/90-Chaperone Activity in Acute Myeloid Leukemia in a Preclinical and Clinical Setting
F. Freisleben, H. Stamm, J. Muschhammer, Vanessa Thaden +5 more
2019Blood5 citations
Semantic Scholar
The bone microenvironment promotes tumor growth and tissue perfusion compared with striated muscle in a preclinical model of prostate cancer in vivo
H. Mussawy, Lennart Viezens, M. Schroeder, Svenja Hettenhausen +4 more
2018BMC Cancer5 citations Open access
Semantic Scholar
Expression Of Hedgehog Pathway Mediator Gli2 Represents a Clinically Negative Prognostic Marker In Acute Myeloid Leukemia and Its Inhibitor GANT61 Exerts Anti-Leukemic Effects In Vitro
J. Wellbrock, J. Koehler, Katharina Wagner, E. Latuske +11 more
20135 citations
Semantic Scholar
Expression of the TIGIT axis and the CD39/CD73 purinergic pathway in bone metastasis-derived immune cells
E. Brauneck, L. Leonhardt, A. Assemissen, Y. Wahid +12 more
2025Cancer Immunology and Immunotherapy4 citations Open access
Semantic Scholar
Mebendazole's Conformational Space and Its Predicted Binding to Human Heat-Shock Protein 90
W. Fiedler, F. Freisleben, J. Wellbrock, K. Kirschner
2021Journal of Chemical Information and Modeling3 citations Open access
Semantic Scholar
Development and Characterization of a Spontaneously Metastatic Patient-Derived Xenograft Model of Human Prostate Cancer
Tobias Lange, S. Oh-Hohenhorst, S. Joosse, K. Pantel +12 more
2018Scientific Reports3 citations Open access
Semantic Scholar
Expression of Novel Immune Checkpoint Molecules PVR and PVRL2 Confers a Negative Prognosis to Patients with Acute Myeloid Leukemia and Their Blockade Augments T-Cell Mediated Lysis of AML Cells Alone or in Combination with the BiTE® Antibody Construct AMG 330
H. Stamm, F. Klingler, D. Pende, E. Vettorazzi +10 more
20153 citations
Semantic Scholar

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