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F. van Maldegem · SciRah

Researcher profile · Semantic Scholar

F. van Maldegem

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F. van Maldegem — researcher profile on SciRah

h-index: 17
Works: 46
Citations: 2,075

Most-cited papers

Lung adenocarcinoma promotion by air pollutants
William Hill, Emilia L. Lim, C. Weeden, Claudia Lee +322 more
2023Nature710 citations Open access
Semantic Scholar
Differential expression of interleukin‐17 family cytokines in intact and complicated human atherosclerotic plaques
O. D. de Boer, J. J. van der Meer, P. Teeling, C. M. van der Loos +4 more
2010Journal of Pathology200 citations
Semantic Scholar
Development of combination therapies to maximize the impact of G12C KRAS inhibitors in lung cancer
M. Molina-Arcas, C. Moore, S. Rana, F. van Maldegem +8 more
2019Science Translational Medicine171 citations Open access
Semantic Scholar
Therapeutic KRASG12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers
E. Mugarza, F. van Maldegem, J. Boumelha, C. Moore +10 more
2021bioRxiv143 citations Open access
Semantic Scholar
In Situ Localization of Gelatinolytic Activity in the Extracellular Matrix of Metastases of Colon Cancer in Rat Liver Using Quenched Fluorogenic DQ-gelatin
O. Mook, Claudia Van Overbeek, Eleonora G Ackema, F. van Maldegem +1 more
2003Journal of Histochemistry and Cytochemistry113 citations Open access
Semantic Scholar
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer
K. Enfield, Emma C. Colliver, Claudia Lee, A. Magness +31 more
2024Cancer Discovery112 citations Open access
Semantic Scholar
The majority of cutaneous marginal zone B-cell lymphomas expresses class-switched immunoglobulins and develops in a T-helper type 2 inflammatory environment.
F. van Maldegem, R. V. van Dijk, T. A. Wormhoudt, P. Kluin +4 more
2008Blood103 citations Open access
Semantic Scholar
Effects of Processing Delay, Formalin Fixation, and Immunohistochemistry on RNA Recovery From Formalin-fixed Paraffin-embedded Tissue Sections
F. van Maldegem, M. D. de Wit, F. Morsink, Alex R. Musler +2 more
2008Diagnostic molecular pathology (Print)86 citations
Semantic Scholar
Germinal centers in human lymph nodes contain reactivated memory B cells
R. J. Bende, F. van Maldegem, M. Triesscheijn, T. A. Wormhoudt +2 more
2007Journal of Experimental Medicine84 citations Open access
Semantic Scholar
Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas
R. J. Bende, F. van Maldegem, C. V. van Noesel
2009Haematologica78 citations Open access
Semantic Scholar
Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry
F. van Maldegem, Karishma Valand, M. Cole, H. Patel +14 more
2021Nature Communications59 citations Open access
Semantic Scholar
Mutant KRAS at the Heart of Tumor Immune Evasion.
F. van Maldegem, J. Downward
2020Immunity33 citations Open access
Semantic Scholar
Chlamydia psittaci-negative ocular adnexal marginal zone B-cell lymphomas have biased VH4-34 immunoglobulin gene expression and proliferate in a distinct inflammatory environment
F. van Maldegem, T. A. Wormhoudt, M. M. S. Mulder, M. E. Oud +8 more
2012Leukemia30 citations Open access
Semantic Scholar
Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor–induced immune responses
M. Cole, P. Anastasiou, Claudia Lee, Xiao-Fei Yu +18 more
2024Science Advances29 citations Open access
Semantic Scholar
Single-arm trial of neoadjuvant ipilimumab plus nivolumab with chemoradiotherapy in patients with resectable and borderline resectable lung cancer: the INCREASE study
I. Bahce, C. Dickhoff, F. Schneiders, J. Veltman +15 more
2024Journal for ImmunoTherapy of Cancer25 citations Open access
Semantic Scholar
CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex
F. van Maldegem, S. Maslen, Christopher M. Johnson, Anita Chandra +3 more
2015Nucleic Acids Research24 citations Open access
Semantic Scholar
Deep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX
A. Magness, Emma C. Colliver, K. Enfield, Claudia Lee +15 more
2024Nature Communications17 citations Open access
Semantic Scholar
AID splice variants lack deaminase activity.
F. van Maldegem, F. Scheeren, R. A. Jibodh, R. J. Bende +2 more
2009Blood17 citations Open access
Semantic Scholar
Deficiency in spliceosome-associated factor CTNNBL1 does not affect ongoing cell cycling but delays exit from quiescence and results in embryonic lethality in mice
Anita Chandra, F. van Maldegem, Simon R. Andrews, M. Neuberger +1 more
2013Cell Cycle14 citations Open access
Semantic Scholar
Activation-Induced Cytidine Deaminase Splice Variants Are Defective Because of the Lack of Structural Support for the Catalytic Site
F. van Maldegem, R. A. Jibodh, R. V. van Dijk, R. J. Bende +1 more
2010Journal of Immunology11 citations Open access
Semantic Scholar
Antigen receptors and somatic hypermutation in B-cell chronic lymphocytic leukemia with Richter's transformation.
L. Smit, F. van Maldegem, A. Langerak, C. Ellen van der Schoot +5 more
2006Haematologica11 citations
Semantic Scholar
Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin α
K. Ganesh, F. van Maldegem, S. Telerman, P. Simpson +4 more
2013FEBS Letters5 citations Open access
Semantic Scholar
Immune-modulating effects on tumor-draining lymph nodes of neoadjuvant chemoradiotherapy combined with dual immunotherapy in patients with T3-4N0-2 NSCLC
E. Ulas, Sofie J I Koomen, A. Vrijmoet, I. Houda +9 more
2025Journal for ImmunoTherapy of Cancer4 citations Open access
Semantic Scholar
Non-Small-Cell Lung Cancer Promotion by Air Pollutants
C. Swanton, F. Crick, W. Hill, Emilia L. Lim +15 more
20223 citations
Semantic Scholar
Rescue by radiotherapy and anti-CTLA4/PD-1 after failure of anti-PD-1 therapy in patients with metastatic NSCLC: the phase II RECLAIM trial
E. Ulas, N. D. Purcell, I. Houda, S. Hashemi +23 more
2026Journal for ImmunoTherapy of Cancer1 citations Open access
Semantic Scholar
MA12.03 Mechanims of Immune Evasion in Patients With KRAS-Mutant Lung Adenocarcinoma: A Role of MAPK Pathway Activation
D. Naves, T. V. van Ee, F. van Maldegem, T. D. de Gruijl +2 more
2022Journal of Thoracic Oncology1 citations Open access
Semantic Scholar
Abstract P111: Therapeutic KRASG12C inhibition alleviates KRAS-driven immunosuppression
E. Mugarza, F. van Maldegem, J. Boumelha, C. Moore +5 more
2021Poster Presentations - Proffered Abstracts1 citations
Semantic Scholar
15 Identification of new combination therapies for lung cancer tumours harbouring KRAS mutations
M. Molina-Arcas, C. Moore, S. Rana, F. van Maldegem +3 more
2018ESMO Open1 citations Open access
Semantic Scholar
Mechanisms of systemic immune modulation in tumor development: Interactions across lymph nodes, bone marrow, and blood
Xiao-Fei Yu, Linh Phạm, T. D. de Gruijl, Marieke F. Fransen +1 more
2026Cancer Metastasis Review0 citations Open access
Semantic Scholar
PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity
A. van Krimpen, Julie Y. Huang, Mike Eterman, V. Gerretsen +31 more
2026Nature0 citations Open access
Semantic Scholar
Spatial proteogenomics of tumour-draining lymph nodes reveals the myeloid cell-secreted PLA2G2D as a targetable regulator of anti-tumour immunity
A. van Krimpen, Mike Eterman, V. Gerretsen, J. Janssen +14 more
2026Lung Cancer0 citations
Semantic Scholar
Statescope: an integrative deconvolution framework for discovering cell states in tumors
J. Janssen, Mischa F. B. Steketee, Aryamaan Bose, Saskia D. van Asten +13 more
2026Nature Communications0 citations Open access
Semantic Scholar
P3.18.16 CROWD: Chemoradiotherapy With Surgery Followed by Consolidation Durvalumab for Initially Unresectable Stage III NSCLC
I. Houda, S. Senan, D. Heineman, M. van Dorp +14 more
2025Journal of Thoracic Oncology0 citations Open access
Semantic Scholar
Spatial proteomic analysis of a lung cancer model reveals regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses
M. Cole, P. Anastasiou, Claudia Lee, C. Moore +15 more
2024bioRxiv0 citations Open access
Semantic Scholar
1472: GeoMX spatial transcriptomics of TDLN after chemoradiotherapy and ICI in T3-4N0-1 NSCLC patients
S. Koomen, E. Ulas, A. Vrijmoet, C. Dickhoff +7 more
2024Radiotherapy and Oncology0 citations
Semantic Scholar
1303P Immune-modulating effects on tumor draining lymph nodes following neoadjuvant chemoradiotherapy combined with immunotherapy in patients with T3-4N0-1 NSCLC
E. Ulas, A. Vrijmoet, S. Koomen, I. Houda +8 more
2023Annals of Oncology0 citations Open access
Semantic Scholar
Abstract 6113: Spatially resolved biomarker detection on single cells in TRACERx using multiplex imaging
M. Angelova, K. Enfield, A. Magness, Emma C. Colliver +11 more
2022Cancer Research0 citations
Semantic Scholar
Targeting oncogenic signalling pathways to modulate the lung cancer immune microenvironment
F. van Maldegem, E. Mugarza, M. Molina-Arcas, K. Valand +6 more
20200 citations
Semantic Scholar
Abstract A145: Study of mechanisms of immune evasion of oncogenic KRAS in NSCLC
E. Mugarza, F. van Maldegem, M. Sopena, M. M. Arcas +1 more
2019Maintenance of Immune Balance: Effects of Targeted and Immune Therapies0 citations
Semantic Scholar
Abstract A160: Deep immunoprofiling of mouse lung cancer models in steady state and upon drug treatment.
F. van Maldegem, Karishma Valand, V. Tsang, E. Mugarza +3 more
2019Maintenance of Immune Balance: Effects of Targeted and Immune Therapies0 citations
Semantic Scholar
environment switched immunoglobulins and develop in a T helper type 2 inflammatory The majority of cutaneous marginal zone B cell lymphomas express class
F. van Maldegem, R. V. van Dijk, P. Kluin, R. Willemze
20130 citations
Semantic Scholar
Chronic Inflammatory Disease, Lymphoid Tissue Neogenesis and Extranodal Marginal Zone B-cell Lymphomas Early Release Paper Review Article
R. J. Bende, F. van Maldegem, C. V. van Noesel, Bende Rj
20090 citations
Semantic Scholar
Immunoglobulin gene alterations in normal and neoplastic B cells
F. van Maldegem
20090 citations
Semantic Scholar
Neuroblastoma, developmental control genes and cell fate decisions in the sympathetic nervous system
V. van Limpt, A. Chan, U. Nuber, F. van Maldegem +7 more
20070 citations
Semantic Scholar
Immunoglobulin gene alterations in the progression of B cell lymphomas
L. Smit, F. van Maldegem, A. Langerak, E. van der Schoot +5 more
0 citations
Semantic Scholar
UvA-DARE (Digital Academic Repository) Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas
R. J. Bende, F. van Maldegem, C. V. van Noesel
0 citations
Semantic Scholar

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