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A. Langerak · SciRah

Researcher profile · Semantic Scholar

A. Langerak

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A. Langerak — researcher profile on SciRah

h-index: 63
Works: 339
Citations: 15K

Most-cited papers

Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions.
K. Fischer, O. Al-Sawaf, J. Bahlo, A. Fink +28 more
2019New England Journal of Medicine754 citations
Semantic Scholar
Fixed Duration of Venetoclax-Rituximab in Relapsed/Refractory Chronic Lymphocytic Leukemia Eradicates Minimal Residual Disease and Prolongs Survival: Post-Treatment Follow-Up of the MURANO Phase III Study.
A. Kater, J. Seymour, P. Hillmen, B. Eichhorst +11 more
2019Journal of Clinical Oncology276 citations Open access
Semantic Scholar
Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study
M. Brüggemann, M. Kotrová, H. Knecht, J. Bartram +33 more
2019Leukemia233 citations Open access
Semantic Scholar
Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL.
A. Agathangelidis, A. Chatzidimitriou, Katerina Gemenetzi, V. Giudicelli +79 more
2020Blood116 citations Open access
Semantic Scholar
Next-generation sequencing of immunoglobulin gene rearrangements for clonality assessment: a technical feasibility study by EuroClonality-NGS
B. Scheijen, R. Meijers, J. Rijntjes, M. Y. van der Klift +16 more
2019Leukemia106 citations Open access
Semantic Scholar
Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: the 2022 update of the recommendations by ERIC, the European Research Initiative on CLL
A. Agathangelidis, A. Chatzidimitriou, T. Chatzikonstantinou, C. Tresoldi +9 more
2022Leukemia83 citations Open access
Semantic Scholar
Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS
H. Knecht, T. Reigl, M. Kotrová, F. Appelt +30 more
2019Leukemia77 citations Open access
Semantic Scholar
ACVIM consensus statement guidelines on diagnosing and distinguishing low‐grade neoplastic from inflammatory lymphocytic chronic enteropathies in cats
S. Marsilio, V. Freiche, Eric G. Johnson, C. Leo +3 more
2023Journal of Veterinary Internal Medicine69 citations Open access
Semantic Scholar
Validation of the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders.
J. Stewart, J. Gazdová, N. Darzentas, D. Wren +30 more
2021Blood Advances47 citations
Semantic Scholar
High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis
P. M. Kolijn, Fatemeh Saberi Hosnijeh, Florentin Späth, P. Hengeveld +20 more
2021Blood45 citations Open access
Semantic Scholar
Risk of second primary malignancies in patients with chronic lymphocytic leukemia: a population-based study in the Netherlands, 1989-2019
L. van der Straten, M. Levin, M. Dinnessen, O. Visser +5 more
2023Blood Cancer Journal40 citations Open access
Semantic Scholar
NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol
M. Svatoň, Aneta Skotnicova, L. Reznickova, Andrea Rennerova +10 more
2022Blood37 citations Open access
Semantic Scholar
Immunoglobulin gene analysis in chronic lymphocytic leukemia in the era of next generation sequencing
F. Davi, A. Langerak, A. D. de Septenville, P. M. Kolijn +7 more
2020Leukemia36 citations Open access
Semantic Scholar
Anti-TRBC1 Antibody-Based Flow Cytometric Detection of T-Cell Clonality: Standardization of Sample Preparation and Diagnostic Implementation
Noemí Muñoz-García, M. Lima, N. Villamor, F. Morán-Plata +11 more
2021Cancers33 citations Open access
Semantic Scholar
Prognostic value of MRD in CLL patients with comorbidities receiving chlorambucil plus obinutuzumab or rituximab.
A. Langerak, M. Ritgen, V. Goede, S. Robrecht +15 more
2019Blood33 citations Open access
Semantic Scholar
Next generation sequencing-based clonality assessment of immunoglobulin gene rearrangements: a multicenter validation study by EuroClonality-NGS.
M. van den Brand, J. Rijntjes, Markus Möbs, Julia Steinhilber +16 more
2021Journal of Molecular Diagnostics30 citations Open access
Semantic Scholar
Quantitative Analysis of Minimal Residual Disease (MRD) Shows High Rates of Undetectable MRD after Fixed-Duration Chemotherapy-Free Treatment and Serves As Surrogate Marker for Progression-Free Survival: A Prospective Analysis of the Randomized CLL14 Trial.
K. Fischer, M. Ritgen, O. Al-Sawaf, S. Robrecht +17 more
2019Blood29 citations Open access
Semantic Scholar
Severe COVID-19 Is Characterised by Perturbations in Plasma Amines Correlated with Immune Response Markers, and Linked to Inflammation and Oxidative Stress
Naama Karu, Alida Kindt, A. V. van Gammeren, A. Ermens +7 more
2022Metabolites28 citations Open access
Semantic Scholar
The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age
Alice F. Muggen, Madelon M. E. de Jong, I. Wolvers-Tettero, M. Kallemeijn +13 more
2019Immunity & Ageing28 citations Open access
Semantic Scholar
Plasma Oxylipins and Their Precursors Are Strongly Associated with COVID-19 Severity and with Immune Response Markers
Naama Karu, Alida Kindt, L. Lamont, A. V. van Gammeren +8 more
2022Metabolites26 citations Open access
Semantic Scholar
Adult-Onset Autoimmune Enteropathy in an European Tertiary Referral Center
R. V. van Wanrooij, E. A. Neefjes-Borst, H. Bontkes, M. Schreurs +3 more
2021Clinical and Translational Gastroenterology26 citations Open access
Semantic Scholar
Rapid Low-Cost Microarray-Based Genotyping for Genetic Screening in Primary Immunodeficiency
Narissara Suratannon, R. V. van Wijck, L. Broer, Lai-Xi Xue +16 more
2020Frontiers in Immunology25 citations Open access
Semantic Scholar
Combined cellular and soluble mediator analysis for improved diagnosis of vitreoretinal lymphoma
J. de Hoog, W. A. Dik, Lucy Lu, Kim C. Heezen +7 more
2019Acta ophthalmologica25 citations Open access
Semantic Scholar
Fixed-duration venetoclax plus obinutuzumab improves quality of life and geriatric impairments in FCR-unfit CLL patients.
L. van der Straten, C. Stege, S. Kersting, K. Nasserinejad +30 more
2023Blood24 citations Open access
Semantic Scholar
BRAF V600E is associated with higher incidence of second cancers in adults with Langerhans cell histiocytosis.
Aldo A. Acosta-Medina, P. Kemps, T. Zondag, J. Abeykoon +35 more
2023Blood23 citations Open access
Semantic Scholar
Immune dysregulation as a leading principle for lymphoma development in diverse immunological backgrounds.
P. M. Kolijn, A. Langerak
2023Immunology Letters22 citations Open access
Semantic Scholar
Detecting measurable residual disease beyond 10-4 through an IGHV leader-based NGS approach improves prognostic stratification in CLL.
P. Hengeveld, M. Y. van der Klift, P. M. Kolijn, F. Davi +12 more
2022Blood22 citations Open access
Semantic Scholar
A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation
M. Betjes, A. Langerak, M. Klepper, N. Litjens
2020Immunity & Ageing22 citations Open access
Semantic Scholar
Reading the B cell receptor Immunome in Chronic Lymphocytic Leukemia: Revelations and Applications.
P. Hengeveld, M. Levin, P. M. Kolijn, A. Langerak
2020Experimental Hematology19 citations Open access
Semantic Scholar
HIGH-THROUGHPUT IMMUNOGENETICS FOR PRECISION MEDICINE IN CANCER.
A. Agathangelidis, E. Vlachonikola, F. Davi, A. Langerak +1 more
2021Seminars in Cancer Biology18 citations Open access
Semantic Scholar
miR-181a is a novel player in the STAT3-mediated survival network of TCRαβ+ CD8+ T large granular lymphocyte leukemia
J. Assmann, L. G. León, Christiaan J. Stavast, Sanne E. van den Bogaerdt +7 more
2021Leukemia18 citations Open access
Semantic Scholar
A New and Simple TRG Multiplex PCR Assay for Assessment of T-cell Clonality: A Comparative Study from the EuroClonality Consortium
M. Armand, C. Derrieux, K. Beldjord, Tamara Wabeke +11 more
2019HemaSphere17 citations Open access
Semantic Scholar
Blood cell counts and lymphocyte subsets of patients admitted during the COVID‐19 pandemic: a prospective cohort study
P. Hengeveld, Aaram O. Khader, L. D. de Bruin, I. Geelen +8 more
2020British Journal of Haematology16 citations Open access
Semantic Scholar
Extensive longitudinal immune profiling reveals sustained innate immune activaton in COVID-19 patients with unfavorable outcome
B. Schrijver, J. Assmann, A. V. van Gammeren, R. Vermeulen +6 more
2020European Cytokine Network14 citations Open access
Semantic Scholar
EuroClonality-NGS recommendations for evaluation of B cell clonality analysis by next-generation sequencing - a structured approach with the DEPART algorithm.
M. van den Brand, Markus Möbs, F. Otto, L. Kroeze +13 more
2023Journal of Molecular Diagnostics13 citations Open access
Semantic Scholar
Association of Altered Plasma Lipidome with Disease Severity in COVID-19 Patients
Zheng-Zheng Zhang, Naama Karu, Alida Kindt, Madhulika Singh +10 more
2024Biomolecules12 citations Open access
Semantic Scholar
The miR-200c/141-ZEB2-TGFb axis is aberrant in human T-cell prolymphocytic leukemia
S. Erkeland, Christiaan J. Stavast, J. Schilperoord-Vermeulen, G. Dal Collo +11 more
2021Haematologica12 citations Open access
Semantic Scholar
Clonotype definitions for immunogenetic studies: proposals from the EuroClonality NGS Working Group
E. Sofou, E. Vlachonikola, L. Zaragoza-Infante, M. Brüggemann +8 more
2023Leukemia10 citations Open access
Semantic Scholar
Long-term trends in the loss in expectation of life after a diagnosis of chronic lymphocytic leukemia: a population-based study in the Netherlands, 1989–2018
L. van der Straten, C. Maas, M. Levin, O. Visser +5 more
2022Blood Cancer Journal10 citations Open access
Semantic Scholar
Extranodal marginal zone lymphoma clonotypes are detectable prior to eMZL diagnosis in tissue biopsies and peripheral blood of Sjögren’s syndrome patients through immunogenetics
P. M. Kolijn, E. Huijser, M. J. Wahadat, C. V. van Helden-Meeuwsen +8 more
2023Frontiers in Oncology9 citations Open access
Semantic Scholar
Treatment Approaches to Chronic Lymphocytic Leukemia With High-Risk Molecular Features
L. van der Straten, P. Hengeveld, A. Kater, A. Langerak +1 more
2021Frontiers in Oncology9 citations Open access
Semantic Scholar
PCR GeneScan and Heteroduplex Analysis of Rearranged Immunoglobulin or T-Cell Receptor Genes for Clonality Diagnostics in Suspect Lymphoproliferations.
E. Boone, Kim C. Heezen, P. Groenen, A. Langerak
2019Methods in molecular biology9 citations
Semantic Scholar
Genetic drivers in the natural history of chronic lymphocytic leukemia development as early as 16 years before diagnosis
P. M. Kolijn, Florentin Späth, M. Khouja, P. Hengeveld +7 more
2023Blood8 citations Open access
Semantic Scholar
Targeted multiomics in childhood-onset SLE reveal distinct biological phenotypes associated with disease activity: results from an explorative study
M. J. Wahadat, S. V. van Tilburg, Yvonne M. Mueller, H. D. de Wit +8 more
2023Lupus Science and Medicine8 citations Open access
Semantic Scholar
Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development
Fatemeh Saberi Hosnijeh, P. Kolijn, D. Casabonne, A. Nieters +26 more
2020Scientific Reports8 citations Open access
Semantic Scholar
Immunoglobulin heavy variable somatic hyper mutation status in chronic lymphocytic leukaemia: on the threshold of a new era?
A. Langerak, F. Davi, K. Stamatopoulos
2020British Journal of Haematology8 citations Open access
Semantic Scholar
Multiple immunoglobulin kappa rearrangements within a single clone unraveled by NGS-based clonality assessment.
A. M. Leenders, L. Kroeze, J. Rijntjes, J. Luijks +5 more
2021Journal of Molecular Diagnostics7 citations Open access
Semantic Scholar
Proteomic markers with prognostic impact on outcome of chronic lymphocytic leukemia patients under chemo-immunotherapy; results from the HOVON 109 study.
Fatemeh Saberi Hosnijeh, L. van der Straten, A. Kater, M. V. van Oers +18 more
2020Experimental Hematology7 citations Open access
Semantic Scholar
Novel Flow Cytometric Antibody Panel and Dedicated Analysis Algorithm for Automated Fully Standardized Minimal Residual Disease Detection in Chronic Lymphocytic Leukemia
Robby Engelmann, J. Flores-Montero, J. Schilperoord-Vermeulen, M. Ritgen +13 more
2025American journal of hematology/oncology6 citations Open access
Semantic Scholar
Clinicobiological characteristics and treatment efficacy of novel agents in chronic lymphocytic leukemia with IGLV3-21R110
P. Hengeveld, Y. E. Ertem, J. Dubois, C. Mellink +13 more
2022Leukemia6 citations Open access
Semantic Scholar

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