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D. Dauch · SciRah

Researcher profile · Semantic Scholar

D. Dauch

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D. Dauch — researcher profile on SciRah

h-index: 22
Works: 55
Citations: 4,299

Most-cited papers

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
T. Kang, T. Yevsa, N. Woller, L. Hoenicke +21 more
2011Nature1,528 citations
Semantic Scholar
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
Mohsen Malehmir, D. Pfister, S. Gallage, M. Szydlowska +63 more
2019Nature Medicine382 citations Open access
Semantic Scholar
A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage.
Jianwei Wang, Qianmei Sun, Yohei Morita, Hong Jiang +16 more
2014Cell333 citations Open access
Semantic Scholar
Cardiac glycosides are broad-spectrum senolytics
Ana Guerrero, Nicolás Herranz, Bin Sun, Verena Wagner +22 more
2019Nature Metabolism313 citations Open access
Semantic Scholar
In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer
R. Rudalska, D. Dauch, T. Longerich, K. McJunkin +17 more
2014Nature Medicine282 citations Open access
Semantic Scholar
A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer
D. Dauch, R. Rudalska, G. Cossa, J. Nault +15 more
2016Nature Medicine263 citations
Semantic Scholar
A critical role for notch signaling in the formation of cholangiocellular carcinomas.
S. Zender, Irina Nickeleit, T. Wuestefeld, Inga Sörensen +11 more
2013Cancer Cell175 citations Open access
Semantic Scholar
A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration.
T. Wuestefeld, M. Pesic, R. Rudalska, D. Dauch +19 more
2013Cell155 citations Open access
Semantic Scholar
IGF2 Is Up-regulated by Epigenetic Mechanisms in Hepatocellular Carcinomas and Is an Actionable Oncogene Product in Experimental Models
Iris Martinez-Quetglas, R. Pinyol, D. Dauch, S. Torrecilla +12 more
2016Gastroenterology116 citations Open access
Semantic Scholar
Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours
E. Brenner, B. Schörg, Fatima Ahmetlić, T. Wieder +31 more
2020Nature Communications114 citations Open access
Semantic Scholar
Assessment of mutation probabilities of KRAS G12 missense mutants and their long-timescale dynamics by atomistic molecular simulations and Markov state modeling
Tatu Pantsar, S. Rissanen, D. Dauch, T. Laitinen +2 more
2018PLoS Comput. Biol.75 citations Open access
Semantic Scholar
Spatial Tissue Proteomics Quantifies Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma (HCC)
Katarzyna Buczak, A. Ori, Joanna M. Kirkpatrick, K. Holzer +11 more
2018Molecular & Cellular Proteomics69 citations Open access
Semantic Scholar
LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer
R. Rudalska, Jule Harbig, M. Snaebjornsson, S. Klotz +22 more
2021Nature Cancer57 citations
Semantic Scholar
A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas.
S. Zender, Irina Nickeleit, T. Wuestefeld, Inga Sörensen +11 more
2013Cancer Cell50 citations Open access
Semantic Scholar
Nucleoporin Nup155 is part of the p53 network in liver cancer
K. Holzer, A. Ori, A. Cooke, D. Dauch +15 more
2019Nature Communications48 citations Open access
Semantic Scholar
Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation
M. Snaebjornsson, Philipp Poeller, D. Komkova, F. Röhrig +14 more
2025Nature Metabolism38 citations Open access
Semantic Scholar
MYC determines lineage commitment in Kras driven primary liver cancer development
L. D’Artista, Athina A. Moschopoulou, I. Barozzi, Amanda J. Craig +16 more
2023Journal of Hepatology35 citations Open access
Semantic Scholar
Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer.
K. Holzer, Elisabeth Drucker, S. Roessler, D. Dauch +9 more
2017American Journal of Pathology35 citations Open access
Semantic Scholar
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.
Jian-Wei Wang, Qiang Sun, Yohei Morita, Hong Jiang +16 more
2012Cell35 citations Open access
Semantic Scholar
Prosurvival function of the cellular apoptosis susceptibility/importin‐α1 transport cycle is repressed by p53 in liver cancer
J. Winkler, A. Ori, K. Holzer, C. Sticht +14 more
2014Hepatology34 citations Open access
Semantic Scholar
Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine.
Heike K Wentsch, N. Walter, M. Buhrmann, S. Mayer-Wrangowski +8 more
2017Angewandte Chemie28 citations
Semantic Scholar
Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity.
Rômulo Silva de Oliveira, Amy J. Shupe, Tim Krause, Timmy Richardo +12 more
2025Cell Reports23 citations Open access
Semantic Scholar
Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles.
Moritz Schwarz, Maksym Kurkunov, Florian Wittlinger, R. Rudalska +8 more
2024Journal of Medicinal Chemistry22 citations Open access
Semantic Scholar
Selective targeting of the αC and DFG-out pocket in p38 MAPK.
Sandra Röhm, Martin Schröder, J. Dwyer, C. Widdowson +10 more
2020European journal of medicinal chemistry20 citations Open access
Semantic Scholar
First-in-class ultralong-target-residence-time p38α inhibitors as a mitosis-targeted therapy for colorectal cancer
R. Rudalska, Jule Harbig, Michael Forster, Pascal Woelffing +24 more
2025Nature Cancer16 citations Open access
Semantic Scholar
HELLS Is Negatively Regulated by Wild-Type P53 in Liver Cancer by a Mechanism Involving P21 and FOXM1
S. Schuller, John H. Sieker, P. Riemenschneider, Bianca Köhler +12 more
2022Cancers14 citations Open access
Semantic Scholar
Design and Optimization of Novel Benzimidazole- and Imidazo[4,5-b]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities.
Teodor Dimitrov, Athina A. Moschopoulou, L. Seidel, Thales Kronenberger +10 more
2023Journal of Medicinal Chemistry10 citations Open access
Semantic Scholar
Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
Mohsen Malehmir, D. Pfister, S. Gallage, M. Szydlowska +63 more
2022Nature Medicine8 citations Open access
Semantic Scholar
Exploiting lipotoxicity for the treatment of liver cancer
R. Rudalska, L. Zender, D. Dauch
2021British Journal of Cancer8 citations Open access
Semantic Scholar
Actionable heterogeneity of hepatocellular carcinoma therapy-induced senescence
Pujan Engels, András Szolek, Sebastian Hörner, Georgios Vavouras Syrigos +14 more
2025Cancer Immunology and Immunotherapy7 citations Open access
Semantic Scholar
Uncovering α-Selectivity for Liver X Receptor Agonists for Lipotoxic Cancer Therapies
J. Pedreira, Pascal Woelffing, Moritz Schwarz, S. Ebner +13 more
2025Journal of Medicinal Chemistry4 citations Open access
Semantic Scholar
Adenosine Receptor 3 in Liver Cancer: Expression Variability, Epigenetic Modulation, and Enhanced Histone Deacetylase Inhibitor Effects
Louise Kaldjob-Heinrich, S. Nuciforo, Steffen Lemke, Aaron Stahl +17 more
2024Gastro Hep Advances4 citations
Semantic Scholar
Optimierte Bindungsdauer am Zielenzym: Typ-I1/2 -Inhibitoren der p38α-MAP-Kinase mit verbesserter Bindungskinetik durch direkte Interaktion mit der R-Spine
Heike K Wentsch, N. Walter, Mike Bührmann, S. Mayer-Wrangowski +8 more
20172 citations
Semantic Scholar
Exploiting Kinase Inhibitors for Cancer Treatment: An Overview of Clinical Results and Outlook
Athina A. Moschopoulou, Stefan Zwirner, L. Zender, D. Dauch
20201 citations
Semantic Scholar
Re-Expression of Fetal Igf2 as Epidriver and Target for Therapy in Hcc
Iris Martinez-Quetglas, R. Pinyol, D. Dauch, S. Torrecilla +11 more
20161 citations
Semantic Scholar
P0265 : IGF2 is an oncogenic driver in HCC and emerges as a potential target for therapies
Iris Martinez-Quetglas, R. Pinyol, D. Dauch, A. Portela +7 more
20151 citations
Semantic Scholar
Über die Bindungsstelle hinausgedacht: Ein sich selbsteinkapselnder Kinase‐Inhibitor modelliert seine Bindetasche und erzielt so Selektivität
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham +17 more
2026Angewandte Chemie0 citations Open access
Semantic Scholar
Thinking Outside the Binding Site: A Self-Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity.
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham +17 more
2026Angewandte Chemie0 citations Open access
Semantic Scholar
Abstract 6419: Stress-induced intratumoral senescence matrix shifts cancer evolution towards metastasis
Omelyan Trompak, Svenja A. Schütte, Jorge Abreu Macedo, Sophia Scheuermann +30 more
2025Cancer Research0 citations
Semantic Scholar
Characterization of selinexor response/resistance in hepatocellular carcinoma
K. Holzer, V. Hollfoth, P. Riemenschneider, Sven Mattern +4 more
202440. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber0 citations
Semantic Scholar
Abstract 3063: Defining oncogene-specific metabolic vulnerabilities in a mouse model of hepatocellular carcinoma
Kamal M. Al-Shami, M. Snaebjornsson, Felix C. E. Vogel, Lisa Schlicker +3 more
2024Cancer Research0 citations
Semantic Scholar
Abstract 4478: Development and characterization of kinase sparing TPX2-tethering Aurora kinase A ligands for cancer therapy
Athina A. Moschopoulou, Melanie Henning, Benedikt Wagner, Dirk Flötgen +18 more
2024Cancer Research0 citations
Semantic Scholar
HELLS is an important p53 repression target in liver cancer
J. Sieker, S. Schuller, Elisabeth Drucker, P. Riemenschneider +5 more
2020Zeitschrift für Gastroenterologie - German Journal of Gastroenterology0 citations
Semantic Scholar
Abstract 4377: Liver X receptor mediated lipotoxicity represents a treatment option for liver cancer
R. Rudalska, Jule Harbig, Marteinn Snaebjoernsson, L. Taranets +14 more
2019Molecular and Cellular Biology / Genetics0 citations
Semantic Scholar
Guanine monophosphate synthetase (GMPS) is an important target of p53-mediated repression in liver cancer
K. Holzer, Elisabeth Drucker, S. Roessler, N. Waldburger +8 more
2016Zeitschrift für Gastroenterologie - German Journal of Gastroenterology0 citations
Semantic Scholar
TITLE : IGF 2 is up-regulated by epigenetic mechanisms in hepatocellular 1 carcinoma and is an actionable oncogene in experimental models
Iris Martinez-Quetglas, R. Pinyol, D. Dauch, S. Torrecilla +13 more
20160 citations
Semantic Scholar
Abstract 3820: Epigenetic re-expression of fetal IGF2 as therapeutic target in hepatocellular carcinoma
Iris Martinez-Quetglas, R. Pinyol, D. Dauch, S. Torrecilla +8 more
20160 citations
Semantic Scholar
466 IGF2 drives IGF oncogenic signaling in HCC and emerges as a potential target for therapies
I. Quetglas, R. Pinyol, D. Dauch, A. Portela +9 more
20140 citations
Semantic Scholar
In vivo RNAi screening identified MKK4 as a new therapeutic target for the improvement of liver regeneration
T. Wuestefeld, M. Pesic, T. Longerich, T. Kang +15 more
20130 citations
Semantic Scholar
Multiplex in vivo RNAi screening instructs combination therapies to increase the therapeutic efficacy of the multikinase inhibitor sorafenib
R. Rudalska, D. Dauch, K. McJunkin, T. Kang +7 more
20130 citations
Semantic Scholar

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