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P. Garzone · SciRah

Researcher profile · Semantic Scholar

P. Garzone

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P. Garzone — researcher profile on SciRah

h-index: 14
Works: 35
Citations: 1,024

Most-cited papers

Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9*
J. Chaparro-Riggers, Hong Liang, Rachel M. Devay, Lanfang Bai +15 more
2012Journal of Biological Chemistry176 citations Open access
Semantic Scholar
Pharmacokinetics of the Newer Benzodiazepines
P. Garzone, P. Kroboth
1989Clinical Pharmacokinetics159 citations
Semantic Scholar
Poly-(L)-glutamic acid-paclitaxel (CT-2103) [XYOTAX], a biodegradable polymeric drug conjugate: characterization, preclinical pharmacology, and preliminary clinical data.
J. Singer, B. Baker, P. D. de Vries, Anil M. Kumar +4 more
2003Advances in Experimental Medicine and Biology144 citations
Semantic Scholar
Clinical evaluation of recombinant factor IX.
Gilbert C. White, Amy D. Shapiro, M. Ragni, P. Garzone +3 more
1998Seminars in hematology (Print)106 citations
Semantic Scholar
Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program
M. Bigal, R. Escandon, M. Bronson, Sarah Walter +3 more
2014Cephalalgia94 citations Open access
Semantic Scholar
Third-Generation and Investigational Cephalosporins: I. Structure-Activity Relationships and Pharmacokinetic Review
P. Garzone, J. Lyon, Victor L. Yu
1983Drug Intelligence & Clinical Pharmacy38 citations
Semantic Scholar
Immunomodulatory activity of humanized anti-IL-7R monoclonal antibody RN168 in subjects with type 1 diabetes.
K. Herold, Samantha Bucktrout, Xiao Wang, B. Bode +14 more
2019JCI Insight36 citations Open access
Semantic Scholar
Third-Generation and Investigational Cephalosporins: II. Microbiologic Review and Clinical Summaries
P. Garzone, J. Lyon, Victor L. Yu
1983Drug Intelligence & Clinical Pharmacy32 citations
Semantic Scholar
First in human (FIH) study of an OX40 agonist monoclonal antibody (mAb) PF-04518600 (PF-8600) in adult patients (pts) with select advanced solid tumors: Preliminary safety and pharmacokinetic (PK)/pharmacodynamic results.
O. Hamid, John A. Thompson, A. Diab, W. Ros +13 more
201627 citations
Semantic Scholar
Comparison of the spectrum of cognitive effects of alprazolam and adinazolam after single doses in healthy subjects
J. Fleishaker, P. Garzone, J. H. Chambers, K. Sirocco +1 more
1995Psychopharmacology19 citations
Semantic Scholar
Abstract 13322: The Effects of Single Dose Administration of RN316 (PF-04950615), a Humanized IgG2a Monoclonal Antibody Binding Proprotein Convertase Subtilisin Kexin Type 9, in Hypercholesterolemic Subjects Treated with and without Atorvastatin
B. Gumbiner, C. Udata, T. Joh, Hong Liang +7 more
201218 citations
Semantic Scholar
Abstract 13524: The Effects of Multiple Dose Administration of RN316 (PF-04950615), a Humanized IgG2a Monoclonal Antibody Binding Proprotein Convertase Subtilisin Kexin Type 9, in Hypercholesterolemic Subjects
B. Gumbiner, C. Udata, T. Joh, Hong Liang +7 more
201216 citations
Semantic Scholar
Effects of 12 weeks of treatment with intravenously administered bococizumab, a humanized monoclonal antibody blocking proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects on high‐dose statin
S. Fazio, David G. Robertson, T. Joh, Hong Wan +5 more
2018Cardiovascular Therapeutics15 citations
Semantic Scholar
The effects of single‐ and multiple‐dose administration of bococizumab (RN316/PF‐04950615), a humanized IgG2&Dgr;a monoclonal antibody binding proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects treated with and without atorvastatin: Results from four phase I studies
B. Gumbiner, T. Joh, Hong Liang, Hong Wan +8 more
2018Cardiovascular Therapeutics15 citations Open access
Semantic Scholar
Molecular Characterization of Familial Hypercholesterolemia in a North American Cohort.
A. Garg, S. Fazio, P. Duell, A. Baass +9 more
2019Journal of the Endocrine Society14 citations Open access
Semantic Scholar
Pharmacokinetic Profile of Orally Administered Scyllo‐Inositol (Elnd005) in Plasma, Cerebrospinal Fluid and Brain, and Corresponding Effect on Amyloid‐Beta in Healthy Subjects
Earvin Liang, P. Garzone, J. Cedarbaum, M. Koller +7 more
2013Clinical pharmacology in drug development13 citations
Semantic Scholar
Model-Based Characterization of the Pharmacokinetics, Target Engagement Biomarkers, and Immunomodulatory Activity of PF-06342674, a Humanized mAb Against IL-7 Receptor-α, in Adults with Type 1 Diabetes
Jason H. Williams, C. Udata, B. Ganguly, Samantha Bucktrout +6 more
2020AAPS Journal12 citations Open access
Semantic Scholar
Single and multiple ascending-dose study of glucagon-receptor antagonist RN909 in type 2 diabetes: a phase 1, randomized, double-blind, placebo-controlled trial
B. Gumbiner, B. Esteves, V. Dell, T. Joh +3 more
2018Endocrine12 citations
Semantic Scholar
Effects of Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibition with Bococizumab on Lipoprotein Particles in Hypercholesterolemic Subjects.
Hong Wan, B. Gumbiner, T. Joh, Tom Riel +3 more
2017Clinical Therapeutics12 citations
Semantic Scholar
P2‐213: Oral amyloid anti‐aggregating agent ELND005 is measurable in CSF and brain of healthy adult men
P. Garzone, M. Koller, A. Pastrak, S. Jhee +5 more
200912 citations
Semantic Scholar
A Mechanism‐Based Pharmacokinetic/Pharmacodynamic Model for Bococizumab, a Humanized Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, and Its Application in Early Clinical Development
C. Udata, P. Garzone, B. Gumbiner, T. Joh +4 more
2017Journal of clinical pharmacology11 citations
Semantic Scholar
Preclinical studies of recombinant factor IX.
R. Schaub, P. Garzone, P. Bouchard, B. Rup +3 more
1998Seminars in hematology (Print)11 citations
Semantic Scholar
Phase I study of CCW702, a bispecific small molecule-antibody conjugate targeting PSMA and CD3 in patients with metastatic castration-resistant prostate cancer (mCRPC).
M. Markowski, D. Kilari, M. Eisenberger, R. McKay +6 more
20218 citations
Semantic Scholar
Steady‐state moxalactam kinetics: Comparisons with other cephalosporins
P. Garzone, J. Lyon, Victor L. Yu, J. Zuravleff +2 more
1981Clinical pharmacology and therapy8 citations
Semantic Scholar
EFFECTS OF RN316 (PF-04950615), A HUMANIZED IGG2ΔA MONOCLONAL ANTIBODY BINDING PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9, ON LIPOPROTEIN PARTICLES IN HYPERCHOLESTEROLEMIC SUBJECTS
Hong Wan, B. Gumbiner, T. Joh, C. Udata +2 more
20134 citations Open access
Semantic Scholar
Clinical pharmacology assessment of PF-06647020 (PF-7020), an antibody-drug conjugate (ADC) targeting protein tyrosine kinase 7 (PTK7), in adult patients (pts) with advanced solid tumors.
D. Xuan, Xiaohua Xin, B. Gibson, T. Joh +12 more
20183 citations
Semantic Scholar
Pharmacokinetics and pharmacodynamics of bapineuzumab following multiple intravenous infusions in patients with mild-to-moderate Alzheimer's disease
M. Raskind, Earvin Liang, R. Sperling, A. Boxer +6 more
2009Alzheimer's & Dementia3 citations
Semantic Scholar
P-219 Preliminary clinical and pharmacokinetic data for CT-2103 (Xyotax™) in patients with non-small cell lung cancer (NSCLC)
H. Burris, D. Shipley, A. Greco, S. Jones +3 more
20033 citations
Semantic Scholar
Phase I, Masked, Placebo-Controlled, Single and Multiple Ascending Intravenous Dose Studies Evaluating Systemic and Ocular Safety, Tolerability, and Visual Acuity Effects of RN6G (PF-04382923) in Subjects with Dry, Age-Related Macular Degeneration (ARMD)
B. Berger, P. Garzone, Ivana Gunderson, P. Fanning +4 more
20132 citations
Semantic Scholar
Chapter 34 – Pharmacokinetic and Pharmacodynamic Considerations in the Development of Biotechnology Products and Large Molecules
P. Garzone
20121 citations
Semantic Scholar
Contributors
D. Abernethy, B. Agoram, John M. Allen, Mark E. Arnold +82 more
2022Atkinson's Principles of Clinical Pharmacology0 citations
Semantic Scholar
672 Phase I clinical trial of autologous T-cells genetically engineered with a chimeric receptor to target the follicle-stimulating hormone receptor (FSHR) in patients with recurrent ovarian cancer (OVCA)
R. Wenham, M. Davila, Daniel Abate-Daga, M. McGettigan +5 more
2022Regular and Young Investigator Award Abstracts0 citations Open access
Semantic Scholar
An investigational therapy for geographic atrophy in age-related macular degeneration
B. Berger, Ivana Gunderson, C. B. Rickman, J. Lin +1 more
20140 citations
Semantic Scholar
A Mechanism-Based Binding Model for the Pharmacokinetics and Pharmacodynamics (PK-PD) of RN6G (PF-04382923), a Humanized Monoclonal Antibody against Amyloid β Peptides, in Subjects with Dry, Age-Related Macular Degeneration Including Geographic Atrophy
Kai H. Liao, P. Garzone, S. Bollini, P. Fanning +2 more
20130 citations
Semantic Scholar
Pharmacokinetic and Pharmacodynamic Considerations in the Development of Biotechnology Products and Large Molecules
P. Garzone
20070 citations
Semantic Scholar

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