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B. Rup · SciRah

Researcher profile · Semantic Scholar

B. Rup

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B. Rup — researcher profile on SciRah

h-index: 23
Works: 41
Citations: 2,241

Most-cited papers

Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products.
E. Koren, Holly W. Smith, E. Shores, G. Shankar +14 more
2008JIM - Journal of Immunological Methods331 citations
Semantic Scholar
Immunogenicity of biologically-derived therapeutics: assessment and interpretation of nonclinical safety studies.
R. Ponce, L. Abad, L. Amaravadi, T. Gelzleichter +14 more
2009Regulatory toxicology and pharmacology : RTP252 citations
Semantic Scholar
Recommendations for the design, optimization, and qualification of cell-based assays used for the detection of neutralizing antibody responses elicited to biological therapeutics.
Shalini Gupta, S. Indelicato, Vijay Jethwa, T. Kawabata +7 more
2007JIM - Journal of Immunological Methods223 citations
Semantic Scholar
Recommendations for the validation of cell-based assays used for the detection of neutralizing antibody immune responses elicited against biological therapeutics.
Shalini Gupta, V. Devanarayan, D. Finco, G. Gunn +5 more
2011Journal of Pharmaceutical and Biomedical Analysis130 citations
Semantic Scholar
Pegunigalsidase alfa, a novel PEGylated enzyme replacement therapy for Fabry disease, provides sustained plasma concentrations and favorable pharmacodynamics: A 1‐year Phase 1/2 clinical trial
R. Schiffmann, O. Goker-Alpan, M. Holida, P. Giraldo +17 more
2019Journal of Inherited Metabolic Disease117 citations Open access
Semantic Scholar
Human recombinant factor IX: safety and efficacy studies in hemophilia B patients previously treated with plasma-derived factor IX concentrates.
D. A. Roth, C. Kessler, K. Pasi, B. Rup +2 more
2001Blood112 citations
Semantic Scholar
Standardizing terms, definitions and concepts for describing and interpreting unwanted immunogenicity of biopharmaceuticals: recommendations of the Innovative Medicines Initiative ABIRISK consortium
B. Rup, M. Pallardy, D. Sikkema, T. Albert +30 more
2015Clinical and Experimental Immunology86 citations Open access
Semantic Scholar
Coupling of Aggregation and Immunogenicity in Biotherapeutics: T- and B-Cell Immune Epitopes May Contain Aggregation-Prone Regions
Sandeep Kumar, S. Singh, Xiaoling Wang, B. Rup +1 more
2011Pharmaceutical Research86 citations
Semantic Scholar
Avian reticuloendotheliosis virus: identification of the hematopoietic target cell for transformation.
Robert B. Lewis, J. Mcclure, B. Rup, David W. Niesel +4 more
1981Cell86 citations
Semantic Scholar
Expression of bone morphogenetic proteins in human osteosarcoma. Immunohistochemical detection with monoclonal antibody
H. Yoshikawa, W. Rettig, K. Takaoka, E. Alderman +6 more
1994Cancer77 citations Open access
Semantic Scholar
Therapeutic outcomes, assessments, risk factors and mitigation efforts of immunogenicity of therapeutic protein products.
Liusong Yin, Xiao-Ying Chen, P. Vicini, B. Rup +1 more
2015Cellular Immunology76 citations
Semantic Scholar
Immunohistochemical detection of bone morphogenetic proteins in bone and soft‐tissue sarcomas
H. Yoshikawa, W. Rettig, J. M. Lane, K. Takaoka +6 more
1994Cancer76 citations Open access
Semantic Scholar
Contribution of enhanced engagement of antigen presentation machinery to the clinical immunogenicity of a human interleukin (IL)‐21 receptor‐blocking therapeutic antibody
L. Xue, Timothy P. Hickling, R. Song, J. Nowak +1 more
2016Clinical and Experimental Immunology62 citations Open access
Semantic Scholar
Critical ligand binding reagent preparation/selection: When specificity depends on reagents
B. Rup, Denise M O'Hara
2007AAPS Journal61 citations Open access
Semantic Scholar
Preclinical Models Used for Immunogenicity Prediction of Therapeutic Proteins
V. Brinks, D. Weinbuch, M. Baker, Yann D. Dean +4 more
2013Pharmaceutical Research58 citations
Semantic Scholar
Evaluation of Pre-existing Antibody Presence as a Risk Factor for Posttreatment Anti-drug Antibody Induction: Analysis of Human Clinical Study Data for Multiple Biotherapeutics
L. Xue, B. Rup
2013AAPS Journal57 citations Open access
Semantic Scholar
Helper viruses associated with avian acute leukemia viruses inhibit the cellular immune response.
B. Rup, Jacalyn D. Hoelzer, H. R. Bose
1982Virology53 citations
Semantic Scholar
Immunogenicity of glycans on biotherapeutic drugs produced in plant expression systems—The taliglucerase alfa story
B. Rup, S. Alon, Bat-chen Amit-Cohen, Einat Brill Almon +3 more
2017PLoS ONE48 citations Open access
Semantic Scholar
Immunosuppression induced by avian reticuloendotheliosis virus: mechanism of induction of the suppressor cell.
B. Rup, J. L. Spence, Jacalyn D. Hoelzer, Robert B. Lewis +3 more
1979Journal of Immunology44 citations Open access
Semantic Scholar
Reduced bleeding events with subcutaneous administration of recombinant human factor IX in immune-tolerant hemophilia B dogs.
K. Russell, E. N. Olsen, R. Raymer, E. Merricks +7 more
2003Blood38 citations
Semantic Scholar
Evaluation of Recombinant Human Factor IX: Pharmacokinetic Studies in the Rat and the Dog
James C. Keith, T. Ferranti, B. Misra, T. Frederick +5 more
1995Thrombosis and Haemostasis31 citations
Semantic Scholar
Specificity in the immunosuppression induced by avian reticuloendotheliosis virus
M. Walker, B. Rup, A. S. Rubin, H. R. Bose
1983Infection and Immunity31 citations Open access
Semantic Scholar
Relationship between potential aggregation-prone regions and HLA-DR-binding T-cell immune epitopes: implications for rational design of novel and follow-on therapeutic antibodies.
Sandeep Kumar, M. Mitchell, B. Rup, S. Singh
2012Journal of Pharmacy and Science29 citations Open access
Semantic Scholar
Survey Outcome on Immunogenicity Risk Assessment Tools for Biotherapeutics: an Insight into Consensus on Methods, Application, and Utility in Drug Development
J. Gokemeijer, Yvonne Ying-Ya Wen, V. Jawa, S. Mitra-Kaushik +18 more
2023AAPS Journal21 citations
Semantic Scholar
Intratracheal Administration of Recombinant Human Factor IX (BeneFix™) Achieves Therapeutic Levels in Hemophilia B Dogs
K. Russell, Marjorie S. Read, D. Bellinger, K. Leitermann +6 more
2001Thrombosis and Haemostasis19 citations
Semantic Scholar
Preclinical studies of recombinant factor IX.
R. Schaub, P. Garzone, P. Bouchard, B. Rup +3 more
1998Seminars in hematology (Print)11 citations
Semantic Scholar
Immunogenicity Risk Assessment for an Engineered Human Cytokine Analogue Expressed in Different Cell Substrates
P. Chamberlain, B. Rup
2020AAPS Journal7 citations
Semantic Scholar
Immunogenicity and immune tolerance coagulation Factors VIII and IX.
B. Rup
2003Developments in Biologicals5 citations
Semantic Scholar
Evaluation of Pre-existing Antibody Presence as a Risk Factor for Posttreatment Anti-drug Antibody Induction: Analysis of Human Clinical Study Data for Multiple Biotherapeutics
L. Xue, B. Rup
2013AAPS Journal4 citations Open access
Semantic Scholar
A bridging assay for detection and characterization of anti-drug antibodies to dostarlimab, a new anti-PD-1 therapeutic monoclonal antibody
M. Patterson, L. A. Beausang, B. Rup, R. Bowsher +3 more
20213 citations Open access
Semantic Scholar
VSV replication in normal and transformed T cells, an assay for T suppressor cell activation.
B. Rup, David W. Scott
1987Cellular Immunology3 citations Open access
Semantic Scholar
Production of large numbers of hybridomas producing monoclonal antibodies against rat IgE using mast cell-deficient w/wv and sl/sld strains of mice.
B. Rup
1989JIM - Journal of Immunological Methods2 citations
Semantic Scholar
Role of dextran-specific suppressor T cells in the regulation of the immune response by a reactive form of dextran.
B. Rup, David W. Scott
1987Cellular Immunology2 citations
Semantic Scholar
Immune responses to recombinant factor IX (BeneFIX) and recombinant B domain deleted factor VIII (ReFacto).
B. Rup
2002Developments in Biologicals1 citations
Semantic Scholar
Identification of a mouse anti-rat IgE monoclonal antibody, 44.7b, which inhibits IgE binding to RBL cells.
B. Rup, L. Kahn
1989International Archives of Allergy and Applied Immunology1 citations
Semantic Scholar
A bridging assay for detection and characterization of anti-drug antibodies to dostarlimab, a new anti-PD-1 therapeutic monoclonal antibody
M. Patterson, L. A. Beausang, B. Rup, R. Bowsher +3 more
2021AAPS Open0 citations Open access
Semantic Scholar
Unwanted Immunogenicity in Biopharmaceutical Therapy of Autoimmune Diseases
B. Rup
20150 citations
Semantic Scholar
Bioanalytical Methods and Immunogenicity Assays
B. Rup, Corinna Krinos-Fiorotti, B. Gorovits, H. Neubert
20140 citations
Semantic Scholar
Preclinical Models Used for Immunogenicity Prediction of Therapeutic Proteins
V. Brinks, D. Weinbuch, M. Baker, Yann D. Dean +4 more
2013Pharmaceutical Research0 citations
Semantic Scholar
B dogs ) in immune tolerant hemophilia TM recombinant human factor IX (BeneFix Reduced bleeding events with subcutaneous administration of
B. Rup, J. Keith, K. McCarthy, R. Schaub +5 more
20120 citations
Semantic Scholar
Contents, Vol. 89, 1989
J. Daniels, L. Kahn, Thomas R. Scott, B. Glick +55 more
19890 citations
Semantic Scholar

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