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A. Duncombe · SciRah

Researcher profile · Semantic Scholar

A. Duncombe

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A. Duncombe — researcher profile on SciRah

h-index: 24
Works: 79
Citations: 4,388

Most-cited papers

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
T. Ernst, A. Chase, J. Score, Claire E. Hidalgo-Curtis +14 more
2010Nature Genetics1,205 citations
Semantic Scholar
Mutations and prognosis in primary myelofibrosis
A. Vannucchi, T. Lasho, P. Guglielmelli, F. Biamonte +28 more
2013Leukemia779 citations Open access
Semantic Scholar
The number of prognostically detrimental mutations and prognosis in primary myelofibrosis: an international study of 797 patients
P. Guglielmelli, T. Lasho, G. Rotunno, J. Score +24 more
2014Leukemia308 citations Open access
Semantic Scholar
EZH2 mutational status predicts poor survival in myelofibrosis.
P. Guglielmelli, F. Biamonte, J. Score, Claire E. Hidalgo-Curtis +14 more
2011Blood270 citations Open access
Semantic Scholar
How common are myeloproliferative neoplasms? A systematic review and meta‐analysis
Glen J. Titmarsh, A. Duncombe, M. McMullin, M. O'Rorke +6 more
2014American journal of hematology/oncology220 citations Open access
Semantic Scholar
Attempts to optimize induction and consolidation treatment in acute myeloid leukemia: results of the MRC AML12 trial.
A. Burnett, R. Hills, D. Milligan, A. Goldstone +5 more
2010Journal of Clinical Oncology218 citations
Semantic Scholar
Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms
W. Tapper, A. Jones, R. Kralovics, A. Harutyunyan +46 more
2015Nature Communications175 citations Open access
Semantic Scholar
Guideline for the investigation and management of eosinophilia
Nauman M. Butt, J. Lambert, Sahra Ali, P. Beer +9 more
2017British Journal of Haematology161 citations Open access
Semantic Scholar
A multicentre, open, non‐comparative phase II study of a combination of fludarabine phosphate, cytarabine and granulocyte colony‐stimulating factor in relapsed and refractory acute myeloid leukaemia and de novo refractory anaemia with excess of blasts in transformation
G. Jackson, P. Taylor, Graeme M. Smith, R. Marcus +16 more
2001British Journal of Haematology110 citations Open access
Semantic Scholar
Guideline for the diagnosis and management of myelofibrosis
J. Reilly, M. McMullin, P. Beer, Nauman M. Butt +12 more
2012British Journal of Haematology107 citations Open access
Semantic Scholar
The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1
Marta Larrayoz, S. Blakemore, R. Dobson, M. Blunt +11 more
2016Leukemia103 citations
Semantic Scholar
Recurrent activating STAT5B N642H mutation in myeloid neoplasms with eosinophilia
N. Cross, Yvette Hoade, W. Tapper, Gonzalo Carreño-Tarragona +32 more
2018Leukemia74 citations Open access
Semantic Scholar
Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.
Alex R. Paterson, C. Ian Mockridge, J. Adams, S. Krysov +5 more
2012Blood62 citations
Semantic Scholar
Fatal disseminated fusarium infection in acute lymphoblastic leukaemia in complete remission
B. Austen, H. McCarthy, B. Wilkins, A. Smith +1 more
2001Journal of Clinical Pathology49 citations Open access
Semantic Scholar
Myeloproliferative neoplasm patient symptom burden and quality of life: Evidence of significant impairment compared to controls
Lesley A. Anderson, Glen James, A. Duncombe, R. Mesa +5 more
2015American journal of hematology/oncology48 citations Open access
Semantic Scholar
Environmental, lifestyle, and familial/ethnic factors associated with myeloproliferative neoplasms
L. Anderson, A. Duncombe, M. Hughes, M. Mills +2 more
2012American journal of hematology/oncology48 citations Open access
Semantic Scholar
The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model.
M. Blunt, M. Carter, Marta Larrayoz, L. Smith +15 more
2015Blood47 citations Open access
Semantic Scholar
Use of JAK inhibitors in the management of myelofibrosis: a revision of the British Committee for Standards in Haematology Guidelines for Investigation and Management of Myelofibrosis 2012
J. Reilly, M. McMullin, P. Beer, Nauman M. Butt +10 more
2014British Journal of Haematology43 citations Open access
Semantic Scholar
Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK.
S. Krysov, A. Steele, Vânia Coelho, Adam J. Linley +9 more
2014Blood41 citations Open access
Semantic Scholar
Structural and Functional Features of the B-Cell Receptor in IgG-Positive Chronic Lymphocytic Leukemia
K. Potter, C. I. Mockridge, L. Neville, I. Wheatley +5 more
2006Clinical Cancer Research41 citations Open access
Semantic Scholar
Genome instability is a consequence of transcription deficiency in patients with bone marrow failure harboring biallelic ERCC6L2 variants
H. Tummala, Arran D. Dokal, A. Walne, A. Ellison +19 more
2018Proceedings of the National Academy of Sciences of the United States of America37 citations Open access
Semantic Scholar
Results of the randomized phase IIB ARCTIC trial of low-dose rituximab in previously untreated CLL
D. Howard, T. Munir, L. McParland, Andrew Rawstron +11 more
2017Leukemia34 citations Open access
Semantic Scholar
ABC of clinical haematology: Bone marrow and stem cell transplantation
A. Duncombe
199730 citations Open access
Semantic Scholar
Modifiable Lifestyle and Medical Risk Factors Associated With Myeloproliferative Neoplasms
A. Duncombe, L. Anderson, Glen James, F. de Vocht +4 more
2020HemaSphere26 citations Open access
Semantic Scholar
Necrobiotic Xanthogranuloma Occurring in an Eyelid Scar
S. Rayner, A. Duncombe, M. Keefe, J. Theaker +1 more
2008Orbit20 citations
Semantic Scholar
Recurrent activating STAT 5 B N 642 H mutation in myeloid neoplasms 1 with eosinophilia
N. Cross, Yvette Hoade, William Tapper, Gonzalo Carreño-Tarragona +34 more
201816 citations
Semantic Scholar
Methysergide in progressive supranuclear palsy
A. Duncombe, A. Lees
1985Neurology15 citations
Semantic Scholar
Chemoimmunotherapy with rituximab, cyclophosphamide and prednisolone in IgM paraproteinemic neuropathy: evidence of sustained improvement in electrophysiological, serological and functional outcomes
N. Colchester, D. Allen, H. Katifi, T. Burt +3 more
2020Haematologica13 citations Open access
Semantic Scholar
Results of a national UK physician reported survey of COVID-19 infection in patients with a myeloproliferative neoplasm
R. Salisbury, N. Curto-Garcia, J. O'Sullivan, Frederick Chen +33 more
2021Leukemia10 citations Open access
Semantic Scholar
Monosomy 7 and Ph-positive acute lymphoblastic leukaemia: cytogenetic and molecular aspects.
S. Eridani, P. Gorman, D. Sheer, A. Duncombe +2 more
1987Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis9 citations
Semantic Scholar
The MOSAICC study: Assessing feasibility for biological sample collection in epidemiology studies and comparison of DNA yields from saliva and whole blood samples
Glen James, M. McMullin, A. Duncombe, M. Clarke +1 more
2018Annals of Human Genetics8 citations
Semantic Scholar
Prognostic Impact of EZH2 and ASXL1 Mutation in Myelofibrosis
P. Guglielmelli, F. Biamonte, J. Score, Claire E. Hidalgo-Curtis +15 more
20118 citations
Semantic Scholar
Secondary haemophagocytic lymphohistiocytosis in hospitalised COVID-19 patients as indicated by a modified HScore is infrequent and high scores do not associate with increased mortality.
M. Ardern-Jones, M. Stammers, H. Phan, F. Borca +5 more
2021Clinical medicine (London)6 citations Open access
Semantic Scholar
Patient perspectives of a diagnosis of myeloproliferative neoplasm in a case control study
M. McMullin, Glen James, A. Duncombe, F. de Vocht +3 more
2016Experimental Hematology & Oncology6 citations Open access
Semantic Scholar
High Surface IgM Levels Associate with Shorter Response Duration and Bypass of the BTK Blockade during Ibrutinib Therapy in CLL Patients
G. Chiodin, D. Dutton, E. Martino, Samantha Drennan +19 more
2019Blood5 citations Open access
Semantic Scholar
Results Of The Randomised Phase II NCRI Arctic (Attenuated dose Rituximab with ChemoTherapy In CLL) Trial Of Low Dose Rituximab In Previously Untreated CLL
P. Hillmen, D. Milligan, A. Schuh, L. McParland +11 more
20135 citations
Semantic Scholar
Lenalidomide, dexamethasone and alemtuzumab or ofatumumab in high-risk chronic lymphocytic leukaemia: final results of the NCRI CLL210 trial.
A. Pettitt, R. Jackson, S. Cicconi, F. Polydoros +22 more
2020Haematologica4 citations Open access
Semantic Scholar
Effect of the Number of Prognostically Relevant Mutated Genes on Survival and Leukemia Progression in Primary Myelofibrosis
T. Lasho, F. Biamonte, J. Score, C. Mannarelli +21 more
20134 citations
Semantic Scholar
The ERCC2 Gln/Gln polymorphism at codon 751 is not associated with leukaemic transformation in primary myelofibrosis
M. Susini, P. Guglielmelli, Ambra Spolverini, F. Biamonte +9 more
2013British Journal of Haematology4 citations
Semantic Scholar
Glioblastoma, IDH-wildtype: A New Association with IgM Paraproteinaemic Neuropathy?
Dana Lewis, N. Colchester, D. Allen, J. Nicoll +2 more
2022Case Reports in Neurology3 citations Open access
Semantic Scholar
The SF 3 B 1 inhibitor spliceostatin A ( SSA ) elicits apoptosis in Chronic Lymphocytic Leukemia cells through downregulation of Mcl-1
Marta Larrayoz, S. Blakemore, R. Dobson, M. Blunt +12 more
20153 citations
Semantic Scholar
Compression of the optic chiasm due to a lymphoreticular malignancy.
R. Howard, A. Duncombe, C. Owens, E. Graham
1987Postgraduate medical journal3 citations Open access
Semantic Scholar
A hyperinflammation clinical risk tool, HI5-NEWS2, stratifies hospitalised COVID-19 patients to associate risk of death and effect of early dexamethasone in an observational cohort
M. Ardern-Jones, H. Phan, F. Borca, M. Stammers +5 more
2023PLoS ONE2 citations Open access
Semantic Scholar
Myeloproliferative Neoplasms: An in-Depth Case-Control (MOSAICC) Study
M. McMullin, A. Duncombe, Glen J. Titmarsh, F. de Vocht +4 more
20152 citations
Semantic Scholar
Myeloproliferative Neoplasm Patient Symptom Burden and Quality of Life: Evidence of Significant Impairment Compared to Controls Using Multivariate Analysis
Lesley A. Anderson, Glen J. Titmarsh, A. Dueck, A. Duncombe +6 more
20152 citations
Semantic Scholar
Prognostic Impact of Mutations in a Large Series of Patients with Myelofibrosis
P. Guglielmelli, F. Biamonte, A. Pereira, J. Score +17 more
20122 citations
Semantic Scholar
Refractory CIDP with chronic lymphocytic leukaemia responding to chemoimmunotherapy
Dana Lewis, C. Osman, D. Allen, Ashwin A. Pinto +2 more
2020Practical Neurology1 citations
Semantic Scholar
BRIEF CO‐ADMINISTRATION OF IDELALISIB MAY IMPROVE THE LONG‐TERM EFFICACY OF FRONTLINE CHEMOIMMUNOTHERAPY IN CHRONIC LYMPHOCYTIC LEUKAEMIA: 3‐YEAR FOLLOW‐UP FROM THE RIALTO TRIAL
Andrew R. Pettitt, N. Kalakonda, S. Cicconi, C. Murphy +18 more
2019Hematological Oncology1 citations
Semantic Scholar
R‐CP CHEMOIMMUNOTHERAPY IN PATIENTS WITH IGM PARAPROTEINAEMIC NEUROPATHY PRODUCES IMPROVEMENTS IN FUNCTIONAL, ELECTROPHYSIOLOGICAL AND SEROLOGICAL OUTCOMES
A. Duncombe, N. Colchester, D. Allen, H. Katifi
20171 citations Open access
Semantic Scholar
EFFECT OF ADDING IDELALISIB TO FRONTLINE OFATUMUMAB PLUS EITHER CHLORAMBUCIL OR BENDAMUSTINE IN LESS FIT PATIENTS WITH CLL: PRELIMINARY RESULTS FROM THE NCRI RIALTO TRIAL.
Andrew R. Pettitt, N. Kalakonda, Fotis Polydoros, M. Bickerstaff +19 more
20171 citations Open access
Semantic Scholar

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