L. Smith

Most-cited papers

1. IL-4 enhances expression and function of surface IgM in CLL cells.

   M. Aguilar-Hernandez, M. Blunt, R. Dobson, Alison Yeomans +13 more

   2016Blood108 citations

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2. The dual Syk/JAK inhibitor cerdulatinib antagonises B-cell receptor and microenvironmental signaling in chronic lymphocytic leukemia

   M. Blunt, Stefan Koehrer, R. Dobson, Marta Larrayoz +15 more

   2016Clinical Cancer Research60 citations Open access

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3. The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model.

   M. Blunt, M. Carter, Marta Larrayoz, L. Smith +15 more

   2015Blood47 citations Open access

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4. Characterization of metabolic alterations of Chronic Lymphocytic Leukemia in the lymph node microenvironment.

   Zhenghao Chen, H. Simon-Molas, Gaspard Cretenet, B. Valle-Argos +12 more

   2022Blood45 citations Open access

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5. BCR Signaling Contributes to Autophagy Regulation in Chronic Lymphocytic Leukemia

   L. Smith, Annabel R. Minton, M. Blunt, Laura I. Karydis +18 more

   2019Leukemia18 citations Open access

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6. Preclinical evaluation of a novel SHIP1 phosphatase activator for inhibition of PI3K signaling in malignant B-cells

   E. Lemm, B. Valle-Argos, L. Smith, J. Richter +19 more

   2019Clinical Cancer Research16 citations Open access

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7. Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

   D. Bryant, L. Smith, Karly-Rai Rogers-Broadway, Laura I. Karydis +10 more

   2022bioRxiv6 citations Open access

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8. The Syk\Jak Inhibitor Cerdulatinib (PRT062070) Shows Promising Preclinical Activity in Chronic Lymphocytic Leukemia By Antagonising B Cell Receptor and Microenvironmental Signalling

   M. Blunt, J. Parnell, Marta Larrayoz, L. Smith +10 more

   20153 citations

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9. B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells

   Annabel R. Minton, L. Smith, D. Bryant, J. Strefford +8 more

   2022Exploration of Targeted Anti-tumor Therapy2 citations Open access

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10. Abstract 1871: Development of pelorol analogues to activate the SHIP1 lipid phosphatase; a novel paradigm to suppress B-cell receptor signaling in human B-cell cancers

    G. Packham, E. Lemm, B. Valle-Argos, L. Smith +11 more

    2018Experimental and Molecular Therapeutics1 citations

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11. Chemical Activation of the SHIP1 Inositol Lipid Phosphatase: A Novel Therapeutic Strategy to Suppress B-Cell Receptor Signaling and CXCR4 Expression in Malignant Human B Cells

    G. Packham, B. Valle-Argos, E. Lemm, L. Smith +9 more

    20161 citations

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12. Biological Significance of B Cell Receptor Mediated Regulation of Autophagy in Chronic Lymphocytic Leukemia

    L. Smith, E. Hogg, A. Haynes, J. Strefford +7 more

    20151 citations

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13. The dual Syk/JAK inhibitor cerdulatinib antagonises B-cell receptor and microenvironmental 1 signaling in chronic lymphocytic leukemia

    M. Blunt, Stefan Koehrer, R. Dobson, Marta Larrayoz +17 more

    20160 citations

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14. Regulation of B-Cell Receptor Signalling By the Tumour Microenvironment in Chronic Lymphocytic Leukemia (CLL) and Its Impact on Adhesion and miRNA Expression

    M. Blunt, R. Dobson, L. Smith, J. Strefford +9 more

    20160 citations

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15. OF THE TUMOUR MICROENVIRONMENT ON B-CELL RECEPTOR (BCR) EXPRESSION AND SIGNALLING IN CHRONIC LYMPHOCYTIC LEUKAEMIA

    R. Dobson, M. Blunt, M. Aguilar-Hernandez, M. Larrayoz-Ilundain +22 more

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