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A. Harutyunyan · SciRah

Researcher profile · Semantic Scholar

A. Harutyunyan

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A. Harutyunyan — researcher profile on SciRah

h-index: 32
Works: 79
Citations: 7,143

Most-cited papers

Somatic mutations of calreticulin in myeloproliferative neoplasms.
T. Klampfl, H. Gisslinger, A. Harutyunyan, H. Nivarthi +25 more
2013New England Journal of Medicine1,931 citations Open access
Semantic Scholar
A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease.
A. Zimprich, A. Benet-Pagès, W. Struhal, E. Graf +30 more
2011American Journal of Human Genetics893 citations Open access
Semantic Scholar
JAK2 or CALR mutation status defines subtypes of essential thrombocythemia with substantially different clinical course and outcomes.
E. Rumi, D. Pietra, V. Ferretti, T. Klampfl +16 more
2014Blood601 citations Open access
Semantic Scholar
A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms
Damla Olcaydu, A. Harutyunyan, R. Jäger, T. Berg +4 more
2009Nature Genetics378 citations
Semantic Scholar
H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape
Daniel N. Weinberg, S. Papillon-Cavanagh, Haifen Chen, Yuan Yue +21 more
2019Nature357 citations Open access
Semantic Scholar
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
A. Harutyunyan, Brian Krug, Haifen Chen, S. Papillon-Cavanagh +29 more
2019Nature Communications285 citations Open access
Semantic Scholar
p53 lesions in leukemic transformation.
A. Harutyunyan, T. Klampfl, M. Cazzola, R. Kralovics
2011New England Journal of Medicine216 citations Open access
Semantic Scholar
H3.3K27M cooperates with Trp53 loss and PDGFRA gain in mouse embryonic neural progenitor cells to induce invasive high-grade gliomas
M. Pathania, N. De Jay, Nicola Maestro, A. Harutyunyan +18 more
2017Cancer Cell212 citations Open access
Semantic Scholar
Genome integrity of myeloproliferative neoplasms in chronic phase and during disease progression.
T. Klampfl, A. Harutyunyan, T. Berg, B. Gisslinger +15 more
2011Blood187 citations Open access
Semantic Scholar
Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms
W. Tapper, A. Jones, R. Kralovics, A. Harutyunyan +46 more
2015Nature Communications175 citations Open access
Semantic Scholar
Deletions of the transcription factor Ikaros in myeloproliferative neoplasms
R. Jäger, H. Gisslinger, F. Passamonti, E. Rumi +8 more
2010Leukemia149 citations
Semantic Scholar
Histone H3.3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis
Carol C. L. Chen, Shriya Deshmukh, Selin Jessa, D. Hadjadj +60 more
2020Cell148 citations Open access
Semantic Scholar
Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas
Brian Krug, N. De Jay, A. Harutyunyan, Shriya Deshmukh +24 more
2019Cancer Cell144 citations Open access
Semantic Scholar
H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2
Siddhant U. Jain, Andrew Q. Rashoff, Samuel D. Krabbenhoft, Dominik Hoelper +10 more
2020bioRxiv116 citations Open access
Semantic Scholar
Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies
Ana Puda, Jelena D. Milosevic, T. Berg, T. Klampfl +16 more
2012American journal of hematology/oncology113 citations Open access
Semantic Scholar
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
Selin Jessa, Abdulshakour Mohammadnia, A. Harutyunyan, Maud Hulswit +30 more
2022Nature Genetics93 citations Open access
Semantic Scholar
CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis.
E. Rumi, A. Harutyunyan, D. Pietra, Jelena D. Milosevic +13 more
2014Blood91 citations Open access
Semantic Scholar
Clinical significance of genetic aberrations in secondary acute myeloid leukemia
Jelena D. Milosevic, Ana Puda, L. Malcovati, T. Berg +25 more
2012American journal of hematology/oncology89 citations Open access
Semantic Scholar
Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors.
C. Marty, C. Saint-Martin, C. Pecquet, Sarah Grosjean +14 more
2013Blood77 citations Open access
Semantic Scholar
Population genetics of familial Mediterranean fever: a review
L. Yepiskoposyan, A. Harutyunyan
2007European Journal of Human Genetics74 citations
Semantic Scholar
The role of the JAK2 GGCC haplotype and the TET2 gene in familial myeloproliferative neoplasms
Damla Olcaydu, E. Rumi, A. Harutyunyan, F. Passamonti +7 more
2011Haematologica72 citations Open access
Semantic Scholar
H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation
A. Harutyunyan, Haifen Chen, Tian-Yuan Lu, Cynthia Horth +9 more
2020Cell Reports65 citations Open access
Semantic Scholar
Pervasive H3K27 acetylation leads to ERV expression and a therapeutic vulnerability in H3K27M gliomas
Brian Krug, N. De Jay, A. Harutyunyan, Shriya Deshmukh +24 more
2019Cancer Cell59 citations Open access
Semantic Scholar
Low rate of calreticulin mutations in refractory anaemia with ring sideroblasts and marked thrombocytosis
J. Broséus, E. Lippert, A. Harutyunyan, S. Jeromin +9 more
2014Leukemia56 citations Open access
Semantic Scholar
Germline RBBP6 mutations in familial myeloproliferative neoplasms.
A. Harutyunyan, R. Giambruno, Christian Krendl, Alexey Stukalov +20 more
2016Blood54 citations Open access
Semantic Scholar
Common germline variation at the TERT locus contributes to familial clustering of myeloproliferative neoplasms
R. Jäger, A. Harutyunyan, E. Rumi, D. Pietra +5 more
2014American journal of hematology/oncology51 citations Open access
Semantic Scholar
Mutant H3 histones drive human pre-leukemic hematopoietic stem cell expansion and promote leukemic aggressiveness
Meaghan Boileau, M. Shirinian, T. Gayden, A. Harutyunyan +22 more
2019Nature Communications46 citations Open access
Semantic Scholar
LNK mutations in familial myeloproliferative neoplasms.
E. Rumi, A. Harutyunyan, D. Pietra, J. D. Milosevic Feenstra +10 more
2016Blood46 citations
Semantic Scholar
Identification of genomic aberrations associated with disease transformation by means of high‐resolution SNP array analysis in patients with myeloproliferative neoplasm
E. Rumi, A. Harutyunyan, C. Elena, D. Pietra +8 more
2011American journal of hematology/oncology43 citations Open access
Semantic Scholar
Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks
A. Chaouch, J. Berlandi, Carol C. L. Chen, Felice Frey +12 more
2021Molecules and Cells41 citations Open access
Semantic Scholar
A novel germline JAK2 mutation in familial myeloproliferative neoplasms
E. Rumi, A. Harutyunyan, I. Casetti, D. Pietra +10 more
2014American journal of hematology/oncology41 citations Open access
Semantic Scholar
Structural variants shape driver combinations and outcomes in pediatric high-grade glioma
F. Dubois, Ofer Shapira, Noah F. Greenwald, T. Zack +36 more
2021Nature Cancer36 citations Open access
Semantic Scholar
H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone
Sima Khazaei, N. De Jay, Shriya Deshmukh, Liam D. Hendrikse +27 more
2020Cancer Discovery32 citations Open access
Semantic Scholar
Human genome meeting 2016
A. K. Srivastava, Y. Wang, R. Huang, C. Skinner +496 more
2016Human Genomics23 citations Open access
Semantic Scholar
PRC2 in the driver’s seat of childhood and young adult brain tumours
Brian Krug, A. Harutyunyan, Shriya Deshmukh, N. Jabado
2021Trends in Cell Biology20 citations Open access
Semantic Scholar
Role of germline genetic factors in MPN pathogenesis.
A. Harutyunyan, R. Kralovics
2012Hematology/Oncology Clinics of North America18 citations
Semantic Scholar
Homologous recombination of wild-type JAK2, a novel early step in the development of myeloproliferative neoplasm.
M. Vilaine, Damla Olcaydu, A. Harutyunyan, Jonathan Bergeman +5 more
2011Blood18 citations
Semantic Scholar
Germline MPLW515R Mutation in a Family with Isolated Thrombocytosis
M. Vilaine, V. Gourain, C. Cleyrat, Delphine Féron +5 more
201215 citations
Semantic Scholar
Complex Patterns of Chromosome 11 Aberrations in Myeloid Malignancies Target CBL, MLL, DDB1 and LMO2
T. Klampfl, Jelena D. Milosevic, Ana Puda, Andreas Schönegger +24 more
2013PLoS ONE14 citations Open access
Semantic Scholar
Regionalized autosomal STR profiles among Armenian groups suggest disparate genetic influences.
Robert K. Lowery, Kristian J. Herrera, Dianne A Barrett, R. Rodriguez +5 more
2011American Journal of Physical Anthropology13 citations
Semantic Scholar
Deletions of the Transcription Factor Ikaros in Myeloproliferative Neoplasms at Transformation to Acute Myeloid Leukemia.
R. Jäger, H. Gisslinger, T. Berg, F. Passamonti +8 more
200912 citations
Semantic Scholar
H3.3 cooperates with Trp53 loss and PDGFRA gain in mouse embryonic neural progenitor cells to induce invasive high-grade gliomas
M. Pathania, N. De Jay, Nicola Maestro, A. Harutyunyan +22 more
20177 citations
Semantic Scholar
Allelic imbalance in CALR somatic mutagenesis
A. Harutyunyan, R. Jäger, Doris Chen, T. Berg +6 more
2015Leukemia7 citations Open access
Semantic Scholar
Rare germline variants in regions of loss of heterozygosity may influence clinical course of hematological malignancies
A. Harutyunyan, B. Gisslinger, T. Klampfl, T. Berg +3 more
2011Leukemia7 citations Open access
Semantic Scholar
Frequent Mutations in the Calreticulin Gene CALR in Myeloproliferative Neoplasms
Klampfl Thorsten, H. Gisslinger, A. Harutyunyan, H. Nivarthi +25 more
20136 citations
Semantic Scholar
Human genome meeting 2016
A. K. Srivastava, Y. Wang, R. Huang, C. Skinner +496 more
2016Human Genomics5 citations Open access
Semantic Scholar
H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs
Brian Krug, Bo Hu, Haifen Chen, Adam Ptack +28 more
2023bioRxiv4 citations Open access
Semantic Scholar
Patrilocality and recent migrations have little impact on shaping patterns of genetic structure of the armenian population
A. Harutyunyan, A. Khudoyan, L. Yepiskoposyan
2009Russian Journal of Genetics4 citations
Semantic Scholar
Paternal Lineage Analysis Supports an Armenian Rather Than a Central Asian Genetic Origin of the Hamshenis
A. Margaryan, A. Harutyunyan, Z. Khachatryan, A. Khudoyan +1 more
2012Human Biology: The Official Publication of the American Association of Anthropological Genetics3 citations Open access
Semantic Scholar
Chromosomal Aberration Network In Myeloproliferative Neoplasms
T. Klampfl, A. Harutyunyan, T. Berg, B. Gisslinger +8 more
20103 citations
Semantic Scholar

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R. Kralovics×28
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R. Kralovics — researcher profile on SciRah
T. Berg×19
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T. Berg — researcher profile on SciRah
M. Cazzola×19
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M. Cazzola — researcher profile on SciRah
E. Rumi×18
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E. Rumi — researcher profile on SciRah

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D. Pietra — researcher profile on SciRah

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N. Jabado — researcher profile on SciRah

H. Gisslinger×14

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H. Gisslinger — researcher profile on SciRah

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T. Klampfl — researcher profile on SciRah

B. Gisslinger×13

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B. Gisslinger — researcher profile on SciRah

C. Kleinman×11

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C. Kleinman — researcher profile on SciRah

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R. Jäger — researcher profile on SciRah

Jelena D. Milosevic×8

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Jelena D. Milosevic — researcher profile on SciRah