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D. Heppner · SciRah

Researcher profile · Semantic Scholar

D. Heppner

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D. Heppner — researcher profile on SciRah

h-index: 60
Works: 142
Citations: 12K

Most-cited papers

Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites.
S. Hoffman, Lucy M L Goh, T. Luke, I. Schneider +13 more
2002Journal of Infectious Diseases763 citations
Semantic Scholar
Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans
S. McConkey, W. H. Reece, V. Moorthy, D. Webster +24 more
2003Nature Medicine598 citations
Semantic Scholar
Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection.
K. Kester, J. Cummings, O. Ofori-Anyinam, Christian F. Ockenhouse +16 more
2009Journal of Infectious Diseases528 citations Open access
Semantic Scholar
Blood Stage Malaria Vaccine Eliciting High Antigen-Specific Antibody Concentrations Confers No Protection to Young Children in Western Kenya
B. Ogutu, Odika J. Apollo, Denise A. McKinney, Willis Okoth +23 more
2009PLoS ONE362 citations Open access
Semantic Scholar
Malaria Blood Stage Parasites Activate Human Plasmacytoid Dendritic Cells and Murine Dendritic Cells through a Toll-Like Receptor 9-Dependent Pathway1
S. Pichyangkul, K. Yongvanitchit, U. Kum-arb, H. Hemmi +8 more
2004Journal of Immunology300 citations Open access
Semantic Scholar
Protective Immunity Induced with Malaria Vaccine, RTS,S, Is Linked to Plasmodium falciparum Circumsporozoite Protein-Specific CD4+ and CD8+ T Cells Producing IFN-γ1
Pei-Fang Sun, R. Schwenk, K. White, J. A. Stoute +6 more
2003Journal of Immunology240 citations
Semantic Scholar
Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen-1 (AMA-1) Administered in Adjuvant System AS01B or AS02A
M. Spring, J. Cummings, C. Ockenhouse, Sheetij Dutta +29 more
2009PLoS ONE215 citations Open access
Semantic Scholar
Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research.
D. Heppner, K. Kester, C. Ockenhouse, N. Tornieporth +38 more
2005Vaccine183 citations
Semantic Scholar
Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design
Kelley VanBuskirk, Matthew T. O'Neill, P. S. de la Vega, A. Maier +13 more
2009Proceedings of the National Academy of Sciences of the United States of America182 citations Open access
Semantic Scholar
A Field Trial to Assess a Blood-Stage Malaria Vaccine
M. Thera, O. Doumbo, D. Coulibaly, M. Laurens +32 more
2011New England Journal of Medicine160 citations Open access
Semantic Scholar
Common and Divergent Immune Response Signaling Pathways Discovered in Peripheral Blood Mononuclear Cell Gene Expression Patterns in Presymptomatic and Clinically Apparent Malaria
C. Ockenhouse, Wan-Chung Hu, K. Kester, J. Cummings +7 more
2006Infection and Immunity147 citations Open access
Semantic Scholar
Update on the clinical development of candidate malaria vaccines.
W. Ballou, M. Arévalo-Herrera, D. Carucci, T. Richie +12 more
2004American Journal of Tropical Medicine and Hygiene147 citations Open access
Semantic Scholar
Evaluation of RTS,S/AS02A and RTS,S/AS01B in Adults in a High Malaria Transmission Area
M. Polhemus, Shon A. Remich, B. Ogutu, J. Waitumbi +16 more
2009PLoS ONE144 citations Open access
Semantic Scholar
First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers.
M. Spring, J. Murphy, R. Nielsen, M. Dowler +24 more
2013Vaccine134 citations
Semantic Scholar
Development of RTS,S/AS02: a purified subunit-based malaria vaccine candidate formulated with a novel adjuvant
N. Garçon, D. Heppner, J. Cohen
2003Expert Review of Vaccines131 citations
Semantic Scholar
Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research.
K. Kester, J. Cummings, Christian F. Ockenhouse, R. Nielsen +16 more
2008Vaccine123 citations Open access
Semantic Scholar
Safety and Immunogenicity of an AMA-1 Malaria Vaccine in Malian Adults: Results of a Phase 1 Randomized Controlled Trial
M. Thera, O. Doumbo, Drissa Coulibaly, D. Diallo +30 more
2008PLoS ONE122 citations Open access
Semantic Scholar
Priming with an Adenovirus 35-Circumsporozoite Protein (CS) Vaccine followed by RTS,S/AS01B Boosting Significantly Improves Immunogenicity to Plasmodium falciparum CS Compared to That with Either Malaria Vaccine Alone
V. Stewart, S. Mcgrath, P. Dubois, M. Pau +14 more
2007Infection and Immunity116 citations Open access
Semantic Scholar
Expression of genes associated with immunoproteasome processing of major histocompatibility complex peptides is indicative of protection with adjuvanted RTS,S malaria vaccine.
M. Vahey, Zhi-Ning Wang, K. Kester, James Cummings +7 more
2010Journal of Infectious Diseases110 citations Open access
Semantic Scholar
A phase I/IIa safety, immunogenicity, and efficacy bridging randomized study of a two-dose regimen of liquid and lyophilized formulations of the candidate malaria vaccine RTS,S/AS02A in malaria-naïve adults.
K. Kester, Denise A. McKinney, N. Tornieporth, Christian F. Ockenhouse +17 more
2007Vaccine110 citations
Semantic Scholar
Forest health and climate change: A British Columbia perspective
A. Woods, D. Heppner, H. Kope, J. Burleigh +1 more
2010109 citations Open access
Semantic Scholar
Development and pre-clinical analysis of a Plasmodium falciparum Merozoite Surface Protein-1(42) malaria vaccine.
E. Angov, B. Aufiero, Anne-Louise Turgeon, Michel Van Handenhove +12 more
2003Molecular and biochemical parasitology (Print)106 citations
Semantic Scholar
Induction in Humans of CD8+ and CD4+ T Cell and Antibody Responses by Sequential Immunization with Malaria DNA and Recombinant Protein1
Ruo-Bing Wang, J. Epstein, Y. Charoenvit, Fe Maria Baraceros +14 more
2004Journal of Immunology105 citations Open access
Semantic Scholar
Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A.
V. Stewart, S. Mcgrath, D. Walsh, S. Davis +11 more
2006Vaccine104 citations
Semantic Scholar
Phase 1 randomized double-blind safety and immunogenicity trial of Plasmodium falciparum malaria merozoite surface protein FMP1 vaccine, adjuvanted with AS02A, in adults in western Kenya.
J. A. Stoute, Joash Gombe, M. Withers, Joram Siangla +17 more
2007Vaccine103 citations
Semantic Scholar
Phase I safety and immunogenicity trial of FMP1/AS02A, a Plasmodium falciparum MSP-1 asexual blood stage vaccine.
C. Ockenhouse, E. Angov, K. Kester, C. Diggs +13 more
2006Vaccine103 citations
Semantic Scholar
Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naïve adults at the Walter Reed Army Institute of Research.
M. Polhemus, A. Magill, J. Cummings, K. Kester +19 more
2007Vaccine102 citations Open access
Semantic Scholar
Randomized trial of 3-dose regimens of tafenoquine (WR238605) versus low-dose primaquine for preventing Plasmodium vivax malaria relapse.
D. Walsh, P. Wilairatana, D. Tang, D. Heppner +6 more
2004Clinical Infectious Diseases100 citations Open access
Semantic Scholar
Improved T cell responses to Plasmodium falciparum circumsporozoite protein in mice and monkeys induced by a novel formulation of RTS,S vaccine antigen.
P. Mettens, P. Dubois, M. Demoitié, B. Bayat +6 more
2008Vaccine98 citations
Semantic Scholar
A clinical trial of prime-boost immunisation with the candidate malaria vaccines RTS,S/AS02A and MVA-CS.
S. Dunachie, M. Walther, J. Vuola, D. Webster +19 more
2006Vaccine98 citations
Semantic Scholar
Safety and immunogenicity of the rVSV∆G-ZEBOV-GP Ebola virus vaccine candidate in healthy adults: a phase 1b randomised, multicentre, double-blind, placebo-controlled, dose-response study.
D. Heppner, Tracy Kemp, B. K. Martin, W. J. Ramsey +34 more
2017Lancet. Infectious Diseases (Print)93 citations Open access
Semantic Scholar
High Antibody Titer against Apical Membrane Antigen-1 Is Required to Protect against Malaria in the Aotus Model
Sheetij Dutta, Joann S. Sullivan, K. Grady, J. Haynes +8 more
2009PLoS ONE93 citations Open access
Semantic Scholar
Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications.
Amed Ouattara, Shannon Takala-Harrison, M. Thera, D. Coulibaly +14 more
2013Journal of Infectious Diseases92 citations Open access
Semantic Scholar
Safety and immunogenicty of RTS,S/AS02A candidate malaria vaccine in Gambian children.
K. Bojang, Folasade Olodude, M. Pinder, O. Ofori-Anyinam +13 more
2005Vaccine91 citations
Semantic Scholar
rVSVΔG-ZEBOV-GP (also designated V920) recombinant vesicular stomatitis virus pseudotyped with Ebola Zaire Glycoprotein: Standardized template with key considerations for a risk/benefit assessment
Thomas P. Monath, P. Fast, K. Modjarrad, D. Clarke +11 more
2019Vaccine: X89 citations Open access
Semantic Scholar
Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-gamma/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection.
J. Cummings, M. Spring, R. Schwenk, Christian F. Ockenhouse +23 more
2010Vaccine89 citations
Semantic Scholar
Devices for Rapid Diagnosis of Malaria: Evaluation of Prototype Assays That Detect Plasmodium falciparum Histidine-Rich Protein 2 and a Plasmodium vivax-Specific Antigen
J. Forney, C. Wongsrichanalai, A. Magill, Leslie G Craig +16 more
2003Journal of Clinical Microbiology88 citations Open access
Semantic Scholar
Protective Immunity Induced with the RTS,S/AS Vaccine Is Associated with IL-2 and TNF-α Producing Effector and Central Memory CD4+ T Cells
J. Lumsden, R. Schwenk, Lisa Rein, P. Moris +6 more
2011PLoS ONE85 citations Open access
Semantic Scholar
Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A.
J. Epstein, Y. Charoenvit, K. Kester, Ruo-Bing Wang +18 more
2004Vaccine84 citations
Semantic Scholar
Opsonization by antigen‐specific antibodies as a mechanism of protective immunity induced by Plasmodium falciparum circumsporozoite protein‐based vaccine
R. Schwenk, L. Asher, Isaac Chalom, D. Lanar +7 more
2003Parasite immunology (Print)84 citations
Semantic Scholar
Assessing the safety and immunogenicity of recombinant vesicular stomatitis virus Ebola vaccine in healthy adults: a randomized clinical trial
M. ElSherif, Catherine Brown, D. MacKinnon-Cameron, Li Li +17 more
2017Canadian Medical Association Journal75 citations Open access
Semantic Scholar
Safety and Allele-Specific Immunogenicity of a Malaria Vaccine in Malian Adults: Results of a Phase I Randomized Trial
M. Thera, O. Doumbo, Drissa Coulibaly, D. Diallo +11 more
2006PLoS Clinical Trials75 citations Open access
Semantic Scholar
Process Development and Analysis of Liver-Stage Antigen 1, a Preerythrocyte-Stage Protein-Based Vaccine for Plasmodium falciparum
Collette J. Hillier, L. Ware, A. Barbosa, E. Angov +3 more
2005Infection and Immunity72 citations Open access
Semantic Scholar
Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study
A. Huttner, S. Agnandji, C. Combescure, J. Fernandes +41 more
2018Lancet. Infectious Diseases (Print)71 citations Open access
Semantic Scholar
Pre-clinical evaluation of the malaria vaccine candidate P. falciparum MSP1(42) formulated with novel adjuvants or with alum.
S. Pichyangkul, M. Gettayacamin, R. Miller, J. Lyon +10 more
2004Vaccine70 citations
Semantic Scholar
A multitope SARS-CoV-2 vaccine provides long-lasting B cell and T cell immunity against Delta and Omicron variants
Chang-Yi Wang, K.-P. Hwang, H. Kuo, Wen-Jiun Peng +46 more
2022Journal of Clinical Investigation66 citations Open access
Semantic Scholar
Safety and Reactogenicity of an MSP-1 Malaria Vaccine Candidate: A Randomized Phase Ib Dose-Escalation Trial in Kenyan Children
M. Withers, Denise A. McKinney, B. Ogutu, J. Waitumbi +19 more
2006PLoS Clinical Trials65 citations Open access
Semantic Scholar
Impact of RTS,S/AS02A and RTS,S/AS01B on Genotypes of P. falciparum in Adults Participating in a Malaria Vaccine Clinical Trial
J. Waitumbi, Samuel B. Anyona, Carol W. Hunja, Carolyne M. Kifude +9 more
2009PLoS ONE59 citations Open access
Semantic Scholar
Adenovirus 5 and 35 vectors expressing Plasmodium falciparum circumsporozoite surface protein elicit potent antigen-specific cellular IFN-gamma and antibody responses in mice.
Joseph P. Shott, S. Mcgrath, M. Pau, Jerome Custers +11 more
2008Vaccine59 citations
Semantic Scholar
Safety and immunogenicity of the RTS,S/AS02A candidate malaria vaccine in children aged 1–4 in Mozambique
E. Macete, J. Aponte, C. Guinovart, J. Sacarlal +14 more
2006Tropical medicine & international health50 citations Open access
Semantic Scholar

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