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Stéphane L. Bogen · SciRah

Researcher profile · Semantic Scholar

Stéphane L. Bogen

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Stéphane L. Bogen — researcher profile on SciRah

h-index: 18
Works: 72
Citations: 1,251

Most-cited papers

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor:
S. Venkatraman, Stéphane L. Bogen, A. Arasappan, F. Bennett +48 more
2006Journal of Medicinal Chemistry238 citations Open access
Semantic Scholar
Mutations Conferring Resistance to SCH6, a Novel Hepatitis C Virus NS3/4A Protease Inhibitor
M. Yi, X. Tong, A. Skelton, R. Chase +10 more
2006Journal of Biological Chemistry109 citations Open access
Semantic Scholar
Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
A. Prongay, Zhu-Yan Guo, N. Yao, J. Pichardo +27 more
2007Journal of Medicinal Chemistry97 citations Open access
Semantic Scholar
Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor.
A. Arasappan, F. Bennett, Stéphane L. Bogen, S. Venkatraman +33 more
2010ACS Medicinal Chemistry Letters87 citations Open access
Semantic Scholar
Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.
Stéphane L. Bogen, A. Arasappan, F. Bennett, Kevin X. Chen +25 more
2006Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Cyclic sulfones as novel P3-caps for hepatitis C virus NS3/4A (HCV NS3/4A) protease inhibitors: synthesis and evaluation of inhibitors with improved potency and pharmacokinetic profiles.
F. Velázquez, M. Sannigrahi, F. Bennett, R. Lovey +13 more
2010Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.
S. Venkatraman, F. Velázquez, Wanli Wu, M. Blackman +14 more
2009Journal of Medicinal Chemistry43 citations Open access
Semantic Scholar
5-Endo-Trig Radical Cyclizations of Bromomethyldimethylsilyl Diisopropylpropargylic Ethers. A Highly Diastereoselective Access to Functionalized Cyclopentanes.
Stéphane L. Bogen, M. Gulea, L. Fensterbank, M. Malacria
1999Journal of Organic Chemistry40 citations
Semantic Scholar
5-endo-trig Radical Cyclizations: A New Means to the Stereoselective Synthesis of Cyclopentanes and Diquinanes
Stéphane L. Bogen, M. Malacria
199636 citations
Semantic Scholar
Second-generation highly potent and selective inhibitors of the hepatitis C virus NS3 serine protease.
Kevin X. Chen, L. Nair, B. Vibulbhan, Weiying Yang +12 more
2009Journal of Medicinal Chemistry34 citations
Semantic Scholar
Study of a Radical Cyclizations Cascade Leading to Bicyclo[3.1.1]heptanes.
Stéphane L. Bogen, L. Fensterbank, M. Malacria
1999Journal of Organic Chemistry29 citations
Semantic Scholar
Total Synthesis of Lankacyclinol
David R. Williams, G. Cortez, Stéphane L. Bogen, Christian M Rojas
200028 citations
Semantic Scholar
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
F. Bennett, Yu-Hua Huang, S. Hendrata, R. Lovey +16 more
2010Bioorganic & Medicinal Chemistry Letters27 citations
Semantic Scholar
Studies of Acyl Nitrene Insertions. A Stereocontrolled Route toward Lankacidin Antibiotics.
David R. Williams, Christian M Rojas, Stéphane L. Bogen
1999Journal of Organic Chemistry26 citations
Semantic Scholar
Toward the back-up of boceprevir (SCH 503034): discovery of new extended P4-capped ketoamide inhibitors of hepatitis C virus NS3 serine protease with improved potency and pharmacokinetic profiles.
Stéphane L. Bogen, W. Pan, S. Ruan, L. Nair +13 more
2009Journal of Medicinal Chemistry24 citations
Semantic Scholar
Computational Study of the Effects of Mutations A156T, D168V, and D168Q on the Binding of HCV Protease Inhibitors.
Zhu-Yan Guo, A. Prongay, X. Tong, T. Fischmann +5 more
2006Journal of Chemical Theory and Computation23 citations
Semantic Scholar
Unprecedented Radical Cyclizations Cascade Leading to Bicyclo[3.1.1]Heptanes. Toward a New Generation of Radical Cascades
Stéphane L. Bogen, L. Fensterbank, M. Malacria
199720 citations
Semantic Scholar
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034.
Stéphane L. Bogen, A. Arasappan, W. Pan, S. Ruan +4 more
2008Bioorganic & Medicinal Chemistry Letters18 citations
Semantic Scholar
In vitro antiviral activity of SCH446211 (SCH6), a novel inhibitor of the hepatitis C virus NS3 serine protease.
Rong Liu, K. Abid, J. Pichardo, V. Pazienza +10 more
2006Journal of Antimicrobial Chemotherapy18 citations Open access
Semantic Scholar
Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors.
Stéphane L. Bogen, W. Pan, Craig R. Gibeau, Brian R. Lahue +22 more
2016ACS Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor.
Yao Ma, Brian R. Lahue, Craig R Gibeau, G. Shipps +4 more
2014ACS Medicinal Chemistry Letters17 citations Open access
Semantic Scholar
Toward second generation hepatitis C virus NS3 serine protease inhibitors: discovery of novel P4 modified analogues with improved potency and pharmacokinetic profile.
A. Arasappan, Angela I. Padilla, E. Jao, F. Bennett +12 more
2009Journal of Medicinal Chemistry17 citations
Semantic Scholar
Core modification of substituted piperidines as novel inhibitors of HDM2-p53 protein-protein interaction.
W. Pan, Brian R. Lahue, Yao Ma, L. Nair +4 more
2014Bioorganic & Medicinal Chemistry Letters15 citations Open access
Semantic Scholar
Discovery of novel P3 sulfonamide-capped inhibitors of HCV NS3 protease. Inhibitors with improved cellular potencies.
S. Venkatraman, Mellissa Blackman, Wanli Wu, L. Nair +11 more
2009Bioorganic & Medicinal Chemistry15 citations
Semantic Scholar
Depeptidization efforts on α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity
Stéphane L. Bogen, S. Ruan, Rong Liu, S. Agrawal +6 more
200615 citations Open access
Semantic Scholar
Discovery of potent sulfonamide P4-capped ketoamide second generation inhibitors of hepatitis C virus NS3 serine protease with favorable pharmacokinetic profiles in preclinical species.
Stéphane L. Bogen, A. Arasappan, F. Velázquez, M. Blackman +9 more
2010Bioorganic & Medicinal Chemistry14 citations
Semantic Scholar
Design of a radical translocation step through 1, n (n = 5, 6, 7) hydrogen transfers for incorporation into new radical cascades
A. Gross, L. Fensterbank, Stéphane L. Bogen, R. Thouvenot +1 more
199714 citations
Semantic Scholar
Design, synthesis, and evaluation of oxygen-containing macrocyclic peptidomimetics as inhibitors of HCV NS3 protease.
F. Velázquez, S. Venkatraman, M. Blackman, P. Pinto +8 more
2009Journal of Medicinal Chemistry13 citations Open access
Semantic Scholar
Syntheses of 4′-spirocyclic phosphono-nucleosides as potential inhibitors of hepatitis C virus NS5B polymerase
Q. Dang, Zhibo Zhang, Shuangsheng He, Yaohong Liu +5 more
201412 citations
Semantic Scholar
P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile.
L. Nair, M. Sannigrahi, Stéphane L. Bogen, P. Pinto +6 more
2010Bioorganic & Medicinal Chemistry Letters12 citations
Semantic Scholar
[3+2] Cycloaddition of trimethylenemethane (TMM) to α,β-unsaturated γ-lactam. Preparation of 5,5-fused proline surrogates
E. Jao, Stéphane L. Bogen, A. Saksena, V. Girijavallabhan
200312 citations
Semantic Scholar
Variations on radical cascades of vinyl radicals generated from bromomethyldimethylsilyl propargyl ethers
L. Fensterbank, Anne-Lise Dhimane, S. Wu, Emmanuel Lacôte +2 more
199612 citations
Semantic Scholar
Radical Cyclization of Bromomethyldimethylsilyl Propargyl Ethers. Diastereoselective Synthesis of Functionalized Cyclopentanone Precursors via a (1,5) Hydrogen-Atom Transfer.
Stéphane L. Bogen, M. Journet, M. Malacria
19949 citations
Semantic Scholar
moieties as potential inhibitors of hepatitis C virus NS5B polymerase
Q. Dang, Zhibo Zhang, B. Tang, Yang-Heon Song +6 more
20147 citations
Semantic Scholar
Synthesis of sterically hindered 3,5,5-trimethyl 2,6-dioxo tetrahydro pyrimidine as HCV protease inhibitors
L. Nair, Stéphane L. Bogen, J. DollRonald, Neng-Yang Shih +1 more
20107 citations
Semantic Scholar
Syntheses of nucleosides with a 1′,2′-β-lactam moiety as potential inhibitors of hepatitis C virus NS5B polymerase
Q. Dang, Zhibo Zhang, Yun-Feng Bai, Ruijun Sun +6 more
20146 citations
Semantic Scholar
Design and synthesis of novel fluoro amino acids: synthons for potent macrocyclic HCV NS3 protease inhibitors
L. Nair, Stéphane L. Bogen, F. Bennett, Kevin X. Chen +6 more
20106 citations
Semantic Scholar
Syntheses of 1′,2′-cyclopentyl nucleosides as potential antiviral agents
Q. Dang, Zhibo Zhang, Tong-Qian Chen, B. Tang +7 more
20145 citations
Semantic Scholar
Effect of propargylic substitution on the 5-endo-trig cyclization of bromomethyldimethylsilyl propargyl ethers
Stéphane L. Bogen, J. Goddard, L. Fensterbank, M. Malacria
20085 citations Open access
Semantic Scholar
Depeptidization efforts on P3-P2' alpha-ketoamide inhibitors of HCV NS3-4A serine protease: effect on HCV replicon activity.
Stéphane L. Bogen, S. Ruan, Rong Liu, S. Agrawal +6 more
2006Bioorganic & Medicinal Chemistry Letters5 citations
Semantic Scholar
Radical Cyclization of Bromomethyldimethylsilyl Propargyl Ethers; a General Method for the Stereoselective Synthesis of Variously Substituted Trimethylenemethane (TMM) Precursors
Stéphane L. Bogen, M. Journet, M. Malacria
19945 citations
Semantic Scholar
Preparation of (2,2-dimethylhexahydrofuro[2,3-c]pyrrol-6-yl)methanol: A conformationally restricted congener of nonproteinogenic 3-hydroxy-4-methylproline
E. Jao, Stéphane L. Bogen, A. Saksena, V. Girijavallabhan
20034 citations
Semantic Scholar
Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors.
Yuan Tian, Yao Ma, Craig R Gibeau, Brian R. Lahue +3 more
2016Bioorganic & Medicinal Chemistry Letters3 citations Open access
Semantic Scholar
134 In vitro antiviral activity of SCH6, a novel inhibitor of the hepatitis C virus NS3 serine protease
K. Abid, Rong Liu, C. Rossi, Stéphane L. Bogen +2 more
20033 citations
Semantic Scholar
Concise syntheses and HCV NS5B polymerase inhibition of (2'R)-3 and (2'S)-2'-ethynyluridine-10 and related nucleosides.
F. Bennett, A. Buevich, Hsueh-Cheng Huang, V. Girijavallabhan +15 more
2017Bioorganic & Medicinal Chemistry Letters2 citations Open access
Semantic Scholar
Totalsynthese von Lankacyclinol
David R. Williams, G. Cortez, Stéphane L. Bogen, Christian M Rojas
20002 citations
Semantic Scholar
5‐endo‐trig Radical Cyclizations: A New Means to the Stereoselective Synthesis of Cyclopentanes and Diquinanes.
Stéphane L. Bogen, M. Malacria
19962 citations
Semantic Scholar
Phe19 Modification of HDM2-p53 PPI Inhibitors to Alleviate CYP3A4 Metabolism/Mechanism-based Inhibition Liability.
Yuan Tian, Brian R. Lahue, Yao Ma, L. Nair +5 more
2022Bioorganic & Medicinal Chemistry Letters1 citations Open access
Semantic Scholar
Novel intramolecular aminohydroxylation toward the syntheses of 2′-amino-2′-ethynyl nucleosides
Yu-Hua Huang, F. Bennett, A. Buevich, V. Girijavallabhan +5 more
20211 citations
Semantic Scholar
Syntheses of Nucleosides with 2′‐Spirolactam and 2′‐Spiropyrrolidine Moieties as Potential Inhibitors of Hepatitis C Virus NS5B Polymerase.
Q. Dang, Zhibo Zhang, B. Tang, Yang-Heon Song +6 more
20141 citations
Semantic Scholar

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