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R. Lovey · SciRah

Researcher profile · Semantic Scholar

R. Lovey

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R. Lovey — researcher profile on SciRah

h-index: 18
Works: 56
Citations: 1,088

Most-cited papers

Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor:
S. Venkatraman, Stéphane L. Bogen, A. Arasappan, F. Bennett +48 more
2006Journal of Medicinal Chemistry238 citations Open access
Semantic Scholar
Antiulcer agents. 1. Gastric antisecretory and cytoprotective properties of substituted imidazo[1,2-a]pyridines.
J. Kaminski, J. Bristol, C. Puchalski, R. Lovey +6 more
1985Journal of Medicinal Chemistry104 citations
Semantic Scholar
Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
A. Prongay, Zhu-Yan Guo, N. Yao, J. Pichardo +27 more
2007Journal of Medicinal Chemistry97 citations Open access
Semantic Scholar
Antiulcer agents. 4. Conformational considerations and the antiulcer activity of substituted imidazo[1,2-a]pyridines and related analogues.
J. Kaminski, C. Puchalski, D. Solomon, R. Rizvi +6 more
1989Journal of Medicinal Chemistry61 citations
Semantic Scholar
Antiulcer agents. 2. Gastric antisecretory, cytoprotective, and metabolic properties of substituted imidazo[1,2-a]pyridines and analogues.
J. Kaminski, J. Hilbert, B. Pramanik, D. Solomon +6 more
1987Journal of Medicinal Chemistry54 citations
Semantic Scholar
A convenient synthesis of polyoxamic acid, 5-O-carbamoylpolyoxamic acid, and their unnatural D isomers
A. Saksena, R. Lovey, V. Girijavallabhan, A. Ganguly +1 more
198653 citations
Semantic Scholar
Discovery of SCH446211 (SCH6): a new ketoamide inhibitor of the HCV NS3 serine protease and HCV subgenomic RNA replication.
Stéphane L. Bogen, A. Arasappan, F. Bennett, Kevin X. Chen +25 more
2006Journal of Medicinal Chemistry49 citations Open access
Semantic Scholar
Cyclic sulfones as novel P3-caps for hepatitis C virus NS3/4A (HCV NS3/4A) protease inhibitors: synthesis and evaluation of inhibitors with improved potency and pharmacokinetic profiles.
F. Velázquez, M. Sannigrahi, F. Bennett, R. Lovey +13 more
2010Journal of Medicinal Chemistry46 citations Open access
Semantic Scholar
Pilot-Scale Lipase-Catalyzed Regioselective Acylation of Ribavirin in Anhydrous Media in the Synthesis of a Novel Prodrug Intermediate
Maria M. Tamarez, B. Morgan, G. S. Wong, Wei-Dong Tong +4 more
200332 citations
Semantic Scholar
Isobenzofurans as conformationally constrained miconazole analogues with improved antifungal potency.
R. Lovey, A. J. Elliott, J. Kaminski, D. Loebenberg +6 more
1992Journal of Medicinal Chemistry32 citations
Semantic Scholar
Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency.
A. Arasappan, F. Njoroge, T. Chan, F. Bennett +32 more
2005Bioorganic & Medicinal Chemistry Letters28 citations Open access
Semantic Scholar
The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
F. Bennett, Yu-Hua Huang, S. Hendrata, R. Lovey +16 more
2010Bioorganic & Medicinal Chemistry Letters27 citations
Semantic Scholar
Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5].
F. Bennett, A. Saksena, R. Lovey, Yi-Tsung Liu +13 more
2006Bioorganic & Medicinal Chemistry Letters27 citations
Semantic Scholar
Gastric antisecretory agents. 2. Antisecretory activity of 9-[(aminoalkyl)thio]-9H-xanthenes and 5-[(aminoalkyl)thio]-5H-[1]benzopyrano[2,3-b]pyridines.
J. Bristol, E. H. Gold, I. Gross, R. Lovey +1 more
1981Journal of Medicinal Chemistry27 citations
Semantic Scholar
Highly stereoselective access to novel 2,2,4-substituted tetrahydrofurans by halocyclization: Practical chemoenzymatic synthesis of Sch 51048, a broad-spectrum orally active antifungal agent
A. Saksena, V. Girijavallabhan, R. Lovey, E. PikeRussell +5 more
199526 citations
Semantic Scholar
Enantioselective synthesis of the optical isomers of broad-spectrum orally active antifungal azoles, Sch 42538 and Sch 45012
A. Saksena, V. Girijavallabhan, R. Lovey, E. PikeRussell +6 more
199425 citations
Semantic Scholar
Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048).
A. Nomeir, B. Pramanik, L. Heimark, F. Bennett +19 more
2008Journal of Mass Spectrometry20 citations
Semantic Scholar
PPL-catalyzed enzymatic asymmetrization of a 2-substituted prochiral 1,3-diol with remote chiral functionality: Improvements toward synthesis of the eutomers of SCH 45012
R. Lovey, A. Saksena, V. Girijavallabhan
199419 citations Open access
Semantic Scholar
A synthesis of nikkomycin Z: Improved synthesis and protection of the pyridyl γ-hydroxy-α-aminobutanoic acid component☆
A. Saksena, R. Lovey, V. Girijavallabhan, H. Guzik +1 more
199318 citations
Semantic Scholar
Stereoselective Grignard additions to N-formyl hydrazone: a concise synthesis of NoxafilR side chain and a synthesis of NoxafilR
Anil K. Saksena, V. Girijavallabhan, Hai-Yan Wang, R. Lovey +3 more
200417 citations
Semantic Scholar
A facile and efficient synthesis of 3,3-dimethyl isopropylidene proline from (+)-3-carene.
L. Nair, A. Saksena, R. Lovey, M. Sannigrahi +4 more
2010Journal of Organic Chemistry16 citations Open access
Semantic Scholar
Chiral high-performance liquid chromatographic analysis of antifungal SCH 56592 and evaluation of its chiral inversion in animals and humans.
Hong Kim, Chin-Chung Lin, M. Laughlin, R. Lovey +3 more
2000Chirality12 citations
Semantic Scholar
Gastric antisecretory agents. 1. Antisecretory and antiulcer activity of 5H-[1]benzopyrano[2,3-b]pyridin-5-ylureas and 5H-[1]benzothiopyrano[2,3-b]pyridin-5-ylureas.
J. Bristol, E. H. Gold, R. Lovey, J. Long
1981Journal of Medicinal Chemistry11 citations
Semantic Scholar
Synthesis and antifungal activity of the 2,2,5-tetrahydrofuran regioisomers of SCH 51048.
R. Lovey, A. Saksena, V. Girijavallabhan, P. Blundell +4 more
2002Bioorganic & Medicinal Chemistry Letters8 citations
Semantic Scholar
Pharmacokinetics of the active antifungal enantiomer, SCH 42427 (RR), and evaluation of its chiral inversion in animals following its oral administration and the oral administration of its racemate genaconazole (RR/SS).
Hong Kim, E. Radwanski, R. Lovey, Chin-Chung Lin +1 more
2002Chirality8 citations
Semantic Scholar
A convenient degradation of polyoxin D to uracil polyoxin C: access to key intermediates and synthesis of antifungal α-aminoacyl derivatives of UPOC
A. Cooper, J. Desai, R. Lovey, A. Saksena +5 more
19937 citations
Semantic Scholar
An Improved Synthesis of 2-Amino-3-alkyloxypyridines by a Phase-Transfer Catalyzed Ether Synthesis
J. Bristol, I. Gross, R. Lovey
19817 citations
Semantic Scholar
A Facile Synthesis of o-Nitrophenylsulfenimines and Applications to Amino Acid Synthesis
R. Lovey, A. Cooper
19946 citations
Semantic Scholar
Highly Stereoselective Access to Novel 2,2,4-Trisubstituted Tetrahydrofurans by Halocyclization: Practical Chemoenzymatic Synthesis of SCH 51048, a Broad-Spectrum Orally Active Antifungal Agent.
A. Saksena, V. Girijavallabhan, R. Lovey, E. PikeRussell +5 more
20103 citations
Semantic Scholar
Advances in the chemistry of novel broad-spectrum orally active azole antifungals: recent studies leading to the discovery of SCH 56592.
A. Saksena, V. Girijavallabhan, R. Lovey, E. PikeRussell +12 more
19973 citations
Semantic Scholar
ANTIULCER AGENTS. 1. GASTRIC ANTISECRETORY AND CYTOPROTECTIVE PROPERTIES OF SUBSTITUTED IMIDAZO(1,2-A)PYRIDINES
J. Kaminski, J. Bristol, C. Puchalski, R. Lovey +11 more
19853 citations
Semantic Scholar
Synthesis of 3,4-dihydro-4-(2-hydroxyphenyl)pyrido[2,3-d]pyrimidin-2(1H)-ones by a novel rearrangement of a 5H-[1]benzopyrano[2,3-b]pyridine derivative
J. Bristol, R. Lovey
19803 citations
Semantic Scholar
New Antifungal Agents: Synthesis and Biological Activity
V. Girijavallabhan, A. Ganguly, A. Saksena, A. Cooper +6 more
19931 citations
Semantic Scholar
Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034
V. Madison, A. Prongay, Zhu-Yan Guo, N. Yao +27 more
2008Journal of Synchrotron Radiation0 citations Open access
Semantic Scholar
Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound
A. Arasappan, F. Njoroge, T. Chan, F. Bennett +32 more
20060 citations
Semantic Scholar
Sulfur compounds as inhibitors of the NS3 serine protease of the hepatitis C virus
F. Bennett, R. Lovey, Yu-Hua Huang, S. Hendrata +11 more
20050 citations
Semantic Scholar
Proline compounds as inhibitors of NS3 serine protease for use in the treatment of infection by Hepatitis C virus.
A. Arasappan, F. Bennett, Stéphane L. Bogen, Kevin X. Chen +10 more
20030 citations
Semantic Scholar
Synthesis and Antifungal Activity of the 2,2,5‐Tetrahydrofuran Regioisomers of SCH 51048.
R. Lovey, A. Saksena, V. Girijavallabhan, P. Blundell +4 more
20020 citations
Semantic Scholar
Diaryl peptidic used as inhibitors of NS3 serine protease Hepatitis C virus.
A. Arasappan, Kevin X. Chen, V. Girijavallabhan, R. Lovey +5 more
20010 citations
Semantic Scholar
Peptides as inhibitors of the NS3 serine protease of hepatitis C virus
A. Saksena, V. Girijavallabhan, R. Lovey, E. Jao +24 more
20010 citations
Semantic Scholar
Diarylrest entfassende peptides as inhibitors of the ns-3 serinproteases of hepatitis C virus
Zhao-Ning Zhu, Zhongxiang Sun, S. Venkatraman, George F. Njoroge +5 more
20010 citations
Semantic Scholar
Sel lactate antifongique soluble a base d'azole
R. Lovey, V. Girijavallabhan, Anil K. Saksena, B. Reidenberg
19990 citations
Semantic Scholar
A process for preparing the antifungal Tetrahydrofuran
A. Saksena, V. Girijavallabhan, R. Lovey, A. Ganguly +4 more
19960 citations
Semantic Scholar
PPL‐Catalyzed Enzymatic Asymmetrization of a 2‐Substituted Prochiral 1, 3‐Diol with Remote Chiral Functionality: Improvements Toward Synthesis of the Eutomers of SCH 45012.
R. Lovey, A. Saksena, V. Girijavallabhan
19950 citations
Semantic Scholar
Sch 51048, a Novel Broad-Spectrum Orally Active Antifungal Agent: Synthesis and Preliminary Structure-Activity Profile.
A. Saksena, V. Girijavallabhan, R. Lovey, J. Desai +8 more
19950 citations
Semantic Scholar
Procede de preparation d'intermediaires de synthese d'agents antifongiques
A. Saksena, V. Girijavallabhan, R. Pike, Haiyan Wang +5 more
19940 citations
Semantic Scholar
Antifungal tri-substituted tetrahydrofurans
A. Saksena, V. Girijavallabhan, A. Ganguly, R. Lovey
19940 citations
Semantic Scholar
A Facile Synthesis of o-Nitrophenylsulfenimines and Applications to Amino Acid Synthesis.
R. Lovey, A. Cooper
19940 citations
Semantic Scholar
A process for the preparation of intermediates for the synthesis of antifungal agents
A. Saksena, V. Girijavallabhan, R. Pike, Hai-Yan Wang +5 more
19940 citations
Semantic Scholar
Composes antifongiques de tetrahydrofurane trisubstitue
A. Ganguly, V. Girijavallabhan, R. Lovey, A. Saksena
19920 citations
Semantic Scholar

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V. Girijavallabhan×35
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V. Girijavallabhan — researcher profile on SciRah
A. Saksena×32
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A. Saksena — researcher profile on SciRah
A. Ganguly×20
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F. Bennett×16
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×13

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A. Arasappan×13

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R. Pike — researcher profile on SciRah

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